JP2017528120A - リガンドに対する受容体を同定するための方法およびその使用 - Google Patents
リガンドに対する受容体を同定するための方法およびその使用 Download PDFInfo
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- JP2017528120A JP2017528120A JP2017501219A JP2017501219A JP2017528120A JP 2017528120 A JP2017528120 A JP 2017528120A JP 2017501219 A JP2017501219 A JP 2017501219A JP 2017501219 A JP2017501219 A JP 2017501219A JP 2017528120 A JP2017528120 A JP 2017528120A
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
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- A—HUMAN NECESSITIES
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- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
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- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Animal Husbandry (AREA)
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- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
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- Tropical Medicine & Parasitology (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14182350.0 | 2014-08-26 | ||
| EP14182350 | 2014-08-26 | ||
| PCT/EP2015/069454 WO2016030378A1 (en) | 2014-08-26 | 2015-08-25 | Methods for identifying a receptor for a ligand and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017528120A true JP2017528120A (ja) | 2017-09-28 |
| JP2017528120A5 JP2017528120A5 (enExample) | 2018-08-16 |
Family
ID=51392198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017501219A Pending JP2017528120A (ja) | 2014-08-26 | 2015-08-25 | リガンドに対する受容体を同定するための方法およびその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10473645B2 (enExample) |
| EP (1) | EP3194978B1 (enExample) |
| JP (1) | JP2017528120A (enExample) |
| WO (1) | WO2016030378A1 (enExample) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020513564A (ja) * | 2016-12-14 | 2020-05-14 | 高砂香料工業株式会社 | 悪臭中和剤を同定するための方法 |
| JP2021504673A (ja) * | 2017-11-22 | 2021-02-15 | フイルメニツヒ ソシエテ アノニムFirmenich Sa | ランドリーの悪臭、カビの悪臭及び/又は汗の悪臭を調節する組成物を同定する方法 |
| JP2021508030A (ja) * | 2017-12-21 | 2021-02-25 | フイルメニツヒ ソシエテ アノニムFirmenich Sa | 匂い物質受容体のためのポジティブなアロステリックモジュレーターを同定するための方法 |
| WO2021085591A1 (ja) * | 2019-11-01 | 2021-05-06 | 高砂香料工業株式会社 | 香料組成物 |
| WO2022259864A1 (ja) * | 2021-06-07 | 2022-12-15 | エステー株式会社 | 嗅覚受容体の阻害剤およびその用途 |
| JP2023117130A (ja) * | 2022-02-10 | 2023-08-23 | エステー株式会社 | アルデヒド臭の抑制剤の探索方法 |
| WO2025047522A1 (ja) * | 2023-08-31 | 2025-03-06 | 高砂香料工業株式会社 | 悪臭抑制素材のスクリーニング方法 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017222572A1 (en) | 2016-02-24 | 2018-08-23 | Aromyx Corporation | Biosensor for detecting smell, scent and taste |
| EP3436609B1 (en) * | 2016-03-30 | 2022-05-04 | The Johns Hopkins University | Olfr90 specificity and methods of detection |
| EP3519815A1 (en) | 2016-09-30 | 2019-08-07 | Mars, Incorporated | Screening methods using olfactory receptors and novel compounds identified using the same |
| US11029308B2 (en) * | 2016-10-27 | 2021-06-08 | Duke University | Methods for vapor detection and discrimination with mammalian odorant receptors expressed in heterologous cells |
| WO2018208332A2 (en) * | 2017-02-17 | 2018-11-15 | Koniku, Inc. | Systems for detection |
| WO2018191603A1 (en) * | 2017-04-14 | 2018-10-18 | University Of Massachusetts | Targeting cell tropism receptors to inhibit cytomegalovirus infection |
| US10209239B1 (en) | 2017-08-16 | 2019-02-19 | Aromyx Corporation | Method of making an aromagraph comprising ectopic olfactory receptors |
| KR102012837B1 (ko) * | 2017-09-18 | 2019-08-21 | 중앙대학교 산학협력단 | G9a 및 LSD1에 의한 후각 수용체 발현 조절을 이용한 백혈병 치료제 스크리닝 방법 |
| US12163950B2 (en) | 2018-06-26 | 2024-12-10 | Duke University | Synthetic odorant receptors |
| WO2020033753A1 (en) | 2018-08-10 | 2020-02-13 | Koniku Inc. | A stacked integrated platform architecture |
| KR20200052189A (ko) | 2018-11-06 | 2020-05-14 | 한국식품연구원 | Spr 센서를 이용한 세포막단백질-리간드 상호작용의 확인 방법 |
| US12165743B2 (en) | 2018-11-09 | 2024-12-10 | The Broad Institute, Inc. | Compressed sensing for screening and tissue imaging |
| CN111939260B (zh) * | 2019-12-11 | 2021-12-14 | 山东大学 | 嗅觉受体or12d3作为糖尿病防治靶点的应用 |
| CN117487815B (zh) * | 2023-10-16 | 2025-03-18 | 中国农业科学院深圳农业基因组研究所(岭南现代农业科学与技术广东省实验室深圳分中心) | 气味受体基因OR49b识别苯并噻唑及其在橘小实蝇防控方面的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6492143B1 (en) | 1998-12-17 | 2002-12-10 | The John Hopkins University | Olfactory receptor expression libraries and methods of making and using them |
| AU2001247366A1 (en) * | 2000-03-13 | 2001-09-24 | Senomyx Inc. | Human olfactory receptors and genes encoding same |
| WO2003020913A2 (en) | 2001-09-04 | 2003-03-13 | Sentigen Corp. | Anopheles gambiae odorant receptors and genes |
| EP1391508A1 (en) | 2002-08-09 | 2004-02-25 | F. Hoffmann-La Roche Ag | Transgenic nematode expressing mammalian GPCRS used for screening assay |
-
2015
- 2015-08-25 JP JP2017501219A patent/JP2017528120A/ja active Pending
- 2015-08-25 WO PCT/EP2015/069454 patent/WO2016030378A1/en not_active Ceased
- 2015-08-25 EP EP15754209.3A patent/EP3194978B1/en active Active
- 2015-08-25 US US15/506,266 patent/US10473645B2/en not_active Expired - Fee Related
Non-Patent Citations (4)
| Title |
|---|
| CHEMICAL SENSES, vol. 37, JPN5017007161, 2011, pages 229 - 240, ISSN: 0004049881 * |
| JOURNAL OF VISUALIZED EXPERIMENTS, vol. 88, JPN6019021052, June 2014 (2014-06-01), pages 51640, ISSN: 0004213484 * |
| PHYSIOLOGICAL ENTOMOLOGY, vol. 37, JPN5017007160, 2012, pages 33 - 41, ISSN: 0004049880 * |
| THE JOURNAL OF NEUROSCIENCE, vol. 21, no. 16, JPN6019021053, 2001, pages 6018 - 6025, ISSN: 0004049879 * |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11448642B2 (en) | 2016-12-14 | 2022-09-20 | Takasago International Corporation | Method for identifying malodour counteractants |
| JP2020513564A (ja) * | 2016-12-14 | 2020-05-14 | 高砂香料工業株式会社 | 悪臭中和剤を同定するための方法 |
| JP7152399B2 (ja) | 2016-12-14 | 2022-10-12 | 高砂香料工業株式会社 | 悪臭中和剤を同定するための方法 |
| JP2024038248A (ja) * | 2017-11-22 | 2024-03-19 | フイルメニツヒ ソシエテ アノニム | ランドリーの悪臭、カビの悪臭及び/又は汗の悪臭を調節する組成物を同定する方法 |
| JP7560357B2 (ja) | 2017-11-22 | 2024-10-02 | フイルメニツヒ ソシエテ アノニム | ランドリーの悪臭、カビの悪臭及び/又は汗の悪臭を調節する組成物を同定する方法 |
| JP2021504673A (ja) * | 2017-11-22 | 2021-02-15 | フイルメニツヒ ソシエテ アノニムFirmenich Sa | ランドリーの悪臭、カビの悪臭及び/又は汗の悪臭を調節する組成物を同定する方法 |
| JP2021508030A (ja) * | 2017-12-21 | 2021-02-25 | フイルメニツヒ ソシエテ アノニムFirmenich Sa | 匂い物質受容体のためのポジティブなアロステリックモジュレーターを同定するための方法 |
| JP7343488B2 (ja) | 2017-12-21 | 2023-09-12 | フイルメニツヒ ソシエテ アノニム | 匂い物質受容体のためのポジティブなアロステリックモジュレーターを同定するための方法 |
| WO2021085591A1 (ja) * | 2019-11-01 | 2021-05-06 | 高砂香料工業株式会社 | 香料組成物 |
| JPWO2021085590A1 (enExample) * | 2019-11-01 | 2021-05-06 | ||
| JPWO2021085591A1 (enExample) * | 2019-11-01 | 2021-05-06 | ||
| WO2021085590A1 (ja) * | 2019-11-01 | 2021-05-06 | 高砂香料工業株式会社 | 悪臭抑制素材のスクリーニング方法 |
| JP7658911B2 (ja) | 2019-11-01 | 2025-04-08 | 高砂香料工業株式会社 | 悪臭抑制素材のスクリーニング方法 |
| JP7671695B2 (ja) | 2019-11-01 | 2025-05-02 | 高砂香料工業株式会社 | 香料組成物 |
| WO2022259864A1 (ja) * | 2021-06-07 | 2022-12-15 | エステー株式会社 | 嗅覚受容体の阻害剤およびその用途 |
| JP2023117130A (ja) * | 2022-02-10 | 2023-08-23 | エステー株式会社 | アルデヒド臭の抑制剤の探索方法 |
| JP7776818B2 (ja) | 2022-02-10 | 2025-11-27 | エステー株式会社 | アルデヒド臭の抑制剤の探索方法 |
| WO2025047522A1 (ja) * | 2023-08-31 | 2025-03-06 | 高砂香料工業株式会社 | 悪臭抑制素材のスクリーニング方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US10473645B2 (en) | 2019-11-12 |
| EP3194978A1 (en) | 2017-07-26 |
| EP3194978B1 (en) | 2018-11-07 |
| WO2016030378A1 (en) | 2016-03-03 |
| US20170285009A1 (en) | 2017-10-05 |
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