JP2017519768A5 - - Google Patents

Info

Publication number

JP2017519768A5

JP2017519768A5 JP2016573926A JP2016573926A JP2017519768A5 JP 2017519768 A5 JP2017519768 A5 JP 2017519768A5 JP 2016573926 A JP2016573926 A JP 2016573926A JP 2016573926 A JP2016573926 A JP 2016573926A JP 2017519768 A5 JP2017519768 A5 JP 2017519768A5

Authority

JP

Japan

Prior art keywords

seq

antigen

antibody

binding fragment

cdr1

Prior art date

2015-06-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 239000000427 antigen Substances 0.000 claims description 73
• 102000036639 antigens Human genes 0.000 claims description 73
• 108091007433 antigens Proteins 0.000 claims description 73
• 239000012634 fragment Substances 0.000 claims description 63
• 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims description 44
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 32
• 241000894006 Bacteria Species 0.000 claims description 16
• 101710092462 Alpha-hemolysin Proteins 0.000 claims description 11
• 101710197219 Alpha-toxin Proteins 0.000 claims description 11
• 101710124951 Phospholipase C Proteins 0.000 claims description 11
• 239000002776 alpha toxin Substances 0.000 claims description 11
• 208000015181 infectious disease Diseases 0.000 claims description 10
• 241000588626 Acinetobacter baumannii Species 0.000 claims description 4
• 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 4
• 241000191967 Staphylococcus aureus Species 0.000 claims description 4
• 230000003115 biocidal effect Effects 0.000 claims description 4
• MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims description 4
• 241000589291 Acinetobacter Species 0.000 claims description 3
• 239000003242 anti bacterial agent Substances 0.000 claims description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 241000588747 Klebsiella pneumoniae Species 0.000 claims description 2
• 229960003405 ciprofloxacin Drugs 0.000 claims description 2
• 230000001332 colony forming effect Effects 0.000 claims description 2
• 230000002401 inhibitory effect Effects 0.000 claims description 2
• 230000000069 prophylactic effect Effects 0.000 claims description 2
• 230000001225 therapeutic effect Effects 0.000 claims description 2
• 208000035143 Bacterial infection Diseases 0.000 claims 1
• 229940124350 antibacterial drug Drugs 0.000 claims 1
• 230000001580 bacterial effect Effects 0.000 claims 1
• 208000022362 bacterial infectious disease Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 description 67
• 241000588748 Klebsiella Species 0.000 description 3
• 206010035664 Pneumonia Diseases 0.000 description 2
• 241000589516 Pseudomonas Species 0.000 description 2
• 206010048038 Wound infection Diseases 0.000 description 2
• 239000004599 antimicrobial Substances 0.000 description 2
• 206010040872 skin infection Diseases 0.000 description 2
• 206010051548 Burn infection Diseases 0.000 description 1
• 101710098119 Chaperonin GroEL 2 Proteins 0.000 description 1
• 206010061788 Corneal infection Diseases 0.000 description 1
• 201000003883 Cystic fibrosis Diseases 0.000 description 1
• 208000001860 Eye Infections Diseases 0.000 description 1
• 208000032376 Lung infection Diseases 0.000 description 1
• 206010031252 Osteomyelitis Diseases 0.000 description 1
• 206010036410 Postoperative wound infection Diseases 0.000 description 1
• 206010062255 Soft tissue infection Diseases 0.000 description 1
• 241000191940 Staphylococcus Species 0.000 description 1
• 208000031650 Surgical Wound Infection Diseases 0.000 description 1
• 208000009470 Ventilator-Associated Pneumonia Diseases 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 208000011323 eye infectious disease Diseases 0.000 description 1