JP2017523776A5 - - Google Patents
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- JP2017523776A5 JP2017523776A5 JP2017502121A JP2017502121A JP2017523776A5 JP 2017523776 A5 JP2017523776 A5 JP 2017523776A5 JP 2017502121 A JP2017502121 A JP 2017502121A JP 2017502121 A JP2017502121 A JP 2017502121A JP 2017523776 A5 JP2017523776 A5 JP 2017523776A5
- Authority
- JP
- Japan
- Prior art keywords
- patient
- gene
- expression
- rpl13a
- ets1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 230000014509 gene expression Effects 0.000 claims 51
- 108090000623 proteins and genes Proteins 0.000 claims 44
- 238000000034 method Methods 0.000 claims 43
- 239000005557 antagonist Substances 0.000 claims 27
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 26
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 26
- 102100022289 60S ribosomal protein L13a Human genes 0.000 claims 19
- 101000681240 Homo sapiens 60S ribosomal protein L13a Proteins 0.000 claims 19
- -1 MBP Proteins 0.000 claims 19
- 101000876829 Homo sapiens Protein C-ets-1 Proteins 0.000 claims 18
- 102100035251 Protein C-ets-1 Human genes 0.000 claims 18
- 239000012472 biological sample Substances 0.000 claims 18
- 102100026596 Bcl-2-like protein 1 Human genes 0.000 claims 17
- 101150008012 Bcl2l1 gene Proteins 0.000 claims 17
- 102000049320 CD36 Human genes 0.000 claims 17
- 108010045374 CD36 Antigens Proteins 0.000 claims 17
- 101000599858 Homo sapiens Intercellular adhesion molecule 2 Proteins 0.000 claims 17
- 101000998146 Homo sapiens Interleukin-17A Proteins 0.000 claims 17
- 101000807561 Homo sapiens Tyrosine-protein kinase receptor UFO Proteins 0.000 claims 17
- 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 claims 17
- 102100033461 Interleukin-17A Human genes 0.000 claims 17
- 102100037236 Tyrosine-protein kinase receptor UFO Human genes 0.000 claims 17
- 108700000711 bcl-X Proteins 0.000 claims 17
- 108010073030 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Proteins 0.000 claims 16
- 102000009069 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Human genes 0.000 claims 16
- 102100026882 Alpha-synuclein Human genes 0.000 claims 16
- 108091007854 Cdh1/Fizzy-related Proteins 0.000 claims 16
- 102000038594 Cdh1/Fizzy-related Human genes 0.000 claims 16
- 102100021179 Dynamin-3 Human genes 0.000 claims 16
- 102100040565 Dynein light chain 1, cytoplasmic Human genes 0.000 claims 16
- 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 claims 16
- 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 claims 16
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims 16
- 101000817599 Homo sapiens Dynamin-3 Proteins 0.000 claims 16
- 101000966403 Homo sapiens Dynein light chain 1, cytoplasmic Proteins 0.000 claims 16
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 16
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 16
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 claims 16
- 101000971468 Homo sapiens Protein kinase C zeta type Proteins 0.000 claims 16
- 101000798007 Homo sapiens RAC-gamma serine/threonine-protein kinase Proteins 0.000 claims 16
- 101000764263 Homo sapiens Tumor necrosis factor ligand superfamily member 4 Proteins 0.000 claims 16
- 101000679921 Homo sapiens Tumor necrosis factor receptor superfamily member 21 Proteins 0.000 claims 16
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 16
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 16
- 108010051742 Platelet-Derived Growth Factor beta Receptor Proteins 0.000 claims 16
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 claims 16
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims 16
- 102100021538 Protein kinase C zeta type Human genes 0.000 claims 16
- 102100032314 RAC-gamma serine/threonine-protein kinase Human genes 0.000 claims 16
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 16
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 16
- 102100026890 Tumor necrosis factor ligand superfamily member 4 Human genes 0.000 claims 16
- 102100022205 Tumor necrosis factor receptor superfamily member 21 Human genes 0.000 claims 16
- 101100107081 Danio rerio zbtb16a gene Proteins 0.000 claims 15
- 101001077600 Homo sapiens Insulin receptor substrate 2 Proteins 0.000 claims 15
- 101100377226 Homo sapiens ZBTB16 gene Proteins 0.000 claims 15
- 102100025092 Insulin receptor substrate 2 Human genes 0.000 claims 15
- 108700003766 Promyelocytic Leukemia Zinc Finger Proteins 0.000 claims 15
- 102100040314 Zinc finger and BTB domain-containing protein 16 Human genes 0.000 claims 15
- 238000011282 treatment Methods 0.000 claims 15
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 14
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 14
- 101000635938 Homo sapiens Transforming growth factor beta-1 proprotein Proteins 0.000 claims 13
- 102100030742 Transforming growth factor beta-1 proprotein Human genes 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 13
- 208000005017 glioblastoma Diseases 0.000 claims 12
- 239000013610 patient sample Substances 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 239000002246 antineoplastic agent Substances 0.000 claims 6
- 229940127089 cytotoxic agent Drugs 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000003247 decreasing effect Effects 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 229960000397 bevacizumab Drugs 0.000 claims 3
- 230000004043 responsiveness Effects 0.000 claims 3
- 238000011319 anticancer therapy Methods 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 102000004506 Blood Proteins Human genes 0.000 claims 1
- 108010017384 Blood Proteins Proteins 0.000 claims 1
- 102220473068 Chemerin-like receptor 2_R17Q_mutation Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 208000018899 proneural glioblastoma Diseases 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462024244P | 2014-07-14 | 2014-07-14 | |
| US62/024,244 | 2014-07-14 | ||
| PCT/US2015/040408 WO2016011052A1 (en) | 2014-07-14 | 2015-07-14 | Diagnostic methods and compositions for treatment of glioblastoma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017523776A JP2017523776A (ja) | 2017-08-24 |
| JP2017523776A5 true JP2017523776A5 (enExample) | 2018-08-30 |
Family
ID=53762365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017502121A Pending JP2017523776A (ja) | 2014-07-14 | 2015-07-14 | 膠芽腫の診断方法及びその治療用組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10208355B2 (enExample) |
| EP (1) | EP3169801A1 (enExample) |
| JP (1) | JP2017523776A (enExample) |
| CN (1) | CN106460067A (enExample) |
| WO (1) | WO2016011052A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10617755B2 (en) | 2013-08-30 | 2020-04-14 | Genentech, Inc. | Combination therapy for the treatment of glioblastoma |
| US10456470B2 (en) | 2013-08-30 | 2019-10-29 | Genentech, Inc. | Diagnostic methods and compositions for treatment of glioblastoma |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| WO2017117464A1 (en) | 2015-12-30 | 2017-07-06 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| JP2018091846A (ja) * | 2016-12-01 | 2018-06-14 | 参天製薬株式会社 | 抗ｖｅｇｆ薬による滲出型加齢黄斑変性の処置の有効性を予測するための方法 |
| CN108728533B (zh) * | 2017-04-20 | 2022-06-14 | 常青 | 用于髓母细胞瘤分子分型的基因群以及snca基因作为4型髓母细胞瘤的生物标志物的用途 |
| BR112020017872A2 (pt) | 2018-03-02 | 2020-12-22 | Kodiak Sciences Inc. | Anticorpos de il-6 e construtos de fusão e conjugados dos mesmos |
| US20220177561A1 (en) | 2018-12-11 | 2022-06-09 | Sanford Burnham Prebys Medical Discovery Institute | Models and Methods Useful for the Treatment of Serrated Colorectal Cancer |
| WO2021072265A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| DE102020004924A1 (de) * | 2020-08-13 | 2022-02-17 | Daimler Ag | Bodenstruktur für eine Karosserie eines Fahrzeugs, Karosserie für ein Fahrzeug sowie Fahrzeug |
| KR102878656B1 (ko) * | 2022-04-08 | 2025-10-31 | 연세대학교 산학협력단 | 유전자로 정의된 암기원세포, 및 이의 분류방법 |
| KR102878653B1 (ko) * | 2022-04-08 | 2025-10-31 | 연세대학교 산학협력단 | 유전자로 정의된 암기원세포, 및 이의 분류방법 |
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| US10617755B2 (en) | 2013-08-30 | 2020-04-14 | Genentech, Inc. | Combination therapy for the treatment of glioblastoma |
-
2015
- 2015-07-14 EP EP15744808.5A patent/EP3169801A1/en not_active Withdrawn
- 2015-07-14 CN CN201580031397.3A patent/CN106460067A/zh active Pending
- 2015-07-14 JP JP2017502121A patent/JP2017523776A/ja active Pending
- 2015-07-14 WO PCT/US2015/040408 patent/WO2016011052A1/en not_active Ceased
-
2016
- 2016-11-08 US US15/346,164 patent/US10208355B2/en not_active Expired - Fee Related
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