JP2014501496A - 消化管間質腫瘍における臨床転帰のシグネチャーおよび消化管間質腫瘍の治療の方法 - Google Patents

消化管間質腫瘍における臨床転帰のシグネチャーおよび消化管間質腫瘍の治療の方法 Download PDF

Info

Publication number
JP2014501496A
JP2014501496A JP2013534446A JP2013534446A JP2014501496A JP 2014501496 A JP2014501496 A JP 2014501496A JP 2013534446 A JP2013534446 A JP 2013534446A JP 2013534446 A JP2013534446 A JP 2013534446A JP 2014501496 A JP2014501496 A JP 2014501496A
Authority
JP
Japan
Prior art keywords
gist
aurka
expression
metastasis
risk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013534446A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014501496A5 (enExample
Inventor
シボン，フレデリク
コワンドル，ジャン−ミシェル
オーリアス，アラン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Bergonie
Original Assignee
Institut Bergonie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Bergonie filed Critical Institut Bergonie
Publication of JP2014501496A publication Critical patent/JP2014501496A/ja
Publication of JP2014501496A5 publication Critical patent/JP2014501496A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2013534446A 2010-10-20 2011-10-20 消化管間質腫瘍における臨床転帰のシグネチャーおよび消化管間質腫瘍の治療の方法 Pending JP2014501496A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10013806 2010-10-20
EP10013806.4 2010-10-20
PCT/IB2011/054688 WO2012052954A1 (en) 2010-10-20 2011-10-20 Signatures of clinical outcome in gastro intestinal stromal tumors and method of treatment of gastroinstestinal stromal tumors

Publications (2)

Publication Number Publication Date
JP2014501496A true JP2014501496A (ja) 2014-01-23
JP2014501496A5 JP2014501496A5 (enExample) 2016-02-04

Family

ID=44999817

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013534446A Pending JP2014501496A (ja) 2010-10-20 2011-10-20 消化管間質腫瘍における臨床転帰のシグネチャーおよび消化管間質腫瘍の治療の方法

Country Status (7)

Country Link
US (1) US20130288250A1 (enExample)
EP (1) EP2630259B8 (enExample)
JP (1) JP2014501496A (enExample)
CA (1) CA2811744A1 (enExample)
DK (1) DK2630259T3 (enExample)
ES (1) ES2541054T3 (enExample)
WO (1) WO2012052954A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019028895A (ja) * 2017-08-02 2019-02-21 富士通株式会社 検出プログラム、検出方法及び検出装置

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3064594A1 (en) 2015-03-06 2016-09-07 Université de Bordeaux Signature of clinical outcome in uterine smooth muscle tumor analysis, and method of diagnosis thereof
KR101860652B1 (ko) 2015-12-23 2018-05-24 연세대학교 산학협력단 위장관 간질 종양 진단용 마커 및 위장관 간질 종양의 진단 방법

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008025526A1 (en) * 2006-08-31 2008-03-06 F. Hoffmann-La Roche Ag Indole derivatives, their manufacture and use as pharmaceutical agents
JP2008524998A (ja) * 2004-12-24 2008-07-17 スティヒティング，カソリケ ユニフェルシテイト，ザ ユニバーシティ メディカル センター ネイメーヘン 前立腺癌の予後判定用マーカー及び／又はテラノスティックマーカーとなる、尿沈渣及び／又は尿のｍＲＮＡ比
JP2009528825A (ja) * 2006-03-03 2009-08-13 ベリデックス・エルエルシー デュークスｂ大腸がんの再発を予測するための分子的解析
JP2010512730A (ja) * 2006-12-13 2010-04-30 オンコセラピー・サイエンス株式会社 肺癌の腫瘍マーカーおよび治療標的としてのｔｔｋ
WO2010068951A1 (en) * 2008-12-12 2010-06-17 Fox Chase Cancer Center Combination therapy based on src and aurora kinase inhibition for the treatment of cancer
JP2010529195A (ja) * 2007-06-14 2010-08-26 シェーリング コーポレイション プロテインキナーゼの阻害剤としてのイミダゾピラジン

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008542345A (ja) * 2005-05-28 2008-11-27 アストラゼネカ アクチボラグ キナゾリン類及びオーロラキナーゼ阻害剤としてのその使用
EP1896462A2 (en) * 2005-05-31 2008-03-12 The Pfahl Family Trust (Dated 9 July 1996) Substituted biarylheterocycle derivatives as protein kinase inhibitors for the treatment of cancer and other diseases

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008524998A (ja) * 2004-12-24 2008-07-17 スティヒティング，カソリケ ユニフェルシテイト，ザ ユニバーシティ メディカル センター ネイメーヘン 前立腺癌の予後判定用マーカー及び／又はテラノスティックマーカーとなる、尿沈渣及び／又は尿のｍＲＮＡ比
JP2009528825A (ja) * 2006-03-03 2009-08-13 ベリデックス・エルエルシー デュークスｂ大腸がんの再発を予測するための分子的解析
WO2008025526A1 (en) * 2006-08-31 2008-03-06 F. Hoffmann-La Roche Ag Indole derivatives, their manufacture and use as pharmaceutical agents
JP2010512730A (ja) * 2006-12-13 2010-04-30 オンコセラピー・サイエンス株式会社 肺癌の腫瘍マーカーおよび治療標的としてのｔｔｋ
JP2010529195A (ja) * 2007-06-14 2010-08-26 シェーリング コーポレイション プロテインキナーゼの阻害剤としてのイミダゾピラジン
WO2010068951A1 (en) * 2008-12-12 2010-06-17 Fox Chase Cancer Center Combination therapy based on src and aurora kinase inhibition for the treatment of cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN. J. CLIN. ONCOL., vol. 36, no. 2, JPN6015036066, 2006, pages 85 - 92, ISSN: 0003149873 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019028895A (ja) * 2017-08-02 2019-02-21 富士通株式会社 検出プログラム、検出方法及び検出装置

Also Published As

Publication number Publication date
US20130288250A1 (en) 2013-10-31
WO2012052954A1 (en) 2012-04-26
EP2630259A1 (en) 2013-08-28
DK2630259T3 (en) 2015-07-06
EP2630259B1 (en) 2015-04-15
ES2541054T3 (es) 2015-07-15
CA2811744A1 (en) 2012-04-26
EP2630259B8 (en) 2015-05-27

Similar Documents

Publication Publication Date Title
Jiang et al. Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatment
JP5843840B2 (ja) 新しい癌マーカー
JP7186700B2 (ja) 腫瘍抑制ｆｏｘｏ活性を酸化ストレスから区別する方法
CN106834462B (zh) 一组胃癌基因的应用
JP6704861B2 (ja) 癌処置のための個別化三剤治療を選択するための方法
JP2008521412A (ja) 肺癌予後判定手段
JP2017532959A (ja) Ｍｄｍ２阻害剤に対する感受性の遺伝子シグネチャーに基づく予測因子に関するアルゴリズム
JP2017508442A (ja) Ｍｄｍ２阻害剤に対する感受性と関連する遺伝子シグネチャー
US20120141603A1 (en) Methods and compositions for lung cancer prognosis
WO2015073949A1 (en) Method of subtyping high-grade bladder cancer and uses thereof
JP2011509689A (ja) Ｉｉ及びｉｉｉ期結腸癌の分子病期分類並びに予後診断
US20180298449A1 (en) Gene expression profiles and uses thereof in breast cancer
EP3122905A2 (en) Circulating micrornas as biomarkers for endometriosis
JP2016105710A (ja) 非小細胞肺癌の予後を決定するための診断方法
CN107208148B (zh) 用于乳腺肿瘤的病理分级的方法和试剂盒
CN111194356B (zh) 用于检测浆细胞恶病质的方法
JP2011520454A (ja) 結腸直腸癌を評価する方法及びかかる方法に使用するための組成物
WO2014127267A1 (en) Methods and tools for the diagnosis and prognosis of urogenital cancers
WO2017119510A1 (ja) 乳がんの診断のための検査方法、遺伝子マーカー、および検査薬
JP5865241B2 (ja) 肉腫の予後分子署名およびその使用
DK2630259T3 (en) SIGNATURES OF CLINICAL OUTCOME In gastrointestinal stromal tumors AND METHOD FOR THE TREATMENT OF gastrointestinal stromal tumors
EP2716767A1 (en) Method for determining the prognosis of pancreatic cancer
JP7471601B2 (ja) 分子シグネチャー及び低悪性度前立腺癌の同定のためのその使用
EP2065474A1 (en) A method to assess prognosis and to predict therapeutic response to endocrine treatment
KR102384992B1 (ko) 대장암 환자의 연령 특이적 바이오마커 및 이의 용도

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20140827

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150908

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20151203

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160510

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20161220