JP2017528464A - 置換ピペリジン化合物 - Google Patents

置換ピペリジン化合物 Download PDF

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Publication number
JP2017528464A
JP2017528464A JP2017513207A JP2017513207A JP2017528464A JP 2017528464 A JP2017528464 A JP 2017528464A JP 2017513207 A JP2017513207 A JP 2017513207A JP 2017513207 A JP2017513207 A JP 2017513207A JP 2017528464 A JP2017528464 A JP 2017528464A
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Prior art keywords
cancer
tumor
cell
alkyl
lymphoma
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Pending
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JP2017513207A
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English (en)
Japanese (ja)
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JP2017528464A5 (enExample
Inventor
ヘレン ミッチェル ローナ
ヘレン ミッチェル ローナ
サイモン ベル アンドリュー
サイモン ベル アンドリュー
チェスウォース リチャード
チェスウォース リチャード
アリーン クルーナン フォーリー メーガン
アリーン クルーナン フォーリー メーガン
ウェイン クンツ ケヴィン
ウェイン クンツ ケヴィン
エドワード ジョン ミルズ ジェイムス
エドワード ジョン ミルズ ジェイムス
ジョン マンチホフ マイケル
ジョン マンチホフ マイケル
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エピザイム，インコーポレイティド
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Publication of JP2017528464A publication Critical patent/JP2017528464A/ja
Publication of JP2017528464A5 publication Critical patent/JP2017528464A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2017513207A 2014-09-10 2015-09-09 置換ピペリジン化合物 Pending JP2017528464A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462048771P 2014-09-10 2014-09-10
US62/048,771 2014-09-10
US201462078845P 2014-11-12 2014-11-12
US62/078,845 2014-11-12
US201562146790P 2015-04-13 2015-04-13
US62/146,790 2015-04-13
PCT/US2015/049235 WO2016040515A1 (en) 2014-09-10 2015-09-09 Substituted piperidine compounds

Publications (2)

Publication Number Publication Date
JP2017528464A true JP2017528464A (ja) 2017-09-28
JP2017528464A5 JP2017528464A5 (enExample) 2018-10-18

Family

ID=55459535

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017513207A Pending JP2017528464A (ja) 2014-09-10 2015-09-09 置換ピペリジン化合物

Country Status (13)

Country Link
US (1) US10577363B2 (enExample)
EP (1) EP3193605A4 (enExample)
JP (1) JP2017528464A (enExample)
KR (1) KR20170047397A (enExample)
CN (1) CN107072207A (enExample)
AU (1) AU2015315182A1 (enExample)
BR (1) BR112017004589A2 (enExample)
CA (1) CA2960280A1 (enExample)
EA (1) EA201790327A1 (enExample)
IL (1) IL250888A0 (enExample)
MX (1) MX2017002986A (enExample)
SG (2) SG11201701597RA (enExample)
WO (1) WO2016040515A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021511382A (ja) * 2018-01-26 2021-05-06 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ （３ｓ，４ｓ）−１−シクロプロピルメチル−４−｛［５−（２，４−ジフルオロ−フェニル）−イソオキサゾール−３−カルボニル］−アミノ｝−ピペリジン−３−カルボン酸 （１−ピリミジン−２−イル−シクロプロピル）−アミドの結晶形
US12213970B2 (en) 2018-10-29 2025-02-04 Boehringer Ingelheim International Gmbh Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016040511A1 (en) 2014-09-10 2016-03-17 Epizyme, Inc. Isoxazole carboxamides as irreversible smyd inhibitors
CA2960274A1 (en) 2014-09-10 2016-03-17 Epizyme, Inc. Isoxazole carboxamide compounds
EP3190891B1 (en) 2014-09-10 2020-01-15 Epizyme, Inc. Isoxazolecarboxamide substituted by a cyclohexylamine as smyd protein inhibitors
AU2015315174B2 (en) 2014-09-10 2019-12-12 Epizyme, Inc. Smyd inhibitors
US10106509B2 (en) * 2015-02-27 2018-10-23 Op Bio Factory Co., Ltd. Method for producing kakeromycin and derivatives thereof
EP3490986B1 (en) 2016-07-28 2021-11-24 Idorsia Pharmaceuticals Ltd Piperidine cxcr7 receptor modulators
WO2018151678A1 (en) * 2017-02-15 2018-08-23 Agency For Science, Technology And Research Compounds for treatment of cancer and epigenetics
CA3112510A1 (en) 2018-10-29 2020-05-07 Boehringer Ingelheim International Gmbh Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof
WO2021065898A1 (ja) 2019-09-30 2021-04-08 日本ケミファ株式会社 アゼパン誘導体
CN114702552B (zh) * 2022-03-11 2024-05-31 苏州思萃免疫技术研究所有限公司 mTORC2抑制剂
CN117800895A (zh) * 2022-09-30 2024-04-02 苏州阿尔脉生物科技有限公司 草酸胺类衍生物、包含其的药物组合物及其医药用途
WO2025133989A1 (en) * 2023-12-20 2025-06-26 Alt-Bio Pte. Ltd. Smyd modulators and uses thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0327379A (ja) * 1989-01-09 1991-02-05 Zambon Group Spa 抗セロトニン活性を有する化合物
WO2008137834A2 (en) * 2007-05-04 2008-11-13 Osi Pharmaceuticals, Inc. Crystal structure of smyd3 protein
WO2009072643A1 (en) * 2007-12-03 2009-06-11 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound and use thereof
JP2014505037A (ja) * 2010-12-16 2014-02-27 クオンベルゲンセ プハルマセウトイカルス リミテッド Ａｓｋ１阻害ピロロピリミジン誘導体
JP2017526706A (ja) * 2014-09-10 2017-09-14 エピザイム，インコーポレイティド イソオキサゾールカルボキサミド化合物
JP2017528460A (ja) * 2014-09-10 2017-09-28 エピザイム インコーポレイテッド 不可逆的ｓｍｙｄ阻害剤としてのイソオキサゾールカルボキサミド

Family Cites Families (7)

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SE9902987D0 (sv) * 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
SE0403106D0 (sv) * 2004-12-20 2004-12-20 Astrazeneca Ab Chemical compounds
TWI535712B (zh) * 2010-08-06 2016-06-01 阿斯特捷利康公司 化合物
JP2017527577A (ja) 2014-09-10 2017-09-21 エピザイム，インコーポレイティド 置換ピロリジン化合物
AU2015315174B2 (en) 2014-09-10 2019-12-12 Epizyme, Inc. Smyd inhibitors
EP3190891B1 (en) 2014-09-10 2020-01-15 Epizyme, Inc. Isoxazolecarboxamide substituted by a cyclohexylamine as smyd protein inhibitors
EP3193609A4 (en) 2014-09-10 2018-02-28 Epizyme, Inc. Substituted pyrrolidine carboxamide compounds

Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
JPH0327379A (ja) * 1989-01-09 1991-02-05 Zambon Group Spa 抗セロトニン活性を有する化合物
WO2008137834A2 (en) * 2007-05-04 2008-11-13 Osi Pharmaceuticals, Inc. Crystal structure of smyd3 protein
WO2009072643A1 (en) * 2007-12-03 2009-06-11 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound and use thereof
JP2014505037A (ja) * 2010-12-16 2014-02-27 クオンベルゲンセ プハルマセウトイカルス リミテッド Ａｓｋ１阻害ピロロピリミジン誘導体
JP2017526706A (ja) * 2014-09-10 2017-09-14 エピザイム，インコーポレイティド イソオキサゾールカルボキサミド化合物
JP2017528460A (ja) * 2014-09-10 2017-09-28 エピザイム インコーポレイテッド 不可逆的ｓｍｙｄ阻害剤としてのイソオキサゾールカルボキサミド

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DATABASE REGISTRY [ONLINE] CHEMICAL ABSTRACT SERVICE， RN 1069623-32-0, JPN7019001587, 2 November 2008 (2008-11-02), ISSN: 0004204628 *
DATABASE REGISTRY [ONLINE] CHEMICAL ABSTRACT SERVICE， RN 1070685-96-9, JPN7019001586, 4 November 2008 (2008-11-04), ISSN: 0004204627 *
DATABASE REGISTRY [ONLINE] CHEMICAL ABSTRACT SERVICE， RN 1347795-87-2, JPN7019001585, 2 December 2011 (2011-12-02), ISSN: 0004204626 *
DATABASE REGISTRY [ONLINE] CHEMICAL ABSTRACT SERVICE， RN 1355798-51-4, JPN7019001584, 8 February 2012 (2012-02-08), ISSN: 0004204625 *
DATABASE REGISTRY [ONLINE] CHEMICAL ABSTRACT SERVICE， RN 1381523-70-1, JPN7019001583, 5 July 2012 (2012-07-05), ISSN: 0004204624 *
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DATABASE REGISTRY [ONLINE] CHEMICAL ABSTRACT SERVICE， RN 1609867-47-1, JPN7019001578, 6 June 2014 (2014-06-06), ISSN: 0004204618 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021511382A (ja) * 2018-01-26 2021-05-06 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ （３ｓ，４ｓ）−１−シクロプロピルメチル−４−｛［５−（２，４−ジフルオロ−フェニル）−イソオキサゾール−３−カルボニル］−アミノ｝−ピペリジン−３−カルボン酸 （１−ピリミジン−２−イル−シクロプロピル）−アミドの結晶形
JP7076010B2 (ja) 2018-01-26 2022-05-26 イドーシア ファーマシューティカルズ リミテッド （３ｓ，４ｓ）－１－シクロプロピルメチル－４－｛［５－（２，４－ジフルオロ－フェニル）－イソオキサゾール－３－カルボニル］－アミノ｝－ピペリジン－３－カルボン酸 （１－ピリミジン－２－イル－シクロプロピル）－アミドの結晶形
US12213970B2 (en) 2018-10-29 2025-02-04 Boehringer Ingelheim International Gmbh Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof

Also Published As

Publication number Publication date
KR20170047397A (ko) 2017-05-04
CA2960280A1 (en) 2016-03-17
CN107072207A (zh) 2017-08-18
WO2016040515A1 (en) 2016-03-17
US20170362217A1 (en) 2017-12-21
SG11201701597RA (en) 2017-03-30
EP3193605A4 (en) 2018-04-18
BR112017004589A2 (pt) 2018-01-23
EP3193605A1 (en) 2017-07-26
MX2017002986A (es) 2017-10-24
IL250888A0 (en) 2017-04-30
AU2015315182A1 (en) 2017-03-16
SG10201901189SA (en) 2019-03-28
US10577363B2 (en) 2020-03-03
EA201790327A1 (ru) 2017-10-31

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