JP2017531038A5 - - Google Patents
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- Publication number
- JP2017531038A5 JP2017531038A5 JP2017538466A JP2017538466A JP2017531038A5 JP 2017531038 A5 JP2017531038 A5 JP 2017531038A5 JP 2017538466 A JP2017538466 A JP 2017538466A JP 2017538466 A JP2017538466 A JP 2017538466A JP 2017531038 A5 JP2017531038 A5 JP 2017531038A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- salt
- pharmaceutical composition
- configuration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 44
- 150000003839 salts Chemical class 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 12
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 125000005843 halogen group Chemical group 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 5
- WZFOPYGRZNUWSP-UHFFFAOYSA-N 7-oxa-2-azaspiro[3.5]nonane Chemical compound C1NCC11CCOCC1 WZFOPYGRZNUWSP-UHFFFAOYSA-N 0.000 claims description 4
- 241000700605 Viruses Species 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 208000015181 infectious disease Diseases 0.000 claims description 4
- CMVJYZNBMRJICR-UHFFFAOYSA-N 2-fluoro-6-methylaniline Chemical compound CC1=CC=CC(F)=C1N CMVJYZNBMRJICR-UHFFFAOYSA-N 0.000 claims description 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 239000003443 antiviral agent Substances 0.000 claims description 2
- 239000012736 aqueous medium Substances 0.000 claims description 2
- -1 carboxylate ester Chemical class 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 230000006806 disease prevention Effects 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 229960000329 ribavirin Drugs 0.000 claims description 2
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims description 2
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 229940121649 protein inhibitor Drugs 0.000 claims 1
- 239000012268 protein inhibitor Substances 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- 239000000460 chlorine Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- GFWAQJYBSDXTOR-UHFFFAOYSA-N Cc1cccc(F)c1NC(c1cc(CCN(C(c(cc2)ccc2N)=O)c2c-3cccc2)c-3[s]1)=O Chemical compound Cc1cccc(F)c1NC(c1cc(CCN(C(c(cc2)ccc2N)=O)c2c-3cccc2)c-3[s]1)=O GFWAQJYBSDXTOR-UHFFFAOYSA-N 0.000 description 1
- 229940076851 F protein inhibitor Drugs 0.000 description 1
- 229940122277 RNA polymerase inhibitor Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229960000402 palivizumab Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14188494.0 | 2014-10-10 | ||
| EP14188494 | 2014-10-10 | ||
| PCT/GB2015/052944 WO2016055791A1 (en) | 2014-10-10 | 2015-10-08 | Novel 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017531038A JP2017531038A (ja) | 2017-10-19 |
| JP2017531038A5 true JP2017531038A5 (cg-RX-API-DMAC10.html) | 2018-11-22 |
| JP6675407B2 JP6675407B2 (ja) | 2020-04-01 |
Family
ID=51842340
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017538466A Active JP6675407B2 (ja) | 2014-10-10 | 2015-10-08 | 新規５，６−ジヒドロ−４Ｈ−ベンゾ［ｂ］チエノ−［２，３−ｄ］アゼピン誘導体 |
| JP2017538467A Withdrawn JP2017531039A (ja) | 2014-10-10 | 2015-10-08 | 新規５，６−ジヒドロ−４Ｈ−ベンゾ［ｂ］チエノ−［２，３−ｄ］アゼピン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017538467A Withdrawn JP2017531039A (ja) | 2014-10-10 | 2015-10-08 | 新規５，６−ジヒドロ−４Ｈ−ベンゾ［ｂ］チエノ−［２，３−ｄ］アゼピン誘導体 |
Country Status (13)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201701184WA (en) | 2014-10-10 | 2017-03-30 | Pulmocide Ltd | Novel 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative |
| JP6694886B2 (ja) | 2014-12-18 | 2020-05-20 | プルモシデ リミテド | ４，５−ジヒドロ−６Ｈ−チエノ［３，２−ｄ］ベンゾアゼピン誘導体及び呼吸器合胞体ウイルス（ＲＳＶ）感染を治療するためのその使用 |
| RS63653B1 (sr) | 2015-07-22 | 2022-11-30 | Enanta Pharm Inc | Benzodiazepinski derivati kao inhibitori rsv |
| WO2017123884A1 (en) | 2016-01-15 | 2017-07-20 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| EP3411028B1 (en) * | 2016-02-03 | 2021-05-05 | Janssen Sciences Ireland Unlimited Company | Combination product for treating or ameliorating respiratory syncytial virus infection |
| US10626126B2 (en) * | 2016-04-08 | 2020-04-21 | Pulmocide Limited | Compounds |
| WO2018129287A1 (en) | 2017-01-06 | 2018-07-12 | Enanta Pharmaceuticals, Inc. | Heteroaryldiazepine derivatives as rsv inhibitors |
| WO2018152413A1 (en) | 2017-02-16 | 2018-08-23 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of benzodiazepine derivatives |
| WO2018226801A1 (en) | 2017-06-07 | 2018-12-13 | Enanta Pharmaceuticals, Inc. | Aryldiazepine derivatives as rsv inhibitors |
| US11091501B2 (en) | 2017-06-30 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| WO2019006291A1 (en) * | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| WO2019067864A1 (en) | 2017-09-29 | 2019-04-04 | Enanta Pharmaceuticals, Inc. | PHARMACEUTICAL AGENTS IN COMBINATION AS INHIBITORS OF RSV |
| US10647711B2 (en) | 2017-11-13 | 2020-05-12 | Enanta Pharmaceuticals, Inc. | Azepin-2-one derivatives as RSV inhibitors |
| CN111343990B (zh) | 2017-11-13 | 2023-08-04 | 英安塔制药有限公司 | 苯并二氮杂䓬-2-酮和苯并氮杂䓬-2-酮衍生物的拆分方法 |
| US10975094B2 (en) | 2018-04-11 | 2021-04-13 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| UY38614A (es) | 2019-03-18 | 2020-10-30 | Enanta Pharm Inc | Derivados de benzodiazepinas como inhibidores del rsv |
| WO2020210246A1 (en) * | 2019-04-09 | 2020-10-15 | Enanta Pharmaceuticals, Inc, | Heterocyclic compounds as rsv inhibitors |
| MX2022003984A (es) | 2019-10-04 | 2022-07-27 | Enanta Pharm Inc | Compuestos heterociclicos antivirales. |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| US11534439B2 (en) | 2020-07-07 | 2022-12-27 | Enanta Pharmaceuticals, Inc. | Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors |
| WO2022086840A1 (en) | 2020-10-19 | 2022-04-28 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| KR20230161976A (ko) | 2021-02-26 | 2023-11-28 | 이난타 파마슈티칼스, 인코포레이티드 | 항바이러스성 헤테로사이클릭 화합물 |
| AR129003A1 (es) | 2022-04-07 | 2024-07-03 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
| WO2023211997A1 (en) | 2022-04-27 | 2023-11-02 | Enanta Pharmaceuticals, Inc. | Antiviral compounds |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5693635A (en) | 1993-07-29 | 1997-12-02 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| DE60027420T2 (de) | 1999-04-28 | 2006-11-16 | Aventis Pharma Deutschland Gmbh | Tri-aryl-säurederivate als ppar rezeptor liganden |
| CA2711644A1 (en) * | 2008-01-07 | 2009-07-16 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
| US8999969B2 (en) | 2009-07-09 | 2015-04-07 | Gilead Sciences, Inc. | Anti-RSV compounds |
| EP2488486B1 (en) | 2009-10-13 | 2019-08-14 | Ligand Pharmaceuticals Inc. | Hematopoietic growth factor mimetic small molecule compounds and their uses |
| AU2011283684B2 (en) | 2010-07-29 | 2015-08-27 | Rigel Pharmaceuticals, Inc. | AMPK-activating heterocyclic compounds and methods for using the same |
| US9464065B2 (en) | 2011-03-24 | 2016-10-11 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
| RU2017106742A (ru) | 2014-08-05 | 2018-09-06 | Элиос Биофарма, Инк. | Комбинированная терапия для лечения парамиксовируса |
| SG11201701184WA (en) * | 2014-10-10 | 2017-03-30 | Pulmocide Ltd | Novel 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative |
| WO2017123884A1 (en) | 2016-01-15 | 2017-07-20 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| EP3411028B1 (en) | 2016-02-03 | 2021-05-05 | Janssen Sciences Ireland Unlimited Company | Combination product for treating or ameliorating respiratory syncytial virus infection |
| WO2019006291A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| US11091501B2 (en) | 2017-06-30 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
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2015
- 2015-10-08 SG SG11201701184WA patent/SG11201701184WA/en unknown
- 2015-10-08 US US15/516,809 patent/US10189863B2/en active Active
- 2015-10-08 WO PCT/GB2015/052945 patent/WO2016055792A1/en not_active Ceased
- 2015-10-08 AU AU2015329789A patent/AU2015329789B2/en active Active
- 2015-10-08 CN CN201580054496.3A patent/CN106852144B/zh active Active
- 2015-10-08 JP JP2017538466A patent/JP6675407B2/ja active Active
- 2015-10-08 KR KR1020177006394A patent/KR20170058921A/ko not_active Withdrawn
- 2015-10-08 JP JP2017538467A patent/JP2017531039A/ja not_active Withdrawn
- 2015-10-08 MX MX2017004652A patent/MX2017004652A/es unknown
- 2015-10-08 EP EP15782045.7A patent/EP3204388B1/en active Active
- 2015-10-08 US US15/305,003 patent/US9732098B2/en active Active
- 2015-10-08 EA EA201790796A patent/EA201790796A8/ru unknown
- 2015-10-08 WO PCT/GB2015/052944 patent/WO2016055791A1/en not_active Ceased
- 2015-10-08 CA CA2957868A patent/CA2957868C/en active Active
- 2015-10-08 EP EP15784440.8A patent/EP3204389B1/en active Active
- 2015-10-08 BR BR112017005104-4A patent/BR112017005104B1/pt active IP Right Grant
-
2017
- 2017-02-27 IL IL250823A patent/IL250823A0/en active IP Right Grant
- 2017-07-06 US US15/642,637 patent/US9926335B2/en active Active
-
2018
- 2018-02-22 US US15/902,077 patent/US10035810B2/en active Active
- 2018-07-12 US US16/033,464 patent/US10273249B2/en active Active
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2019
- 2019-03-11 US US16/298,460 patent/US10472375B2/en active Active