JP2017527628A5 - - Google Patents

Info

Publication number

JP2017527628A5

JP2017527628A5 JP2017533748A JP2017533748A JP2017527628A5 JP 2017527628 A5 JP2017527628 A5 JP 2017527628A5 JP 2017533748 A JP2017533748 A JP 2017533748A JP 2017533748 A JP2017533748 A JP 2017533748A JP 2017527628 A5 JP2017527628 A5 JP 2017527628A5

Authority

JP

Japan

Prior art keywords

indazol

fluorophenyl

imidazolidin

alkyl

oxoethyl

Prior art date

2015-09-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

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• 150000001875 compounds Chemical class 0.000 claims 44
• 229910052736 halogen Inorganic materials 0.000 claims 30
• 150000002367 halogens Chemical group 0.000 claims 30
• 229910052739 hydrogen Inorganic materials 0.000 claims 29
• 239000001257 hydrogen Substances 0.000 claims 29
• 125000001424 substituent group Chemical group 0.000 claims 27
• 125000005843 halogen group Chemical group 0.000 claims 23
• 125000000217 alkyl group Chemical group 0.000 claims 22
• 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 20
• 208000002193 Pain Diseases 0.000 claims 18
• 150000002431 hydrogen Chemical class 0.000 claims 18
• 125000000753 cycloalkyl group Chemical group 0.000 claims 17
• -1 hydroxy, hydroxy Chemical group 0.000 claims 15
• 125000003118 aryl group Chemical group 0.000 claims 12
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
• 125000001188 haloalkyl group Chemical group 0.000 claims 11
• 125000003342 alkenyl group Chemical group 0.000 claims 9
• 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 6
• 125000005330 8 membered heterocyclic group Chemical group 0.000 claims 6
• 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 6
• 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 6
• 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 5
• 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 5
• 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 5
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 4
• 125000000623 heterocyclic group Chemical group 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• CNURFKXXVWIURY-UHFFFAOYSA-N 1,3-dioxolane-2-carbonitrile Chemical compound N#CC1OCCO1 CNURFKXXVWIURY-UHFFFAOYSA-N 0.000 claims 3
• ABADUMLIAZCWJD-UHFFFAOYSA-N 1,3-dioxole Chemical compound C1OC=CO1 ABADUMLIAZCWJD-UHFFFAOYSA-N 0.000 claims 3
• 208000006820 Arthralgia Diseases 0.000 claims 3
• 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 3
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
• 150000002923 oximes Chemical class 0.000 claims 3
• RHLVCLIPMVJYKS-UHFFFAOYSA-N 3-octanone Chemical compound CCCCCC(=O)CC RHLVCLIPMVJYKS-UHFFFAOYSA-N 0.000 claims 2
• 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 2
• YMFNEDCMMBFIPN-ZHACJKMWSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)/C=C/C(=O)OCC)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)/C=C/C(=O)OCC)=O YMFNEDCMMBFIPN-ZHACJKMWSA-N 0.000 claims 2
• XAKVAWSRGYJQBL-SOGBHIHOSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)\C=C\C(=O)N1C[C@H](CC1)F)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)\C=C\C(=O)N1C[C@H](CC1)F)=O XAKVAWSRGYJQBL-SOGBHIHOSA-N 0.000 claims 2
• 241000124008 Mammalia Species 0.000 claims 2
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
• YAMHXTCMCPHKLN-UHFFFAOYSA-N imidazolidin-2-one Chemical compound O=C1NCCN1 YAMHXTCMCPHKLN-UHFFFAOYSA-N 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• 208000004296 neuralgia Diseases 0.000 claims 2
• 208000021722 neuropathic pain Diseases 0.000 claims 2
• 239000011734 sodium Substances 0.000 claims 2
• 208000011580 syndromic disease Diseases 0.000 claims 2
• BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 claims 1
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
• 206010002383 Angina Pectoris Diseases 0.000 claims 1
• 208000008035 Back Pain Diseases 0.000 claims 1
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• PAPZGFXOZGWYRC-UHFFFAOYSA-N C(C)(=O)N1CC(C1)CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O Chemical compound C(C)(=O)N1CC(C1)CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O PAPZGFXOZGWYRC-UHFFFAOYSA-N 0.000 claims 1
• MKMDYQKQLZDLCL-UHFFFAOYSA-N C(C)(C)(C)C1=CN=C(O1)CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O Chemical compound C(C)(C)(C)C1=CN=C(O1)CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O MKMDYQKQLZDLCL-UHFFFAOYSA-N 0.000 claims 1
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• ZHRXHPYREILALX-UHFFFAOYSA-N C(C)(C)(C)NC(CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O)=O Chemical compound C(C)(C)(C)NC(CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O)=O ZHRXHPYREILALX-UHFFFAOYSA-N 0.000 claims 1
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• FYEZCEZHRQTFMN-UHFFFAOYSA-N C(C)C1(CN(C1)C(CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O)=O)O Chemical compound C(C)C1(CN(C1)C(CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O)=O)O FYEZCEZHRQTFMN-UHFFFAOYSA-N 0.000 claims 1
• ZIWCYJLCOBSUNK-UHFFFAOYSA-N C(C)C1=NN=C(O1)CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O Chemical compound C(C)C1=NN=C(O1)CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O ZIWCYJLCOBSUNK-UHFFFAOYSA-N 0.000 claims 1
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• SATBEMFZJZCMMB-UHFFFAOYSA-N C(C)C1N(CCC1)C(CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O)=O Chemical compound C(C)C1N(CCC1)C(CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O)=O SATBEMFZJZCMMB-UHFFFAOYSA-N 0.000 claims 1
• UXKKESLZCQZZSW-UHFFFAOYSA-N C(C)C=1SC=C(N=1)CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O Chemical compound C(C)C=1SC=C(N=1)CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O UXKKESLZCQZZSW-UHFFFAOYSA-N 0.000 claims 1
• JUOJEKPEUYPNOH-UHFFFAOYSA-N C(C)N(C(CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O)=O)CC Chemical compound C(C)N(C(CN1C(N(CC1)C1=C2C=NN(C2=CC=C1)C1=C(C=CC=C1)F)=O)=O)CC JUOJEKPEUYPNOH-UHFFFAOYSA-N 0.000 claims 1
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• XAIDALAOPONQMG-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC(C1)C)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC(C1)C)=O XAIDALAOPONQMG-UHFFFAOYSA-N 0.000 claims 1
• WHLBDMXDGIDZKV-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC(C1)O)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC(C1)O)=O WHLBDMXDGIDZKV-UHFFFAOYSA-N 0.000 claims 1
• MMXLZJFKMRQVHB-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC(C1)OC(C)C)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC(C1)OC(C)C)=O MMXLZJFKMRQVHB-UHFFFAOYSA-N 0.000 claims 1
• VYMDJNRKKHZPQO-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC(C1)OC)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC(C1)OC)=O VYMDJNRKKHZPQO-UHFFFAOYSA-N 0.000 claims 1
• XCKOJHQDQVQSMM-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC(CCC1)F)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC(CCC1)F)=O XCKOJHQDQVQSMM-UHFFFAOYSA-N 0.000 claims 1
• LRCSMYYNTDTNRG-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC(NC(C1)=O)=O)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC(NC(C1)=O)=O)=O LRCSMYYNTDTNRG-UHFFFAOYSA-N 0.000 claims 1
• GLFIJNDOAVOTQN-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC2C(C1)CCC2)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC2C(C1)CCC2)=O GLFIJNDOAVOTQN-UHFFFAOYSA-N 0.000 claims 1
• YBXQVMZVJYPUDD-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC2CCC(C1)C2OC)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC2CCC(C1)C2OC)=O YBXQVMZVJYPUDD-UHFFFAOYSA-N 0.000 claims 1
• RBYNSAHEOVRHJH-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC2CN(CC2C1)C)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC2CN(CC2C1)C)=O RBYNSAHEOVRHJH-UHFFFAOYSA-N 0.000 claims 1
• HMJOKXLVCLCOMG-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC2N(CC1)CCC2)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC2N(CC1)CCC2)=O HMJOKXLVCLCOMG-UHFFFAOYSA-N 0.000 claims 1
• ZLSJBRKQHTYPJU-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC2N(CCCC2C1)C)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CC2N(CCCC2C1)C)=O ZLSJBRKQHTYPJU-UHFFFAOYSA-N 0.000 claims 1
• QZTAOLNUGHNMJR-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CCC(CC1)F)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CCC(CC1)F)=O QZTAOLNUGHNMJR-UHFFFAOYSA-N 0.000 claims 1
• NBYPYZVXLKVKHJ-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CCC(CCC1)=O)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1CCC(CCC1)=O)=O NBYPYZVXLKVKHJ-UHFFFAOYSA-N 0.000 claims 1
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• VVMSTQZOIKYVBV-OAHLLOKOSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@@H](CC1)F)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@@H](CC1)F)=O VVMSTQZOIKYVBV-OAHLLOKOSA-N 0.000 claims 1
• GROVRLXOCLXUMV-OAHLLOKOSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@@H](CC1)O)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@@H](CC1)O)=O GROVRLXOCLXUMV-OAHLLOKOSA-N 0.000 claims 1
• XCKOJHQDQVQSMM-MRXNPFEDSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@@H](CCC1)F)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@@H](CCC1)F)=O XCKOJHQDQVQSMM-MRXNPFEDSA-N 0.000 claims 1
• WSZIYBYLKLGALZ-MRXNPFEDSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@@H](CCC1)O)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@@H](CCC1)O)=O WSZIYBYLKLGALZ-MRXNPFEDSA-N 0.000 claims 1
• CBSFFDHAHKZAQR-CALCHBBNSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@@H]2[C@H](C1)C(N(C2=O)C)=O)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@@H]2[C@H](C1)C(N(C2=O)C)=O)=O CBSFFDHAHKZAQR-CALCHBBNSA-N 0.000 claims 1
• AVRYQFZORHIDON-KRWDZBQOSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H](CC1)C(C)(C)O)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H](CC1)C(C)(C)O)=O AVRYQFZORHIDON-KRWDZBQOSA-N 0.000 claims 1
• WNEKEVXOWXVZKU-INIZCTEOSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H](CC1)C)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H](CC1)C)=O WNEKEVXOWXVZKU-INIZCTEOSA-N 0.000 claims 1
• VVMSTQZOIKYVBV-HNNXBMFYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H](CC1)F)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H](CC1)F)=O VVMSTQZOIKYVBV-HNNXBMFYSA-N 0.000 claims 1
• GROVRLXOCLXUMV-HNNXBMFYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H](CC1)O)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H](CC1)O)=O GROVRLXOCLXUMV-HNNXBMFYSA-N 0.000 claims 1
• XCKOJHQDQVQSMM-INIZCTEOSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H](CCC1)F)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H](CCC1)F)=O XCKOJHQDQVQSMM-INIZCTEOSA-N 0.000 claims 1
• WSZIYBYLKLGALZ-INIZCTEOSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H](CCC1)O)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H](CCC1)O)=O WSZIYBYLKLGALZ-INIZCTEOSA-N 0.000 claims 1
• HMJOKXLVCLCOMG-SFHVURJKSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H]2N(CC1)CCC2)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H]2N(CC1)CCC2)=O HMJOKXLVCLCOMG-SFHVURJKSA-N 0.000 claims 1
• YMXCOVVYEAYQJR-GHSBBIOCSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H]2[C@H]3CC[C@@H]([C@H]2C1)C3)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1C[C@H]2[C@H]3CC[C@@H]([C@H]2C1)C3)=O YMXCOVVYEAYQJR-GHSBBIOCSA-N 0.000 claims 1
• OGVWYTUSEQSXRP-AREMUKBSSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@@H](C(=O)NC2=CC=CC=C2)CCC1)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@@H](C(=O)NC2=CC=CC=C2)CCC1)=O OGVWYTUSEQSXRP-AREMUKBSSA-N 0.000 claims 1
• PMCOFMQYQPBCEX-OAQYLSRUSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@@H](C(=O)OC)CCC1)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@@H](C(=O)OC)CCC1)=O PMCOFMQYQPBCEX-OAQYLSRUSA-N 0.000 claims 1
• TVEDCPCPFDXYDD-FQEVSTJZSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@@H](CCC1)C(C)C)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@@H](CCC1)C(C)C)=O TVEDCPCPFDXYDD-FQEVSTJZSA-N 0.000 claims 1
• YLELLJBJHGZZKH-MRXNPFEDSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@@H](CCC1)C)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@@H](CCC1)C)=O YLELLJBJHGZZKH-MRXNPFEDSA-N 0.000 claims 1
• GXRACZTZTYRHIY-MRXNPFEDSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@@H](COCC1)C)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@@H](COCC1)C)=O GXRACZTZTYRHIY-MRXNPFEDSA-N 0.000 claims 1
• CAUZWQKJQIONNF-MRXNPFEDSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@H](CCC1)C#N)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@H](CCC1)C#N)=O CAUZWQKJQIONNF-MRXNPFEDSA-N 0.000 claims 1
• TVEDCPCPFDXYDD-HXUWFJFHSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@H](CCC1)C(C)C)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@H](CCC1)C(C)C)=O TVEDCPCPFDXYDD-HXUWFJFHSA-N 0.000 claims 1
• YLELLJBJHGZZKH-INIZCTEOSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@H](CCC1)C)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@H](CCC1)C)=O YLELLJBJHGZZKH-INIZCTEOSA-N 0.000 claims 1
• JPFXENKNWLULEO-QGZVFWFLSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@H](CCC1)COC)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@H](CCC1)COC)=O JPFXENKNWLULEO-QGZVFWFLSA-N 0.000 claims 1
• VVXMHBPGVVBDDJ-OAQYLSRUSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@H](CCCC1)C(C)C)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N1[C@H](CCCC1)C(C)C)=O VVXMHBPGVVBDDJ-OAQYLSRUSA-N 0.000 claims 1
• CEBVFJSGFQFFMO-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC(C)C)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC(C)C)=O CEBVFJSGFQFFMO-UHFFFAOYSA-N 0.000 claims 1
• FROQFRBZOADSSB-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1(CC1)C)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1(CC1)C)=O FROQFRBZOADSSB-UHFFFAOYSA-N 0.000 claims 1
• KMSFSKSZUWYISV-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1(CCC1)C(F)(F)F)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1(CCC1)C(F)(F)F)=O KMSFSKSZUWYISV-UHFFFAOYSA-N 0.000 claims 1
• AYINKXAUZZYSQB-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1(CCC1)CO)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1(CCC1)CO)=O AYINKXAUZZYSQB-UHFFFAOYSA-N 0.000 claims 1
• HMVCFKVSBZILQL-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1CC(C1)=NO)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1CC(C1)=NO)=O HMVCFKVSBZILQL-UHFFFAOYSA-N 0.000 claims 1
• MSOWAAZETDYQEV-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1CC(C1)=NOC)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1CC(C1)=NOC)=O MSOWAAZETDYQEV-UHFFFAOYSA-N 0.000 claims 1
• DKUZFDSXNZNQHT-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1CC(C1)=O)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1CC(C1)=O)=O DKUZFDSXNZNQHT-UHFFFAOYSA-N 0.000 claims 1
• JKHHLTKGRJCGBE-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1CC(C1)O)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1CC(C1)O)=O JKHHLTKGRJCGBE-UHFFFAOYSA-N 0.000 claims 1
• AIPQKVPSUVTUDB-UHFFFAOYSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1CCOCC1)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)NC1CCOCC1)=O AIPQKVPSUVTUDB-UHFFFAOYSA-N 0.000 claims 1
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• HBONYBKMFPBIEJ-UTKZUKDTSA-N FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N[C@H]1[C@H](CCC1)O)=O Chemical compound FC1=C(C=CC=C1)N1N=CC2=C(C=CC=C12)N1C(N(CC1)CC(=O)N[C@H]1[C@H](CCC1)O)=O HBONYBKMFPBIEJ-UTKZUKDTSA-N 0.000 claims 1
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