JP2017525680A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017525680A5 JP2017525680A5 JP2017502195A JP2017502195A JP2017525680A5 JP 2017525680 A5 JP2017525680 A5 JP 2017525680A5 JP 2017502195 A JP2017502195 A JP 2017502195A JP 2017502195 A JP2017502195 A JP 2017502195A JP 2017525680 A5 JP2017525680 A5 JP 2017525680A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sodium
- crystals
- crystal
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000013078 crystal Substances 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 18
- 238000008214 LDL Cholesterol Methods 0.000 claims description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 210000002966 serum Anatomy 0.000 claims description 8
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 7
- 239000011548 crystallization buffer Substances 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 5
- BDKLKNJTMLIAFE-UHFFFAOYSA-N 2-(3-fluorophenyl)-1,3-oxazole-4-carbaldehyde Chemical compound FC1=CC=CC(C=2OC=C(C=O)N=2)=C1 BDKLKNJTMLIAFE-UHFFFAOYSA-N 0.000 claims description 4
- 239000008001 CAPS buffer Substances 0.000 claims description 4
- 239000008000 CHES buffer Substances 0.000 claims description 4
- MKWKNSIESPFAQN-UHFFFAOYSA-N N-cyclohexyl-2-aminoethanesulfonic acid Chemical compound OS(=O)(=O)CCNC1CCCCC1 MKWKNSIESPFAQN-UHFFFAOYSA-N 0.000 claims description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 4
- 239000007983 Tris buffer Substances 0.000 claims description 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 4
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 4
- 229940044197 ammonium sulfate Drugs 0.000 claims description 4
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 4
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims description 4
- 239000001639 calcium acetate Substances 0.000 claims description 4
- 235000011092 calcium acetate Nutrition 0.000 claims description 4
- 229960005147 calcium acetate Drugs 0.000 claims description 4
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims description 4
- 235000019838 diammonium phosphate Nutrition 0.000 claims description 4
- 229910000388 diammonium phosphate Inorganic materials 0.000 claims description 4
- OGGXGZAMXPVRFZ-UHFFFAOYSA-M dimethylarsinate Chemical compound C[As](C)([O-])=O OGGXGZAMXPVRFZ-UHFFFAOYSA-M 0.000 claims description 4
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 4
- INHCSSUBVCNVSK-UHFFFAOYSA-L lithium sulfate Inorganic materials [Li+].[Li+].[O-]S([O-])(=O)=O INHCSSUBVCNVSK-UHFFFAOYSA-L 0.000 claims description 4
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 4
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 4
- 229910000160 potassium phosphate Inorganic materials 0.000 claims description 4
- 235000011009 potassium phosphates Nutrition 0.000 claims description 4
- LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical compound [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 claims description 4
- 229940074439 potassium sodium tartrate Drugs 0.000 claims description 4
- VZOPRCCTKLAGPN-ZFJVMAEJSA-L potassium;sodium;(2r,3r)-2,3-dihydroxybutanedioate;tetrahydrate Chemical compound O.O.O.O.[Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VZOPRCCTKLAGPN-ZFJVMAEJSA-L 0.000 claims description 4
- 235000017281 sodium acetate Nutrition 0.000 claims description 4
- 229940087562 sodium acetate trihydrate Drugs 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- 229960002668 sodium chloride Drugs 0.000 claims description 4
- 235000002639 sodium chloride Nutrition 0.000 claims description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 4
- 229960000999 sodium citrate dihydrate Drugs 0.000 claims description 4
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 4
- 239000001488 sodium phosphate Substances 0.000 claims description 4
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 4
- 235000011008 sodium phosphates Nutrition 0.000 claims description 4
- 235000011006 sodium potassium tartrate Nutrition 0.000 claims description 4
- 229940074446 sodium potassium tartrate tetrahydrate Drugs 0.000 claims description 4
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 4
- 235000011152 sodium sulphate Nutrition 0.000 claims description 4
- RBTVSNLYYIMMKS-UHFFFAOYSA-N tert-butyl 3-aminoazetidine-1-carboxylate;hydrochloride Chemical compound Cl.CC(C)(C)OC(=O)N1CC(N)C1 RBTVSNLYYIMMKS-UHFFFAOYSA-N 0.000 claims description 4
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 4
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 2
- 238000005119 centrifugation Methods 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 238000002425 crystallisation Methods 0.000 claims description 2
- 230000008025 crystallization Effects 0.000 claims description 2
- 229910001873 dinitrogen Inorganic materials 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000006259 organic additive Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 238000009101 premedication Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462024393P | 2014-07-14 | 2014-07-14 | |
| US62/024,393 | 2014-07-14 | ||
| PCT/US2015/040217 WO2016010927A1 (en) | 2014-07-14 | 2015-07-13 | Crystalline antibody formulations |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018091269A Division JP2018150337A (ja) | 2014-07-14 | 2018-05-10 | 結晶性抗体製剤 |
| JP2020115765A Division JP2020172526A (ja) | 2014-07-14 | 2020-07-03 | 結晶性抗体製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017525680A JP2017525680A (ja) | 2017-09-07 |
| JP2017525680A5 true JP2017525680A5 (cg-RX-API-DMAC7.html) | 2018-06-21 |
Family
ID=53836192
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017502195A Withdrawn JP2017525680A (ja) | 2014-07-14 | 2015-07-13 | 結晶性抗体製剤 |
| JP2018091269A Pending JP2018150337A (ja) | 2014-07-14 | 2018-05-10 | 結晶性抗体製剤 |
| JP2020115765A Pending JP2020172526A (ja) | 2014-07-14 | 2020-07-03 | 結晶性抗体製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018091269A Pending JP2018150337A (ja) | 2014-07-14 | 2018-05-10 | 結晶性抗体製剤 |
| JP2020115765A Pending JP2020172526A (ja) | 2014-07-14 | 2020-07-03 | 結晶性抗体製剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20170198059A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3169710A1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP2017525680A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2015289874A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2954767A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2017000527A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016010927A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017525680A (ja) * | 2014-07-14 | 2017-09-07 | アムジェン インコーポレイテッド | 結晶性抗体製剤 |
| CA2954773C (en) | 2014-07-14 | 2023-10-03 | Amgen Inc. | Crystalline antibody formulations |
| US20170056504A1 (en) * | 2015-09-02 | 2017-03-02 | Kenneth I. Kohn | Method of extending half-life of crystaline antibodies |
| DK3596101T3 (da) | 2017-03-14 | 2022-03-14 | Amgen Inc | Fremgangsmåder rettet mod krystallinske biomolekyler |
| WO2018200533A1 (en) * | 2017-04-28 | 2018-11-01 | Amgen Inc. | Excipients to reduce the viscosity of antibody formulations and formulation compositions |
| WO2018201064A1 (en) * | 2017-04-28 | 2018-11-01 | Amgen Inc. | N-acetylated and non-acetylated dipeptides containing arginine to reduce the viscosity of viscous compositions of therapeutic polypeptides |
| BR112020005959A2 (pt) * | 2017-09-26 | 2020-10-06 | Biocon Biologics India Limited | filtração automatizada integrada para separação, lavagem e secagem de cristais de peptídeos |
| GB2584687B (en) * | 2019-06-11 | 2023-08-23 | Univ Newcastle | Crystallisation of chemical molecules |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10503179A (ja) | 1994-06-24 | 1998-03-24 | イミュネックス・コーポレーション | 放出制御性ポリペプチド組成物および炎症性腸疾患の治療方法 |
| IL112834A (en) | 1995-03-01 | 2000-12-06 | Yeda Res & Dev | Pharmaceutical compositions for controlled release of soluble receptors |
| US6020004A (en) | 1997-04-17 | 2000-02-01 | Amgen Inc. | Biodegradable microparticles for the sustained delivery of therapeutic drugs |
| US6541606B2 (en) | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
| US6432449B1 (en) | 1998-05-18 | 2002-08-13 | Amgen Inc. | Biodegradable sustained-release alginate gels |
| US6541033B1 (en) | 1998-06-30 | 2003-04-01 | Amgen Inc. | Thermosensitive biodegradable hydrogels for sustained delivery of leptin |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| US6451346B1 (en) | 1998-12-23 | 2002-09-17 | Amgen Inc | Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents |
| EP2325205A3 (en) * | 2000-12-28 | 2011-10-12 | Altus Pharmaceuticals Inc. | Crystals of whole antibodies and fragments thereof and methods for making and using them |
| US8821086B2 (en) * | 2006-12-22 | 2014-09-02 | Tennine Corporation | Method and apparatus for controlled-fracture machining |
| WO2008109871A2 (en) * | 2007-03-08 | 2008-09-12 | Irm Llc | Crystal structure of proprotein convertase 9 (pcsk9) and uses thereof |
| CA2681428A1 (en) * | 2007-04-13 | 2008-10-23 | Novartis Ag | Molecules and methods for modulating proprotein convertase subtilisin/kexin type 9 (pcsk9) |
| US20130072665A1 (en) * | 2007-08-23 | 2013-03-21 | Simon Mark Jackson | Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9) |
| JOP20080381B1 (ar) * | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
| WO2009131740A2 (en) * | 2008-04-23 | 2009-10-29 | Amgen Inc. | Neutralizing proprotein convertase subtilisin kexin type 9 (pcsk9) variants and uses thereof |
| KR100985090B1 (ko) * | 2008-05-23 | 2010-10-04 | 한국과학기술연구원 | 크라이센 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법 |
| WO2011028938A1 (en) * | 2009-09-02 | 2011-03-10 | Alnylam Pharmaceuticals, Inc. | Methods for lowering serum cholestrol in a subject using inhibition of pcsk9 |
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| CA2777542A1 (en) * | 2009-10-30 | 2011-05-05 | Merck Sharp & Dohme Corp. | Ax213 and ax132 pcsk9 antagonists and variants |
| JO3756B1 (ar) * | 2010-11-23 | 2021-01-31 | Regeneron Pharma | اجسام مضادة بشرية لمستقبلات الجلوكاجون |
| WO2012101252A2 (en) * | 2011-01-28 | 2012-08-02 | Sanofi | Human antibodies to pcsk9 for use in methods of treating particular groups of subjects |
| US20140004122A1 (en) * | 2011-05-10 | 2014-01-02 | Amgen Inc. | Methods for treating or preventing cholesterol related disorders |
| JOP20200043A1 (ar) * | 2011-05-10 | 2017-06-16 | Amgen Inc | طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول |
| ITPN20110039A1 (it) * | 2011-05-24 | 2012-11-25 | Keyline S P A | Blocchetto di presa perfezionato per macchina duplicatrice di chiavi |
| AR087305A1 (es) * | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| EA039663B1 (ru) * | 2012-05-03 | 2022-02-24 | Амген Инк. | Применение антитела против pcsk9 для снижения сывороточного холестерина лпнп и лечения связанных с холестерином расстройств |
| US9255154B2 (en) * | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| EP2849788B1 (en) * | 2012-05-17 | 2018-01-03 | Cyon Therapeutics Inc. | Proprotein convertase subtilisin kexin 9 (pcsk9) inhibitors for use in treating sepsis and septic shock |
| CA2875096A1 (en) * | 2012-06-15 | 2013-12-19 | Genentech, Inc. | Anti-pcsk9 antibodies, formulations, dosing, and methods of use |
| US20150335615A1 (en) * | 2013-01-04 | 2015-11-26 | Toshihisa Kawai | Cholesterol-lowering compounds in combination with lipid metabolism-altering compounds of non-absorbable sugars, compounds that convert nh3 to nh4+, or hydrogen-generating compounds for the treatment of high cholesterol and inflammation |
| CA2906508A1 (en) * | 2013-03-15 | 2014-09-25 | Amgen, Inc. | Human antigen binding proteins that bind to proprotein convertase subtilisin kexin type 9 |
| AR095615A1 (es) * | 2013-03-15 | 2015-10-28 | Alder Biopharmaceuticals Inc | Purificación de anticuerpos y monitoreo de pureza |
| EA201592267A1 (ru) * | 2013-06-07 | 2016-04-29 | Ридженерон Фармасьютикалз, Инк. | Способы ингибирования атеросклероза посредством введения ингибитора pcsk9 |
| AU2013396206B2 (en) * | 2013-06-28 | 2019-11-14 | Amgen Inc. | Methods for treating homozygous familial hypercholesterolemia |
| US20150004174A1 (en) * | 2013-06-28 | 2015-01-01 | Amgen Inc. | Methods for treating homozygous familial hypercholesterolemia |
| EA037526B1 (ru) * | 2013-10-11 | 2021-04-08 | Санофи Байотекнолоджи | Применение ингибитора pcsk9 для лечения гиперлипидемии |
| EA201690889A1 (ru) * | 2013-11-12 | 2016-11-30 | Санофи Байотекнолоджи | Режимы дозирования для применения ингибиторов pcsk9 |
| US9034332B1 (en) * | 2014-07-15 | 2015-05-19 | Kymab Limited | Precision medicine by targeting rare human PCSK9 variants for cholesterol treatment |
| US8883157B1 (en) * | 2013-12-17 | 2014-11-11 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
| US9023359B1 (en) * | 2014-07-15 | 2015-05-05 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
| CA2939507A1 (en) * | 2014-02-14 | 2015-08-20 | Regeneron Pharmaceuticals, Inc. | Methods for treating patients with hypercholesterolemia that is not adequately controlled by moderate-dose statin therapy |
| WO2015127273A1 (en) * | 2014-02-21 | 2015-08-27 | Medimmune, Llc | Anti-pcsk9~glp-1 fusions and methods for use |
| CN106794244A (zh) * | 2014-03-17 | 2017-05-31 | 赛诺菲生物技术公司 | 用于降低心血管风险的方法 |
| WO2015140079A1 (en) * | 2014-03-17 | 2015-09-24 | Sanofi | Methods for treating subjects with primary hypercholesterolemia that is not adequately controlled |
| CA2954773C (en) * | 2014-07-14 | 2023-10-03 | Amgen Inc. | Crystalline antibody formulations |
| JP2017525680A (ja) * | 2014-07-14 | 2017-09-07 | アムジェン インコーポレイテッド | 結晶性抗体製剤 |
| PL3169353T3 (pl) * | 2014-07-16 | 2020-06-01 | Sanofi Biotechnology | SPOSOBY LECZENIA PACJENTÓW Z HETEROZYGOTYCZNĄ HIPERCHOLESTEROLEMIĄ RODZINNĄ (heFH) |
| EP3197492A1 (en) * | 2014-09-23 | 2017-08-02 | Pfizer Inc | Treatment with anti-pcsk9 antibodies |
| US11129936B2 (en) * | 2016-04-08 | 2021-09-28 | Amgen Inc. | Drug delivery device, method of manufacture, and method of use |
| EP3448427A1 (en) * | 2016-04-29 | 2019-03-06 | CureVac AG | Rna encoding an antibody |
| US11059908B2 (en) * | 2016-09-29 | 2021-07-13 | Amgen Inc. | Low-viscosity antigen binding proteins and methods of making them |
| US11459401B2 (en) * | 2016-10-06 | 2022-10-04 | Amgen Inc. | Reduced viscosity protein pharmaceutical formulations |
| JOP20190112A1 (ar) * | 2016-11-14 | 2019-05-14 | Amgen Inc | علاجات مدمجة لتصلب الشرايين، شاملة مرض قلبي وعائي تصلبي |
| US20190031774A1 (en) * | 2017-06-09 | 2019-01-31 | Sanofi Biotechnology | Methods for treating hyperlipidemia in diabetic patients by administering a pcsk9 inhibitor |
| EP4509527A3 (en) * | 2017-10-18 | 2025-04-30 | REGENXBIO Inc. | Post-translationally modified fully human antibody therapeutic agents |
| JP7332691B2 (ja) * | 2018-07-08 | 2023-08-23 | スペシフィカ インコーポレイティド | 抗体の開発可能性が最大化された抗体ライブラリー |
-
2015
- 2015-07-13 JP JP2017502195A patent/JP2017525680A/ja not_active Withdrawn
- 2015-07-13 EP EP15750159.4A patent/EP3169710A1/en active Pending
- 2015-07-13 WO PCT/US2015/040217 patent/WO2016010927A1/en not_active Ceased
- 2015-07-13 US US15/326,341 patent/US20170198059A1/en not_active Abandoned
- 2015-07-13 CA CA2954767A patent/CA2954767A1/en not_active Abandoned
- 2015-07-13 MX MX2017000527A patent/MX2017000527A/es unknown
- 2015-07-13 AU AU2015289874A patent/AU2015289874A1/en not_active Abandoned
-
2018
- 2018-05-10 JP JP2018091269A patent/JP2018150337A/ja active Pending
- 2018-11-06 US US16/182,279 patent/US11267902B2/en active Active
-
2020
- 2020-07-03 JP JP2020115765A patent/JP2020172526A/ja active Pending
-
2021
- 2021-03-04 AU AU2021201422A patent/AU2021201422A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017525680A5 (cg-RX-API-DMAC7.html) | ||
| JP2017525679A5 (cg-RX-API-DMAC7.html) | ||
| NZ723369A (en) | Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema | |
| SI2780368T1 (en) | INGREDIENTS AND PROCEDURES FOR INCREASING PURE MASS AND MICROWAVE WITH SPECIFIC ANTAGONISING OF GDF8 AND / OR ACTIVITY A | |
| RU2019138507A (ru) | Составы антител против lag3 и совместные составы антител против lag3 и антител против pd-1 | |
| JP2021501744A5 (cg-RX-API-DMAC7.html) | ||
| JP2020518599A5 (cg-RX-API-DMAC7.html) | ||
| JP2016020389A5 (cg-RX-API-DMAC7.html) | ||
| IL257281A (en) | Anti-pd-1 antibodies and methods of using them | |
| HRP20240182T1 (hr) | Ljudska monoklonska protutijela za teški akutni respiratorni sindrom koronavirusa 2 (sars-cov-2) | |
| JP2014522236A5 (cg-RX-API-DMAC7.html) | ||
| JP2011528902A5 (cg-RX-API-DMAC7.html) | ||
| JP2023055904A5 (cg-RX-API-DMAC7.html) | ||
| JP2015535828A5 (cg-RX-API-DMAC7.html) | ||
| HRP20192288T1 (hr) | Postupci liječenja raka primjenom pd-1 antagonista koji vežu os i taksana | |
| JP2018521638A5 (cg-RX-API-DMAC7.html) | ||
| PE20142242A1 (es) | Anticuerpos humanos anti-cd27, metodos, y usos | |
| JP2017507657A5 (cg-RX-API-DMAC7.html) | ||
| NZ623347A (en) | Novel anti-dr5 antibody | |
| AR085575A1 (es) | Formulaciones de anticuerpos | |
| JP2015503909A5 (cg-RX-API-DMAC7.html) | ||
| JP2012523417A5 (cg-RX-API-DMAC7.html) | ||
| JP2020502198A5 (cg-RX-API-DMAC7.html) | ||
| EA032189B9 (ru) | Изолированные человеческие моноклональные антитела против ингибитора пути тканевого фактора (tfpi) и фармацевтическая композиция, содержащая их | |
| JP2021501569A5 (cg-RX-API-DMAC7.html) |