JP2017532378A5 - - Google Patents

Download PDF

Info

Publication number
JP2017532378A5
JP2017532378A5 JP2017538918A JP2017538918A JP2017532378A5 JP 2017532378 A5 JP2017532378 A5 JP 2017532378A5 JP 2017538918 A JP2017538918 A JP 2017538918A JP 2017538918 A JP2017538918 A JP 2017538918A JP 2017532378 A5 JP2017532378 A5 JP 2017532378A5
Authority
JP
Japan
Prior art keywords
phospholipid
polymer
liposome composition
aromatic
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017538918A
Other languages
English (en)
Japanese (ja)
Other versions
JP6505235B2 (ja
JP2017532378A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/054732 external-priority patent/WO2016057812A1/en
Publication of JP2017532378A publication Critical patent/JP2017532378A/ja
Publication of JP2017532378A5 publication Critical patent/JP2017532378A5/ja
Application granted granted Critical
Publication of JP6505235B2 publication Critical patent/JP6505235B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017538918A 2014-10-08 2015-10-08 リポソームを用いるアミロイド斑のmriイメージング Active JP6505235B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462061514P 2014-10-08 2014-10-08
US62/061,514 2014-10-08
US201562111057P 2015-02-02 2015-02-02
US62/111,057 2015-02-02
PCT/US2015/054732 WO2016057812A1 (en) 2014-10-08 2015-10-08 Mri imaging of amyloid plaque using liposomes

Publications (3)

Publication Number Publication Date
JP2017532378A JP2017532378A (ja) 2017-11-02
JP2017532378A5 true JP2017532378A5 (https=) 2018-11-22
JP6505235B2 JP6505235B2 (ja) 2019-04-24

Family

ID=55653789

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017538918A Active JP6505235B2 (ja) 2014-10-08 2015-10-08 リポソームを用いるアミロイド斑のmriイメージング

Country Status (10)

Country Link
US (4) US9744251B2 (https=)
EP (3) EP3204051B1 (https=)
JP (1) JP6505235B2 (https=)
KR (1) KR102409017B1 (https=)
CN (1) CN107106708B (https=)
AU (2) AU2015330824A1 (https=)
CA (1) CA2963941C (https=)
ES (2) ES2743704T3 (https=)
MX (1) MX371295B (https=)
WO (1) WO2016057812A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102035187B1 (ko) 2011-04-06 2019-11-08 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 지질-기반 나노입자들
MX366972B (es) 2012-01-20 2019-08-01 Ananth Annapragada Metodos y composiciones para caracterizar imagenes medicas en forma objetiva.
AU2015330824A1 (en) 2014-10-08 2017-05-25 Ananth Annapragada MRI imaging of amyloid plaque using liposomes
KR102472003B1 (ko) 2016-07-22 2022-11-29 에이씨 이뮨 에스에이 타우 단백질 응집체를 이미징하기 위한 화합물
EP3487545A1 (en) 2016-07-22 2019-05-29 AC Immune S.A. Compounds for imaging tau protein aggregates
US11052162B2 (en) 2016-09-16 2021-07-06 Texas Children's Hospital Liposomal gadolinium (GD) contrast agent “NMRX” for T1-MRI
EP3548002B1 (en) * 2016-11-30 2025-04-30 Texas Children's Hospital Hydrophilic fluorinated molecules for liposomal 19f mri probes with unique mr signatures
WO2019145291A1 (en) 2018-01-24 2019-08-01 Ac Immune Sa Gamma-carboline compounds for the detection of tau aggregates
WO2019145292A1 (en) 2018-01-24 2019-08-01 Ac Immune Sa Azacarboline compounds for the detection of tau aggregates
EP3773500A4 (en) * 2018-03-29 2022-03-16 Microvascular Therapeutics LLC COMPOSITIONS AND METHODS FOR DETECTION AND TREATMENT OF ALZHEIMER'S DISEASE
IL279219B2 (en) 2018-06-08 2024-08-01 Ac Immune Sa Novel compounds for diagnosis
US20200261605A1 (en) * 2019-01-24 2020-08-20 Alzeca Biosciences, LLC Functionalized liposomes for imaging misfolded proteins
JP7702381B2 (ja) * 2019-07-08 2025-07-03 アルゼカ バイオサイエンシズ、エルエルシー タウ病理のためのターゲティングリガンド
US11614451B2 (en) 2019-07-08 2023-03-28 Alzeca Biosciences, LLC Targeting ligands for tau pathology
CN115916263B (zh) * 2020-01-29 2025-10-03 德克萨斯儿童医院 用于淀粉样蛋白沉积mri的靶向对比剂
US11779664B2 (en) 2020-02-12 2023-10-10 Texas Children's Hospital Targeted contrast agents for MRI of alpha-synuclein deposition
EP4103239A4 (en) * 2020-02-12 2024-03-20 Texas Children's Hospital Targeted contrast agents for mri of alpha-synuclein deposition
CN115970009A (zh) * 2023-02-08 2023-04-18 丽水市中心医院 Vhpk多肽修饰的荧光纳米脂质体给药系统、其制备方法及应用
CN116869938A (zh) * 2023-07-26 2023-10-13 安徽医科大学 一种1,2,4-噁二唑-吡啶脂质体及其制备方法和应用

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204085A (en) 1985-01-08 1993-04-20 Mallinckrodt Medical, Inc. Method for enhancing the safety of metal-ligand chelates as X-ray contrast agents
WO1995026205A1 (en) 1994-03-28 1995-10-05 Nycomed Imaging A/S Liposomes
US6071532A (en) * 1996-10-15 2000-06-06 Emory University Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
DE60017787T2 (de) 1999-11-30 2006-01-05 ARIZONA BOARD OF REGENTS, on behalf of THE UNIVERSITY OF ARIZONA, Tucson Strahlung-sensitive liposomen
WO2002028441A2 (en) 2000-10-04 2002-04-11 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
US6821504B2 (en) 2001-05-23 2004-11-23 New York University Detection of alzheimer's amyloid by magnetic resonance imaging
EP1480691A4 (en) 2002-03-05 2007-11-28 Univ State Cleveland AGGLOMERATED PARTICLES FOR THE DISPOSAL OF A MEDICINAL PRODUCT IN AEROSOL FORM
EP1641742A4 (en) 2003-05-01 2006-11-29 Nst Neurosurvival Technologies COMPOUNDS BINDING SELECTIVELY TO MEMBRANES OF APOPTOTIC CELLS
US7208174B2 (en) 2003-12-18 2007-04-24 Hoffmann-La Roche Inc. Liposome compositions
US20100031378A1 (en) 2008-08-04 2010-02-04 Edwards Joel A Novel gene disruptions, compositions and methods relating thereto
US8357351B2 (en) 2004-04-21 2013-01-22 Ananth Annapragada Nano-scale contrast agents and methods of use
US7713517B2 (en) 2004-04-21 2010-05-11 Marval Biosciences, Inc. Compositions and methods for enhancing contrast in imaging
JP2008513533A (ja) 2004-09-23 2008-05-01 ゲルベ Cestイメージング用の造影剤封入システム
CA2626005A1 (en) 2005-10-13 2007-10-25 Waratah Pharmaceuticals Inc. Inositol derivatives and their uses in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence
US20070160658A1 (en) 2005-10-20 2007-07-12 The Penn State Research Foundation Delivery system for diagnostic and therapeutic agents
US20090123047A1 (en) 2007-03-21 2009-05-14 Yfantis Spyros A Method and system for characterizing prostate images
EP1982733A1 (en) 2007-04-17 2008-10-22 Bayer Schering Pharma Aktiengesellschaft Use of a contrast agent for magnetic resonance imaging of endoleaks
WO2008134618A2 (en) 2007-04-27 2008-11-06 The General Hospital Corporation Novel imaging tracers for early detection and treatment of amyloid plaques caused by alzheimer's disease and related disorders
EP2182924A1 (en) 2007-07-26 2010-05-12 Nanoscan Imaging, Llc Methods for imaging using improved nanoparticulate contrast agents
JP2011506325A (ja) 2007-12-05 2011-03-03 マーバル バイオサイエンシーズ インコーポレイテッド ナノスケールのコントラスト剤及びその使用方法
CA2711503A1 (en) * 2008-01-08 2009-07-16 Biogenerix Ag Glycoconjugation of polypeptides using oligosaccharyltransferases
ITMI20081052A1 (it) 2008-06-10 2009-12-11 Univ Milano Bicocca Liposomi in grado di legare efficacemente il peptide beta-amiloide
US20090311191A1 (en) 2008-06-13 2009-12-17 Ananth Annapragada Imaging of atherosclerotic plaques using liposomal imaging agents
WO2010017094A2 (en) 2008-07-31 2010-02-11 The General Hospital Corporation CURCUMIN DERIVATIVES FOR AMYLOID-β PLAQUE IMAGING
AR074760A1 (es) 2008-12-18 2011-02-09 Metabolex Inc Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
WO2010107990A1 (en) 2009-03-19 2010-09-23 Marval Biosciences, Inc. Compositions and methods for enhancing contrast in imaging
EP2501696B1 (en) 2009-10-15 2016-12-28 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
JP5746334B2 (ja) * 2010-06-16 2015-07-08 シマベイ セラピューティクス, インコーポレーテッド Gpr120受容体作動薬及びその使用
CN103429226A (zh) 2011-03-02 2013-12-04 森苏林公司 囊泡组合物
KR102035187B1 (ko) 2011-04-06 2019-11-08 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 지질-기반 나노입자들
GB201112056D0 (en) * 2011-07-14 2011-08-31 Univ Leuven Kath Antibodies
MX366972B (es) 2012-01-20 2019-08-01 Ananth Annapragada Metodos y composiciones para caracterizar imagenes medicas en forma objetiva.
WO2013164763A2 (en) 2012-04-30 2013-11-07 Innovative Health Diagnostics A biological complex specific for alzheimer's disease detection in vitro and use thereof
MX2015011677A (es) * 2013-03-14 2016-07-08 Celtaxsys Inc Inhibidores de leucotrieno a4 hidrolasa.
AU2015330824A1 (en) 2014-10-08 2017-05-25 Ananth Annapragada MRI imaging of amyloid plaque using liposomes

Similar Documents

Publication Publication Date Title
JP2017532378A5 (https=)
TW319763B (https=)
US20200179540A1 (en) Mri imaging of amyloid plaque using liposomes
JP6722663B2 (ja) マクロファージおよび他のマンノース結合c型レクチン受容体高発現細胞を標的化するための化合物および組成物、ならびにそれらを使用して治療するおよび診断する方法
JP6212032B2 (ja) 脂質ベースのナノ粒子
CA2575649C (en) Lanthanide rich nanoparticles, and their investigative uses in mri and related technologies
RU2012124266A (ru) Хелаты марганца и их применение в качестве контрастных агентов в магнитно-резонансной визуализации (mpb)
CN108289970A (zh) 包含mri造影剂的组合的制剂
JP2014523854A5 (https=)
JP7114074B2 (ja) 画像化のためのニトロキシドを含むアミロイド結合剤およびその治療的使用
CN102802672B (zh) 髓鞘碱性蛋白的成像
JP7663663B2 (ja) アミロイド沈着のmriのための標的造影剤
Urbanovsky et al. Lanthanide complexes of DO3A–(Dibenzylamino) methylphosphinate: effect of Protonation of the Dibenzylamino Group on the water-exchange rate and the binding of human serum albumin
Li et al. Protein MRI contrast agents as an effective approach for precision molecular imaging
Lucas et al. Comparison of a tartaric acid derived polymeric MRI contrast agent to a small molecule model chelate
Pushparaj et al. Trinuclear Gd (III) metal complex with amide core display remarkable enhancement in relaxivity
JP4786112B2 (ja) 金属イオンキレート化錯体と共役させた胆汁酸誘導体の微小血管の診断評価のための使用
Granato et al. Synthesis and relaxometric characterization of new Poly [N, N‐bis (3‐aminopropyl) glycine](PAPGly) Dendrons Gd‐based contrast agents and their in vivo study by using the dynamic contrast‐enhanced MRI technique at low field (1 T)
WO2007128567A1 (de) Verwendung von perfluoralkylhaltigen metallkomplexen als kontrastmittel zur diagnose der alzheimer krankheit
Nakajima et al. Current Clinical Issues: Deposition
Chang et al. Dynamic contrast-enhanced magnetic resonance imaging evaluation of VX2 carcinoma in a rabbit model: comparison of 1.0-M gadobutrol and 0.5-M gadopentetate dimeglumine
Petiet et al. Improvement of microscopic MR imaging of amyloid plaques with targeting and non-targeting contrast agents
US20230022136A1 (en) Diffusivity contrast agents for medical imaging
Djanashvili et al. Responsive nanozeolites: Smart porosity and surface tailoring for multimodal imaging and therapy of cancer
Fransen et al. r1 and r2 Relaxivities of Dendrons Based on a OEG‐DTPA Architecture: Effect of Gd3+ Placement and Dendron Functionalization