JP2017523211A - 新規化合物およびそれを用いてil−1r媒介性の疾患または障害を処置するかまたは寛解させる方法 - Google Patents
新規化合物およびそれを用いてil−1r媒介性の疾患または障害を処置するかまたは寛解させる方法 Download PDFInfo
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- JP2017523211A JP2017523211A JP2017506261A JP2017506261A JP2017523211A JP 2017523211 A JP2017523211 A JP 2017523211A JP 2017506261 A JP2017506261 A JP 2017506261A JP 2017506261 A JP2017506261 A JP 2017506261A JP 2017523211 A JP2017523211 A JP 2017523211A
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- 0 *c1nnc2[n]1c(*)nc1c2nn[n]1* Chemical compound *c1nnc2[n]1c(*)nc1c2nn[n]1* 0.000 description 6
- NMPKNGZIISJONK-ALCCZGGFSA-N CC(C)(/C(/SC)=N/C)S Chemical compound CC(C)(/C(/SC)=N/C)S NMPKNGZIISJONK-ALCCZGGFSA-N 0.000 description 1
- VDXADYOWHQEHPH-UHFFFAOYSA-N CCOC(C(C1c2c(cccc3)c3cc3ccccc23)=C(C)NC(CC(C)(C)C2)=C1C2=O)=O Chemical compound CCOC(C(C1c2c(cccc3)c3cc3ccccc23)=C(C)NC(CC(C)(C)C2)=C1C2=O)=O VDXADYOWHQEHPH-UHFFFAOYSA-N 0.000 description 1
- YDEOCHPWIMGSML-UHFFFAOYSA-N COCC(OC(N)=C(C1c2cccc3c2cccc3)C#N)=C1C(OC)=O Chemical compound COCC(OC(N)=C(C1c2cccc3c2cccc3)C#N)=C1C(OC)=O YDEOCHPWIMGSML-UHFFFAOYSA-N 0.000 description 1
- KJRRQXYWFQKJIP-UHFFFAOYSA-N Cc1c[o]cc1 Chemical compound Cc1c[o]cc1 KJRRQXYWFQKJIP-UHFFFAOYSA-N 0.000 description 1
- YWBYDNKDUSJGHK-UHFFFAOYSA-N N#CC(C(C1)c2c(cccc3)c3ccc2)=C2SCN(Cc3ccc[o]3)CN2C1=O Chemical compound N#CC(C(C1)c2c(cccc3)c3ccc2)=C2SCN(Cc3ccc[o]3)CN2C1=O YWBYDNKDUSJGHK-UHFFFAOYSA-N 0.000 description 1
- WLYHHLMMWMBERB-UHFFFAOYSA-N NC(OC(c(cccc1)c1O1)=C(C2c3cccc4c3cccc4)C1=O)=C2C#N Chemical compound NC(OC(c(cccc1)c1O1)=C(C2c3cccc4c3cccc4)C1=O)=C2C#N WLYHHLMMWMBERB-UHFFFAOYSA-N 0.000 description 1
- XJWBXBTXTQLQPB-UHFFFAOYSA-N O=C(CN(C(CS(CC(Nc(cc1)ccc1F)=O)=O)=O)c1c(cccc2)c2ccc1)NC1CCCCC1 Chemical compound O=C(CN(C(CS(CC(Nc(cc1)ccc1F)=O)=O)=O)c1c(cccc2)c2ccc1)NC1CCCCC1 XJWBXBTXTQLQPB-UHFFFAOYSA-N 0.000 description 1
- TZFSZMAJNIKWBE-UHFFFAOYSA-N O=C(CNc1ccc2OCOc2c1)CS(CC(N(CC(NC1CCCC1)=O)Cc1ccccc1Cl)=O)=O Chemical compound O=C(CNc1ccc2OCOc2c1)CS(CC(N(CC(NC1CCCC1)=O)Cc1ccccc1Cl)=O)=O TZFSZMAJNIKWBE-UHFFFAOYSA-N 0.000 description 1
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| PCT/US2015/043403 WO2016022465A1 (en) | 2014-08-04 | 2015-08-03 | Novel compounds and methods of treating or ameliorating an il-1r-mediated disease or disorder using same |
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| GB201706806D0 (en) | 2017-04-28 | 2017-06-14 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| WO2018226155A1 (en) | 2017-06-05 | 2018-12-13 | National University Of Singapore | Compounds useful in inhibiting human trefoil factor 3 |
| EP3773678A4 (en) | 2018-04-12 | 2022-05-04 | Mayo Foundation for Medical Education and Research | PROCEDURES FOR GUIDING TREATMENT DECISIONS IN USE |
| GB202015187D0 (en) | 2020-09-25 | 2020-11-11 | Sentinel Oncology Ltd | A pharmaceutical salt |
| WO2025210193A1 (en) * | 2024-04-03 | 2025-10-09 | Nxi Therapeutics Ag | 4-(hetero)aryl-7-(hetero)aryl-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-ca rboxylic acid derivatives as coronin-1 modulators |
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- 2015-08-03 JP JP2017506261A patent/JP2017523211A/ja active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| US10428059B2 (en) | 2019-10-01 |
| WO2016022465A1 (en) | 2016-02-11 |
| US20190367503A1 (en) | 2019-12-05 |
| US11345696B2 (en) | 2022-05-31 |
| EP3189070A4 (en) | 2018-06-27 |
| EP3189070A1 (en) | 2017-07-12 |
| US20180030046A1 (en) | 2018-02-01 |
| US20170204089A1 (en) | 2017-07-20 |
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