JP2017535566A - 疼痛に対する多様な活性を有する１，９−ジアザスピロウンデカン化合物 - Google Patents

疼痛に対する多様な活性を有する１，９−ジアザスピロウンデカン化合物 Download PDF

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JP2017535566A
JP2017535566A JP2017527365A JP2017527365A JP2017535566A JP 2017535566 A JP2017535566 A JP 2017535566A JP 2017527365 A JP2017527365 A JP 2017527365A JP 2017527365 A JP2017527365 A JP 2017527365A JP 2017535566 A JP2017535566 A JP 2017535566A
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JP2017535566A5 (enExample
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ヴィルヒリ−ベルナード マリーナ
ヴィルヒリ−ベルナード マリーナ
アレフレト−モリーナ カルロス
アレフレト−モリーナ カルロス
アルマンサ−ロザレス カルメン
アルマンサ−ロザレス カルメン
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Esteve Pharmaceuticals SA
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Esteve Pharmaceuticals SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2017527365A 2014-11-21 2015-11-20 疼痛に対する多様な活性を有する１，９−ジアザスピロウンデカン化合物 Ceased JP2017535566A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14382466.2 2014-11-21
EP14382466 2014-11-21
PCT/EP2015/002333 WO2016078771A1 (en) 2014-11-21 2015-11-20 1,9-diazaspiro undecane compounds having multimodal activity against pain

Publications (2)

Publication Number Publication Date
JP2017535566A true JP2017535566A (ja) 2017-11-30
JP2017535566A5 JP2017535566A5 (enExample) 2018-12-27

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JP2017527365A Ceased JP2017535566A (ja) 2014-11-21 2015-11-20 疼痛に対する多様な活性を有する１，９−ジアザスピロウンデカン化合物

Country Status (7)

Country Link
US (1) US10022359B2 (enExample)
EP (1) EP3221315A1 (enExample)
JP (1) JP2017535566A (enExample)
CN (1) CN107001368B (enExample)
CA (1) CA2967857A1 (enExample)
MX (1) MX2017006513A (enExample)
WO (1) WO2016078771A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023537357A (ja) * 2020-08-14 2023-08-31 ノバルティス アーゲー ヘテロアリール置換スピロピペリジニル誘導体及びその薬学的使用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
SI3365346T1 (sl) 2015-10-23 2020-04-30 Esteve Pharmaceuticals, S.A. Spojine oksa diazaspiro s protibolečinskim delovanjem
WO2018153545A1 (en) * 2017-02-27 2018-08-30 Laboratorios Del Dr. Esteve, S.A. Piperidine methanone derivatives having multimodal activity against pain
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013101A1 (fr) * 1991-12-27 1993-07-08 Yoshitomi Pharmaceutical Industries, Ltd. Compose de pyridonecarboxylate, son utilisation pharmaceutique et compose spiro
JPH07503247A (ja) * 1992-02-03 1995-04-06 デルタ　ファーマソウティカルズ，インコーポレイテッド オピオイドジアリールメチルピペラジンおよびピペリジン
WO2001070689A1 (en) * 2000-03-24 2001-09-27 Meiji Seika Kaisha, Ltd. DIPHENYLALKYLAMINE DERIVATIVES USEFUL AS OPIOID δ RECEPTOR AGONISTS
JP2010530395A (ja) * 2007-06-20 2010-09-09 ラボラトリオス・デル・デエレ・エステベ・エセ・ア チエノ−ピラノ誘導体
JP2013540792A (ja) * 2010-10-26 2013-11-07 ノバルティス アーゲー オレキシン受容体アンタゴニストとして有用なジアザ−スピロ［５．５］ウンデカン類
JP2016540793A (ja) * 2013-12-20 2016-12-28 ラボラトリオス・デル・デエレ・エステベ・エセ・ア 疼痛に対して多重モードの活性を有するピペリジン化合物
JP2017516817A (ja) * 2014-06-02 2017-06-22 ラボラトリオス・デル・デエレ・エステベ・エセ・ア 疼痛に対する多様な活性を有する１−オキサ−４，９−ジアザスピロウンデカン化合物のアミド誘導体
JP2017535545A (ja) * 2014-11-21 2017-11-30 ラボラトリオス・デル・デエレ・エステベ・エセ・ア 疼痛に対する多様な活性を有するスピロ−イソキノリン−１，４’−ピペリジン化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2251317B1 (es) 2004-10-14 2007-03-16 Laboratorios Del Dr. Esteve, S.A. Inhibidores del receptor sigma.
IT1394217B1 (it) * 2009-05-15 2012-06-01 Chemi Spa Metodo di preparazione di fesoterodina e/o fesoterodina fumarato.
JP6402115B2 (ja) * 2013-02-04 2018-10-10 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 神経学的疾患および状態の処置に有用なスピロ−キナゾリノン誘導体

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013101A1 (fr) * 1991-12-27 1993-07-08 Yoshitomi Pharmaceutical Industries, Ltd. Compose de pyridonecarboxylate, son utilisation pharmaceutique et compose spiro
JPH07503247A (ja) * 1992-02-03 1995-04-06 デルタ　ファーマソウティカルズ，インコーポレイテッド オピオイドジアリールメチルピペラジンおよびピペリジン
WO2001070689A1 (en) * 2000-03-24 2001-09-27 Meiji Seika Kaisha, Ltd. DIPHENYLALKYLAMINE DERIVATIVES USEFUL AS OPIOID δ RECEPTOR AGONISTS
JP2010530395A (ja) * 2007-06-20 2010-09-09 ラボラトリオス・デル・デエレ・エステベ・エセ・ア チエノ−ピラノ誘導体
JP2013540792A (ja) * 2010-10-26 2013-11-07 ノバルティス アーゲー オレキシン受容体アンタゴニストとして有用なジアザ−スピロ［５．５］ウンデカン類
JP2016540793A (ja) * 2013-12-20 2016-12-28 ラボラトリオス・デル・デエレ・エステベ・エセ・ア 疼痛に対して多重モードの活性を有するピペリジン化合物
JP2017516817A (ja) * 2014-06-02 2017-06-22 ラボラトリオス・デル・デエレ・エステベ・エセ・ア 疼痛に対する多様な活性を有する１−オキサ−４，９−ジアザスピロウンデカン化合物のアミド誘導体
JP2017535545A (ja) * 2014-11-21 2017-11-30 ラボラトリオス・デル・デエレ・エステベ・エセ・ア 疼痛に対する多様な活性を有するスピロ−イソキノリン−１，４’−ピペリジン化合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHARLOTTE E. ALLEN, ET AL.: "Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-bi", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21(18), JPN6019009172, 2013, pages 5707 - 5724, ISSN: 0003996628 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023537357A (ja) * 2020-08-14 2023-08-31 ノバルティス アーゲー ヘテロアリール置換スピロピペリジニル誘導体及びその薬学的使用
JP7545570B2 (ja) 2020-08-14 2024-09-04 ノバルティス アーゲー ヘテロアリール置換スピロピペリジニル誘導体及びその薬学的使用
JP2024123025A (ja) * 2020-08-14 2024-09-10 ノバルティス アーゲー ヘテロアリール置換スピロピペリジニル誘導体及びその薬学的使用

Also Published As

Publication number Publication date
CN107001368A (zh) 2017-08-01
MX2017006513A (es) 2018-04-11
US20170354648A1 (en) 2017-12-14
WO2016078771A1 (en) 2016-05-26
CN107001368B (zh) 2019-05-31
EP3221315A1 (en) 2017-09-27
US10022359B2 (en) 2018-07-17
CA2967857A1 (en) 2016-05-26

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