JP2017535551A5 - - Google Patents

Info

Publication number

JP2017535551A5

JP2017535551A5 JP2017526138A JP2017526138A JP2017535551A5 JP 2017535551 A5 JP2017535551 A5 JP 2017535551A5 JP 2017526138 A JP2017526138 A JP 2017526138A JP 2017526138 A JP2017526138 A JP 2017526138A JP 2017535551 A5 JP2017535551 A5 JP 2017535551A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

vegf

compound

stroke

Prior art date

2015-11-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 27
• 102000009521 Vascular Endothelial Growth Factor B Human genes 0.000 claims 19
• 108010073925 Vascular Endothelial Growth Factor B Proteins 0.000 claims 19
• 150000001875 compounds Chemical class 0.000 claims 19
• 208000006011 Stroke Diseases 0.000 claims 12
• 230000011664 signaling Effects 0.000 claims 12
• 239000003146 anticoagulant agent Substances 0.000 claims 7
• 230000002537 thrombolytic effect Effects 0.000 claims 7
• 102000004169 proteins and genes Human genes 0.000 claims 5
• 108090000623 proteins and genes Proteins 0.000 claims 5
• 208000032843 Hemorrhage Diseases 0.000 claims 3
• 208000034158 bleeding Diseases 0.000 claims 3
• 230000000740 bleeding effect Effects 0.000 claims 3
• 239000008280 blood Substances 0.000 claims 2
• 210000004369 blood Anatomy 0.000 claims 2
• 206010012601 diabetes mellitus Diseases 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 208000024891 symptom Diseases 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108010058207 Anistreplase Proteins 0.000 claims 1
• 206010048962 Brain oedema Diseases 0.000 claims 1
• 102000053642 Catalytic RNA Human genes 0.000 claims 1
• 108090000994 Catalytic RNA Proteins 0.000 claims 1
• 206010008111 Cerebral haemorrhage Diseases 0.000 claims 1
• 208000002330 Congenital Heart Defects Diseases 0.000 claims 1
• 108091027757 Deoxyribozyme Proteins 0.000 claims 1
• 108010057987 Desmodus rotundus salivary plasminogen activator alpha 1 Proteins 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 206010020772 Hypertension Diseases 0.000 claims 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
• 206010061216 Infarction Diseases 0.000 claims 1
• 208000032382 Ischaemic stroke Diseases 0.000 claims 1
• 102000007330 LDL Lipoproteins Human genes 0.000 claims 1
• 108010007622 LDL Lipoproteins Proteins 0.000 claims 1
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 108091030071 RNAI Proteins 0.000 claims 1
• 108020004459 Small interfering RNA Proteins 0.000 claims 1
• 101710145796 Staphylokinase Proteins 0.000 claims 1
• 108010023197 Streptokinase Proteins 0.000 claims 1
• 108090000373 Tissue Plasminogen Activator Proteins 0.000 claims 1
• 102000003978 Tissue Plasminogen Activator Human genes 0.000 claims 1
• 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims 1
• 102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims 1
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
• 229960000983 anistreplase Drugs 0.000 claims 1
• 230000000692 anti-sense effect Effects 0.000 claims 1
• 230000008499 blood brain barrier function Effects 0.000 claims 1
• 210000001218 blood-brain barrier Anatomy 0.000 claims 1
• 208000006752 brain edema Diseases 0.000 claims 1
• 238000007675 cardiac surgery Methods 0.000 claims 1
• 229950001282 desmoteplase Drugs 0.000 claims 1
• 230000009368 gene silencing by RNA Effects 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 230000005831 heart abnormality Effects 0.000 claims 1
• 208000019622 heart disease Diseases 0.000 claims 1
• 238000011540 hip replacement Methods 0.000 claims 1
• 230000007574 infarction Effects 0.000 claims 1
• 208000020658 intracerebral hemorrhage Diseases 0.000 claims 1
• 230000000302 ischemic effect Effects 0.000 claims 1
• 108010051044 lanoteplase Proteins 0.000 claims 1
• 229950010645 lanoteplase Drugs 0.000 claims 1
• 231100000518 lethal Toxicity 0.000 claims 1
• 230000001665 lethal effect Effects 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 108010051412 reteplase Proteins 0.000 claims 1
• 229960002917 reteplase Drugs 0.000 claims 1
• 108091092562 ribozyme Proteins 0.000 claims 1
• 229960005202 streptokinase Drugs 0.000 claims 1
• 238000001356 surgical procedure Methods 0.000 claims 1
• 229960000187 tissue plasminogen activator Drugs 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
• 229960005356 urokinase Drugs 0.000 claims 1