JP2017536114A5 - - Google Patents

Info

Publication number

JP2017536114A5

JP2017536114A5 JP2017524014A JP2017524014A JP2017536114A5 JP 2017536114 A5 JP2017536114 A5 JP 2017536114A5 JP 2017524014 A JP2017524014 A JP 2017524014A JP 2017524014 A JP2017524014 A JP 2017524014A JP 2017536114 A5 JP2017536114 A5 JP 2017536114A5

Authority

JP

Japan

Prior art keywords

vnar

amino acid

encode

domain

codons

Prior art date

2015-10-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001413 amino acids Chemical class 0.000 claims 16
• 235000001014 amino acid Nutrition 0.000 claims 15
• 238000000034 method Methods 0.000 claims 11
• 108091033319 polynucleotide Proteins 0.000 claims 10
• 239000002157 polynucleotide Substances 0.000 claims 10
• 102000040430 polynucleotide Human genes 0.000 claims 10
• 108020004705 Codon Proteins 0.000 claims 7
• 235000018417 cysteine Nutrition 0.000 claims 6
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 6
• 239000000427 antigen Substances 0.000 claims 4
• 102000036639 antigens Human genes 0.000 claims 4
• 108091007433 antigens Proteins 0.000 claims 4
• 102000004169 proteins and genes Human genes 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 239000004472 Lysine Substances 0.000 claims 3
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
• 239000004473 Threonine Substances 0.000 claims 3
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 3
• 210000004899 c-terminal region Anatomy 0.000 claims 3
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
• 235000018102 proteins Nutrition 0.000 claims 3
• 108091006020 Fc-tagged proteins Proteins 0.000 claims 2
• 101710160107 Outer membrane protein A Proteins 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 239000013068 control sample Substances 0.000 claims 2
• 108020001507 fusion proteins Proteins 0.000 claims 2
• 102000037865 fusion proteins Human genes 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108010032595 Antibody Binding Sites Proteins 0.000 claims 1
• 241000251730 Chondrichthyes Species 0.000 claims 1
• 101100421450 Drosophila melanogaster Shark gene Proteins 0.000 claims 1
• 238000002965 ELISA Methods 0.000 claims 1
• 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
• 102000007562 Serum Albumin Human genes 0.000 claims 1
• 108010071390 Serum Albumin Proteins 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 238000000684 flow cytometry Methods 0.000 claims 1
• 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 238000002823 phage display Methods 0.000 claims 1
• 238000003498 protein array Methods 0.000 claims 1