JP2017527304A5 - - Google Patents
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- JP2017527304A5 JP2017527304A5 JP2017523184A JP2017523184A JP2017527304A5 JP 2017527304 A5 JP2017527304 A5 JP 2017527304A5 JP 2017523184 A JP2017523184 A JP 2017523184A JP 2017523184 A JP2017523184 A JP 2017523184A JP 2017527304 A5 JP2017527304 A5 JP 2017527304A5
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- JP
- Japan
- Prior art keywords
- genes
- subject
- lung cancer
- identified
- clusters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims 26
- 238000000034 method Methods 0.000 claims 16
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 11
- 201000005202 lung cancer Diseases 0.000 claims 11
- 208000020816 lung neoplasm Diseases 0.000 claims 11
- 230000014509 gene expression Effects 0.000 claims 9
- 239000012472 biological sample Substances 0.000 claims 7
- 108020004999 messenger RNA Proteins 0.000 claims 6
- -1 APOCI Proteins 0.000 claims 3
- 230000000391 smoking effect Effects 0.000 claims 3
- 230000002380 cytological effect Effects 0.000 claims 2
- 238000010195 expression analysis Methods 0.000 claims 2
- 102100026443 Adhesion G-protein coupled receptor F1 Human genes 0.000 claims 1
- 108010003133 Aldo-Keto Reductase Family 1 Member C2 Proteins 0.000 claims 1
- 102100024089 Aldo-keto reductase family 1 member C2 Human genes 0.000 claims 1
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims 1
- 108010065524 CD52 Antigen Proteins 0.000 claims 1
- 101150028614 CERS3 gene Proteins 0.000 claims 1
- 102100035435 Ceramide synthase 3 Human genes 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 102100035300 Cystine/glutamate transporter Human genes 0.000 claims 1
- 102100039353 Epoxide hydrolase 3 Human genes 0.000 claims 1
- 101150043847 FOXD1 gene Proteins 0.000 claims 1
- 102100037057 Forkhead box protein D1 Human genes 0.000 claims 1
- 102100040517 Golgi-associated kinase 1B Human genes 0.000 claims 1
- 101000718228 Homo sapiens Adhesion G-protein coupled receptor F1 Proteins 0.000 claims 1
- 101000812391 Homo sapiens Epoxide hydrolase 3 Proteins 0.000 claims 1
- 101000893979 Homo sapiens Golgi-associated kinase 1B Proteins 0.000 claims 1
- 101001030184 Homo sapiens Myotilin Proteins 0.000 claims 1
- 101000972799 Homo sapiens NKAP-like protein Proteins 0.000 claims 1
- 101000613391 Homo sapiens Protocadherin beta-16 Proteins 0.000 claims 1
- 101001134788 Homo sapiens Protocadherin beta-4 Proteins 0.000 claims 1
- 101100078258 Homo sapiens RUNX1T1 gene Proteins 0.000 claims 1
- 101000620773 Homo sapiens Ras GTPase-activating protein 3 Proteins 0.000 claims 1
- 101000839339 Homo sapiens Synaptotagmin-8 Proteins 0.000 claims 1
- 101000764274 Homo sapiens Troponin T, fast skeletal muscle Proteins 0.000 claims 1
- 102100038894 Myotilin Human genes 0.000 claims 1
- 102100022579 NKAP-like protein Human genes 0.000 claims 1
- 102100024952 Protein CBFA2T1 Human genes 0.000 claims 1
- 102100040927 Protocadherin beta-16 Human genes 0.000 claims 1
- 102100033435 Protocadherin beta-4 Human genes 0.000 claims 1
- 108700040655 RUNX1 Translocation Partner 1 Proteins 0.000 claims 1
- 102100022879 Ras GTPase-activating protein 3 Human genes 0.000 claims 1
- 108091006241 SLC7A11 Proteins 0.000 claims 1
- 102100028201 Synaptotagmin-8 Human genes 0.000 claims 1
- 102100026896 Troponin T, fast skeletal muscle Human genes 0.000 claims 1
- 230000002596 correlated effect Effects 0.000 claims 1
- 230000007717 exclusion Effects 0.000 claims 1
- 210000001533 respiratory mucosa Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462024456P | 2014-07-14 | 2014-07-14 | |
| US62/024,456 | 2014-07-14 | ||
| US201562160403P | 2015-05-12 | 2015-05-12 | |
| US62/160,403 | 2015-05-12 | ||
| PCT/US2015/040437 WO2016011068A1 (en) | 2014-07-14 | 2015-07-14 | Methods for evaluating lung cancer status |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020126239A Division JP2020182489A (ja) | 2014-07-14 | 2020-07-27 | 肺がん状態の評価方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527304A JP2017527304A (ja) | 2017-09-21 |
| JP2017527304A5 true JP2017527304A5 (enExample) | 2018-08-30 |
| JP6775499B2 JP6775499B2 (ja) | 2020-10-28 |
Family
ID=55078998
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017523184A Active JP6775499B2 (ja) | 2014-07-14 | 2015-07-14 | 肺がん状態の評価方法 |
| JP2020126239A Pending JP2020182489A (ja) | 2014-07-14 | 2020-07-27 | 肺がん状態の評価方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020126239A Pending JP2020182489A (ja) | 2014-07-14 | 2020-07-27 | 肺がん状態の評価方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20160130656A1 (enExample) |
| EP (2) | EP3916110A1 (enExample) |
| JP (2) | JP6775499B2 (enExample) |
| KR (1) | KR102461014B1 (enExample) |
| CN (2) | CN114807368A (enExample) |
| AU (2) | AU2015289758B2 (enExample) |
| CA (1) | CA2954169A1 (enExample) |
| WO (1) | WO2016011068A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2360278A1 (en) | 2005-04-14 | 2011-08-24 | Trustees Of Boston University | Diagnostic for lung disorders using class prediction |
| EP1999472A2 (en) | 2006-03-09 | 2008-12-10 | The Trustees Of Boston University | Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells |
| AU2008302076B2 (en) | 2007-09-19 | 2015-06-11 | The Trustees Of Boston University | Identification of novel pathways for drug development for lung disease |
| US9495515B1 (en) | 2009-12-09 | 2016-11-15 | Veracyte, Inc. | Algorithms for disease diagnostics |
| US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
| US8669057B2 (en) | 2009-05-07 | 2014-03-11 | Veracyte, Inc. | Methods and compositions for diagnosis of thyroid conditions |
| WO2014186036A1 (en) | 2013-03-14 | 2014-11-20 | Allegro Diagnostics Corp. | Methods for evaluating copd status |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| US12297505B2 (en) | 2014-07-14 | 2025-05-13 | Veracyte, Inc. | Algorithms for disease diagnostics |
| CN114606309A (zh) | 2014-11-05 | 2022-06-10 | 威拉赛特公司 | 使用机器学习和高维转录数据的诊断系统和方法 |
| EP4180531A3 (en) | 2016-05-12 | 2023-08-23 | Trustees of Boston University | Nasal epithelium gene expression signature and classifier for the prediction of lung cancer |
| CN109715830A (zh) * | 2016-06-21 | 2019-05-03 | 威斯塔解剖学和生物学研究所 | 用于使用基因表达谱诊断肺癌的组合物和方法 |
| WO2018009915A1 (en) | 2016-07-08 | 2018-01-11 | Trustees Of Boston University | Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions |
| EP3513344A1 (en) * | 2016-09-14 | 2019-07-24 | Philip Morris Products S.a.s. | Systems, methods, and gene signatures for predicting a biological status of an individual |
| US11244764B2 (en) | 2016-12-21 | 2022-02-08 | Cerner Innovation, Inc. | Monitoring predictive models |
| US11408887B2 (en) | 2017-05-22 | 2022-08-09 | The National Institute for Biotechnology in the Negev Ltd. | Biomarkers for diagnosis of lung cancer |
| JP2020522690A (ja) * | 2017-06-02 | 2020-07-30 | ベラサイト インコーポレイテッド | 肺疾病の特定又はモニタリング方法及びシステム |
| CA3085464A1 (en) | 2017-12-19 | 2019-06-27 | The Wistar Institute Of Anatomy And Biology | Compositions and methods for diagnosing lung cancers using gene expression profiles |
| EP3817650A4 (en) * | 2018-07-02 | 2022-04-13 | 3M Innovative Properties Company | Sensing system and method for monitoring time-dependent processes |
| KR102274564B1 (ko) * | 2018-07-03 | 2021-07-07 | (주) 프로큐라티오 | 빅데이터분석기반 암진단장치 |
| CN108998531B (zh) * | 2018-08-31 | 2021-10-01 | 昆明医科大学第一附属医院 | 肺癌下调长链非编码rna标志物及其应用 |
| CN109615075B (zh) * | 2018-12-14 | 2022-08-19 | 大连海事大学 | 一种基于多层聚类模型的居民日常行为识别方法 |
| US20210287795A1 (en) * | 2020-03-12 | 2021-09-16 | Optellum Limited | Cad device and method for assisting an estimation of lung disease from medical images |
| CN113801936B (zh) * | 2020-03-30 | 2022-04-19 | 中国医学科学院肿瘤医院 | 用于肺癌诊断的试剂盒、装置及方法 |
| CN114317745B (zh) * | 2020-03-30 | 2022-06-07 | 中国医学科学院肿瘤医院 | 外泌体arpc5、eri3等在肺癌诊断中的应用 |
| CN111863130A (zh) * | 2020-04-07 | 2020-10-30 | 至本医疗科技（上海）有限公司 | 肿瘤免疫治疗预后标志物的筛选方法及应用 |
| CN112034185A (zh) * | 2020-09-11 | 2020-12-04 | 上海市胸科医院 | Gpr110、vegfr、cd34在鉴别肺腺癌亚型中的用途 |
| WO2022212283A1 (en) * | 2021-03-29 | 2022-10-06 | Veracyte, Inc. | Methods and systems to identify a lung disorder |
| US12094107B2 (en) * | 2021-04-07 | 2024-09-17 | Optellum Limited | CAD device and method for analyzing medical images |
| CN113444796B (zh) * | 2021-06-29 | 2023-02-07 | 浙江医院 | 与肺癌相关的生物标志物及其在诊断癌症中的应用 |
| KR102417602B1 (ko) * | 2021-11-30 | 2022-07-07 | (주)플라스바이오 | 인공 지능 모델 기반 종양 관리 장치 및 방법 |
| CN114854755B (zh) * | 2022-05-30 | 2023-05-23 | 陕西师范大学 | 一种抑制vstm2l表达的慢病毒载体及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003097666A2 (en) | 2002-05-16 | 2003-11-27 | Euro-Celtique, S.A. | Use of gastrin releasing peptide (grp) and its receptor in cancer screening |
| EP1633892A4 (en) | 2003-06-10 | 2007-10-24 | Univ Boston | DETECTION METHODS FOR LUNG DISEASES |
| EP1692255A4 (en) | 2003-11-12 | 2010-12-08 | Univ Boston | EXTRACTION OF NUCLEIC ACID FROM EPITHELIAL CELLS FROM THE MOUTH |
| EP2360278A1 (en) | 2005-04-14 | 2011-08-24 | Trustees Of Boston University | Diagnostic for lung disorders using class prediction |
| US9347945B2 (en) | 2005-12-22 | 2016-05-24 | Abbott Molecular Inc. | Methods and marker combinations for screening for predisposition to lung cancer |
| EP1999472A2 (en) | 2006-03-09 | 2008-12-10 | The Trustees Of Boston University | Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells |
| WO2007142936A2 (en) * | 2006-05-30 | 2007-12-13 | Duke University | Prediction of lung cancer tumor recurrence |
| KR101443214B1 (ko) * | 2007-01-09 | 2014-09-24 | 삼성전자주식회사 | 폐암 환자 또는 폐암 치료를 받은 폐암 환자의 폐암 재발 위험을 진단하기 위한 조성물, 키트 및 마이크로어레이 |
| WO2008140774A2 (en) | 2007-05-08 | 2008-11-20 | Picobella Llc | Methods for diagnosing and treating prostate and lung cancer |
| AU2008302076B2 (en) | 2007-09-19 | 2015-06-11 | The Trustees Of Boston University | Identification of novel pathways for drug development for lung disease |
| US20100055689A1 (en) | 2008-03-28 | 2010-03-04 | Avrum Spira | Multifactorial methods for detecting lung disorders |
| GB0811413D0 (en) * | 2008-06-20 | 2008-07-30 | Kanton Basel Stadt | Gene expression signatures for lung cancers |
| MX2012014268A (es) * | 2010-07-09 | 2013-02-12 | Somalogic Inc | Biomarcadores de cancer de pulmon y usos de los mismos. |
| KR20130017525A (ko) | 2011-08-11 | 2013-02-20 | 주식회사 젠닥스 | 대장암, 유방암, 신장암 또는 갑상선암의 조기 진단을 위한 바이오 마커 및 이의 용도 |
| CA2846837A1 (en) * | 2011-08-29 | 2013-03-07 | Cardiodx, Inc. | Methods and compositions for determining smoking status |
| US9753043B2 (en) * | 2011-12-18 | 2017-09-05 | 20/20 Genesystems, Inc. | Methods and algorithms for aiding in the detection of cancer |
| US20150088430A1 (en) * | 2012-04-26 | 2015-03-26 | Allegro Diagnostics Corp | Methods for evaluating lung cancer status |
| US20140220006A1 (en) * | 2013-02-01 | 2014-08-07 | Meso Scale Technologies, Llc | Lung cancer biomarkers |
-
2015
- 2015-07-14 CA CA2954169A patent/CA2954169A1/en active Pending
- 2015-07-14 AU AU2015289758A patent/AU2015289758B2/en active Active
- 2015-07-14 KR KR1020177004127A patent/KR102461014B1/ko active Active
- 2015-07-14 US US14/799,472 patent/US20160130656A1/en not_active Abandoned
- 2015-07-14 EP EP21185798.2A patent/EP3916110A1/en active Pending
- 2015-07-14 CN CN202210456480.7A patent/CN114807368A/zh active Pending
- 2015-07-14 JP JP2017523184A patent/JP6775499B2/ja active Active
- 2015-07-14 WO PCT/US2015/040437 patent/WO2016011068A1/en not_active Ceased
- 2015-07-14 CN CN201580048833.8A patent/CN106795565B/zh active Active
- 2015-07-14 EP EP15822338.8A patent/EP3169814B1/en active Active
-
2020
- 2020-05-15 US US16/875,673 patent/US20210040562A1/en not_active Abandoned
- 2020-07-27 JP JP2020126239A patent/JP2020182489A/ja active Pending
-
2021
- 2021-08-20 AU AU2021218178A patent/AU2021218178A1/en not_active Abandoned
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