JP2017524725A5 - - Google Patents
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- JP2017524725A5 JP2017524725A5 JP2017514958A JP2017514958A JP2017524725A5 JP 2017524725 A5 JP2017524725 A5 JP 2017524725A5 JP 2017514958 A JP2017514958 A JP 2017514958A JP 2017514958 A JP2017514958 A JP 2017514958A JP 2017524725 A5 JP2017524725 A5 JP 2017524725A5
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- JP
- Japan
- Prior art keywords
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- amino acid
- acid sequence
- antibody
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 30
- 239000012634 fragment Substances 0.000 claims description 18
- 101000884279 Homo sapiens CD276 antigen Proteins 0.000 claims description 15
- 102000048770 human CD276 Human genes 0.000 claims description 15
- 239000000427 antigen Substances 0.000 claims description 13
- 102000036639 antigens Human genes 0.000 claims description 13
- 108091007433 antigens Proteins 0.000 claims description 13
- 101710185679 CD276 antigen Proteins 0.000 claims description 12
- 108060003951 Immunoglobulin Proteins 0.000 claims description 12
- 102000018358 immunoglobulin Human genes 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 238000002965 ELISA Methods 0.000 claims description 2
- 241000700159 Rattus Species 0.000 claims description 2
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 10
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 8
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 8
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 8
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 7
- 239000012472 biological sample Substances 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 238000003365 immunocytochemistry Methods 0.000 claims 2
- 238000003364 immunohistochemistry Methods 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 1
- 241000282693 Cercopithecidae Species 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 241000009328 Perro Species 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010005084 bladder transitional cell carcinoma Diseases 0.000 claims 1
- 201000001528 bladder urothelial carcinoma Diseases 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000005243 lung squamous cell carcinoma Diseases 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 description 10
- 102000037865 fusion proteins Human genes 0.000 description 10
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 210000003719 b-lymphocyte Anatomy 0.000 description 3
- 102000014914 Carrier Proteins Human genes 0.000 description 2
- 108010078791 Carrier Proteins Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 2
- 241000283707 Capra Species 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 238000013390 scatchard method Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462004605P | 2014-05-29 | 2014-05-29 | |
| US62/004,605 | 2014-05-29 | ||
| US201462082681P | 2014-11-21 | 2014-11-21 | |
| US62/082,681 | 2014-11-21 | ||
| PCT/EP2015/061777 WO2015181267A1 (en) | 2014-05-29 | 2015-05-28 | Anti-b7-h3 antibodies and diagnostic uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017524725A JP2017524725A (ja) | 2017-08-31 |
| JP2017524725A5 true JP2017524725A5 (cg-RX-API-DMAC7.html) | 2018-07-12 |
| JP6636016B2 JP6636016B2 (ja) | 2020-01-29 |
Family
ID=53267378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017514958A Active JP6636016B2 (ja) | 2014-05-29 | 2015-05-28 | 抗ｂ７−ｈ３抗体及びその診断用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10501544B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3149040A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6636016B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015265976B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2947660C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015181267A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6636016B2 (ja) * | 2014-05-29 | 2020-01-29 | スプリング バイオサイエンス コーポレーション | 抗ｂ７−ｈ３抗体及びその診断用途 |
| MX2018015277A (es) * | 2016-06-08 | 2019-09-06 | Abbvie Inc | Anticuerpos anti-b7-h3 y conjugados de anticuerpo y farmaco. |
| US10899837B2 (en) | 2017-03-31 | 2021-01-26 | Jiangsu Hengrui Medicine Co., Ltd. | B7-H3 antibody, antigen-binding fragment thereof and medical use thereof |
| JP2021528393A (ja) | 2018-06-15 | 2021-10-21 | フラグシップ パイオニアリング イノベーションズ ブイ，インコーポレーテッド | 後細胞シグナル伝達因子の調節による免疫活性の上昇 |
| WO2020018964A1 (en) | 2018-07-20 | 2020-01-23 | Fred Hutchinson Cancer Research Center | Compositions and methods for controlled expression of antigen-specific receptors |
| US12331110B2 (en) | 2018-09-05 | 2025-06-17 | The Board Of Regents Of The University Of Texas System | Monoclonal antibodies against endotrophin and the use thereof |
| WO2020076970A1 (en) * | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | B7h3 single domain antibodies and therapeutic compositions thereof |
| JP7682789B2 (ja) * | 2018-11-16 | 2025-05-26 | アルバート アインシュタイン カレッジ オブ メディスン | Ｂ７－Ｈ３のＩｇＶドメインに対するモノクローナル抗体及びその使用 |
| CN109851673B (zh) * | 2019-01-22 | 2023-07-25 | 苏州旭光科星抗体生物科技有限公司 | 一种抗人b7-h3单克隆抗体的制备方法及其免疫组化检测方法及其应用及其试剂盒 |
| WO2020227159A2 (en) | 2019-05-03 | 2020-11-12 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity |
| US20220332829A1 (en) * | 2019-09-16 | 2022-10-20 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Anti-b7-h3 antibody and application thereof |
| CN110642948B (zh) * | 2019-10-09 | 2021-06-29 | 达石药业(广东)有限公司 | B7-h3纳米抗体、其制备方法及用途 |
| US20230114107A1 (en) | 2019-12-17 | 2023-04-13 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| CN113754766A (zh) * | 2020-06-02 | 2021-12-07 | 明慧医药（上海）有限公司 | 抗b7-h3抗体及其制备和应用 |
| CA3184366A1 (en) | 2020-06-29 | 2022-01-06 | Darby Rye Schmidt | Viruses engineered to promote thanotransmission and their use in treating cancer |
| CN115279417B (zh) | 2021-02-09 | 2025-01-03 | 苏州宜联生物医药有限公司 | 生物活性物偶联物及其制备方法和用途 |
| WO2022203414A1 (ko) * | 2021-03-26 | 2022-09-29 | 세라노틱스(주) | B7-h3 항체 또는 이의 항원 결합 단편 및 이의 용도 |
| CA3214085A1 (en) | 2021-03-31 | 2022-10-06 | Darby Rye Schmidt | Thanotransmission polypeptides and their use in treating cancer |
| CA3224374A1 (en) | 2021-06-29 | 2023-01-05 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| CN118715242A (zh) * | 2021-10-05 | 2024-09-27 | 得克萨斯州大学系统董事会 | 包含b7-h3结合多肽的组合物和方法 |
| WO2023086772A1 (en) | 2021-11-12 | 2023-05-19 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and nkg2d |
| CN114380910B (zh) * | 2022-01-07 | 2023-04-28 | 苏州旭光科星抗体生物科技有限公司 | 靶向人b7-h3分子的人源化单克隆抗体及其应用 |
| WO2023155808A1 (zh) | 2022-02-16 | 2023-08-24 | 苏州宜联生物医药有限公司 | 抗体-艾日布林或其衍生物的偶联物、其中间体、制备方法、药物组合物和用途 |
| WO2023177232A1 (ko) * | 2022-03-18 | 2023-09-21 | 세종대학교산학협력단 | 항 b7-h3 단일클론항체 및 이의 용도 |
| WO2023221975A1 (zh) | 2022-05-18 | 2023-11-23 | 苏州宜联生物医药有限公司 | 包含蛋白降解剂类生物活性化合物的抗体药物偶联物及其制备方法和用途 |
| CN114773477B (zh) * | 2022-06-23 | 2022-09-09 | 上海优替济生生物医药有限公司 | 抗b7-h3抗体及其用途 |
| WO2024077191A1 (en) | 2022-10-05 | 2024-04-11 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
| WO2024102636A1 (en) | 2022-11-07 | 2024-05-16 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and mica/b |
| WO2024102693A2 (en) | 2022-11-07 | 2024-05-16 | Xencor, Inc. | Il-18-fc fusion proteins |
| CN120787161A (zh) * | 2023-01-30 | 2025-10-14 | 德克萨斯大学体系董事会 | 对B7-H3的4Ig同种型具有选择性的抗体及其使用方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060154313A1 (en) * | 2000-04-13 | 2006-07-13 | Immunex Corporation | Human B7 polypeptide B7-H3A |
| US20050070474A1 (en) * | 2003-04-28 | 2005-03-31 | Krissansen Geoffrey Wayne | Methods of treatment and compositions therefor |
| ES2259270B1 (es) * | 2005-03-09 | 2007-11-01 | Consejo Superior De Investigaciones Cientificas | Metodo de diagnostico in vitro de la enfermedad de alzheimer mediante un anticuerpo monoclonal. |
| CA2729593A1 (en) * | 2009-02-20 | 2010-08-26 | John Wayne Cancer Institute | B7-h3 as a biomarker for diagnosing the progression and early lymph node metastasis of cancer |
| CN101959216B (zh) | 2009-07-20 | 2014-06-18 | 电信科学技术研究院 | 一种分载波配置增强cell_fach的方法、系统和设备 |
| EP2982380B1 (en) * | 2010-03-04 | 2021-09-01 | MacroGenics, Inc. | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| PH12012501751A1 (en) * | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| KR20130043104A (ko) * | 2010-04-06 | 2013-04-29 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 질병용 순환 생물학적 지표들 |
| AU2011291599B2 (en) * | 2010-08-18 | 2015-09-10 | Caris Life Sciences Switzerland Holdings Gmbh | Circulating biomarkers for disease |
| ES2667568T3 (es) * | 2011-04-25 | 2018-05-11 | Daiichi Sankyo Company, Limited | Anticuerpo anti-B7-H3 |
| JP6636016B2 (ja) * | 2014-05-29 | 2020-01-29 | スプリング バイオサイエンス コーポレーション | 抗ｂ７−ｈ３抗体及びその診断用途 |
-
2015
- 2015-05-28 JP JP2017514958A patent/JP6636016B2/ja active Active
- 2015-05-28 WO PCT/EP2015/061777 patent/WO2015181267A1/en not_active Ceased
- 2015-05-28 CA CA2947660A patent/CA2947660C/en active Active
- 2015-05-28 EP EP15724692.7A patent/EP3149040A1/en not_active Withdrawn
- 2015-05-28 AU AU2015265976A patent/AU2015265976B2/en active Active
-
2016
- 2016-11-29 US US15/363,992 patent/US10501544B2/en active Active
-
2019
- 2019-10-28 US US16/665,359 patent/US11525003B2/en active Active
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