JP2017528505A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017528505A5 JP2017528505A5 JP2017516375A JP2017516375A JP2017528505A5 JP 2017528505 A5 JP2017528505 A5 JP 2017528505A5 JP 2017516375 A JP2017516375 A JP 2017516375A JP 2017516375 A JP2017516375 A JP 2017516375A JP 2017528505 A5 JP2017528505 A5 JP 2017528505A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- alopecia
- subject
- item
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 38
- 201000004384 Alopecia Diseases 0.000 claims description 22
- 229960005345 trimebutine Drugs 0.000 claims description 15
- 231100000360 alopecia Toxicity 0.000 claims description 11
- LORDFXWUHHSAQU-UHFFFAOYSA-N 3,4,5-trimethoxybenzoic acid [2-(dimethylamino)-2-phenylbutyl] ester Chemical compound C=1C=CC=CC=1C(CC)(N(C)C)COC(=O)C1=CC(OC)=C(OC)C(OC)=C1 LORDFXWUHHSAQU-UHFFFAOYSA-N 0.000 claims description 9
- 230000003676 hair loss Effects 0.000 claims description 9
- 208000024963 hair loss Diseases 0.000 claims description 9
- 210000004209 hair Anatomy 0.000 claims description 7
- FSRLGULMGJGKGI-BTJKTKAUSA-N Trimebutine maleate Chemical group OC(=O)\C=C/C(O)=O.C=1C=CC=CC=1C(CC)(N(C)C)COC(=O)C1=CC(OC)=C(OC)C(OC)=C1 FSRLGULMGJGKGI-BTJKTKAUSA-N 0.000 claims description 6
- 206010040844 Skin exfoliation Diseases 0.000 claims description 5
- 230000003779 hair growth Effects 0.000 claims description 5
- 208000027418 Wounds and injury Diseases 0.000 claims description 4
- ZFPDLGDYDUPYEZ-UHFFFAOYSA-N [2-(methylamino)-2-phenylbutyl] 3,4,5-trimethoxybenzoate Chemical compound C=1C=CC=CC=1C(CC)(NC)COC(=O)C1=CC(OC)=C(OC)C(OC)=C1 ZFPDLGDYDUPYEZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000002207 metabolite Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 230000001737 promoting effect Effects 0.000 claims description 3
- 230000000284 resting effect Effects 0.000 claims description 3
- 238000011200 topical administration Methods 0.000 claims description 3
- 208000025865 Ulcer Diseases 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 claims description 2
- 208000004631 alopecia areata Diseases 0.000 claims description 2
- 230000003698 anagen phase Effects 0.000 claims description 2
- 201000002996 androgenic alopecia Diseases 0.000 claims description 2
- 231100000481 chemical toxicant Toxicity 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 208000014674 injury Diseases 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 230000037452 priming Effects 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 230000037390 scarring Effects 0.000 claims description 2
- 210000003625 skull Anatomy 0.000 claims description 2
- 230000009469 supplementation Effects 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 239000003440 toxic substance Substances 0.000 claims description 2
- 238000002054 transplantation Methods 0.000 claims description 2
- 231100000397 ulcer Toxicity 0.000 claims description 2
- 230000029663 wound healing Effects 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 2
- 239000011976 maleic acid Substances 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 description 31
- 229940113178 5 Alpha reductase inhibitor Drugs 0.000 description 4
- 239000002677 5-alpha reductase inhibitor Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000003803 hair density Effects 0.000 description 3
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 description 2
- LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- 229960000711 alprostadil Drugs 0.000 description 2
- 229960000997 bicalutamide Drugs 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 239000002934 diuretic Substances 0.000 description 2
- 230000001882 diuretic effect Effects 0.000 description 2
- 229960004199 dutasteride Drugs 0.000 description 2
- JWJOTENAMICLJG-QWBYCMEYSA-N dutasteride Chemical compound O=C([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)N[C@@H]4CC3)C)CC[C@@]21C)NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F JWJOTENAMICLJG-QWBYCMEYSA-N 0.000 description 2
- 229960004039 finasteride Drugs 0.000 description 2
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 description 2
- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 2
- 229960002074 flutamide Drugs 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000003662 hair growth rate Effects 0.000 description 2
- 239000004036 potassium channel stimulating agent Substances 0.000 description 2
- 150000003126 pregnane derivatives Chemical class 0.000 description 2
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 239000006071 cream Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 description 1
- 229960001160 latanoprost Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 150000003145 progesterone derivatives Chemical class 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000003762 total hair loss Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462055195P | 2014-09-25 | 2014-09-25 | |
| US62/055,195 | 2014-09-25 | ||
| PCT/CA2015/050966 WO2016044951A1 (en) | 2014-09-25 | 2015-09-25 | Compositions and methods for enhancing hair growth, promoting skin regeneration, and wound healing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017528505A JP2017528505A (ja) | 2017-09-28 |
| JP2017528505A5 true JP2017528505A5 (enExample) | 2018-11-08 |
Family
ID=55580010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516375A Pending JP2017528505A (ja) | 2014-09-25 | 2015-09-25 | 発毛増進、皮膚再生促進及び創傷治癒のための組成物及び方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9962360B2 (enExample) |
| EP (1) | EP3197443A4 (enExample) |
| JP (1) | JP2017528505A (enExample) |
| CA (1) | CA3000117A1 (enExample) |
| WO (1) | WO2016044951A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9962360B2 (en) * | 2014-09-25 | 2018-05-08 | The Hospital For Sick Children | Compositions and methods for enhancing hair growth, promoting skin regeneration, and wound healing |
| HK1251593A1 (zh) | 2015-07-24 | 2019-02-01 | 豪夫迈‧罗氏有限公司 | Bace1抑制剂肽 |
| KR102112736B1 (ko) * | 2017-08-01 | 2020-05-20 | 주식회사 씨케이바이오텍 | 탈모 방지 또는 발모 촉진용 조성물 |
| CN113924090A (zh) | 2019-04-04 | 2022-01-11 | 大邱庆北尖端医疗产业振兴财团 | 用于预防或治疗癌症的包含曲美布汀或其药学上可接受的盐作为活性成分的药物组合物 |
| US20220362292A1 (en) * | 2019-07-26 | 2022-11-17 | Tufts Medical Center, Inc. | Adoptive transfer of plasmacytoid dendritic cells to prevent or treat hair loss |
| WO2022225427A1 (ru) * | 2021-04-22 | 2022-10-27 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Новые соли [2-(диметиламино)-2-фенилбутил]-3,4,5-триметоксибензоата и их применение |
| US12667526B1 (en) * | 2021-10-27 | 2026-06-30 | James D. Welch | Method of encouraging growth and regrowth of hair in human males |
| US11744788B2 (en) * | 2021-10-27 | 2023-09-05 | James D. Welch | Method of encouraging growth and regrowth of hair in human males technical area |
| CN117899085A (zh) * | 2023-12-27 | 2024-04-19 | 无锡市南京大学锡山应用生物技术研究所 | 用于提升全层皮肤移植成功率的药物组合物和药物制剂及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0485470B1 (en) * | 1989-07-31 | 1994-03-16 | Massachusetts Institute Of Technology | Use of calcium antagonists for treating scars |
| FR2793681B1 (fr) | 1999-05-18 | 2001-06-22 | Oreal | Utilisation d'au moins un inhibiteur d'au moins un canal calcique dans le traitement des rides |
| US20080318910A1 (en) * | 2005-10-04 | 2008-12-25 | Mistral Pharma, Inc. | Controlled-Release Oral Dosage Form |
| RU2008152751A (ru) | 2006-06-06 | 2010-07-20 | Антиб Терапьютикс Инк. (Ca) | Соли тримебутина и n-десметилтримебутина |
| US8748177B2 (en) | 2008-09-30 | 2014-06-10 | The Hospital For Sick Children | Compositions for proliferation of cells and related methods |
| US9333209B2 (en) * | 2012-02-10 | 2016-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions for increasing hair growth |
| US9962360B2 (en) * | 2014-09-25 | 2018-05-08 | The Hospital For Sick Children | Compositions and methods for enhancing hair growth, promoting skin regeneration, and wound healing |
-
2015
- 2015-09-25 US US15/513,877 patent/US9962360B2/en active Active
- 2015-09-25 JP JP2017516375A patent/JP2017528505A/ja active Pending
- 2015-09-25 CA CA3000117A patent/CA3000117A1/en not_active Abandoned
- 2015-09-25 EP EP15845138.5A patent/EP3197443A4/en not_active Withdrawn
- 2015-09-25 WO PCT/CA2015/050966 patent/WO2016044951A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016538271A5 (enExample) | ||
| JP2016512246A5 (enExample) | ||
| RU2012133969A (ru) | Локальные трансдермальные композиции дексмедетомидина и способы их применения | |
| JP4234198B2 (ja) | 獣医学および医学用途用化合物 | |
| WO2012099258A1 (ja) | 脱毛症治療剤 | |
| MX2012004890A (es) | Metodos para tratar o prevenir eritema agudo. | |
| JP2008513439A (ja) | 発毛を誘導するための組成物および方法 | |
| JP2015512393A5 (enExample) | ||
| US20120064174A1 (en) | Method for stimulating hair growth | |
| PL190755B1 (pl) | Preparat do leczenia i profilaktyki chorób skóry | |
| JP2018528259A5 (enExample) | ||
| KR20110028494A (ko) | 탈모 치료용 조성물 | |
| JP2017528505A (ja) | 発毛増進、皮膚再生促進及び創傷治癒のための組成物及び方法 | |
| JP2016517882A5 (enExample) | ||
| CN102441006B (zh) | 一种含二氧化氯的生发溶液及其制备和使用方法 | |
| KR102534457B1 (ko) | 방사선 피부염의 치료를 위한 국소 BRaF 억제제 조성물의 용도 | |
| JP2022519675A5 (enExample) | ||
| Patel et al. | Addressing androgenetic Alopecia-A complex disorder-with a multilateral treatment strategy | |
| CN119587557A (zh) | D-甘露糖在预防和治疗雄激素性秃发中的应用 | |
| EP2928460B1 (en) | Methods for preventing and treating inflammatory skin conditions | |
| JP2017501186A (ja) | 発毛促進用または脱毛防止用組成物 | |
| CN102659823B (zh) | 一种防脱发、生发、护肤作用的氨基酸铜络合物、制备方法及应用 | |
| Brzezińska-Wcisło et al. | Hair diseases: a big problem on a small surface | |
| JP2016501236A5 (enExample) | ||
| EP3548017B1 (en) | Composition comprising glutathion tioester and secoiridoids of the plant olea europea for treating hair loss |