JP2017521401A - 疾患および障害の処置においてレナラーゼを制御する組成物および方法 - Google Patents
疾患および障害の処置においてレナラーゼを制御する組成物および方法 Download PDFInfo
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Abstract
Description
本発明は、政府の支援により、アメリカ国立衛生研究所(National Institutes of Health)によって与えられた助成金第RC1DK086465号、第RC1DK086402号、第DK54021号、および第R01DK081037号を受けてなされた。
(定義)
(説明)
(治療用の阻害剤組成物と使用法)
(抗レナラーゼ抗体の生成)
(ヒト化抗体)
(レナラーゼ結合性分子の使用法)
(併用療法)
パラウアミン;パルミトイルリゾキシン(palmitoylrhizoxin);パミドロン酸;パナキシトリオール;パノミフェン;パラバクチン;パゼリプチン;ペガスパルガーゼ;ペルデシン;ペントサン多硫酸ナトリウム;ペントスタチン;ペントロゾール(pentrozole);ペルフルブロン;ペルホスファミド;ペリリルアルコール;フェナジノマイシン;フェニルアセタート;ホスファターゼ阻害剤;ピシバニール(登録商標);ピロカルピン塩酸塩;ピラルビシン;ピリトレキシム;プラセチンA(placetin A);プラセチンB(placetin B);プラスミノーゲン活性化因子阻害因子;白金錯体;白金化合物;白金−トリアミン錯体;ポルフィマーナトリウム;ポルフィロマイシン;プレドニゾン;プロピルビスアクリドン(propyl bis−acridone);プロスタグランジンJ2;プロテアソーム阻害剤;タンパク質Aに基づく免疫調節剤;プロテインキナーゼC阻害剤;微細藻類のプロテインキナーゼC阻害剤;タンパク質チロシンホスファターゼ阻害剤;プリンヌクレオシドホスホリラーゼ阻害剤;プルプリン類;ピラゾロアクリジン; ピリドキシル化ヘモグロビン−ポリオキシエチレン複合体;Raf拮抗剤;ラルチトレキセド;ラモセトロン;Rasタンパク質ファルネシルトランスフェラーゼ阻害剤;Ras阻害剤;Ras−GAP阻害剤;脱メチル化レテリプチン;エチドロン酸レニウム(Re;原子量186);リゾキシン;リボザイム類;RIIレチンアミド;ログレチミド;ロヒツキン;ロムルチド;ロキニメクス;ルビギノンB1;ルボキシル;サフィンゴール;サイントピン;SarCNU;サルコフィトールA;サルグラモスチム;Sdi1模倣物;セムスチン;老化由来阻害剤1(senescence derived inhibitor 1);センスオリゴヌクレオチド類;シグナル伝達阻害剤;シグナル伝達調節剤;単鎖抗原結合性タンパク質;シゾフィラン;ソブゾキサン;ボロカプテイトナトリウム;フェニル酢酸ナトリウム;ソルベロール(solverol);ソマトメジン結合性タンパク質;ソネルミン;スパルホス酸;スピカマイシンD;スピロムスチン;スプレノペンチン;スポンギスタチン1(spongistatin 1);スクアラミン;幹細胞阻害剤;幹細胞分裂阻害剤;スチピアミド;ストロメライシン阻害剤;スルフィノシン;過活性(superactive)血管作用性腸ペプチド拮抗剤;スラジスタ(suradista);スラミン;スウェインソニン;合成グリコサミノグリカン類;タリムスチン;タモキシフェンメチオジド;タウロムスチン;タザロテン;テコガランナトリウム;テガフール;テルラピリリウム(tellurapyrylium);テロメラーゼ阻害剤;テモポルフィン;テモゾロミド;テニポシド;テトラクロロデカオキシド(tetrachlorodecaoxide);テトラゾミン;タリブラスチン;チオコラリン;トロンボポエチン;トロンボポエチン模倣物;サイマルファシン;サイモポエチン受容体作用剤;チモトリナン;甲状腺刺激ホルモン;エチルエチオプルプリンスズ(tin ethyl etiopurpurin);チラパザミン;二塩化チタノセン;トプセンチン;トレミフェン;全能性幹細胞因子;翻訳阻害剤;トレチノイン;トリアセチルウリジン;トリシリビン;トリメトレキサート;トリプトレリン;トロピセトロン;ツロステリド;チロシンキナーゼ阻害剤;チルホスチン類;UBC阻害剤;ウベニメックス;泌尿生殖洞由来増殖阻害因子;ウロキナーゼ受容体拮抗剤;バプレオチド;バリオリンB;ベクター系、赤血球遺伝子治療;ベラレソール;べラミン(veramine);ベルジン(verdin)類;ベルテポルフィン;ビノレルビン;ビンキサルチン(vinxaltine);ビタキシン(vitaxin);ボロゾール;ザノテロン;ゼニプラチン;ジラスコルブ;イミリムマブ(imilimumab);ミルタザピン;BrUOG 278;BrUOG 292;RAD0001;CT−011; FOLFIRINOX;ティピファルニブ;R115777;LDE225;カルシトリオール;AZD6244;AMG655;AMG479;BKM120;mFOLFOX6;NC−6004;セツキシマブ;IM−C225;LGX818;MEK162;BBI608;MEDI4736;ベムラフェニブ;イピリムマブ;イボルマブ(ivolumab);二ボルマブ;パノビノスタット;レフルノミド;CEP−32496;アレムツズマブ;ベバシズマブ;オファツムマブ;パニツムマブ;ペムブロリズマブ;リツキシマブ;トラスツズマブ;STAT3阻害剤(たとえばSTA−21、LLL−3、LLL12、XZH−5、S31−201、SF−1066、SF−1087、STX−0119、クリプトタンシノン、クルクミン、ジフェルロイルメタン、FLLL11、FLLL12、FLLL32、FLLL62、C3、C30、C188、C188−9、LY5、OPB−31121、ピリメタミン、OPB−51602、AZD9150など);低酸素誘導因子1(hypoxia inducing factor 1;HIF−1)阻害剤(たとえば、LW6、ジゴキシン、ラウレンジテルペノール(laurenditerpenol)、PX−478、RX−0047、ビテキシン、KC7F2、YC−1など);ならびにジノスタチンスチマラマー。一態様では、抗がん剤は5−フルオロウラシル、タキソール(登録商標)、またはロイコボリンである。
(診断方法)
(キット)
(実施例1:レナラーゼ抗体の開発)
Biacore T100(登録商標)で結合試験を実施した。泳動用緩衝液として25mMのTris(pH8;NaCl(150mM)、EDTA(1mM)、グリセロール(10%)、Tween(登録商標)20(0.005%)、BSA(0.1mg/mL))を用いて25℃で結合試験を行った。ビオチン化抗体を以下のように個々のストレプトアビジンセンサーチップフローセル上に固定化した。本試験では2個のセンサーチップを用いたため、別のセンサーチップでもmAbのうち2個を分析し、これを繰り返すことでより多くのデータを収集した。レナラーゼ−1は、50nMを最高濃度として3倍希釈系列で試験した。5種類の濃度で2回ずつ試験を行った。結合した複合体を、リン酸濃度を1/1000にして短いパルスを用いて再生した。データセットを全体に適合し、結合定数の推定値を抽出した。概要を表2に示す。
(抗レナラーゼ抗体のヌクレオチド配列およびアミノ酸配列)
(抗体がレナラーゼのシグナル伝達を阻害することによってがん細胞生存率が低下する)
(黒色腫患者の予後不良に関連するレナラーゼ過剰発現)
(実施例2:代替活性化した腫瘍関連マクロファージによるレナラーゼ発現はSTAT3が媒介する機構を介して黒色腫の増殖を促進する)
(試薬)
(抗RNLSモノクローナル抗体m28−RNLS(1D−28−4ともいう)とm37−RNLS(1D−37−10ともいう)の合成)
(組織標本)
(定量RT−PCR)
(免疫組織化学染色分析とウェスタンブロット分析)
(組織マイクロアレイ)
(細胞生存率試験)
(RNA干渉)
(マウス腫瘍モデル)
(統計分析)
(黒色腫でのRNLS過剰発現)
(RNLSの過剰発現はがん細胞の生存に有利である)
(RNLSシグナル伝達の阻害は生体外で黒色腫細胞に対し細胞障害性を示す)
(RNLSシグナル伝達の阻害は生体内で腫瘍の増殖を阻止する)
(RNLSシグナル伝達を阻害すると内因性RNLS発現とSTAT3活性化が阻止されアポトーシスと細胞周期停止が誘発される)
(RNLSシグナル伝達の阻害によってCD86陽性TAMのCD163陽性TAMに対する比が増加する)
(実施例3:細胞膜カルシウムATPアーゼPMCA4bを介する持続的なレナラーゼシグナル伝達により膵臓がんの増殖が促進される)
(試薬)
(抗RNLSモノクローナル抗体m28−RNLS(1D−28−4ともいう)とm37−RNLS(1D−37−10ともいう)の合成)
(組織標本)
(定量PCR)
(免疫組織染色分析とウェスタンブロット分析)
(組織マイクロアレイ)
(細胞生存率試験)
(アポトーシスおよび細胞周期の分析)
(RNA干渉)
マウス異種移植腫瘍モデル
(統計分析)
(PDACでのRNLS過剰発現と生存率低下との関連)
(RNLSはPMCA4bを介してシグナル伝達し膵臓がん細胞の生存因子として作用する)
(RNLSシグナル伝達を阻害すると膵臓がんの増殖が阻止される)
(m28−RNLS腫瘍細胞のアポトーシスおよび細胞周期停止の誘導)
(正のRNLS−STAT3フィードバックループの存在とm28−RNLSによるその妨害)
<配列表>
AVWDKADDSGGRMTTAC
AVWDKAEDSGGRMTTAC
CTPHYAKKHQRFYDEL
CIRFVSIDNKKRNIESSEIGP
PGQMTLHHKPFLAC
CVLEALKNYI
PSAGVILGC
LSSFAVG
IISSVGITRYASWAAG
YGYSGDVNRLDL
SQSVYDNNNLA
GASTLAS
LGEFSCSSADCFA
LSDYAII
IIGSSGDTFYATWAKG
RYAGTTDYHDAFDP
SQNIYNYLS
KASTLTS
QINYSIYNHYNII
LSSYGVT
LIGDRGTTFYASWAKS
GSGYGARI
SQSVYKNNYLA
ETSKLAS
QGGYSGVDFMA
LTTYGVT
LIGDRGTTYYASWVNG
GSGYGARI
SQTVYNNNYLS
ETSKLSS
QGGYSGVDFM
LNNYHIY
IIFNGGTYYARWTKG
GDGI
SQSVFNNNYLA
SASTLAS
AGSFDCNSGDCVA
ctcagtagttttgcagtgggc
atcattagtagtgttggtattacacgctacgcgagctgggcggccggc
tatggttatagtggtgatgttaatcggttggatctc
agtcagagtgtttatgataacaacaacttagcc
ggtgcatccactctggcatct
ctaggcgaatttagttgtagtagtgctgattgttttgct
ctcagtgactatgcaataatc
attattggtagtagtggtgacacattctacgcgacctgggcgaaaggc
cgttatgctggtactactgattatcatgatgcttttgatccc
agtcagaacatttacaactacttatcc
aaggcctccactctgacttct
caaatcaattactctatttataatcattataatattatt
ctcagtagctatggagtgacc
ttgattggtgatcgtggtactacgttctacgcgagctgggcgaaaagc
Gggagtgggtatggtgctcgcatc
agtcagagtgtttataagaacaactacttagcc
gaaacatccaaactggcatct
caaggcggttatagtggtgttgattttatggct
ctcactacctatggagtgacc
ttgattggtgatcgcggtaccacttactacgcgagctgggtgaatggc
gggagtggatatggtgctcgcatc
agtcagactgtttataacaataactacttatcc
gaaacatccaaactgtcatct
ggcggttatagtggtgttgattttatggct
ctcaataactaccacatatac
atcattttcaatggtggcacatattacgcgagatggacaaaaggc
ggggacggcatc
agtcagagtgtttttaataacaactatttagcc
tctgcatccactctggcgtct
Gcaggcagttttgattgtaatagtggtgattgtgttgct
Claims (36)
- 化合物、タンパク質、ペプチド、ペプチド模倣物、レナラーゼ受容体、レナラーゼ受容体断片、抗体、抗体断片、抗体模倣物、リボザイム、小分子化合物、低分子ヘアピン型RNA、アンチセンス核酸分子、低分子干渉RNA(siRNA)、マイクロRNA(miRNA)、アンチセンス核酸分子をコードする核酸、タンパク質をコードする核酸配列からなる群より選択される少なくとも1種のレナラーゼ阻害剤を含む組成物。
- 前記レナラーゼ阻害剤はレナラーゼ結合性分子である、請求項1に記載の組成物。
- 前記レナラーゼ結合性分子は抗体またはその結合性部分である、請求項2に記載の組成物。
- 少なくとも10-6Mの親和性でレナラーゼに特異的に結合する抗体またはその結合性部分を含む、請求項3に記載の組成物。
- 前記抗体は配列番号1〜7からなる群より選択されるペプチド配列に特異的に結合する、請求項3に記載の組成物。
- 前記レナラーゼはヒトレナラーゼである、請求項3に記載の組成物。
- 前記抗体はモノクローナル抗体、ポリクローナル抗体、単鎖抗体、免疫複合体、脱フコシル化抗体、二重特異性抗体からなる群より選択される、請求項3に記載の組成物。
- 前記免疫複合体は治療薬または検出用成分を含む、請求項7に記載の組成物。
- 前記抗体はヒト化抗体、キメラ抗体、完全ヒト抗体、抗体模倣物からなる群より選択される、請求項3に記載の組成物。
- 前記抗体は、以下のa)〜f)からなる群より選択される少なくとも1つの配列を含む、請求項3に記載の組成物:a)配列番号11および配列番号19からなる群より選択される重鎖CDR1配列;b)配列番号12および配列番号20からなる群より選択される重鎖CDR2配列;c)配列番号13および配列番号21からなる群より選択される重鎖CDR3配列;d)配列番号14および配列番号22からなる群より選択される軽鎖CDR1配列;e)配列番号15および配列番号23からなる群より選択される軽鎖CDR2配列;ならびにf)配列番号16および配列番号24からなる群より選択される軽鎖CDR3配列。
- 前記抗体は配列番号4のアミノ酸配列を含むポリペプチドに特異的に結合する、請求項4に記載の組成物。
- 前記抗体は以下のa)〜f)からなる群より選択される少なくとも1つの配列を含む、請求項3に記載の組成物:a)配列番号27および配列番号35からなる群より選択される重鎖CDR1配列;b)配列番号28および配列番号36からなる群より選択される重鎖CDR2配列;c)配列番号29および配列番号37からなる群より選択される重鎖CDR3配列;d)配列番号30および配列番号38からなる群より選択される軽鎖CDR1配列;e)配列番号31および配列番号39からなる群より選択される軽鎖CDR2配列;ならびにf)配列番号32および配列番号40からなる群より選択される軽鎖CDR3配列。
- 前記抗体は配列番号6のアミノ酸配列を含むポリペプチドに特異的に結合する、請求項6に記載の組成物。
- 前記抗体はa)配列番号43の重鎖CDR1配列;b)配列番号44の重鎖CDR2配列;c)配列番号45の重鎖CDR3配列;d)配列番号46の軽鎖CDR1配列;e)配列番号47の軽鎖CDR2配列;およびf)配列番号48の軽鎖CDR3配列からなる群より選択される少なくとも1つの配列を含む、請求項3に記載の組成物。
- 前記抗体は配列番号7のアミノ酸配列を含むポリペプチドに特異的に結合する、請求項7に記載の組成物。
- 前記抗体は配列番号9、17、25、33、および41からなる群より選択される重鎖配列を含む、請求項3に記載の組成物。
- 前記抗体は配列番号10、18、26、34、および42からなる群より選択される軽鎖配列を含む、請求項3に記載の組成物。
- レナラーゼに結合し請求項3の抗体のレナラーゼに対する結合と競合する抗体を含む、組成物。
- 対象のレナラーゼ関連疾患または障害を処置または予防する方法であって、該対象に請求項1の組成物を投与する工程を含む方法。
- 前記請求項1の組成物は第二の治療薬と併用して前記対象に投与される、請求項19に記載の方法。
- 前記レナラーゼ関連疾患または障害は、腎疾患、心血管系疾患、がん、およびそれらの任意の組み合わせからなる群より選択される、請求項19に記載の方法。
- 前記疾患または障害はがんであり、該がんは膵臓がんまたは黒色腫である、請求項21に記載の方法。
- 請求項2に記載のレナラーゼ結合性分子をコードする単離核酸分子。
- 請求項23に記載の核酸分子を含む発現ベクター。
- 請求項23に記載の核酸分子を含む宿主細胞。
- 診断を必要とする対象の疾患または障害を診断する方法であって、
a.該対象の生体試料のレナラーゼ値を決定することと、
b.該対象の該生体試料のレナラーゼ値を比較対照と比較することと、
c.該対象の該生体試料のレナラーゼ値が該比較対照のレナラーゼ値に比べて高い場合に該対象が疾患または障害を有すると診断することと
を含む、方法。 - 疾患または障害を有すると診断された前記対象に処置を施す工程をさらに含む、請求項26に記載の方法。
- 前記生体試料のレナラーゼ値を該生体試料のレナラーゼmRNA値の測定によって決定する、請求項26に記載の方法。
- 前記生体試料のレナラーゼ値を該生体試料のレナラーゼポリペプチド値の測定によって決定する、請求項26に記載の方法。
- 前記生体試料のレナラーゼポリペプチド値をレナラーゼ結合性分子を用いて決定する、請求項26に記載の方法。
- 前記生体試料のレナラーゼ値を該生体試料でのレナラーゼポリペプチドの酵素活性を測定することによって決定する、請求項26に記載の方法。
- レナラーゼ値が比較対照に比べて少なくとも10%、少なくとも20%、少なくとも30%、少なくとも40%、少なくとも50%、少なくとも60%、少なくとも70%、少なくとも80%、少なくとも90%、少なくとも100%、少なくとも200%、少なくとも300%、少なくとも400%、少なくとも500%、少なくとも600%、少なくとも700%、少なくとも800%、少なくとも900%、少なくとも1000%増加している場合に前記生体試料のレナラーゼ値が高いと決定する、請求項26に記載の方法。
- 前記比較対照は陽性対照、陰性対照、歴史的対照、歴史的標準、該生体試料中の基準分子の値からなる群より選択される少なくとも1つである、前記請求項26に記載の方法。
- 前記疾患または障害は、腎疾患、心血管系疾患、およびそれらの任意の組み合わせからなる群より選択される少なくとも1つである、請求項26に記載の方法。
- 前記疾患または障害はがんであり該がんは膵臓がんまたは黒色腫である、請求項34に記載の方法。
- 前記対象はヒトである、請求項26に記載の方法。
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US201462017487P | 2014-06-26 | 2014-06-26 | |
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PCT/US2015/037971 WO2015200790A2 (en) | 2014-06-26 | 2015-06-26 | Compositions and methods to regulate renalase in the treatment of diseases and disorders |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021508709A (ja) * | 2017-12-29 | 2021-03-11 | イェール ユニバーシティーYale University | 疾患及び障害の治療及び予防のための抗レナラーゼ抗体 |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017521362A (ja) | 2014-05-16 | 2017-08-03 | イェール ユニバーシティーYale University | 膵臓炎、腎損傷および腎臓癌を治療および予防するための組成物および方法 |
EP3779447B1 (en) * | 2016-03-15 | 2023-02-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method to activate the anti-tumoral cd8+t cell response of a patient affected with a cancer |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
AU2018230964A1 (en) * | 2017-03-08 | 2019-10-10 | Yale University | Compositions and methods for treating cancer with anti-renalase antibodies and anti-PD1 antibodies |
WO2019133665A2 (en) * | 2017-12-29 | 2019-07-04 | Yale University | Methods for measuring renalase |
AU2019227715B2 (en) | 2018-02-28 | 2022-03-31 | Ap Biosciences, Inc. | Bifunctional proteins combining checkpoint blockade for targeted therapy |
CA3144712A1 (en) * | 2019-06-27 | 2020-12-30 | Industrial Cooperation Foundation Chonbuk National University | Novel adp-ribosyl cyclase and inhibitor thereof |
WO2021003284A1 (en) * | 2019-07-02 | 2021-01-07 | Astute Medical, Inc | Antibodies and assays for ccl14 |
AU2020331301A1 (en) * | 2019-08-09 | 2022-02-24 | The Board Of Trustees Of The Leland Stanford Junior University | Therapeutic antibodies against osteopontin |
US20210106819A1 (en) * | 2019-10-15 | 2021-04-15 | University Of Cincinnati | Combination Therapy of Electric Fields and an Additional Treatment for Cancer and Imaging |
WO2021087462A1 (en) * | 2019-10-31 | 2021-05-06 | The Research Foundation For The State University Of New York | Rage antibodies, fragments and uses thereof |
WO2023225178A1 (en) * | 2022-05-18 | 2023-11-23 | Mellitus, Llc | Methods and reagents for the assessment of gestational diabetes |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014014899A1 (en) * | 2012-07-16 | 2014-01-23 | Yale University | Compositions and methods for detecting, treating and preventing diseases and disorders |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4309989A (en) | 1976-02-09 | 1982-01-12 | The Curators Of The University Of Missouri | Topical application of medication by ultrasound with coupling agent |
JPS57106673A (en) | 1980-12-24 | 1982-07-02 | Chugai Pharmaceut Co Ltd | Dibenzo(b,f)(1,4)oxazepin derivative |
US5023243A (en) | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
US5190931A (en) | 1983-10-20 | 1993-03-02 | The Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US4767402A (en) | 1986-07-08 | 1988-08-30 | Massachusetts Institute Of Technology | Ultrasound enhancement of transdermal drug delivery |
US4861581A (en) | 1986-12-05 | 1989-08-29 | Cancer Biologics, Inc. | Detection of necrotic malignant tissue and associated therapy |
US5019368A (en) | 1989-02-23 | 1991-05-28 | Cancer Biologics, Inc. | Detection of necrotic malignant tissue and associated therapy |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US5168053A (en) | 1989-03-24 | 1992-12-01 | Yale University | Cleavage of targeted RNA by RNAase P |
US6713610B1 (en) | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
DE69233745D1 (de) | 1991-12-02 | 2008-10-23 | Cambridge Antibody Tech | Herstellung von Autoantikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken |
IL120943A (en) | 1997-05-29 | 2004-03-28 | Univ Ben Gurion | A system for administering drugs through the skin |
CN1487996B (zh) | 2000-11-30 | 2010-06-16 | 米德列斯公司 | 用于生产人类抗体的转基因转染色体啮齿动物 |
US20040185040A1 (en) * | 2001-11-21 | 2004-09-23 | Celltech R & D Limited | Modulating immune responses |
CN100415765C (zh) | 2003-08-07 | 2008-09-03 | 宜康公司 | 兔单克隆抗体的人源化方法 |
CN101076586A (zh) * | 2004-03-19 | 2007-11-21 | 耶鲁大学 | 肾酶(单胺氧化酶c)的检测、分离和应用 |
AU2005223847A1 (en) * | 2004-03-19 | 2005-09-29 | Yale University | Detection, isolation and uses of renalase (Monoamine Oxidase C) |
AR060312A1 (es) * | 2005-11-21 | 2008-06-11 | Univ Yale | Metodos para regular renalasa (monoamina oxidasa c) |
WO2008091408A2 (en) * | 2006-09-25 | 2008-07-31 | Yale University | Circulating renalase and methods of increasing same |
US9056905B2 (en) * | 2007-05-21 | 2015-06-16 | Alderbio Holdings Llc | Antibodies to TNF-α and use thereof |
WO2009009142A2 (en) * | 2007-07-10 | 2009-01-15 | Monsanto Technology, Llc | Transgenic plants with enhanced agronomic traits |
WO2010006214A1 (en) | 2008-07-09 | 2010-01-14 | Ambrx, Inc. | Fgf-21 neutralizing antibodies and their uses |
WO2010063011A2 (en) * | 2008-11-28 | 2010-06-03 | Emory University | Methods for the treatment of infections and tumors |
CN102597779B (zh) * | 2009-10-30 | 2016-03-23 | 学校法人庆应义塾 | 抗癌剂感受性的判定方法 |
-
2015
- 2015-06-26 US US15/321,015 patent/US10273311B2/en active Active
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014014899A1 (en) * | 2012-07-16 | 2014-01-23 | Yale University | Compositions and methods for detecting, treating and preventing diseases and disorders |
Non-Patent Citations (2)
Title |
---|
BERTHIER-VERGNES O ET AL.: "Gene expression profiles of human melanoma cells with different invasive potential reveal TSPAN8 as", BRITISH JOURNAL OF CANCER, vol. 104, no. 1, JPN6019002430, 2011, pages 155 - 165, ISSN: 0004186458 * |
池上 恒雄: "膵癌に関与するPI3K-AKT-mTORシグナル解析の動向", 肝・胆・膵, vol. 第62巻,第3号, JPN6019002429, 2011, pages 499 - 504, ISSN: 0004186457 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021508709A (ja) * | 2017-12-29 | 2021-03-11 | イェール ユニバーシティーYale University | 疾患及び障害の治療及び予防のための抗レナラーゼ抗体 |
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US10273311B2 (en) | 2019-04-30 |
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