JP2017522316A5 - - Google Patents
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- Publication number
- JP2017522316A5 JP2017522316A5 JP2017502259A JP2017502259A JP2017522316A5 JP 2017522316 A5 JP2017522316 A5 JP 2017522316A5 JP 2017502259 A JP2017502259 A JP 2017502259A JP 2017502259 A JP2017502259 A JP 2017502259A JP 2017522316 A5 JP2017522316 A5 JP 2017522316A5
- Authority
- JP
- Japan
- Prior art keywords
- patient
- antibody
- antigen
- binding fragment
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 19
- 102000036639 antigens Human genes 0.000 claims 19
- 108091007433 antigens Proteins 0.000 claims 19
- 239000012634 fragment Substances 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 108010028554 LDL Cholesterol Proteins 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 208000029078 coronary artery disease Diseases 0.000 claims 6
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 108010023302 HDL Cholesterol Proteins 0.000 claims 3
- 230000002411 adverse Effects 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 229940102223 injectable solution Drugs 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 101001098868 Homo sapiens Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 claims 2
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 2
- 101710180553 Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 claims 2
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 231100000682 maximum tolerated dose Toxicity 0.000 claims 2
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims 1
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims 1
- 102000006991 Apolipoprotein B-100 Human genes 0.000 claims 1
- 108010008150 Apolipoprotein B-100 Proteins 0.000 claims 1
- 102000018616 Apolipoproteins B Human genes 0.000 claims 1
- 108010027006 Apolipoproteins B Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000032382 Ischaemic stroke Diseases 0.000 claims 1
- 108010033266 Lipoprotein(a) Proteins 0.000 claims 1
- 102000057248 Lipoprotein(a) Human genes 0.000 claims 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims 1
- 229940090047 auto-injector Drugs 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462025371P | 2014-07-16 | 2014-07-16 | |
| US62/025,371 | 2014-07-16 | ||
| US201462043167P | 2014-08-28 | 2014-08-28 | |
| US62/043,167 | 2014-08-28 | ||
| US201462080725P | 2014-11-17 | 2014-11-17 | |
| US62/080,725 | 2014-11-17 | ||
| US201562132709P | 2015-03-13 | 2015-03-13 | |
| US62/132,709 | 2015-03-13 | ||
| EP15305830.0 | 2015-05-29 | ||
| EP15305830 | 2015-05-29 | ||
| PCT/US2015/040765 WO2016011260A1 (en) | 2014-07-16 | 2015-07-16 | Methods for treating high cardiovascular risk patients with hypercholesterolemia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017522316A JP2017522316A (ja) | 2017-08-10 |
| JP2017522316A5 true JP2017522316A5 (OSRAM) | 2018-08-23 |
| JP6912374B2 JP6912374B2 (ja) | 2021-08-04 |
Family
ID=53365943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017502259A Active JP6912374B2 (ja) | 2014-07-16 | 2015-07-16 | 高コレステロール血症を有する高心血管リスク患者を処置するための方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20160137746A1 (OSRAM) |
| EP (2) | EP3169362B1 (OSRAM) |
| JP (1) | JP6912374B2 (OSRAM) |
| KR (3) | KR20230007538A (OSRAM) |
| CN (2) | CN114306592A (OSRAM) |
| AU (1) | AU2015289617B2 (OSRAM) |
| CA (1) | CA2955304C (OSRAM) |
| MX (2) | MX378872B (OSRAM) |
| PL (1) | PL3169362T3 (OSRAM) |
| RU (1) | RU2723018C2 (OSRAM) |
| WO (1) | WO2016011260A1 (OSRAM) |
| ZA (1) | ZA201700196B (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| HRP20180959T1 (hr) | 2011-01-28 | 2018-07-27 | Sanofi Biotechnology | Ljudska protutijela za pcsk9 za uporabu u postupcima liječenja određenih skupina subjekata |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| CA2848201C (en) | 2011-09-16 | 2020-10-27 | Regeneron Pharmaceuticals, Inc. | Methods for reducing lipoprotein(a) levels by administering an inhibitor of proprotein convertase subtilisin kexin-9 (pcsk9) |
| US10111953B2 (en) | 2013-05-30 | 2018-10-30 | Regeneron Pharmaceuticals, Inc. | Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9) |
| CN111920954A (zh) | 2013-06-07 | 2020-11-13 | 再生元制药公司 | 通过施用pcsk9抑制剂抑制动脉粥样硬化的方法 |
| CN106062003A (zh) | 2013-11-12 | 2016-10-26 | 赛诺菲生物技术公司 | 用于与pcsk9抑制剂一起使用的给药方案 |
| KR20170029613A (ko) | 2014-07-16 | 2017-03-15 | 사노피 바이오테크놀로지 | 이형접합성 가족성 고콜레스테롤혈증(heFH) 환자의 치료방법 |
| US10472424B2 (en) * | 2014-09-23 | 2019-11-12 | Pfizer Inc. | Treatment with anti-PCSK9 antibodies |
| IL314925A (en) | 2015-08-18 | 2024-10-01 | Regeneron Pharma | Antibodies against PCSK9 for the treatment of patients with hyperlipidemia undergoing lipoprotein-lowering therapy |
| MA43734A (fr) | 2016-03-03 | 2018-11-28 | Regeneron Pharma | Procédés de traitement de patients atteints d'hyperlipidémie par administration d'un inhibiteur de pcsk9 en combinaison avec un inhibiteur d'angptl3 |
| TW202310872A (zh) * | 2017-06-09 | 2023-03-16 | 法商賽諾菲生物技術公司 | 藉由投予ｐｃｓｋ９抑制劑治療糖尿病患者高血脂症之方法 |
| EP3762026A1 (en) * | 2018-03-06 | 2021-01-13 | Sanofi Biotechnology | Use of pcsk9 inhibitor for reducing cardiovascular risk |
| CA3160071A1 (en) * | 2019-11-18 | 2021-05-27 | Ad Pharmaceuticals Co., Ltd. | Anti-pcsk9 antibody and use thereof |
| BR112023002085A2 (pt) * | 2020-08-07 | 2023-02-28 | Regeneron Pharma | Métodos para tratar hipercolesterolemia refratária envolvendo inibidor de angptl3 |
| CN116983434B (zh) * | 2023-09-28 | 2024-03-15 | 康霖生物科技（杭州）有限公司 | 用于基因治疗的核酸构建体及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| JO3672B1 (ar) * | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| HRP20180959T1 (hr) * | 2011-01-28 | 2018-07-27 | Sanofi Biotechnology | Ljudska protutijela za pcsk9 za uporabu u postupcima liječenja određenih skupina subjekata |
| JOP20200043A1 (ar) * | 2011-05-10 | 2017-06-16 | Amgen Inc | طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول |
| US20130006482A1 (en) * | 2011-06-30 | 2013-01-03 | Ramadev Burigsay Hukkeri | Guidance system for a mobile machine |
| CA2848201C (en) * | 2011-09-16 | 2020-10-27 | Regeneron Pharmaceuticals, Inc. | Methods for reducing lipoprotein(a) levels by administering an inhibitor of proprotein convertase subtilisin kexin-9 (pcsk9) |
| EP2706070A1 (en) * | 2012-09-06 | 2014-03-12 | Sanofi | Combination treatments involving antibodies to human PCSK9 |
| US20150284473A1 (en) * | 2014-03-17 | 2015-10-08 | Laurence Bessac | Methods for reducing cardiovascular risk |
-
2015
- 2015-07-16 KR KR1020227045465A patent/KR20230007538A/ko not_active Ceased
- 2015-07-16 EP EP15760317.6A patent/EP3169362B1/en active Active
- 2015-07-16 CA CA2955304A patent/CA2955304C/en active Active
- 2015-07-16 AU AU2015289617A patent/AU2015289617B2/en active Active
- 2015-07-16 RU RU2017104799A patent/RU2723018C2/ru active
- 2015-07-16 KR KR1020247028498A patent/KR20240132123A/ko not_active Ceased
- 2015-07-16 PL PL15760317T patent/PL3169362T3/pl unknown
- 2015-07-16 US US14/801,392 patent/US20160137746A1/en not_active Abandoned
- 2015-07-16 JP JP2017502259A patent/JP6912374B2/ja active Active
- 2015-07-16 EP EP20174278.0A patent/EP3753575A1/en not_active Withdrawn
- 2015-07-16 CN CN202111397525.XA patent/CN114306592A/zh active Pending
- 2015-07-16 WO PCT/US2015/040765 patent/WO2016011260A1/en not_active Ceased
- 2015-07-16 KR KR1020177004219A patent/KR102482375B1/ko active Active
- 2015-07-16 MX MX2017000628A patent/MX378872B/es unknown
- 2015-07-16 CN CN201580049703.6A patent/CN107106678A/zh active Pending
-
2017
- 2017-01-10 ZA ZA2017/00196A patent/ZA201700196B/en unknown
- 2017-01-13 MX MX2021000289A patent/MX2021000289A/es unknown
-
2019
- 2019-10-24 US US16/662,313 patent/US20200255544A1/en not_active Abandoned
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