JP2017527299A5 - - Google Patents
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- JP2017527299A5 JP2017527299A5 JP2017514828A JP2017514828A JP2017527299A5 JP 2017527299 A5 JP2017527299 A5 JP 2017527299A5 JP 2017514828 A JP2017514828 A JP 2017514828A JP 2017514828 A JP2017514828 A JP 2017514828A JP 2017527299 A5 JP2017527299 A5 JP 2017527299A5
- Authority
- JP
- Japan
- Prior art keywords
- curved
- inlet
- microfluidic system
- microchannel
- outlets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 19
- 239000011541 reaction mixture Substances 0.000 claims 14
- 230000010412 perfusion Effects 0.000 claims 9
- 230000014759 maintenance of location Effects 0.000 claims 7
- 239000002245 particle Substances 0.000 claims 4
- 239000012530 fluid Substances 0.000 claims 3
- 238000004064 recycling Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 2
- 239000000047 product Substances 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000002551 biofuel Substances 0.000 claims 1
- 239000013060 biological fluid Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 239000002699 waste material Substances 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051497P | 2014-09-17 | 2014-09-17 | |
| US62/051,497 | 2014-09-17 | ||
| PCT/US2015/050604 WO2016044537A1 (en) | 2014-09-17 | 2015-09-17 | Microfluidic system and method for perfusion bioreactor cell retention |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017527299A JP2017527299A (ja) | 2017-09-21 |
| JP2017527299A5 true JP2017527299A5 (cg-RX-API-DMAC7.html) | 2018-10-25 |
Family
ID=55533830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017514828A Pending JP2017527299A (ja) | 2014-09-17 | 2015-09-17 | 灌流バイオリアクター細胞保持のためのマイクロ流体システム及び方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20170292104A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3194560A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2017527299A (cg-RX-API-DMAC7.html) |
| CN (1) | CN107250341A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016044537A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150061643A (ko) | 2012-09-21 | 2015-06-04 | 메사추세츠 인스티튜트 오브 테크놀로지 | 미소 유체 장치 및 그의 용도 |
| SG11201606832YA (en) | 2014-02-18 | 2016-09-29 | Massachusetts Inst Technology | Biophysically sorted osteoprogenitors from culture expanded bone marrow derived mesenchymal stromal cells (mscs) |
| US10806845B2 (en) | 2014-09-17 | 2020-10-20 | Massachusetts Institute Of Technology | System and method for inertial focusing microfiltration for intra-operative blood salvage autotransfusion |
| JP6912161B2 (ja) * | 2016-02-25 | 2021-07-28 | 株式会社神戸製鋼所 | 流路装置及び液滴形成方法 |
| SG11201900170VA (en) | 2016-07-21 | 2019-02-27 | Agency Science Tech & Res | Apparatus for outer wall focusing for high volume fraction particle microfiltration and method for manufacture thereof |
| EP3523003B1 (en) * | 2016-10-07 | 2023-09-13 | Massachusetts Institute of Technology | Particle isolation/enrichment using continuous closed-loop micro-fluidics |
| US10697964B2 (en) | 2016-11-15 | 2020-06-30 | Massachusetts Institute Of Technology | Liquid biopsy detection of leukemia using closed-loop microfluidics |
| KR101901672B1 (ko) | 2017-01-25 | 2018-10-25 | 주식회사 디오스템스 | 줄기세포 배양기 및 배양 방법, 줄기세포 연속 배양, 추출 및 분리 시스템 및 방법 |
| CN108435265A (zh) * | 2017-01-25 | 2018-08-24 | 富士康(昆山)电脑接插件有限公司 | 微流体盒及其堆叠测试组件 |
| US11161113B2 (en) * | 2017-03-17 | 2021-11-02 | Istanbul Teknik Universitesi | Microchannel having a spiral geometry structured with asymmetrical curls for continuous separation of cancer cells from blood and enrichment thereof in the circulatory system |
| CN106994369A (zh) * | 2017-05-22 | 2017-08-01 | 东南大学 | 通量可调控的微流控集成器件及其制作方法 |
| JP7124475B2 (ja) * | 2018-01-17 | 2022-08-24 | 株式会社Ihi | 細胞培養システム及び細胞培養方法 |
| CN108517284A (zh) * | 2018-03-19 | 2018-09-11 | 复旦大学 | 一种用于研究藻类生长和生殖的微流控芯片 |
| TWI898645B (zh) | 2018-05-04 | 2025-09-21 | 美商健臻公司 | 灌注式細胞培養裝置 |
| EP3797149A1 (en) * | 2018-05-22 | 2021-03-31 | Nantkwest, Inc. | Methods and systems for cell bed formation during bioprocessing |
| EP4477315A3 (en) | 2018-05-31 | 2025-03-05 | Donaldson Company, Inc. | Droplet sensors for fuel systems |
| JP7087704B2 (ja) * | 2018-06-13 | 2022-06-21 | 株式会社Ihi | 細胞培養システム及び細胞培養方法 |
| WO2019245070A1 (ko) * | 2018-06-20 | 2019-12-26 | 주식회사 디오스템스 | 줄기세포 증식기 및 증식 방법, 줄기세포 연속 증식, 추출 및 분리 시스템 및 방법 |
| EP3902630B1 (en) | 2018-11-15 | 2024-09-25 | Massachusetts Institute of Technology | Multi-dimensional double spiral device and methods of use thereof |
| JP2021013333A (ja) * | 2019-07-12 | 2021-02-12 | 株式会社Ihi | 微生物選別システム及び微生物選別方法 |
| CN111774103B (zh) * | 2020-06-01 | 2021-09-07 | 东南大学 | 一种高通量血浆分离的多核螺旋惯性分选微流控器件 |
| SE544733C2 (en) * | 2020-07-20 | 2022-10-25 | Javier Cruz | Microfluidic device and method for manipulation of particles in fluids |
| CN116601285A (zh) * | 2020-10-13 | 2023-08-15 | 勃林格殷格翰国际公司 | 用水力旋流器细胞保留装置生产生物分子的系统和方法 |
| KR102474060B1 (ko) * | 2020-10-14 | 2022-12-05 | 한국과학기술연구원 | 미세유체칩 유동에 의한 세포입자의 크기별 분리 장치와 방법 |
| EP4251296B1 (en) * | 2020-11-25 | 2025-06-25 | Donaldson Company, Inc. | Hydrodynamic separator with optimal microchannel length |
| US12478899B2 (en) | 2021-06-02 | 2025-11-25 | Donaldson Company, Inc. | Maintenance of hydrodynamic separators |
| US12252678B2 (en) | 2021-12-01 | 2025-03-18 | Microfluidx Ltd | Systems and methods for bioprocessing |
| CN114260037B (zh) * | 2021-12-27 | 2023-02-03 | 杭州电子科技大学 | 一种3d堆叠式多级惯性微流控分选芯片及其制备方法 |
| WO2023211901A1 (en) | 2022-04-28 | 2023-11-02 | Massachusetts Institute Of Technology | Spiral inertial microfluidic devices and methods to remove contaminants |
| CN114813466B (zh) * | 2022-05-05 | 2025-02-18 | 山东大学 | 一种预测水力旋流器分选细胞活性的方法及系统 |
| CN119947829A (zh) * | 2022-09-21 | 2025-05-06 | 佳能株式会社 | 微流路装置、分离装置和分离方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9486812B2 (en) * | 2006-11-30 | 2016-11-08 | Palo Alto Research Center Incorporated | Fluidic structures for membraneless particle separation |
| US8931644B2 (en) * | 2006-11-30 | 2015-01-13 | Palo Alto Research Center Incorporated | Method and apparatus for splitting fluid flow in a membraneless particle separation system |
| EP2482055A3 (en) * | 2007-04-16 | 2013-10-30 | The General Hospital Corporation d/b/a Massachusetts General Hospital | Systems and methods for particle focusing in microchannels |
| US20120028272A1 (en) * | 2009-04-01 | 2012-02-02 | University Of Louisville Research Foundation, Inc. | Device and methods for isolating cells |
| SG10201501485QA (en) * | 2010-03-04 | 2015-04-29 | Univ Singapore | Microfluidics sorter for cell detection and isolation |
| CN104160013B (zh) * | 2012-01-18 | 2017-07-28 | 拜尔健康护理有限责任公司 | 灌流式生物反应器系统及操作其的方法 |
| US9987632B2 (en) * | 2012-02-03 | 2018-06-05 | University Of Cincinnati | Microfluidic methods for passive separation of cells and particles |
| US9416344B2 (en) * | 2012-03-15 | 2016-08-16 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
| US20150072413A1 (en) * | 2012-03-29 | 2015-03-12 | Arizona Board Of Regents On Behalf University Of Arizona | Cell culture apparatus and culture methods using same |
| KR20150061643A (ko) * | 2012-09-21 | 2015-06-04 | 메사추세츠 인스티튜트 오브 테크놀로지 | 미소 유체 장치 및 그의 용도 |
| EP2900351B1 (en) * | 2012-09-28 | 2022-05-25 | Canon U.S. Life Sciences, Inc. | Particle separation and concentration using spiral inertial filtration |
| US20140093952A1 (en) * | 2012-10-02 | 2014-04-03 | David Serway | Bioreactor Tangential Flow Perfusion Filter System |
| CN103981093B (zh) * | 2014-04-24 | 2017-01-04 | 上海泰因生物技术有限公司 | 一种用生物反应器进行细胞特性筛选的装置与方法 |
-
2015
- 2015-09-17 JP JP2017514828A patent/JP2017527299A/ja active Pending
- 2015-09-17 CN CN201580062211.0A patent/CN107250341A/zh active Pending
- 2015-09-17 US US15/512,003 patent/US20170292104A1/en not_active Abandoned
- 2015-09-17 EP EP15841214.8A patent/EP3194560A4/en not_active Withdrawn
- 2015-09-17 WO PCT/US2015/050604 patent/WO2016044537A1/en not_active Ceased
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