HK1246316A1 - 細胞因子融合蛋白 - Google Patents

細胞因子融合蛋白

Info

Publication number
HK1246316A1
HK1246316A1 HK18105729.7A HK18105729A HK1246316A1 HK 1246316 A1 HK1246316 A1 HK 1246316A1 HK 18105729 A HK18105729 A HK 18105729A HK 1246316 A1 HK1246316 A1 HK 1246316A1
Authority
HK
Hong Kong
Prior art keywords
fusion proteins
cytokine fusion
cytokine
proteins
fusion
Prior art date
Application number
HK18105729.7A
Other languages
English (en)
Inventor
Ugur Sahin
Friederike Gieseke
Ronald Backer
Sebastian Kreiter
Roland Kontermann
K Laus Pfizenmaier
Sina Fellermaier
Dafne Müller
Original Assignee
Biontech Rna Pharmaceuticals Gmbh
Univ Stuttgart
Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biontech Rna Pharmaceuticals Gmbh, Univ Stuttgart, Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh filed Critical Biontech Rna Pharmaceuticals Gmbh
Publication of HK1246316A1 publication Critical patent/HK1246316A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
HK18105729.7A 2015-01-15 2018-05-03 細胞因子融合蛋白 HK1246316A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2015/050682 WO2016112983A1 (en) 2015-01-15 2015-01-15 Cytokine fusion proteins
PCT/EP2016/050773 WO2016113395A1 (en) 2015-01-15 2016-01-15 Cytokine fusion proteins

Publications (1)

Publication Number Publication Date
HK1246316A1 true HK1246316A1 (zh) 2018-09-07

Family

ID=52394237

Family Applications (2)

Application Number Title Priority Date Filing Date
HK18105702.8A HK1246315A1 (zh) 2015-01-15 2018-05-03 細胞因子融合蛋白
HK18105729.7A HK1246316A1 (zh) 2015-01-15 2018-05-03 細胞因子融合蛋白

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK18105702.8A HK1246315A1 (zh) 2015-01-15 2018-05-03 細胞因子融合蛋白

Country Status (11)

Country Link
US (2) US10301368B2 (zh)
EP (1) EP3245223B1 (zh)
JP (1) JP6813491B2 (zh)
CN (2) CN113801241A (zh)
AU (1) AU2016207955B2 (zh)
BR (1) BR112017013956B8 (zh)
CA (1) CA2971950A1 (zh)
HK (2) HK1246315A1 (zh)
MX (2) MX2017009153A (zh)
NZ (1) NZ733266A (zh)
WO (2) WO2016112983A1 (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013156054A1 (en) * 2012-04-16 2013-10-24 Universität Stuttgart The igm and ige heavy chain domain 2 as covalently linked homodimerization modules for the generation of fusion proteins with dual specificity
MA41460A (fr) 2015-02-03 2017-12-12 Oncomed Pharm Inc Agents de liaison à la tnfrsf et leurs utilisations
WO2018027025A1 (en) * 2016-08-03 2018-02-08 Oncomed Pharmaceuticals, Inc. Cd40-binding agents and uses thereof
AU2018223821B2 (en) * 2017-02-27 2022-05-19 Shattuck Labs, Inc. TIGIT- and LIGHT-based chimeric proteins
CR20190444A (es) * 2017-02-28 2019-12-17 Sanofi Sa Arn terapéutico
US11142558B2 (en) 2017-04-06 2021-10-12 Universität Stuttgart Tumor necrosis factor receptor (TNFR) binding protein complex with improved binding and bioactivity
EP3675892A4 (en) 2017-07-03 2021-10-06 Torque Therapeutics, Inc. IMMUNOSTIMULATORY FUSION MOLECULES AND THEIR USES
CA3087476A1 (en) * 2018-01-10 2019-07-18 The General Hospital Corporation Immune cells expressing a chimeric antigen receptor
AU2019276372A1 (en) 2018-06-01 2020-12-24 Evotec International Gmbh Combination therapy for treating hepatitis B virus infection
EP3866846A4 (en) * 2018-10-17 2022-08-31 Albert Einstein College of Medicine METHOD OF INCREASING ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY (ADCC)
CN112625137B (zh) * 2019-10-08 2021-10-08 北京东方百泰生物科技股份有限公司 一种人白细胞介素10-Fc融合蛋白及其医药用途
EP4041410A4 (en) * 2019-10-08 2023-12-06 Fred Hutchinson Cancer Center GENETICALLY MODIFIED TRIMERIC CD70 PROTEINS AND THEIR USES
CN111018999B (zh) * 2019-12-05 2022-07-12 沣潮医药科技（上海）有限公司 二聚体免疫融合蛋白、药物组合物和用途
WO2022036495A1 (en) * 2020-08-17 2022-02-24 Utc Therapeutics Inc. Lymphocytes-antigen presenting cells co-stimulators and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19963859A1 (de) 1999-12-30 2001-07-12 Apotech Res & Dev Ltd Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
DE102004014983A1 (de) * 2004-03-26 2005-10-20 Univ Stuttgart Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
US9931386B2 (en) * 2008-06-16 2018-04-03 Atsuo Ochi Recombinant multiple domain fusion protein mitogens and use thereof for inducing enhancement or repression of antigen-specific immunity
EP2310509B1 (en) * 2008-07-21 2015-01-21 Apogenix GmbH Tnfsf single chain molecules
US9221895B2 (en) * 2009-03-13 2015-12-29 The Trustees Of The University Of Pennsylvania OX40/TRAIL fusion proteins
WO2013156054A1 (en) 2012-04-16 2013-10-24 Universität Stuttgart The igm and ige heavy chain domain 2 as covalently linked homodimerization modules for the generation of fusion proteins with dual specificity
NZ629672A (en) * 2012-04-24 2016-05-27 Nordischer Maschinenbau A fish corral
DK2970427T3 (da) * 2013-03-15 2020-03-09 Geoffrey W Stone Sammensætning bestående af antigen bundet til en tnf-superfamilieligand

Also Published As

Publication number Publication date
HK1246315A1 (zh) 2018-09-07
CN113801241A (zh) 2021-12-17
US20190276511A1 (en) 2019-09-12
MX2021010668A (es) 2021-09-28
US10808019B2 (en) 2020-10-20
EP3245223B1 (en) 2020-03-04
BR112017013956A2 (pt) 2018-01-16
WO2016113395A1 (en) 2016-07-21
BR112017013956B1 (pt) 2024-01-23
EP3245223A1 (en) 2017-11-22
MX2017009153A (es) 2018-02-01
AU2016207955A1 (en) 2017-07-20
BR112017013956A8 (pt) 2019-04-02
CN107428842B (zh) 2021-10-01
JP2018503379A (ja) 2018-02-08
AU2016207955B2 (en) 2020-05-28
US20180002392A1 (en) 2018-01-04
JP6813491B2 (ja) 2021-01-13
CA2971950A1 (en) 2016-07-21
BR112017013956B8 (pt) 2024-02-06
US10301368B2 (en) 2019-05-28
NZ733266A (en) 2022-04-29
WO2016112983A1 (en) 2016-07-21
CN107428842A (zh) 2017-12-01

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