JP2017518750A5 - - Google Patents

Download PDF

Info

Publication number
JP2017518750A5
JP2017518750A5 JP2016571250A JP2016571250A JP2017518750A5 JP 2017518750 A5 JP2017518750 A5 JP 2017518750A5 JP 2016571250 A JP2016571250 A JP 2016571250A JP 2016571250 A JP2016571250 A JP 2016571250A JP 2017518750 A5 JP2017518750 A5 JP 2017518750A5
Authority
JP
Japan
Prior art keywords
polymerase
amino acid
acid sequence
functionally equivalent
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016571250A
Other languages
English (en)
Japanese (ja)
Other versions
JP6737710B2 (ja
JP2017518750A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/037785 external-priority patent/WO2015200693A1/en
Publication of JP2017518750A publication Critical patent/JP2017518750A/ja
Publication of JP2017518750A5 publication Critical patent/JP2017518750A5/ja
Application granted granted Critical
Publication of JP6737710B2 publication Critical patent/JP6737710B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016571250A 2014-06-27 2015-06-25 ヌクレオチドアナログの取り込みを改善するための修飾ポリメラーゼ Active JP6737710B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462018470P 2014-06-27 2014-06-27
US62/018,470 2014-06-27
PCT/US2015/037785 WO2015200693A1 (en) 2014-06-27 2015-06-25 Modified polymerases for improved incorporation of nucleotide analogues

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020079698A Division JP2020127415A (ja) 2014-06-27 2020-04-28 ヌクレオチドアナログの取り込みを改善するための修飾ポリメラーゼ

Publications (3)

Publication Number Publication Date
JP2017518750A JP2017518750A (ja) 2017-07-13
JP2017518750A5 true JP2017518750A5 (https=) 2018-08-02
JP6737710B2 JP6737710B2 (ja) 2020-08-12

Family

ID=53716556

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016571250A Active JP6737710B2 (ja) 2014-06-27 2015-06-25 ヌクレオチドアナログの取り込みを改善するための修飾ポリメラーゼ
JP2020079698A Pending JP2020127415A (ja) 2014-06-27 2020-04-28 ヌクレオチドアナログの取り込みを改善するための修飾ポリメラーゼ
JP2021196287A Pending JP2022033882A (ja) 2014-06-27 2021-12-02 ヌクレオチドアナログの取り込みを改善するための修飾ポリメラーゼ

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020079698A Pending JP2020127415A (ja) 2014-06-27 2020-04-28 ヌクレオチドアナログの取り込みを改善するための修飾ポリメラーゼ
JP2021196287A Pending JP2022033882A (ja) 2014-06-27 2021-12-02 ヌクレオチドアナログの取り込みを改善するための修飾ポリメラーゼ

Country Status (10)

Country Link
US (3) US9765309B2 (https=)
EP (2) EP3702471B1 (https=)
JP (3) JP6737710B2 (https=)
CN (1) CN106536728A (https=)
AU (2) AU2015279794B2 (https=)
DK (1) DK3161154T3 (https=)
ES (2) ES3060591T3 (https=)
PL (1) PL3161154T3 (https=)
PT (1) PT3161154T (https=)
WO (1) WO2015200693A1 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3702471B1 (en) * 2014-06-27 2025-12-24 Illumina, Inc. Modified polymerases for improved incorporation of nucleotide analogues
WO2016054096A1 (en) 2014-09-30 2016-04-07 Illumina, Inc. Modified polymerases for improved incorporation of nucleotide analogues
TWI658139B (zh) * 2016-11-01 2019-05-01 體學生物科技股份有限公司 用以提升核苷酸類似物併入之重組dna聚合酶
WO2018126470A1 (zh) * 2017-01-09 2018-07-12 深圳华大智造科技有限公司 重组dna聚合酶
US20200002689A1 (en) 2017-02-13 2020-01-02 Qiagen Sciences, Llc Polymerase enzyme from 9°n
US20220127587A1 (en) 2017-02-13 2022-04-28 IsoPlexis Corporation Polymerase enzyme from pyrococcus furiosus
WO2018148724A1 (en) * 2017-02-13 2018-08-16 Qiagen Waltham Inc. Polymerase enzyme from pyrococcus furiosus
FI3842545T3 (fi) 2017-04-23 2023-01-31 Koostumuksia ja menetelmiä näytteiden tunnistuksen parantamiseksi indeksoiduissa nukleiinihappokirjastoissa
CA3059840C (en) 2017-04-23 2022-04-26 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
EP3615671B1 (en) 2017-04-23 2021-07-21 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
CN108795900B (zh) * 2017-04-27 2021-02-02 深圳华大智造科技股份有限公司 Dna聚合酶及其制备方法
CN117802065A (zh) * 2018-09-03 2024-04-02 深圳华大生命科学研究院 聚合活性提高的重组型kod聚合酶
WO2020056044A1 (en) 2018-09-11 2020-03-19 Singular Genomics Systems, Inc. Modified archaeal family b polymerases
US11104888B2 (en) * 2018-10-31 2021-08-31 Illumina, Inc. Polymerases, compositions, and methods of use
EP3891275A2 (en) * 2018-12-05 2021-10-13 Illumina, Inc. Polymerases, compositions, and methods of use
US11293061B2 (en) * 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US11512295B2 (en) 2019-09-12 2022-11-29 Singular Genomics Systems, Inc. Modified thermoccocus polymerases
WO2021058438A1 (en) 2019-09-23 2021-04-01 Dna Script Increasing long-sequence yields in template-free enzymatic synthesis of polynucleotides
US11591629B2 (en) * 2019-12-23 2023-02-28 Cheng-Yao Chen Method and kit for template-independent nucleic acid synthesis
US11034942B1 (en) 2020-02-27 2021-06-15 Singular Genomics Systems, Inc. Modified pyrococcus polymerases and uses thereof
WO2021224677A1 (en) 2020-05-05 2021-11-11 Akershus Universitetssykehus Hf Compositions and methods for characterizing bowel cancer
US20240392263A1 (en) * 2020-10-21 2024-11-28 Bgi Shenzhen Recombinant kod polymerase
WO2023277953A1 (en) 2021-06-29 2023-01-05 Agilent Technologies, Inc. Polymerase mutants and use with 3'-oh unblocked reversible terminators
US12077789B2 (en) 2021-08-14 2024-09-03 Illumina, Inc. Polymerases, compositions, and methods of use
TWI869710B (zh) * 2021-09-29 2025-01-11 呈堯 陳 用於無模板ｒｎａ合成的核酸聚合酶變體、試劑套組及方法
WO2024039652A1 (en) 2022-08-16 2024-02-22 Aldevron, L.L.C. Cell-free method of producing synthetic circular nucleic acid
US20240141427A1 (en) 2022-09-30 2024-05-02 Illumina, Inc. Polymerases, compositions, and methods of use
WO2024155578A1 (en) * 2023-01-16 2024-07-25 The Regents Of The University Of California Engineered polymerase for threose nucleic acid synthesis
CN116286720A (zh) * 2023-03-29 2023-06-23 赛纳生物科技(北京)有限公司 一种dna聚合酶
WO2025260380A1 (zh) * 2024-06-21 2025-12-26 华大工程生物学长荡湖研究所 重组型kod聚合酶

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2044616A1 (en) 1989-10-26 1991-04-27 Roger Y. Tsien Dna sequencing
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
US6228628B1 (en) 1997-07-09 2001-05-08 Roche Molecular Systems Mutant chimeric DNA polymerase
US5948666A (en) 1997-08-06 1999-09-07 Diversa Corporation Isolation and identification of polymerases
US20050181440A1 (en) 1999-04-20 2005-08-18 Illumina, Inc. Nucleic acid sequencing using microsphere arrays
US6492161B1 (en) * 1999-06-02 2002-12-10 Prokaria Ltd. Bacteriophage RM 378 of a thermophilic host organism
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US20030228616A1 (en) * 1999-10-29 2003-12-11 Stratagene DNA polymerase mutants with reverse transcriptase activity
WO2002004680A2 (en) 2000-07-07 2002-01-17 Visigen Biotechnologies, Inc. Real-time sequence determination
US7211414B2 (en) 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
EP3002289B1 (en) 2002-08-23 2018-02-28 Illumina Cambridge Limited Modified nucleotides for polynucleotide sequencing
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
GB0321306D0 (en) 2003-09-11 2003-10-15 Solexa Ltd Modified polymerases for improved incorporation of nucleotide analogues
US7315019B2 (en) 2004-09-17 2008-01-01 Pacific Biosciences Of California, Inc. Arrays of optical confinements and uses thereof
US20070048748A1 (en) * 2004-09-24 2007-03-01 Li-Cor, Inc. Mutant polymerases for sequencing and genotyping
WO2006120433A1 (en) 2005-05-10 2006-11-16 Solexa Limited Improved polymerases
GB0509508D0 (en) * 2005-05-10 2005-06-15 Solexa Ltd Improved polymerases
US20070022459A1 (en) 2005-07-20 2007-01-25 Gaebel Thomas M Jr Method and apparatus for boundary-based network operation
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
US8921086B2 (en) 2005-12-22 2014-12-30 Pacific Biosciences Of California, Inc. Polymerases for nucleotide analogue incorporation
EP3722409A1 (en) 2006-03-31 2020-10-14 Illumina, Inc. Systems and devices for sequence by synthesis analysis
DK2044188T3 (en) 2006-07-14 2015-12-14 Novozymes As Polypeptides with lipase activity and polynucleotides encoding them
US8343746B2 (en) 2006-10-23 2013-01-01 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US7948015B2 (en) 2006-12-14 2011-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
WO2009131919A2 (en) * 2008-04-22 2009-10-29 New England Biolabs, Inc. Polymerases for incorporating modified nucleotides
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8481685B2 (en) * 2008-11-03 2013-07-09 Kapa Biosystems Modified DNA polymerases
WO2010062776A2 (en) * 2008-11-03 2010-06-03 Kapabiosystems Chimeric dna polymerases
GB201007384D0 (en) 2010-04-30 2010-06-16 Medical Res Council Enzymes
WO2012154934A1 (en) 2011-05-11 2012-11-15 New England Biolabs, Inc. Dna polymerase variants with reduced exonuclease activity and uses thereof
US8921044B2 (en) * 2011-05-11 2014-12-30 New England Biolabs, Inc. DNA polymerase variants with reduced exonuclease activity and uses thereof
US8819970B2 (en) 2011-08-04 2014-09-02 Diana Foster Multi-layered ornamental clothing
US10421996B2 (en) 2013-03-14 2019-09-24 Illumina, Inc. Modified polymerases for improved incorporation of nucleotide analogues
EP3702471B1 (en) * 2014-06-27 2025-12-24 Illumina, Inc. Modified polymerases for improved incorporation of nucleotide analogues
WO2016054096A1 (en) 2014-09-30 2016-04-07 Illumina, Inc. Modified polymerases for improved incorporation of nucleotide analogues

Similar Documents

Publication Publication Date Title
JP2017518750A5 (https=)
Kantor et al. Methods for gene transfer to the central nervous system
EA201792663A1 (ru) Способы скрининга бактерий, архей, водорослей и дрожжей с использованием нуклеиновых кислот crispr
EP4303314A3 (en) Polypeptide tagged nucleotides and use thereof in nucleic acid sequencing by nanopore detection
SA517381912B1 (ar) "عناصر تنظيمية معدلة بعد الانتساخ لعلاج الالتهاب الكبدي pre
JP2016073298A5 (https=)
WO2016057951A3 (en) Crispr oligonucleotides and gene editing
JP2016526529A5 (https=)
WO2015191693A3 (en) Method for gene editing
EP4652926A3 (en) Anti-c1s antibodies and methods of use thereof
JP2016530380A5 (https=)
EP3252172A3 (en) Fast hybridization for next generation sequencing target enrichment
MX372992B (es) Vector de virus adeno-asociado.
SG11201801809VA (en) Method for modifying genome sequence that specifically converts nucleobase of targeted dna sequence, and molecular complex used in said method
SG11201609211VA (en) Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
WO2015200717A3 (en) Pcr-activated sorting (pas)
HK1246316A1 (zh) 细胞因子融合蛋白
WO2015196150A3 (en) Mutations that confer genetic stability to additional genes in influenza viruses
WO2016055971A3 (en) Methods, systems and processes of de novo assembly of sequencing reads
WO2014153258A3 (en) Improved thymidine kinase gene
EP3546576A4 (en) MODIFIED HEAT RESISTANT DNA POLYMERASE
CN110050092A (zh) 水稻全基因组育种芯片及其应用
WO2013030176A3 (en) Live attenuated influenza virus
IL273877A (en) Compounds consisting of an adenovirus-related virus for the purpose of restoring HBB gene activity and methods for their use
EP3795681A3 (en) Polymerase compositions and methods of making and using same