JP2017526700A - 抗ｐｄ１若しくは抗ｐｄｌ１モノクローナル抗体と組み合わせてシチジン類似体の経口製剤を使用する疾患または障害の治療方法 - Google Patents

抗ｐｄ１若しくは抗ｐｄｌ１モノクローナル抗体と組み合わせてシチジン類似体の経口製剤を使用する疾患または障害の治療方法 Download PDF

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JP2017526700A
JP2017526700A JP2017513044A JP2017513044A JP2017526700A JP 2017526700 A JP2017526700 A JP 2017526700A JP 2017513044 A JP2017513044 A JP 2017513044A JP 2017513044 A JP2017513044 A JP 2017513044A JP 2017526700 A JP2017526700 A JP 2017526700A
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certain embodiments
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azacytidine
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disease
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ファンディ アブデラヒム
ファンディ アブデラヒム
レイセル デビッド
レイセル デビッド
バートン デボラ
バートン デボラ
ベジク ダミル
ベジク ダミル
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Celgene Corp
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JP2017513044A 2014-09-08 2015-09-08 抗ｐｄ１若しくは抗ｐｄｌ１モノクローナル抗体と組み合わせてシチジン類似体の経口製剤を使用する疾患または障害の治療方法 Pending JP2017526700A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462047463P 2014-09-08 2014-09-08
US62/047,463 2014-09-08
PCT/US2015/048812 WO2016040238A1 (en) 2014-09-08 2015-09-08 Methods for treating a disease or disorder using oral formulations of cytidine analogs in combination with an anti-pd1 or anti-pdl1 monoclonal antibody

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JP2017526700A true JP2017526700A (ja) 2017-09-14
JP2017526700A5 JP2017526700A5 (https=) 2018-03-08

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US (1) US20160067336A1 (https=)
EP (1) EP3191104A1 (https=)
JP (1) JP2017526700A (https=)
KR (1) KR20170045237A (https=)
CN (1) CN106604745A (https=)
AU (1) AU2015315435A1 (https=)
CA (1) CA2960490A1 (https=)
EA (1) EA201790543A1 (https=)
IL (1) IL250887A0 (https=)
MX (1) MX2017002875A (https=)
SG (1) SG11201701710SA (https=)
WO (1) WO2016040238A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022522843A (ja) * 2019-03-04 2022-04-20 ノース カロライナ ステート ユニバーシティ エピジェネティック調節と免疫チェックポイント遮断の組み合わせのための薬物送達

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201804945WA (en) 2013-12-12 2018-07-30 Shanghai hengrui pharmaceutical co ltd Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
WO2016022955A1 (en) 2014-08-07 2016-02-11 Mayo Foundation For Medical Education And Research Compounds and methods for treating cancer
CN108112254B (zh) * 2015-03-13 2022-01-28 西托姆克斯治疗公司 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
WO2016196389A1 (en) * 2015-05-29 2016-12-08 Bristol-Myers Squibb Company Treatment of renal cell carcinoma
MX383464B (es) 2015-07-13 2025-03-14 Cytomx Therapeutics Inc Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y métodos de uso de los mismos.
WO2017161154A2 (en) * 2016-03-16 2017-09-21 H. Lee Moffitt Cancer Center & Research Institute, Inc. Pd1 and pdl-1 expression during progression from myelodysplastic syndrome to acute myelogenous leukemia
WO2017214575A1 (en) * 2016-06-10 2017-12-14 Io Therapeutics, Inc. Receptor selective retinoid and rexinoid compounds and immune modulators for cancer immunotherapy
WO2018007554A1 (en) * 2016-07-06 2018-01-11 Pierre Fabre Medicament Vinflunine and pd1 and/or pdl1 inhibitor as pharmaceutical combination
KR20190062515A (ko) * 2016-10-06 2019-06-05 화이자 인코포레이티드 암의 치료를 위한 아벨루맙의 투약 용법
JP7267914B2 (ja) 2016-11-02 2023-05-02 エンクマフ エスアーエールエル Ｂｃｍａ及びｃｄ３に対する二重特異性抗体、及び多発性骨髄腫を治療するために併用して使用される免疫療法薬
EP4606431A3 (en) * 2017-02-28 2025-11-19 Mayo Foundation for Medical Education and Research Compounds and methods for treating cancer
JP7382232B2 (ja) * 2017-05-02 2023-11-16 メルク・シャープ・アンド・ドーム・エルエルシー 抗ｌａｇ３抗体の製剤および抗ｌａｇ３抗体と抗ｐｄ－１抗体との共製剤
CN111278459A (zh) 2017-05-19 2020-06-12 赛达克斯制药股份有限公司 组合疗法
CN110914302A (zh) 2017-06-01 2020-03-24 赛托姆克斯治疗学股份有限公司 可活化抗pdl1抗体及其使用方法
WO2019014468A1 (en) 2017-07-13 2019-01-17 Io Therapeutics, Inc. RECEPTOR SUBTYPE AND RETINOID COMPOUNDS AND SELECTIVE REXINOIDS OF A FUNCTION IN COMBINATION WITH IMMUNE MODULATORS FOR ANTICANCER IMMUNOTHERAPY
US10363272B2 (en) 2017-08-31 2019-07-30 Io Therapeutics, Inc. RAR selective agonists in combination with immune modulators for cancer immunotherapy
US20220008383A1 (en) * 2018-11-13 2022-01-13 Amy Yee Compositions and methods of enhancing immunotherapies
JP2022537551A (ja) 2019-06-20 2022-08-26 セルジーン・クオンティセル・リサーチ・インコーポレイテッド ベネトクラクス、ギルテリチニブ、ミドスタウリン、または白血病もしくは骨髄異形成症候群を治療するための他の化合物との組み合わせにおけるアザシチジン
KR20210097882A (ko) * 2020-01-30 2021-08-10 삼성바이오에피스 주식회사 안정한 항-pd-1 항체 약제학적 제제
US20230144385A1 (en) * 2020-04-07 2023-05-11 Metanoi Therapeutics, Inc. Ethanolamine formulation for treating epithelial ovarian carcinoma
US11938143B2 (en) 2021-10-19 2024-03-26 Akirabio, Inc. Compositions comprising 2′-deoxycytidine analogs and use thereof for the treatment of sickle cell disease, thalassemia, and cancers
CN121712524A (zh) 2023-08-18 2026-03-20 百时美施贵宝公司 包含结合bcma和cd3的抗体的组合物以及治疗方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR036993A1 (es) * 2001-04-02 2004-10-20 Wyeth Corp Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
US8552154B2 (en) * 2008-09-26 2013-10-08 Emory University Anti-PD-L1 antibodies and uses therefor
US8492361B2 (en) * 2009-02-10 2013-07-23 Celgene Corporation Methods for treating non-small cell lung cancer using 5-azacytidine
WO2013043569A1 (en) * 2011-09-20 2013-03-28 Vical Incorporated Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
US20140357567A1 (en) * 2011-11-01 2014-12-04 Celgene Corporation Methods for treating cancers using oral formulations of cytidine analogs
EP2958571B1 (en) * 2013-02-21 2024-04-10 Michele Maio Dna hypomethylating agents for cancer therapy
US10966998B2 (en) * 2013-09-05 2021-04-06 The Johns Hopkins University Cancer therapy via a combination of epigenetic modulation and immune modulation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CANCER RES., 2012, VOL.72, NO.9, PP.2197-2205, JPN6018015446, ISSN: 0003960858 *
CLIN. CANCER RES., 2013, VOL.19, NO.5, PP.1009-1020, JPN6018015448, ISSN: 0003960859 *
ERIC LAILLE; TAO SHI; GUILLERMO GARCIA-MANERO; ET AL: "EXTENDED DOSING OF ORAL AZACITIDINE (CC-486) FOR 14 AND 21 DAYS PROVIDES MORE EFFECTIVE 以下備考", AMERICAN SOCIETY OF HEMATOLOGY,54TH ASH ANNUAL MEETING AND EXPOSITION, JPN5017007170, December 2012 (2012-12-01), ISSN: 0003960860 *
LEUKEMIA, 2014, VOL.28, NO.6, PP.1280-1288, JPN6018015444, ISSN: 0003960857 *
ONCOTARGET, 2013, VOL.4, NO.11, PP.2067-2079, JPN6018015441, ISSN: 0003960856 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022522843A (ja) * 2019-03-04 2022-04-20 ノース カロライナ ステート ユニバーシティ エピジェネティック調節と免疫チェックポイント遮断の組み合わせのための薬物送達

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US20160067336A1 (en) 2016-03-10
AU2015315435A1 (en) 2017-03-23
WO2016040238A1 (en) 2016-03-17
MX2017002875A (es) 2017-05-30
EP3191104A1 (en) 2017-07-19
EA201790543A1 (ru) 2017-07-31
SG11201701710SA (en) 2017-04-27
KR20170045237A (ko) 2017-04-26
IL250887A0 (en) 2017-04-30
CN106604745A (zh) 2017-04-26

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