JP2017528120A - リガンドに対する受容体を同定するための方法およびその使用 - Google Patents

リガンドに対する受容体を同定するための方法およびその使用 Download PDF

Info

Publication number
JP2017528120A
JP2017528120A JP2017501219A JP2017501219A JP2017528120A JP 2017528120 A JP2017528120 A JP 2017528120A JP 2017501219 A JP2017501219 A JP 2017501219A JP 2017501219 A JP2017501219 A JP 2017501219A JP 2017528120 A JP2017528120 A JP 2017528120A
Authority
JP
Japan
Prior art keywords
chemoreceptor
receptor
olfactory
level
biological sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017501219A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017528120A5 (enExample
Inventor
ロドリゲス、イバン
ジャック アンリ サイラス カールトン、アラン
ジャック アンリ サイラス カールトン、アラン
ロスィエ、ダニエル
Original Assignee
ユニベルシテ ドゥ ジュネーブ
ユニベルシテ ドゥ ジュネーブ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ユニベルシテ ドゥ ジュネーブ, ユニベルシテ ドゥ ジュネーブ filed Critical ユニベルシテ ドゥ ジュネーブ
Publication of JP2017528120A publication Critical patent/JP2017528120A/ja
Publication of JP2017528120A5 publication Critical patent/JP2017528120A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2017501219A 2014-08-26 2015-08-25 リガンドに対する受容体を同定するための方法およびその使用 Pending JP2017528120A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14182350 2014-08-26
EP14182350.0 2014-08-26
PCT/EP2015/069454 WO2016030378A1 (en) 2014-08-26 2015-08-25 Methods for identifying a receptor for a ligand and uses thereof

Publications (2)

Publication Number Publication Date
JP2017528120A true JP2017528120A (ja) 2017-09-28
JP2017528120A5 JP2017528120A5 (enExample) 2018-08-16

Family

ID=51392198

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017501219A Pending JP2017528120A (ja) 2014-08-26 2015-08-25 リガンドに対する受容体を同定するための方法およびその使用

Country Status (4)

Country Link
US (1) US10473645B2 (enExample)
EP (1) EP3194978B1 (enExample)
JP (1) JP2017528120A (enExample)
WO (1) WO2016030378A1 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020513564A (ja) * 2016-12-14 2020-05-14 高砂香料工業株式会社 悪臭中和剤を同定するための方法
JP2021504673A (ja) * 2017-11-22 2021-02-15 フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ ランドリーの悪臭、カビの悪臭及び／又は汗の悪臭を調節する組成物を同定する方法
JP2021508030A (ja) * 2017-12-21 2021-02-25 フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ 匂い物質受容体のためのポジティブなアロステリックモジュレーターを同定するための方法
WO2021085590A1 (ja) * 2019-11-01 2021-05-06 高砂香料工業株式会社 悪臭抑制素材のスクリーニング方法
WO2022259864A1 (ja) * 2021-06-07 2022-12-15 エステー株式会社 嗅覚受容体の阻害剤およびその用途
JP2023117130A (ja) * 2022-02-10 2023-08-23 エステー株式会社 アルデヒド臭の抑制剤の探索方法
WO2025047522A1 (ja) * 2023-08-31 2025-03-06 高砂香料工業株式会社 悪臭抑制素材のスクリーニング方法

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4365591A3 (en) 2016-02-24 2024-08-07 Suntory Holdings Limited Biosensor detecting smell, scent and taste
EP3436609B1 (en) * 2016-03-30 2022-05-04 The Johns Hopkins University Olfr90 specificity and methods of detection
MX2019003507A (es) * 2016-09-30 2019-08-01 Mars Inc Metodos de evaluacion usando receptores olfatorios y compuestos novedosos identificados usando los mismos.
US11029308B2 (en) 2016-10-27 2021-06-08 Duke University Methods for vapor detection and discrimination with mammalian odorant receptors expressed in heterologous cells
JP2020510417A (ja) * 2017-02-17 2020-04-09 コニク インコーポレイテッド 検出のためのシステム
EP3609521A4 (en) 2017-04-14 2021-06-16 University of Massachusetts TARGETING OF CELL TROPISM RECEPTORS TO INHIBIT INFECTION BY THE CYTOMEGALOVIRUS
US10209239B1 (en) * 2017-08-16 2019-02-19 Aromyx Corporation Method of making an aromagraph comprising ectopic olfactory receptors
KR102012837B1 (ko) * 2017-09-18 2019-08-21 중앙대학교 산학협력단 G9a 및 LSD1에 의한 후각 수용체 발현 조절을 이용한 백혈병 치료제 스크리닝 방법
US12163950B2 (en) 2018-06-26 2024-12-10 Duke University Synthetic odorant receptors
WO2020033753A1 (en) 2018-08-10 2020-02-13 Koniku Inc. A stacked integrated platform architecture
KR20200052189A (ko) 2018-11-06 2020-05-14 한국식품연구원 Spr 센서를 이용한 세포막단백질-리간드 상호작용의 확인 방법
US12165743B2 (en) 2018-11-09 2024-12-10 The Broad Institute, Inc. Compressed sensing for screening and tissue imaging
CN111939260B (zh) * 2019-12-11 2021-12-14 山东大学 嗅觉受体or12d3作为糖尿病防治靶点的应用
CN117487815B (zh) * 2023-10-16 2025-03-18 中国农业科学院深圳农业基因组研究所(岭南现代农业科学与技术广东省实验室深圳分中心) 气味受体基因OR49b识别苯并噻唑及其在橘小实蝇防控方面的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492143B1 (en) * 1998-12-17 2002-12-10 The John Hopkins University Olfactory receptor expression libraries and methods of making and using them
US20030088059A1 (en) * 2000-03-13 2003-05-08 Sergey Zozulya Human olfactory receptors and genes encoding same
WO2003020913A2 (en) * 2001-09-04 2003-03-13 Sentigen Corp. Anopheles gambiae odorant receptors and genes
EP1391508A1 (en) * 2002-08-09 2004-02-25 F. Hoffmann-La Roche Ag Transgenic nematode expressing mammalian GPCRS used for screening assay

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMICAL SENSES, vol. 37, JPN5017007161, 2011, pages 229 - 240, ISSN: 0004049881 *
JOURNAL OF VISUALIZED EXPERIMENTS, vol. 88, JPN6019021052, June 2014 (2014-06-01), pages 51640, ISSN: 0004213484 *
PHYSIOLOGICAL ENTOMOLOGY, vol. 37, JPN5017007160, 2012, pages 33 - 41, ISSN: 0004049880 *
THE JOURNAL OF NEUROSCIENCE, vol. 21, no. 16, JPN6019021053, 2001, pages 6018 - 6025, ISSN: 0004049879 *

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020513564A (ja) * 2016-12-14 2020-05-14 高砂香料工業株式会社 悪臭中和剤を同定するための方法
US11448642B2 (en) 2016-12-14 2022-09-20 Takasago International Corporation Method for identifying malodour counteractants
JP7152399B2 (ja) 2016-12-14 2022-10-12 高砂香料工業株式会社 悪臭中和剤を同定するための方法
JP2021504673A (ja) * 2017-11-22 2021-02-15 フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ ランドリーの悪臭、カビの悪臭及び／又は汗の悪臭を調節する組成物を同定する方法
JP7888632B2 (ja) 2017-11-22 2026-07-13 フイルメニツヒ ソシエテ アノニム ランドリーの悪臭、カビの悪臭及び／又は汗の悪臭を調節する組成物を同定する方法
JP7560357B2 (ja) 2017-11-22 2024-10-02 フイルメニツヒ ソシエテ アノニム ランドリーの悪臭、カビの悪臭及び／又は汗の悪臭を調節する組成物を同定する方法
JP2024038248A (ja) * 2017-11-22 2024-03-19 フイルメニツヒ ソシエテ アノニム ランドリーの悪臭、カビの悪臭及び／又は汗の悪臭を調節する組成物を同定する方法
JP7343488B2 (ja) 2017-12-21 2023-09-12 フイルメニツヒ ソシエテ アノニム 匂い物質受容体のためのポジティブなアロステリックモジュレーターを同定するための方法
JP2021508030A (ja) * 2017-12-21 2021-02-25 フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ 匂い物質受容体のためのポジティブなアロステリックモジュレーターを同定するための方法
JP7658911B2 (ja) 2019-11-01 2025-04-08 高砂香料工業株式会社 悪臭抑制素材のスクリーニング方法
WO2021085591A1 (ja) * 2019-11-01 2021-05-06 高砂香料工業株式会社 香料組成物
JPWO2021085591A1 (enExample) * 2019-11-01 2021-05-06
JPWO2021085590A1 (enExample) * 2019-11-01 2021-05-06
JP7671695B2 (ja) 2019-11-01 2025-05-02 高砂香料工業株式会社 香料組成物
US12533310B2 (en) 2019-11-01 2026-01-27 Takasago International Corporation Fragrance or flavor composition
US12605330B2 (en) 2019-11-01 2026-04-21 Takasago International Corporation Screening method for offensive odor-suppressing material
WO2021085590A1 (ja) * 2019-11-01 2021-05-06 高砂香料工業株式会社 悪臭抑制素材のスクリーニング方法
WO2022259864A1 (ja) * 2021-06-07 2022-12-15 エステー株式会社 嗅覚受容体の阻害剤およびその用途
JP2023117130A (ja) * 2022-02-10 2023-08-23 エステー株式会社 アルデヒド臭の抑制剤の探索方法
JP7776818B2 (ja) 2022-02-10 2025-11-27 エステー株式会社 アルデヒド臭の抑制剤の探索方法
WO2025047522A1 (ja) * 2023-08-31 2025-03-06 高砂香料工業株式会社 悪臭抑制素材のスクリーニング方法

Also Published As

Publication number Publication date
US10473645B2 (en) 2019-11-12
EP3194978A1 (en) 2017-07-26
US20170285009A1 (en) 2017-10-05
EP3194978B1 (en) 2018-11-07
WO2016030378A1 (en) 2016-03-03

Similar Documents

Publication Publication Date Title
US10473645B2 (en) Methods for identifying a receptor for a ligand and uses thereof
Ameku et al. Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner
Thorne et al. Atypical expression of Drosophila gustatory receptor genes in sensory and central neurons
Sakurai et al. A single sex pheromone receptor determines chemical response specificity of sexual behavior in the silkmoth Bombyx mori
Wang et al. Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors
Larter et al. Organization and function of Drosophila odorant binding proteins
Inagaki et al. Visualizing neuromodulation in vivo: TANGO-mapping of dopamine signaling reveals appetite control of sugar sensing
Malik et al. Mammalian taste cells express functional olfactory receptors
Penn et al. Regulation of sexually dimorphic expression of major urinary proteins
JP2018520665A (ja) 匂い物質および芳香の受容体をスクリーニングするための細胞株
JP2020510436A (ja) 悪臭調節化合物の同定方法
Misu et al. Two different functions of connexin43 confer two different bone phenotypes in zebrafish
Li et al. Mouthparts enriched odorant binding protein AfasOBP11 plays a role in the gustatory perception of Adelphocoris fasciaticollis
Vyas et al. Oestrus pheromones in farm mammals, with special reference to cow
Lehmann et al. SNMP1 is critical for sensitive detection of the desert locust aromatic courtship inhibition pheromone phenylacetonitrile
Igual Gil et al. Neuronal Chemosensation and Osmotic Stress Response Converge in the Regulation of aqp-8 in C. elegans
Lesch et al. The homeodomain protein hmbx-1 maintains asymmetric gene expression in adult C. elegans olfactory neurons
Kondo et al. Impaired pheromone detection and abnormal sexual behavior in female mice deficient for ancV1R
US8476006B2 (en) Store-operated calcium cellular assay
Bennett et al. Odor-evoked gene regulation and visualization in olfactory receptor neurons
Touhara Molecular biology of peptide pheromone production and reception in mice
JP6830949B2 (ja) 嗅覚系における嗅覚受容体の出現を増大させるｄｎａ配列
Rollmann et al. Pinocchio, a novel protein expressed in the antenna, contributes to olfactory behavior in Drosophila melanogaster
Park et al. Molecular and cellular organization of odorant binding protein genes in Drosophila
Na et al. Identification and expression patterns of two TRPV channel genes in antennae and Johnston's organ of the dengue and Zika virus vector mosquito, Aedes aegypti

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180707

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180707

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190611

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190911

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191025

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20200218