JP2017518071A5 - - Google Patents

Info

Publication number

JP2017518071A5

JP2017518071A5 JP2017508762A JP2017508762A JP2017518071A5 JP 2017518071 A5 JP2017518071 A5 JP 2017518071A5 JP 2017508762 A JP2017508762 A JP 2017508762A JP 2017508762 A JP2017508762 A JP 2017508762A JP 2017518071 A5 JP2017518071 A5 JP 2017518071A5

Authority

JP

Japan

Prior art keywords

chain

chimeric antigen

antigen receptor

seq

specific multi

Prior art date

2015-04-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 15
• 229920001184 polypeptide Polymers 0.000 claims 10
• 102000004196 processed proteins & peptides Human genes 0.000 claims 10
• 108090000765 processed proteins & peptides Proteins 0.000 claims 10
• 102000009438 IgE Receptors Human genes 0.000 claims 6
• 108010073816 IgE Receptors Proteins 0.000 claims 6
• 210000002865 immune cell Anatomy 0.000 claims 5
• 108020001756 ligand binding domains Proteins 0.000 claims 3
• 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 2
• 230000000139 costimulatory effect Effects 0.000 claims 2
• 230000001747 exhibiting effect Effects 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 230000011664 signaling Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 1
• 102100027207 CD27 antigen Human genes 0.000 claims 1
• 101150013553 CD40 gene Proteins 0.000 claims 1
• 102100035793 CD83 antigen Human genes 0.000 claims 1
• 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
• 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims 1
• 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 1
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
• 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
• 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 1
• -1 ICOS Proteins 0.000 claims 1
• 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 1
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
• 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
• 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 1
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
• 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
• 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 1
• 230000003213 activating effect Effects 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 230000001086 cytosolic effect Effects 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 150000007523 nucleic acids Chemical group 0.000 claims 1
• 108091033319 polynucleotide Proteins 0.000 claims 1
• 102000040430 polynucleotide Human genes 0.000 claims 1
• 239000002157 polynucleotide Substances 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 230000019491 signal transduction Effects 0.000 claims 1
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
• 108010065816 zeta chain antigen T cell receptor Proteins 0.000 claims 1