JP2017535581A5 - - Google Patents
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- Publication number
- JP2017535581A5 JP2017535581A5 JP2017528090A JP2017528090A JP2017535581A5 JP 2017535581 A5 JP2017535581 A5 JP 2017535581A5 JP 2017528090 A JP2017528090 A JP 2017528090A JP 2017528090 A JP2017528090 A JP 2017528090A JP 2017535581 A5 JP2017535581 A5 JP 2017535581A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- pmpc
- layer
- composition
- methacryloxyloxyethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 38
- 102000004169 proteins and genes Human genes 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 32
- -1 poly (2-methacryloxyloxyethyl Chemical group 0.000 claims description 11
- 239000000126 substance Substances 0.000 claims description 9
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 claims description 8
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 7
- 239000004971 Cross linker Substances 0.000 claims description 6
- 239000000178 monomer Substances 0.000 claims description 6
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims description 6
- 102000004142 Trypsin Human genes 0.000 claims description 5
- 108090000631 Trypsin Proteins 0.000 claims description 5
- 230000001268 conjugating effect Effects 0.000 claims description 5
- 239000012588 trypsin Substances 0.000 claims description 5
- 238000001727 in vivo Methods 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 108700022034 Opsonin Proteins Proteins 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 230000001934 delay Effects 0.000 claims description 2
- 210000000987 immune system Anatomy 0.000 claims description 2
- 210000002540 macrophage Anatomy 0.000 claims description 2
- 239000002088 nanocapsule Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 230000000379 polymerizing effect Effects 0.000 claims description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462084887P | 2014-11-26 | 2014-11-26 | |
| US62/084,887 | 2014-11-26 | ||
| PCT/US2015/061838 WO2016085808A1 (en) | 2014-11-26 | 2015-11-20 | Stealth nanocapsules for protein delivery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017535581A JP2017535581A (ja) | 2017-11-30 |
| JP2017535581A5 true JP2017535581A5 (enExample) | 2018-12-27 |
| JP6802157B2 JP6802157B2 (ja) | 2020-12-16 |
Family
ID=56074921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528090A Active JP6802157B2 (ja) | 2014-11-26 | 2015-11-20 | タンパク質送達のためのステルス性ナノカプセル |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10722475B2 (enExample) |
| EP (1) | EP3223802A4 (enExample) |
| JP (1) | JP6802157B2 (enExample) |
| CN (1) | CN107530445B (enExample) |
| WO (1) | WO2016085808A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11103462B2 (en) | 2015-12-18 | 2021-08-31 | The Regents Of The University Of California | Protein nanocapsules with detachable zwitterionic coating for protein delivery |
| JP6784973B2 (ja) * | 2017-03-30 | 2020-11-18 | 国立研究開発法人産業技術総合研究所 | 単層カーボンナノチューブ |
| EP3655534B1 (en) | 2017-07-18 | 2025-07-16 | CSL Behring Gene Therapy, Inc. | Compositions and methods for treating beta-hemoglobinopathies |
| EP3717023A1 (en) * | 2017-11-29 | 2020-10-07 | Vivibaba, Inc | Compositions and methods for drug delivery |
| CN113543848A (zh) | 2018-12-23 | 2021-10-22 | 美国杰特贝林生物制品有限公司 | 具有杀伤开关的供体t细胞 |
| CN109954128A (zh) * | 2019-03-08 | 2019-07-02 | 南开大学 | 一种可干扰β-淀粉样蛋白聚集并协助清除的功能化纳米凝胶及制备方法 |
| JP7226787B2 (ja) * | 2019-04-26 | 2023-02-21 | 学校法人 関西大学 | ハイドロゲルおよびその作製方法 |
| CN115997015A (zh) | 2020-06-26 | 2023-04-21 | 美国杰特贝林生物制品有限公司 | 具有杀伤开关的供体t细胞 |
| CN112516304B (zh) * | 2020-12-29 | 2023-02-03 | 天津医科大学总医院 | 包裹静脉注射免疫球蛋白的纳米微囊和制备方法及其在制备治疗缺血性脑卒药物中的用途 |
| WO2022255479A1 (ja) * | 2021-06-04 | 2022-12-08 | タグシクス・バイオ株式会社 | 中分子化合物の血中動態改善のための中分子化合物コンジュゲート体およびその製造方法 |
| CN116920117A (zh) * | 2022-04-14 | 2023-10-24 | 上海巴久巴生物技术有限公司 | 一种与光动力染料结合的过氧化氢酶纳米胶囊，制备方法及应用 |
| CN119770675A (zh) * | 2023-10-06 | 2025-04-08 | 张铭 | 一种乳酸氧化酶纳米胶囊及其制备方法 |
| CN119837820B (zh) * | 2023-12-13 | 2025-10-10 | 上海交通大学 | 一种基于蛋白载体的活性成分透皮递送系统及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPH11322857A (ja) * | 1998-05-08 | 1999-11-26 | Nof Corp | 静電結合型高分子複合体および製造方法 |
| EP1988910B1 (en) | 2006-02-28 | 2017-12-06 | Kodiak Sciences Inc. | Acryloyloxyethylphosphorylcholine containing polymer conjugates and their preparation |
| EP2118150B1 (en) | 2007-02-14 | 2015-09-23 | Biocompatibles UK Limited | Derivatisation of biological molecules |
| CN101584860A (zh) * | 2009-04-27 | 2009-11-25 | 西安杰诺瓦生物科技有限公司 | 重组人Claudin18.2肿瘤疫苗及其制备方法 |
| EP2260873B1 (en) * | 2009-06-08 | 2019-07-24 | Biocompatibles UK Limited | Pcylation of proteins |
| US9283194B2 (en) | 2010-04-16 | 2016-03-15 | The Regents Of The University Of California | Methods for protease assisted protein delivery |
| US10016490B2 (en) | 2011-07-06 | 2018-07-10 | The Regents Of The University Of California | Multiple-enzyme nanocomplexes |
| US20140248212A1 (en) | 2011-08-05 | 2014-09-04 | The Regents Of The University Of California | Non-immunogenic positron emission tomography reporter gene systems |
| WO2013033717A1 (en) * | 2011-09-02 | 2013-03-07 | The Regents Of The University Of California | Enzyme responsive nanocapsules for protein delivery |
| EP2931903B1 (en) | 2012-12-14 | 2021-07-28 | The Regents of the University of California | Viral vector nanocapsule for targeting gene therapy and its preparation |
| CN103483480B (zh) * | 2013-09-13 | 2015-09-02 | 苏州维泰生物技术有限公司 | 一种可应用于光诱导枝接的人造细胞膜材料及其合成方法 |
-
2015
- 2015-11-20 JP JP2017528090A patent/JP6802157B2/ja active Active
- 2015-11-20 CN CN201580074565.7A patent/CN107530445B/zh active Active
- 2015-11-20 EP EP15863165.5A patent/EP3223802A4/en active Pending
- 2015-11-20 US US15/531,356 patent/US10722475B2/en active Active
- 2015-11-20 WO PCT/US2015/061838 patent/WO2016085808A1/en not_active Ceased
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