TWI719938B - 多重細菌感染之治療 - Google Patents

多重細菌感染之治療 Download PDF

Info

Publication number
TWI719938B
TWI719938B TW104119861A TW104119861A TWI719938B TW I719938 B TWI719938 B TW I719938B TW 104119861 A TW104119861 A TW 104119861A TW 104119861 A TW104119861 A TW 104119861A TW I719938 B TWI719938 B TW I719938B
Authority
TW
Taiwan
Prior art keywords
seq
antibody
antigen
pseudomonas aeruginosa
amino acid
Prior art date
Application number
TW104119861A
Other languages
English (en)
Chinese (zh)
Other versions
TW201613575A (en
Inventor
布里特 希爾曼
詹姆西 強森 西里爾德
歐馬利 瓊斯
查理斯 肯 史多夫
Original Assignee
美商麥迪紐有限責任公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商麥迪紐有限責任公司 filed Critical 美商麥迪紐有限責任公司
Publication of TW201613575A publication Critical patent/TW201613575A/zh
Application granted granted Critical
Publication of TWI719938B publication Critical patent/TWI719938B/zh

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515Complete light chain, i.e. VL + CL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW104119861A 2014-06-19 2015-06-18 多重細菌感染之治療 TWI719938B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462014506P 2014-06-19 2014-06-19
US62/014,506 2014-06-19
US201562140849P 2015-03-31 2015-03-31
US62/140,849 2015-03-31

Publications (2)

Publication Number Publication Date
TW201613575A TW201613575A (en) 2016-04-16
TWI719938B true TWI719938B (zh) 2021-03-01

Family

ID=54936121

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104119861A TWI719938B (zh) 2014-06-19 2015-06-18 多重細菌感染之治療

Country Status (11)

Country Link
US (1) US11168132B2 (cg-RX-API-DMAC7.html)
EP (1) EP3157565B1 (cg-RX-API-DMAC7.html)
JP (2) JP6845016B2 (cg-RX-API-DMAC7.html)
KR (1) KR102549870B1 (cg-RX-API-DMAC7.html)
CN (1) CN106456767B (cg-RX-API-DMAC7.html)
AU (1) AU2015276938B2 (cg-RX-API-DMAC7.html)
CA (1) CA2952278A1 (cg-RX-API-DMAC7.html)
ES (1) ES2983252T3 (cg-RX-API-DMAC7.html)
SG (2) SG11201609652RA (cg-RX-API-DMAC7.html)
TW (1) TWI719938B (cg-RX-API-DMAC7.html)
WO (1) WO2015196011A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12492243B2 (en) 2016-05-05 2025-12-09 The Trustees Of The University Of Pennsylvania DNA antibody constructs for use against Pseudomonas aeruginosa

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2718320T (lt) 2011-06-10 2018-04-10 Medimmune Limited Anti-pseodomonas psl surišančios molekulės ir jų panaudojimas
MX374826B (es) 2011-11-07 2025-03-06 Medimmune Llc Un anticuerpo biespecífico que se une a pcrv y psl de pseudomonas.
KR102272744B1 (ko) 2012-11-06 2021-07-06 메디뮨 엘엘씨 에스.아우레우스 연관 질병의 치료 방법
EP3640338A1 (en) * 2012-11-06 2020-04-22 Medlmmune, LLC Antibodies to s. aureus surface determinants
WO2017095744A1 (en) 2015-11-30 2017-06-08 Medimmune, Llc Method for preventing or treating nosocomial pneumonia
TW202311284A (zh) 2017-01-03 2023-03-16 美商再生元醫藥公司 抗金黃色葡萄球菌溶血素a毒素之人類抗體
BR112021001214A2 (pt) 2018-07-24 2021-04-27 Medimmune, Llc anticorpo dirigido contra o fator de aglutinação a (clfa) de s. aureus
CN113015745B (zh) 2018-10-09 2025-02-11 免疫医疗有限责任公司 针对金黄色葡萄球菌白细胞毒素的抗体
US11168133B2 (en) 2018-10-09 2021-11-09 Medimmune, Llc Combinations of anti-Staphylococcus aureus antibodies
GB201816554D0 (en) 2018-10-10 2018-11-28 Centauri Therapeutics Ltd Novel compounds and therapeutic uses thereof
GB201816553D0 (en) 2018-10-10 2018-11-28 Centauri Therapeutics Ltd Novel compounds and therapeutic uses thereof
WO2020172233A1 (en) * 2019-02-22 2020-08-27 The Trustees Of Columbia University In The City Of New York Treatment of prostate cancer by androgen ablation and il-8 blockade
WO2020185986A1 (en) * 2019-03-13 2020-09-17 Medimmune, Llc Decreasing staphylococcus aureus infections in colonized patients
MX2021015156A (es) * 2019-06-11 2022-01-18 Regeneron Pharma Anticuerpos anti-pcrv que se unen a pcrv, composiciones que comprenden anticuerpos anti-pcrv, y metodos de uso de estos.
US20220259290A1 (en) * 2019-07-24 2022-08-18 Japan Science And Technology Agency Innovative production technique for antibody-enzyme
FR3114970B1 (fr) * 2020-10-08 2023-06-30 Univ Tours Combinaison d’anticorps inhalés avec des agents immunomodulateurs pour le traitement ou la prévention d’inféctions respiratoires
WO2025117765A1 (en) * 2023-12-01 2025-06-05 University Of Washington Protective monoclonal antibodies to pseudomonas aeruginosa

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110165172A1 (en) * 2009-12-22 2011-07-07 Kalobios Pharmaceuticals, Inc. Method of treating a staphylococcus infection in a patient having a low-level pathogenic pseudomonas aeruginosa infection
CN103443285A (zh) * 2011-02-08 2013-12-11 米迪缪尼有限公司 特异性结合金黄色葡萄球菌α毒素的抗体以及使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2043690A1 (en) 2006-06-12 2009-04-08 Nabi Biopharmaceuticals Use of alpha-toxin for treating and preventing staphylococcus infections
MX374826B (es) * 2011-11-07 2025-03-06 Medimmune Llc Un anticuerpo biespecífico que se une a pcrv y psl de pseudomonas.
SG11201502937PA (en) * 2012-11-06 2015-06-29 Medimmune Llc COMBINATION THERAPIES USING ANTI-<i>PSEUDOMONAS</i> PSL AND PCRV BINDING MOLECULES
KR102272744B1 (ko) 2012-11-06 2021-07-06 메디뮨 엘엘씨 에스.아우레우스 연관 질병의 치료 방법
EP3640338A1 (en) 2012-11-06 2020-04-22 Medlmmune, LLC Antibodies to s. aureus surface determinants
US20190077851A1 (en) 2015-10-30 2019-03-14 Bruno Francois Methods of using anti-alpha toxin antibody

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110165172A1 (en) * 2009-12-22 2011-07-07 Kalobios Pharmaceuticals, Inc. Method of treating a staphylococcus infection in a patient having a low-level pathogenic pseudomonas aeruginosa infection
CN103443285A (zh) * 2011-02-08 2013-12-11 米迪缪尼有限公司 特异性结合金黄色葡萄球菌α毒素的抗体以及使用方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Mashburn LM et al., J Bacteriol. 2005 Jan;187(2):554-66. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12492243B2 (en) 2016-05-05 2025-12-09 The Trustees Of The University Of Pennsylvania DNA antibody constructs for use against Pseudomonas aeruginosa

Also Published As

Publication number Publication date
TW201613575A (en) 2016-04-16
EP3157565A1 (en) 2017-04-26
SG11201609652RA (en) 2016-12-29
JP6845016B2 (ja) 2021-03-17
SG10201811361XA (en) 2019-01-30
JP2021063090A (ja) 2021-04-22
AU2015276938B2 (en) 2020-11-19
EP3157565B1 (en) 2024-04-24
KR102549870B1 (ko) 2023-06-29
CA2952278A1 (en) 2015-12-23
WO2015196011A1 (en) 2015-12-23
CN106456767A (zh) 2017-02-22
CN106456767B (zh) 2021-07-09
JP2017519768A (ja) 2017-07-20
AU2015276938A1 (en) 2017-01-05
US11168132B2 (en) 2021-11-09
US20170129943A1 (en) 2017-05-11
KR20170015329A (ko) 2017-02-08
ES2983252T3 (es) 2024-10-22
EP3157565A4 (en) 2018-03-21

Similar Documents

Publication Publication Date Title
TWI719938B (zh) 多重細菌感染之治療
US11447543B2 (en) Antibodies to S. aureus surface determinants
EP2464665B1 (en) Human monoclonal antibody against s. aureus derived alpha-toxin and its use in treating or preventing abscess formation
WO2021052461A1 (zh) 抗α-溶血素的抗体及其应用
KR20210072057A (ko) 항-황색포도상구균 항체의 조합
HK1236126B (en) Treatment of polybacterials infections
HK1236126A1 (en) Treatment of polybacterials infections
RU2808018C2 (ru) Антитела к поверхностным детерминантам s. aureus
HK1215452B (zh) 金黃色葡萄球菌表面決定簇的抗體