JP2017527567A5 - - Google Patents

Info

Publication number

JP2017527567A5

JP2017527567A5 JP2017512976A JP2017512976A JP2017527567A5 JP 2017527567 A5 JP2017527567 A5 JP 2017527567A5 JP 2017512976 A JP2017512976 A JP 2017512976A JP 2017512976 A JP2017512976 A JP 2017512976A JP 2017527567 A5 JP2017527567 A5 JP 2017527567A5

Authority

JP

Japan

Prior art keywords

formulation

preparation

formula

compound

leukemia

Prior art date

2015-09-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 238000009472 formulation Methods 0.000 claims 24
• 239000000203 mixture Substances 0.000 claims 24
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 11
• 150000001875 compounds Chemical class 0.000 claims 9
• 239000003153 chemical reaction reagent Substances 0.000 claims 5
• 239000002904 solvent Substances 0.000 claims 5
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
• 229960004106 citric acid Drugs 0.000 claims 3
• 208000032839 leukemia Diseases 0.000 claims 3
• 230000008707 rearrangement Effects 0.000 claims 3
• ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 3
• 229920000858 Cyclodextrin Polymers 0.000 claims 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
• 230000008030 elimination Effects 0.000 claims 2
• 238000003379 elimination reaction Methods 0.000 claims 2
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical group O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
• 206010000830 Acute leukaemia Diseases 0.000 claims 1
• 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
• 206010006895 Cachexia Diseases 0.000 claims 1
• YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• FMGZEUWROYGLAY-UHFFFAOYSA-N Halosulfuron-methyl Chemical compound ClC1=NN(C)C(S(=O)(=O)NC(=O)NC=2N=C(OC)C=C(OC)N=2)=C1C(=O)OC FMGZEUWROYGLAY-UHFFFAOYSA-N 0.000 claims 1
• 102100039489 Histone-lysine N-methyltransferase, H3 lysine-79 specific Human genes 0.000 claims 1
• 101000963360 Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-79 specific Proteins 0.000 claims 1
• 150000001204 N-oxides Chemical class 0.000 claims 1
• 229960004543 anhydrous citric acid Drugs 0.000 claims 1
• 230000001754 anti-pyretic effect Effects 0.000 claims 1
• 239000002221 antipyretic Substances 0.000 claims 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 201000010902 chronic myelomonocytic leukemia Diseases 0.000 claims 1
• 229960002303 citric acid monohydrate Drugs 0.000 claims 1
• 239000008121 dextrose Substances 0.000 claims 1
• 239000002552 dosage form Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 230000011132 hemopoiesis Effects 0.000 claims 1
• 239000007951 isotonicity adjuster Substances 0.000 claims 1
• 230000011987 methylation Effects 0.000 claims 1
• 238000007069 methylation reaction Methods 0.000 claims 1
• 238000011084 recovery Methods 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000011780 sodium chloride Substances 0.000 claims 1
• 230000005945 translocation Effects 0.000 claims 1