JP2017531033A - 認知症における激越の処置のためのデキストロメトルファン化合物およびキニジンを含む医薬組成物 - Google Patents

認知症における激越の処置のためのデキストロメトルファン化合物およびキニジンを含む医薬組成物 Download PDF

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JP2017531033A
JP2017531033A JP2017533726A JP2017533726A JP2017531033A JP 2017531033 A JP2017531033 A JP 2017531033A JP 2017533726 A JP2017533726 A JP 2017533726A JP 2017533726 A JP2017533726 A JP 2017533726A JP 2017531033 A JP2017531033 A JP 2017531033A
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Prior art keywords
quinidine
dextromethorphan
salt
administered
deuterated
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Japanese (ja)
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JP2017531033A5 (OSRAM
Inventor
ジョーオ シファート，
ジョーオ シファート，
Original Assignee
アヴェニール ファーマシューティカルズ， インコーポレイテッド
アヴェニール ファーマシューティカルズ， インコーポレイテッド
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Publication of JP2017531033A publication Critical patent/JP2017531033A/ja
Publication of JP2017531033A5 publication Critical patent/JP2017531033A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/49—Cinchonan derivatives, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2017533726A 2014-09-14 2015-09-14 認知症における激越の処置のためのデキストロメトルファン化合物およびキニジンを含む医薬組成物 Pending JP2017531033A (ja)

Applications Claiming Priority (35)

Application Number Priority Date Filing Date Title
US201462050170P 2014-09-14 2014-09-14
US62/050,170 2014-09-14
US201462061451P 2014-10-08 2014-10-08
US62/061,451 2014-10-08
US201462063122P 2014-10-13 2014-10-13
US62/063,122 2014-10-13
US201462063861P 2014-10-14 2014-10-14
US62/063,861 2014-10-14
US201462068742P 2014-10-26 2014-10-26
US62/068,742 2014-10-26
US201562111053P 2015-02-02 2015-02-02
US62/111,053 2015-02-02
US201562111590P 2015-02-03 2015-02-03
US62/111,590 2015-02-03
US201562128446P 2015-03-04 2015-03-04
US62/128,446 2015-03-04
US201562162140P 2015-05-15 2015-05-15
US62/162,140 2015-05-15
US201562165535P 2015-05-22 2015-05-22
US62/165,535 2015-05-22
US201562169997P 2015-06-02 2015-06-02
US62/169,997 2015-06-02
US201562180026P 2015-06-15 2015-06-15
US62/180,026 2015-06-15
US201562193347P 2015-07-16 2015-07-16
US62/193,347 2015-07-16
US201562205061P 2015-08-14 2015-08-14
US62/205,061 2015-08-14
US201562216636P 2015-09-10 2015-09-10
US62/216,636 2015-09-10
US201562217470P 2015-09-11 2015-09-11
US201562217142P 2015-09-11 2015-09-11
US62/217,142 2015-09-11
US62/217,470 2015-09-11
PCT/US2015/049934 WO2016040930A1 (en) 2014-09-14 2015-09-14 Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia

Related Child Applications (1)

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JP2019201410A Division JP2020019818A (ja) 2014-09-14 2019-11-06 認知症における激越の処置のためのデキストロメトルファン化合物およびキニジンを含む医薬組成物

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JP2017531033A true JP2017531033A (ja) 2017-10-19
JP2017531033A5 JP2017531033A5 (OSRAM) 2017-11-30

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JP2017533726A Pending JP2017531033A (ja) 2014-09-14 2015-09-14 認知症における激越の処置のためのデキストロメトルファン化合物およびキニジンを含む医薬組成物
JP2019201410A Withdrawn JP2020019818A (ja) 2014-09-14 2019-11-06 認知症における激越の処置のためのデキストロメトルファン化合物およびキニジンを含む医薬組成物
JP2021036318A Active JP7360409B2 (ja) 2014-09-14 2021-03-08 認知症における激越の処置のためのデキストロメトルファン化合物およびキニジンを含む医薬組成物
JP2023096152A Pending JP2023105265A (ja) 2014-09-14 2023-06-12 認知症における激越の処置のためのデキストロメトルファン化合物およびキニジンを含む医薬組成物

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JP2019201410A Withdrawn JP2020019818A (ja) 2014-09-14 2019-11-06 認知症における激越の処置のためのデキストロメトルファン化合物およびキニジンを含む医薬組成物
JP2021036318A Active JP7360409B2 (ja) 2014-09-14 2021-03-08 認知症における激越の処置のためのデキストロメトルファン化合物およびキニジンを含む医薬組成物
JP2023096152A Pending JP2023105265A (ja) 2014-09-14 2023-06-12 認知症における激越の処置のためのデキストロメトルファン化合物およびキニジンを含む医薬組成物

Country Status (15)

Country Link
US (3) US20190111047A1 (OSRAM)
EP (4) EP4166141A1 (OSRAM)
JP (4) JP2017531033A (OSRAM)
KR (1) KR20170052684A (OSRAM)
CN (3) CN117427077A (OSRAM)
AU (3) AU2015314710A1 (OSRAM)
CA (1) CA2960031A1 (OSRAM)
IL (2) IL250786A0 (OSRAM)
MX (3) MX2017003066A (OSRAM)
MY (1) MY198587A (OSRAM)
PH (1) PH12017500444A1 (OSRAM)
RU (1) RU2017112747A (OSRAM)
SG (2) SG10201901242PA (OSRAM)
TW (3) TW201613591A (OSRAM)
WO (1) WO2016040930A1 (OSRAM)

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JP2022516361A (ja) * 2019-01-07 2022-02-25 アンテシップ バイオベンチャーズ トゥー エルエルシー うつ病の治療のためのデキストロメトルファンおよびブプロピオンの組み合わせ
JP2023523373A (ja) * 2020-04-27 2023-06-02 アバニア ファーマシューティカルズ， インコーポレイテッド アルツハイマー病に関連する激越を治療する方法

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CN113209042A (zh) * 2021-05-28 2021-08-06 珠海润都制药股份有限公司 一种氢溴酸右美沙芬硫酸奎尼丁胶囊及其制备方法
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KR20250129211A (ko) 2024-02-22 2025-08-29 단국대학교 천안캠퍼스 산학협력단 데가렐릭스를 유효성분으로 포함하는 신경 질환 예방 또는 치료용 약학적 조성물

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
JP2022516361A (ja) * 2019-01-07 2022-02-25 アンテシップ バイオベンチャーズ トゥー エルエルシー うつ病の治療のためのデキストロメトルファンおよびブプロピオンの組み合わせ
JP2023523373A (ja) * 2020-04-27 2023-06-02 アバニア ファーマシューティカルズ， インコーポレイテッド アルツハイマー病に関連する激越を治療する方法

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IL250786A0 (en) 2017-04-30
EP4166141A1 (en) 2023-04-19
RU2017112747A (ru) 2018-10-15
AU2020289733A1 (en) 2021-01-21
CN107072990A (zh) 2017-08-18
EP3932907A2 (en) 2022-01-05
MY198587A (en) 2023-09-06
TWI869633B (zh) 2025-01-11
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