JP2017530373A5 - - Google Patents
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- Publication number
- JP2017530373A5 JP2017530373A5 JP2017533721A JP2017533721A JP2017530373A5 JP 2017530373 A5 JP2017530373 A5 JP 2017530373A5 JP 2017533721 A JP2017533721 A JP 2017533721A JP 2017533721 A JP2017533721 A JP 2017533721A JP 2017530373 A5 JP2017530373 A5 JP 2017530373A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- soluble
- sample
- misfolded
- soluble misfolded
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 claims 131
- 108090000623 proteins and genes Proteins 0.000 claims 131
- 239000000203 mixture Substances 0.000 claims 32
- 239000000178 monomer Substances 0.000 claims 24
- 230000003321 amplification Effects 0.000 claims 11
- 238000003199 nucleic acid amplification method Methods 0.000 claims 11
- 102000004965 antibodies Human genes 0.000 claims 9
- 108090001123 antibodies Proteins 0.000 claims 9
- 239000012530 fluid Substances 0.000 claims 6
- -1 m-I-stilbene Chemical compound 0.000 claims 6
- 239000011780 sodium chloride Substances 0.000 claims 6
- 206010012289 Dementia Diseases 0.000 claims 5
- 230000001149 cognitive Effects 0.000 claims 5
- IQFVPQOLBLOTPF-HKXUKFGYSA-L Congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 claims 4
- 241000282414 Homo sapiens Species 0.000 claims 4
- 102000030002 Prion Proteins Human genes 0.000 claims 4
- 108091000054 Prion Proteins Proteins 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 238000004166 bioassay Methods 0.000 claims 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 4
- 238000000159 protein binding assay Methods 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- JADVWWSKYZXRGX-UHFFFAOYSA-M thioflavin T Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1C1=[N+](C)C2=CC=C(C)C=C2S1 JADVWWSKYZXRGX-UHFFFAOYSA-M 0.000 claims 4
- 238000004220 aggregation Methods 0.000 claims 3
- 230000002776 aggregation Effects 0.000 claims 3
- 230000000875 corresponding Effects 0.000 claims 3
- RNZSUFNTAWGTJP-CZYCKNNWSA-N (3E)-3-[[4-[4-[(2E)-2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]phenyl]phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylic acid Chemical compound C1=CC(=O)C(C(=O)O)=C\C1=N\NC1=CC=C(C=2C=CC(N\N=C/3C=C(C(=O)C=C\3)C(O)=O)=CC=2)C=C1 RNZSUFNTAWGTJP-CZYCKNNWSA-N 0.000 claims 2
- IAVCEBMLYVGBLA-UHFFFAOYSA-N 2-[1-[6-[2-fluoroethyl(methyl)amino]naphthalen-2-yl]ethylidene]propanedinitrile Chemical compound C1=C(C(C)=C(C#N)C#N)C=CC2=CC(N(CCF)C)=CC=C21 IAVCEBMLYVGBLA-UHFFFAOYSA-N 0.000 claims 2
- QEFHOXDSUONGRN-UHFFFAOYSA-N 3,5-dihydro-2H-imidazo[1,2-b]pyrazole Chemical compound N1C=CC2=NCCN21 QEFHOXDSUONGRN-UHFFFAOYSA-N 0.000 claims 2
- 241000282979 Alces alces Species 0.000 claims 2
- 210000004381 Amniotic Fluid Anatomy 0.000 claims 2
- 206010003445 Ascites Diseases 0.000 claims 2
- 239000007992 BES buffer Substances 0.000 claims 2
- 210000000941 Bile Anatomy 0.000 claims 2
- 210000004369 Blood Anatomy 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 2
- 241000282472 Canis lupus familiaris Species 0.000 claims 2
- 241000283707 Capra Species 0.000 claims 2
- 210000001175 Cerebrospinal Fluid Anatomy 0.000 claims 2
- 210000002939 Cerumen Anatomy 0.000 claims 2
- 206010050337 Cerumen impaction Diseases 0.000 claims 2
- 241000282994 Cervidae Species 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 241000283073 Equus caballus Species 0.000 claims 2
- 210000000416 Exudates and Transudates Anatomy 0.000 claims 2
- 210000003608 Feces Anatomy 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N HEPES Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 2
- 239000007995 HEPES buffer Substances 0.000 claims 2
- 210000002751 Lymph Anatomy 0.000 claims 2
- 239000007987 MES buffer Substances 0.000 claims 2
- 239000007993 MOPS buffer Substances 0.000 claims 2
- 210000004080 Milk Anatomy 0.000 claims 2
- 210000004400 Mucous Membrane Anatomy 0.000 claims 2
- 210000003097 Mucus Anatomy 0.000 claims 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 2
- 241000283898 Ovis Species 0.000 claims 2
- 239000007990 PIPES buffer Substances 0.000 claims 2
- 210000002381 Plasma Anatomy 0.000 claims 2
- 208000002151 Pleural Effusion Diseases 0.000 claims 2
- 229920002367 Polyisobutene Polymers 0.000 claims 2
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 210000004915 Pus Anatomy 0.000 claims 2
- 241000700159 Rattus Species 0.000 claims 2
- 210000003296 Saliva Anatomy 0.000 claims 2
- 210000003491 Skin Anatomy 0.000 claims 2
- 241000282898 Sus scrofa Species 0.000 claims 2
- 210000001179 Synovial Fluid Anatomy 0.000 claims 2
- 239000007994 TES buffer Substances 0.000 claims 2
- 210000001138 Tears Anatomy 0.000 claims 2
- 210000002700 Urine Anatomy 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 238000004630 atomic force microscopy Methods 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 230000000052 comparative effect Effects 0.000 claims 2
- 238000001493 electron microscopy Methods 0.000 claims 2
- 230000002496 gastric Effects 0.000 claims 2
- 238000003018 immunoassay Methods 0.000 claims 2
- 238000001114 immunoprecipitation Methods 0.000 claims 2
- 239000008267 milk Substances 0.000 claims 2
- 235000013336 milk Nutrition 0.000 claims 2
- 229920000123 polythiophene Polymers 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 230000002285 radioactive Effects 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
- 238000004611 spectroscopical analysis Methods 0.000 claims 2
- 238000001262 western blot Methods 0.000 claims 2
- KLFRZDOQQDHVSS-UHFFFAOYSA-N 2-[[5-[5-(4-hydroxyphenyl)thiophen-2-yl]thiophen-2-yl]methylidene]propanedinitrile Chemical compound C1=CC(O)=CC=C1C1=CC=C(C=2SC(C=C(C#N)C#N)=CC=2)S1 KLFRZDOQQDHVSS-UHFFFAOYSA-N 0.000 claims 1
- 102000003802 alpha-Synuclein Human genes 0.000 claims 1
- 108090000185 alpha-Synuclein Proteins 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 102000034387 fluorescent proteins Human genes 0.000 claims 1
- 108091006031 fluorescent proteins Proteins 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000002797 proteolythic Effects 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021081274A JP7104943B2 (ja) | 2014-09-11 | 2021-05-12 | ミスフォールディングタンパク質の検出 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462049306P | 2014-09-11 | 2014-09-11 | |
| US62/049,306 | 2014-09-11 | ||
| PCT/US2015/049844 WO2016040907A1 (en) | 2014-09-11 | 2015-09-11 | Detection of misfolded proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021081274A Division JP7104943B2 (ja) | 2014-09-11 | 2021-05-12 | ミスフォールディングタンパク質の検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530373A JP2017530373A (ja) | 2017-10-12 |
| JP2017530373A5 true JP2017530373A5 (US07794700-20100914-C00194.png) | 2018-10-25 |
| JP6980953B2 JP6980953B2 (ja) | 2021-12-15 |
Family
ID=55454515
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533721A Active JP6980953B2 (ja) | 2014-09-11 | 2015-09-11 | ミスフォールディングタンパク質の検出 |
| JP2021081274A Active JP7104943B2 (ja) | 2014-09-11 | 2021-05-12 | ミスフォールディングタンパク質の検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021081274A Active JP7104943B2 (ja) | 2014-09-11 | 2021-05-12 | ミスフォールディングタンパク質の検出 |
Country Status (15)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016040905A1 (en) | 2014-09-11 | 2016-03-17 | Board Of Regents Of The University Of Texas System | Detection of misfolded alpha synuclein protein |
| GB201611840D0 (en) * | 2016-07-07 | 2016-08-24 | Univ Court Of The Univ Of Edinburgh The | Alpha-synuclein detection assay |
| SG11201906947SA (en) | 2017-02-17 | 2019-08-27 | Bristol Myers Squibb Co | Antibodies to alpha-synuclein and uses thereof |
| EP3635393A4 (en) * | 2017-05-16 | 2021-03-10 | Claudio Soto-Jara | DETECTION OF MISFOLDED TAU PROTEIN |
| EP3692373A1 (en) * | 2017-10-02 | 2020-08-12 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Assay for the detection of alpha-synuclein seeding activity associated with synucleinopathies |
| GB201720970D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
| GB201720975D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
| US20200309796A1 (en) * | 2017-12-21 | 2020-10-01 | H. Lundbeck A/S | Assay, method and treatment of alpha-synucleinopathies |
| CN108088816A (zh) * | 2018-01-23 | 2018-05-29 | 深圳市国赛生物技术有限公司 | 小型特定蛋白分析仪 |
| GB201803553D0 (en) | 2018-03-06 | 2018-04-18 | Univ Newcastle | Detection of pathological protein aggregation |
| WO2019222554A2 (en) * | 2018-05-16 | 2019-11-21 | Amprion, Inc. | Detection of brain injury or neurological disease using tau protein |
| CN112585685A (zh) * | 2018-09-21 | 2021-03-30 | 渊慧科技有限公司 | 确定蛋白结构的机器学习 |
| JP7376040B2 (ja) * | 2019-09-03 | 2023-11-08 | 国立大学法人京都工芸繊維大学 | 神経変性疾患におけるバイオマーカー分子の検出方法 |
| WO2021046174A1 (en) * | 2019-09-04 | 2021-03-11 | Amprion, Inc. | Alpha-synuclein detection using beads |
| KR102277871B1 (ko) * | 2019-12-17 | 2021-07-15 | 원광대학교산학협력단 | 소변의 알파-씨누클레인 중합체 측정에 의한 파킨슨병 진단 정보의 수집방법 및 그 키트 |
| WO2021198098A1 (en) | 2020-04-03 | 2021-10-07 | Universität Zürich | Improved method of detecting biomarkers in a biological sample |
| CA3199642A1 (en) * | 2020-11-21 | 2022-05-27 | Shuwen Biotech Co. Ltd. | Apparatus and method for detecting misfolded protein in biological sample |
| WO2022221876A1 (en) * | 2021-04-15 | 2022-10-20 | The Brigham And Women's Hospital, Inc. | Digital protein misfolding assays |
| CN114199875B (zh) * | 2022-02-18 | 2022-05-20 | 之江实验室 | 一种蛋白质多聚体是否可作为力缓冲剂的判断方法及装置 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE335204T1 (de) | 2000-07-07 | 2006-08-15 | Applied Research Systems | Frühdiagnose von konformationellen erkrankungen |
| WO2002054083A2 (en) | 2001-01-03 | 2002-07-11 | Ortho-Mcneil Pharmaceutical, Inc. | Alpha synuclein aggregation assays |
| GB0203446D0 (en) * | 2002-02-14 | 2002-04-03 | Univ Lancaster | Detection and/or monitoring of synuclein-related diseases |
| EP1820806A1 (en) * | 2006-02-16 | 2007-08-22 | Crossbeta Biosciences B.V. | Affinity regions |
| AU2006214463B2 (en) * | 2005-02-15 | 2012-08-30 | Presympto, Inc. | Method for detecting misfolded proteins and prions |
| ATE528008T1 (de) * | 2006-05-19 | 2011-10-15 | Alnylam Pharmaceuticals Inc | Rnai-modulation von aha und ihre therapeutische verwendung |
| EP2074222A4 (en) * | 2006-09-06 | 2010-03-03 | Univ Texas | METHODS AND COMPOSITIONS FOR DETECTION OF PROTEIN FOLDING DISORDERS |
| JP2010043865A (ja) * | 2006-12-12 | 2010-02-25 | Olympus Corp | 異常型プリオンの検出方法 |
| JP2013511734A (ja) * | 2009-11-24 | 2013-04-04 | プロビオドルグ エージー | アルツハイマー病又は軽度認知障害の診断のための新規診断方法 |
| US9133343B2 (en) * | 2009-11-30 | 2015-09-15 | Enzo Biochem, Inc. | Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications |
| EP2666020A1 (en) * | 2011-01-18 | 2013-11-27 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Methods for amplification and detection of prions |
| US9534044B2 (en) | 2013-02-28 | 2017-01-03 | United Arab Emirates University | Alpha-synuclein antibodies and uses thereof |
| WO2016040903A1 (en) * | 2014-09-11 | 2016-03-17 | Board Of Regents Of The University Of Texas System | Detection of misfolded amyloid beta protein |
-
2015
- 2015-09-11 EP EP23189057.5A patent/EP4292654A3/en active Pending
- 2015-09-11 CN CN201580058606.3A patent/CN107208125A/zh active Pending
- 2015-09-11 PL PL15839278.7T patent/PL3191599T3/pl unknown
- 2015-09-11 JP JP2017533721A patent/JP6980953B2/ja active Active
- 2015-09-11 HR HRP20231232TT patent/HRP20231232T1/hr unknown
- 2015-09-11 US US14/852,478 patent/US20160077112A1/en not_active Abandoned
- 2015-09-11 KR KR1020177009707A patent/KR102448128B1/ko active IP Right Grant
- 2015-09-11 BR BR112017004899A patent/BR112017004899A2/pt active Search and Examination
- 2015-09-11 SG SG11201701953RA patent/SG11201701953RA/en unknown
- 2015-09-11 CA CA2960830A patent/CA2960830C/en active Active
- 2015-09-11 EP EP15839278.7A patent/EP3191599B1/en active Active
- 2015-09-11 MX MX2017003269A patent/MX2017003269A/es unknown
- 2015-09-11 WO PCT/US2015/049844 patent/WO2016040907A1/en active Application Filing
- 2015-09-11 SG SG10202008464UA patent/SG10202008464UA/en unknown
- 2015-09-11 AU AU2015314783A patent/AU2015314783B2/en active Active
- 2015-09-11 ES ES15839278T patent/ES2953855T3/es active Active
-
2017
- 2017-03-09 IL IL251052A patent/IL251052B/en unknown
-
2021
- 2021-05-12 JP JP2021081274A patent/JP7104943B2/ja active Active
-
2022
- 2022-03-30 IL IL291809A patent/IL291809B2/en unknown
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