JP2014501496A5 - - Google Patents
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- JP2014501496A5 JP2014501496A5 JP2013534446A JP2013534446A JP2014501496A5 JP 2014501496 A5 JP2014501496 A5 JP 2014501496A5 JP 2013534446 A JP2013534446 A JP 2013534446A JP 2013534446 A JP2013534446 A JP 2013534446A JP 2014501496 A5 JP2014501496 A5 JP 2014501496A5
- Authority
- JP
- Japan
- Prior art keywords
- aurka
- gist
- years
- expression
- risk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 102000004000 Aurora Kinase A Human genes 0.000 claims description 18
- 108090000461 Aurora Kinase A Proteins 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 10
- 206010027476 Metastases Diseases 0.000 claims description 8
- 230000009401 metastasis Effects 0.000 claims description 6
- 230000004083 survival effect Effects 0.000 claims description 3
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 11
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 8
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 102100032311 Aurora kinase A Human genes 0.000 description 2
- 101000798300 Homo sapiens Aurora kinase A Proteins 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000010200 validation analysis Methods 0.000 description 2
- 238000011529 RT qPCR Methods 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10013806 | 2010-10-20 | ||
| EP10013806.4 | 2010-10-20 | ||
| PCT/IB2011/054688 WO2012052954A1 (en) | 2010-10-20 | 2011-10-20 | Signatures of clinical outcome in gastro intestinal stromal tumors and method of treatment of gastroinstestinal stromal tumors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014501496A JP2014501496A (ja) | 2014-01-23 |
| JP2014501496A5 true JP2014501496A5 (enExample) | 2016-02-04 |
Family
ID=44999817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013534446A Pending JP2014501496A (ja) | 2010-10-20 | 2011-10-20 | 消化管間質腫瘍における臨床転帰のシグネチャーおよび消化管間質腫瘍の治療の方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20130288250A1 (enExample) |
| EP (1) | EP2630259B8 (enExample) |
| JP (1) | JP2014501496A (enExample) |
| CA (1) | CA2811744A1 (enExample) |
| DK (1) | DK2630259T3 (enExample) |
| ES (1) | ES2541054T3 (enExample) |
| WO (1) | WO2012052954A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3064594A1 (en) | 2015-03-06 | 2016-09-07 | Université de Bordeaux | Signature of clinical outcome in uterine smooth muscle tumor analysis, and method of diagnosis thereof |
| KR101860652B1 (ko) | 2015-12-23 | 2018-05-24 | 연세대학교 산학협력단 | 위장관 간질 종양 진단용 마커 및 위장관 간질 종양의 진단 방법 |
| JP6965621B2 (ja) * | 2017-08-02 | 2021-11-10 | 富士通株式会社 | 検出プログラム、検出方法及び検出装置 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2491067A1 (en) * | 2004-12-24 | 2006-06-24 | Stichting Katholieke Universiteit | Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer |
| US20080194556A1 (en) * | 2005-05-28 | 2008-08-14 | Astrazeneca Ab | Quinazolines and Their Use as Aurora Kinase Inhibitors |
| WO2006130613A2 (en) * | 2005-05-31 | 2006-12-07 | The Pfahl Family Trust (Dated 9 July 1996) | Substituted biarylheterocycle derivatives as protein kinase inhibitors for the treatment of cancer and other diseases |
| WO2008045133A2 (en) * | 2006-03-03 | 2008-04-17 | Veridex, Llc | Molecular assay to predict recurrence of dukes' b colon cancer |
| WO2008025526A1 (en) * | 2006-08-31 | 2008-03-06 | F. Hoffmann-La Roche Ag | Indole derivatives, their manufacture and use as pharmaceutical agents |
| WO2008072777A2 (en) * | 2006-12-13 | 2008-06-19 | Oncotherapy Science, Inc. | Ttk as tumor marker and therapeutic target for lung cancer |
| CA2690557A1 (en) * | 2007-06-14 | 2008-12-24 | Schering Corporation | Imidazopyrazines as protein kinase inhibitors |
| WO2010068951A1 (en) * | 2008-12-12 | 2010-06-17 | Fox Chase Cancer Center | Combination therapy based on src and aurora kinase inhibition for the treatment of cancer |
-
2011
- 2011-10-20 EP EP11785107.1A patent/EP2630259B8/en not_active Not-in-force
- 2011-10-20 CA CA2811744A patent/CA2811744A1/en not_active Abandoned
- 2011-10-20 DK DK11785107.1T patent/DK2630259T3/en active
- 2011-10-20 ES ES11785107.1T patent/ES2541054T3/es active Active
- 2011-10-20 WO PCT/IB2011/054688 patent/WO2012052954A1/en not_active Ceased
- 2011-10-20 US US13/880,155 patent/US20130288250A1/en not_active Abandoned
- 2011-10-20 JP JP2013534446A patent/JP2014501496A/ja active Pending
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