JP2017531041A5 - - Google Patents

Download PDF

Info

Publication number
JP2017531041A5
JP2017531041A5 JP2017538930A JP2017538930A JP2017531041A5 JP 2017531041 A5 JP2017531041 A5 JP 2017531041A5 JP 2017538930 A JP2017538930 A JP 2017538930A JP 2017538930 A JP2017538930 A JP 2017538930A JP 2017531041 A5 JP2017531041 A5 JP 2017531041A5
Authority
JP
Japan
Prior art keywords
compound
alkyl
macrocyclic compound
alkenyl
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017538930A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017531041A (ja
JP6678679B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/055317 external-priority patent/WO2016061097A1/en
Publication of JP2017531041A publication Critical patent/JP2017531041A/ja
Publication of JP2017531041A5 publication Critical patent/JP2017531041A5/ja
Application granted granted Critical
Publication of JP6678679B2 publication Critical patent/JP6678679B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017538930A 2014-10-13 2015-10-13 毛細血管拡張性運動失調症およびRad3関連(ATR)プロテインキナーゼ阻害剤 Active JP6678679B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462063176P 2014-10-13 2014-10-13
US62/063,176 2014-10-13
US201562104274P 2015-01-16 2015-01-16
US62/104,274 2015-01-16
PCT/US2015/055317 WO2016061097A1 (en) 2014-10-13 2015-10-13 Ataxia telengiectasia and rad3-related (atr) protein kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2017531041A JP2017531041A (ja) 2017-10-19
JP2017531041A5 true JP2017531041A5 (US07794700-20100914-C00125.png) 2018-11-15
JP6678679B2 JP6678679B2 (ja) 2020-04-08

Family

ID=55654998

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017538930A Active JP6678679B2 (ja) 2014-10-13 2015-10-13 毛細血管拡張性運動失調症およびRad3関連(ATR)プロテインキナーゼ阻害剤

Country Status (12)

Country Link
US (3) US9663535B2 (US07794700-20100914-C00125.png)
EP (1) EP3207031B1 (US07794700-20100914-C00125.png)
JP (1) JP6678679B2 (US07794700-20100914-C00125.png)
KR (1) KR102569226B1 (US07794700-20100914-C00125.png)
CN (1) CN107108527B (US07794700-20100914-C00125.png)
AU (1) AU2015333738B2 (US07794700-20100914-C00125.png)
BR (1) BR112017007708B8 (US07794700-20100914-C00125.png)
CA (1) CA2963973C (US07794700-20100914-C00125.png)
ES (1) ES2879441T3 (US07794700-20100914-C00125.png)
IL (1) IL251595B (US07794700-20100914-C00125.png)
MX (1) MX2017004515A (US07794700-20100914-C00125.png)
WO (1) WO2016061097A1 (US07794700-20100914-C00125.png)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016061097A1 (en) 2014-10-13 2016-04-21 Atrin Pharmaceuticals LLC Ataxia telengiectasia and rad3-related (atr) protein kinase inhibitors
WO2017180723A1 (en) * 2016-04-12 2017-10-19 Atrin Pharmaceuticals LLC Ataxia telengiectasia and rad3-related (atr) inhibitors and methods of their use
EP3630116B1 (en) 2017-05-26 2024-05-01 The Board Of Regents Of The University Of Texas System Tetrahydropyrido[4,3-d]pyrimidine inhibitors of atr kinase
CN111867590B (zh) 2017-07-13 2023-11-17 德州大学系统董事会 Atr激酶的杂环抑制剂
WO2019036641A1 (en) 2017-08-17 2019-02-21 Board Of Regents, The University Of Texas System HETEROCYCLIC INHIBITORS OF KINASE ATR
WO2019055657A1 (en) * 2017-09-14 2019-03-21 The Board Of Trustees Of The Leland Stanford Junior University BAF COMPLEX MODULATION COMPOUNDS AND METHODS OF USE
WO2019178590A1 (en) 2018-03-16 2019-09-19 Board Of Regents, The University Of Texas System Heterocyclic inhibitors of atr kinase
CN110357905B (zh) * 2018-03-26 2021-10-01 武汉誉祥医药科技有限公司 作为蛋白激酶抑制剂的大环类衍生物及其制备方法和用途
WO2020014524A1 (en) 2018-07-12 2020-01-16 The Board Of Trustees Of The Leland Stanford Junior University Methods for reversing hiv latency using baf complex modulating compounds
CN110950890B (zh) * 2018-09-27 2022-07-01 北京赛林泰医药技术有限公司 取代的咪唑并[4,5-c]喹啉大环化合物作为多靶点激酶抑制剂
KR20230088709A (ko) 2020-10-16 2023-06-20 상하이 드 노보 파마테크 컴퍼니 리미티드 트리헤테로사이클릭 유도체, 이의 약학적 조성물 및 용도
WO2023201320A1 (en) 2022-04-14 2023-10-19 Atrin Pharmaceuticals LLC Atr inhibitors
WO2023242302A1 (en) 2022-06-15 2023-12-21 Astrazeneca Ab Combination therapy for treating cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2476667E (pt) * 2003-02-26 2014-09-18 Sugen Inc Compostos de aminoheteroarilo como inibidores da proteína quinase
US7163939B2 (en) * 2003-11-05 2007-01-16 Abbott Laboratories Macrocyclic kinase inhibitors
KR101745331B1 (ko) 2008-12-19 2017-06-09 버텍스 파마슈티칼스 인코포레이티드 Atr 키나제의 억제제로서 유용한 피라진 유도체
EP2569287B1 (en) 2010-05-12 2014-07-09 Vertex Pharmaceuticals Inc. Compounds useful as inhibitors of atr kinase
WO2012125603A1 (en) * 2011-03-16 2012-09-20 Cephalon, Inc. Macrocyclic compounds as alk, fak and jak2 inhibitors
CN104169286B (zh) * 2012-03-06 2016-06-08 辉瑞大药厂 用于治疗增殖性疾病的大环衍生物
DK2836485T3 (en) * 2012-03-17 2018-04-23 Polyphor Ag CONFORMITY LIMITED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS
CN104513253A (zh) * 2013-10-01 2015-04-15 南京波尔泰药业科技有限公司 用于治疗增殖性疾病的大环化合物
WO2016061097A1 (en) 2014-10-13 2016-04-21 Atrin Pharmaceuticals LLC Ataxia telengiectasia and rad3-related (atr) protein kinase inhibitors

Similar Documents

Publication Publication Date Title
JP2017531041A5 (US07794700-20100914-C00125.png)
JP2020521740A5 (US07794700-20100914-C00125.png)
KR101364762B1 (ko) 증식성 장애의 치료를 위한 화합물
AU2006272652B2 (en) 1,2,3-triazoles inhibitors of tubulin polymerization for the treatment of proliferative disorders
JP2016504365A5 (US07794700-20100914-C00125.png)
JP2019517487A5 (US07794700-20100914-C00125.png)
JP2017511360A5 (US07794700-20100914-C00125.png)
JP2014503574A5 (US07794700-20100914-C00125.png)
JP5337491B2 (ja) スリンダクの誘導体類、その使用及びその調製
JP2018511631A5 (US07794700-20100914-C00125.png)
JP2016503799A5 (US07794700-20100914-C00125.png)
JP2017528498A5 (US07794700-20100914-C00125.png)
JP2008535902A5 (US07794700-20100914-C00125.png)
JP2016516043A5 (US07794700-20100914-C00125.png)
JP2014521688A5 (US07794700-20100914-C00125.png)
JP2019524883A5 (US07794700-20100914-C00125.png)
JP2012532136A5 (US07794700-20100914-C00125.png)
RU2017136715A (ru) Производное имидазоизоиндола, способ его получения и медицинское применение
JP2008545718A5 (US07794700-20100914-C00125.png)
JP2010528021A5 (US07794700-20100914-C00125.png)
JP2010526097A5 (US07794700-20100914-C00125.png)
JP2013503139A5 (US07794700-20100914-C00125.png)
JP2016513696A5 (US07794700-20100914-C00125.png)
JP2014524441A5 (US07794700-20100914-C00125.png)
JP2019522055A5 (US07794700-20100914-C00125.png)