JP2017526700A5 - - Google Patents
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- JP2017526700A5 JP2017526700A5 JP2017513044A JP2017513044A JP2017526700A5 JP 2017526700 A5 JP2017526700 A5 JP 2017526700A5 JP 2017513044 A JP2017513044 A JP 2017513044A JP 2017513044 A JP2017513044 A JP 2017513044A JP 2017526700 A5 JP2017526700 A5 JP 2017526700A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- administered
- monoclonal antibody
- day
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- NMUSYJAQQFHJEW-UHFFFAOYSA-N 5-Azacytidine Natural products O=C1N=C(N)N=CN1C1C(O)C(O)C(CO)O1 NMUSYJAQQFHJEW-UHFFFAOYSA-N 0.000 claims description 13
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims description 13
- 229960002756 azacitidine Drugs 0.000 claims description 13
- 201000010099 disease Diseases 0.000 claims description 10
- 229950009791 durvalumab Drugs 0.000 claims description 7
- 206010061818 Disease progression Diseases 0.000 claims description 2
- 229960003852 atezolizumab Drugs 0.000 claims description 2
- 230000005750 disease progression Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 43
- 150000003839 salts Chemical class 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 12
- 208000035475 disorder Diseases 0.000 claims 9
- 206010033128 Ovarian cancer Diseases 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 208000007571 Ovarian Epithelial Carcinoma Diseases 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 4
- 229960003301 nivolumab Drugs 0.000 claims 4
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 3
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 3
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000007894 caplet Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000014951 hematologic disease Diseases 0.000 claims 1
- 229950010773 pidilizumab Drugs 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 231100000402 unacceptable toxicity Toxicity 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 description 4
- 238000001802 infusion Methods 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 230000006842 hematologic response Effects 0.000 description 1
- 230000009851 immunogenic response Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462047463P | 2014-09-08 | 2014-09-08 | |
| US62/047,463 | 2014-09-08 | ||
| PCT/US2015/048812 WO2016040238A1 (en) | 2014-09-08 | 2015-09-08 | Methods for treating a disease or disorder using oral formulations of cytidine analogs in combination with an anti-pd1 or anti-pdl1 monoclonal antibody |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017526700A JP2017526700A (ja) | 2017-09-14 |
| JP2017526700A5 true JP2017526700A5 (https=) | 2018-03-08 |
Family
ID=54150681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017513044A Pending JP2017526700A (ja) | 2014-09-08 | 2015-09-08 | 抗ｐｄ１若しくは抗ｐｄｌ１モノクローナル抗体と組み合わせてシチジン類似体の経口製剤を使用する疾患または障害の治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20160067336A1 (https=) |
| EP (1) | EP3191104A1 (https=) |
| JP (1) | JP2017526700A (https=) |
| KR (1) | KR20170045237A (https=) |
| CN (1) | CN106604745A (https=) |
| AU (1) | AU2015315435A1 (https=) |
| CA (1) | CA2960490A1 (https=) |
| EA (1) | EA201790543A1 (https=) |
| IL (1) | IL250887A0 (https=) |
| MX (1) | MX2017002875A (https=) |
| SG (1) | SG11201701710SA (https=) |
| WO (1) | WO2016040238A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY184154A (en) | 2013-12-12 | 2021-03-23 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
| WO2016022955A1 (en) | 2014-08-07 | 2016-02-11 | Mayo Foundation For Medical Education And Research | Compounds and methods for treating cancer |
| CN108112254B (zh) * | 2015-03-13 | 2022-01-28 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| US11078278B2 (en) * | 2015-05-29 | 2021-08-03 | Bristol-Myers Squibb Company | Treatment of renal cell carcinoma |
| CN114591433A (zh) | 2015-07-13 | 2022-06-07 | 西托姆克斯治疗公司 | 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 |
| WO2017161154A2 (en) * | 2016-03-16 | 2017-09-21 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Pd1 and pdl-1 expression during progression from myelodysplastic syndrome to acute myelogenous leukemia |
| SG11201810951RA (en) | 2016-06-10 | 2019-01-30 | Io Therapeutics Inc | Receptor selective retinoid and rexinoid compounds and immune modulators for cancer immunotherapy |
| WO2018007554A1 (en) * | 2016-07-06 | 2018-01-11 | Pierre Fabre Medicament | Vinflunine and pd1 and/or pdl1 inhibitor as pharmaceutical combination |
| KR20190062515A (ko) * | 2016-10-06 | 2019-06-05 | 화이자 인코포레이티드 | 암의 치료를 위한 아벨루맙의 투약 용법 |
| EP4295918A3 (en) | 2016-11-02 | 2024-03-20 | Bristol-Myers Squibb Company | Bispecific antibody against bcma and cd3 and an immunological drug for combined use in treating multiple myeloma |
| EP3589659B1 (en) | 2017-02-28 | 2025-04-09 | Mayo Foundation for Medical Education and Research | Combinations for use in the treatment of cancer |
| AU2018263868A1 (en) * | 2017-05-02 | 2019-12-12 | Merck Sharp & Dohme Llc | Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies |
| WO2018213665A1 (en) | 2017-05-19 | 2018-11-22 | Syndax Pharmaceuticals, Inc. | Combination therapies |
| JP2020522486A (ja) | 2017-06-01 | 2020-07-30 | サイトメックス セラピューティクス インコーポレイテッド | 活性化可能抗ｐｄｌ１抗体、およびその使用方法 |
| KR20200029544A (ko) | 2017-07-13 | 2020-03-18 | 아이오 테라퓨틱스, 인크. | 암 면역요법을 위해 면역 조절제와 조합된 면역조절 레티노이드 및 렉시노이드 화합물 |
| KR20200044889A (ko) | 2017-08-31 | 2020-04-29 | 아이오 테라퓨틱스, 인크. | 암 면역요법을 위해 면역 조절제와 조합된 rar 선택적 작용제 |
| US20220008383A1 (en) * | 2018-11-13 | 2022-01-13 | Amy Yee | Compositions and methods of enhancing immunotherapies |
| EP3934690A4 (en) * | 2019-03-04 | 2023-08-09 | North Carolina State University | DRUG DELIVERY FOR COMBINING EPIGENETIC MODULATION AND IMMUNE CHECKPOINT BLOCKADE |
| BR112021025537A2 (pt) | 2019-06-20 | 2022-03-03 | Celgene Quanticel Res Inc | Azacitidina em combinação com venetoclax, gilteritinibe, midostaurina ou outros compostos para o tratamento de leucemia ou síndrome mielodisplásica |
| KR20210097882A (ko) * | 2020-01-30 | 2021-08-10 | 삼성바이오에피스 주식회사 | 안정한 항-pd-1 항체 약제학적 제제 |
| CA3178156A1 (en) * | 2020-04-07 | 2021-10-14 | Metanoi Therapeutics, Inc. | Ethanolamine formulation for treating epithelial ovarian carcinoma |
| KR20240108406A (ko) | 2021-10-19 | 2024-07-09 | 아키라바이오, 인크. | 2'-데옥시시티딘 유사체를 포함하는 조성물 및 겸상 적혈구 질환, 지중해빈혈, 및 암의 치료를 위한 그의 용도 |
| WO2025042742A1 (en) | 2023-08-18 | 2025-02-27 | Bristol-Myers Squibb Company | Compositions comprising antibodies that bind bcma and cd3 and methods of treatment |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR036993A1 (es) * | 2001-04-02 | 2004-10-20 | Wyeth Corp | Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas |
| KR101814408B1 (ko) * | 2008-09-26 | 2018-01-04 | 다나-파버 캔서 인스티튜트 인크. | 인간 항-ｐｄ-１, ｐｄ-ｌ１, 및 ｐｄ-ｌ2 항체 및 그의 용도 |
| WO2010093435A1 (en) * | 2009-02-10 | 2010-08-19 | Celgene International Sarl | Methods for treating non-small cell lung cancer using 5-azacytidine |
| WO2013043569A1 (en) * | 2011-09-20 | 2013-03-28 | Vical Incorporated | Synergistic anti-tumor efficacy using alloantigen combination immunotherapy |
| US20140357567A1 (en) * | 2011-11-01 | 2014-12-04 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
| EP2958571B1 (en) * | 2013-02-21 | 2024-04-10 | Michele Maio | Dna hypomethylating agents for cancer therapy |
| WO2015035112A1 (en) * | 2013-09-05 | 2015-03-12 | The Johns Hopkins University | Cancer therapy via a combination of epigenetic modulation and immune modulation |
-
2015
- 2015-09-08 WO PCT/US2015/048812 patent/WO2016040238A1/en not_active Ceased
- 2015-09-08 AU AU2015315435A patent/AU2015315435A1/en not_active Abandoned
- 2015-09-08 US US14/847,570 patent/US20160067336A1/en not_active Abandoned
- 2015-09-08 CN CN201580048157.4A patent/CN106604745A/zh not_active Withdrawn
- 2015-09-08 JP JP2017513044A patent/JP2017526700A/ja active Pending
- 2015-09-08 SG SG11201701710SA patent/SG11201701710SA/en unknown
- 2015-09-08 CA CA2960490A patent/CA2960490A1/en not_active Abandoned
- 2015-09-08 EP EP15766985.4A patent/EP3191104A1/en not_active Withdrawn
- 2015-09-08 MX MX2017002875A patent/MX2017002875A/es unknown
- 2015-09-08 EA EA201790543A patent/EA201790543A1/ru unknown
- 2015-09-08 KR KR1020177006031A patent/KR20170045237A/ko not_active Abandoned
-
2017
- 2017-03-02 IL IL250887A patent/IL250887A0/en unknown
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