JP2017517507A5 - - Google Patents
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- Publication number
- JP2017517507A5 JP2017517507A5 JP2016568657A JP2016568657A JP2017517507A5 JP 2017517507 A5 JP2017517507 A5 JP 2017517507A5 JP 2016568657 A JP2016568657 A JP 2016568657A JP 2016568657 A JP2016568657 A JP 2016568657A JP 2017517507 A5 JP2017517507 A5 JP 2017517507A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- variable region
- chain variable
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 CC(C)(CN(CCOCCOCCOC)c1cc(COc(c(OC)c2)cc(NC(*)[C@]3N4c5ccccc5C3)c2C4=O)cc(COc(c(OC)c2)cc(NC[C@@](C3)N4c5c3cccc5)c2C4=O)c1)S Chemical compound CC(C)(CN(CCOCCOCCOC)c1cc(COc(c(OC)c2)cc(NC(*)[C@]3N4c5ccccc5C3)c2C4=O)cc(COc(c(OC)c2)cc(NC[C@@](C3)N4c5c3cccc5)c2C4=O)c1)S 0.000 description 14
- JSHOVKSMJRQOGY-UHFFFAOYSA-N O=C(CCCSSc1ncccc1)ON(C(CC1)=O)C1=O Chemical compound O=C(CCCSSc1ncccc1)ON(C(CC1)=O)C1=O JSHOVKSMJRQOGY-UHFFFAOYSA-N 0.000 description 6
- FUHCFUVCWLZEDQ-UHFFFAOYSA-N OS(C(CCSSc1ccccn1)C(ON(C(CC1)=O)C1=O)=O)(=O)=O Chemical compound OS(C(CCSSc1ccccn1)C(ON(C(CC1)=O)C1=O)=O)(=O)=O FUHCFUVCWLZEDQ-UHFFFAOYSA-N 0.000 description 3
- DOKWDOLZCMETIJ-ZAQUEYBZSA-N CC(C)(CN(CCOCCOCCOC)c1cc(COc(c(OC)c2)cc(N=C[C@H]3N4c5ccccc5C3)c2C4=O)cc(COc(c(OC)c2)cc(NC[C@H](C3)N4c5c3cccc5)c2C4=O)c1)S Chemical compound CC(C)(CN(CCOCCOCCOC)c1cc(COc(c(OC)c2)cc(N=C[C@H]3N4c5ccccc5C3)c2C4=O)cc(COc(c(OC)c2)cc(NC[C@H](C3)N4c5c3cccc5)c2C4=O)c1)S DOKWDOLZCMETIJ-ZAQUEYBZSA-N 0.000 description 2
- VEVCIXHNMIPJED-MGAVHJTQSA-N CC(C)(CN(CCOCCOCCOC)c1cc(COc(c(OC)c2)cc(NC([C@H]3N4c5ccccc5C3)S(O)(=O)=O)c2C4=O)cc(COc(c(OC)c2)cc(NC[C@H](C3)N4c5c3cccc5)c2C4=O)c1)S Chemical compound CC(C)(CN(CCOCCOCCOC)c1cc(COc(c(OC)c2)cc(NC([C@H]3N4c5ccccc5C3)S(O)(=O)=O)c2C4=O)cc(COc(c(OC)c2)cc(NC[C@H](C3)N4c5c3cccc5)c2C4=O)c1)S VEVCIXHNMIPJED-MGAVHJTQSA-N 0.000 description 2
- NJFZGSDCOLQLAD-CBYVCPMDSA-N CC(C)(CN(CCOCCOCCOC)c1cc(COc(c(OC)c2)cc(N=CC3(C)N4c5ccccc5C3)c2C4=O)cc(COc(cc(c2c3)NC[C@H](Cc4ccccc44)N4C2=O)c3OC)c1)SSCCCC(NC(C)(C)C1CCCC1)=O Chemical compound CC(C)(CN(CCOCCOCCOC)c1cc(COc(c(OC)c2)cc(N=CC3(C)N4c5ccccc5C3)c2C4=O)cc(COc(cc(c2c3)NC[C@H](Cc4ccccc44)N4C2=O)c3OC)c1)SSCCCC(NC(C)(C)C1CCCC1)=O NJFZGSDCOLQLAD-CBYVCPMDSA-N 0.000 description 1
- IJZPSYGVMFYGJO-ORTKPCQYSA-N CC(C)(CN(CCOCCOCCOC)c1cc(COc(c(OC)c2)cc(N=C[C@H]3N4c5ccccc5C3)c2C4=O)cc(COc(cc(c2c3)NC[C@H](Cc4ccccc44)N4C2=O)c3OC)c1)SSCCC(C(NC(C)(C)C1CCCC1)=O)S(O)(=O)=O Chemical compound CC(C)(CN(CCOCCOCCOC)c1cc(COc(c(OC)c2)cc(N=C[C@H]3N4c5ccccc5C3)c2C4=O)cc(COc(cc(c2c3)NC[C@H](Cc4ccccc44)N4C2=O)c3OC)c1)SSCCC(C(NC(C)(C)C1CCCC1)=O)S(O)(=O)=O IJZPSYGVMFYGJO-ORTKPCQYSA-N 0.000 description 1
- OCRAJZOPOBJAEN-GCOKTQCFSA-N CC(C)(CN(CCOCCOCCOC)c1cc(COc(c(OC)c2)cc(NC([C@H]3N4c5ccccc5C3)S(O)(=O)=O)c2C4=O)cc(COc(cc(c2c3)NC#CC(Cc4ccccc44)N4C2=O)c3OC)c1)S Chemical compound CC(C)(CN(CCOCCOCCOC)c1cc(COc(c(OC)c2)cc(NC([C@H]3N4c5ccccc5C3)S(O)(=O)=O)c2C4=O)cc(COc(cc(c2c3)NC#CC(Cc4ccccc44)N4C2=O)c3OC)c1)S OCRAJZOPOBJAEN-GCOKTQCFSA-N 0.000 description 1
- GQGJQCFYSSWHRF-HYNIKSJISA-N CC(C)(CN(CCOCCOCCOC)c1cc(COc(c(OC)c2)cc(NC([C@H]3N4c5ccccc5C3)S(O)(=O)=O)c2C4=O)cc(COc(cc(c2c3)NC[C@H](CC4=C5CCC=C4)N5C2=O)c3OC)c1)SSCCCC(NC(C)(C)C1CCC1)=O Chemical compound CC(C)(CN(CCOCCOCCOC)c1cc(COc(c(OC)c2)cc(NC([C@H]3N4c5ccccc5C3)S(O)(=O)=O)c2C4=O)cc(COc(cc(c2c3)NC[C@H](CC4=C5CCC=C4)N5C2=O)c3OC)c1)SSCCCC(NC(C)(C)C1CCC1)=O GQGJQCFYSSWHRF-HYNIKSJISA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462001015P | 2014-05-20 | 2014-05-20 | |
| US62/001,015 | 2014-05-20 | ||
| US201462011456P | 2014-06-12 | 2014-06-12 | |
| US62/011,456 | 2014-06-12 | ||
| US201462075715P | 2014-11-05 | 2014-11-05 | |
| US62/075,715 | 2014-11-05 | ||
| PCT/US2015/031580 WO2015179400A2 (en) | 2014-05-20 | 2015-05-19 | Methods for characterizing and treating acute myeloid leukemia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017517507A JP2017517507A (ja) | 2017-06-29 |
| JP2017517507A5 true JP2017517507A5 (enExample) | 2018-07-05 |
Family
ID=54554957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016568657A Pending JP2017517507A (ja) | 2014-05-20 | 2015-05-19 | 急性骨髄性白血病を特徴付け、治療する方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20170080102A1 (enExample) |
| EP (1) | EP3145542A4 (enExample) |
| JP (1) | JP2017517507A (enExample) |
| KR (1) | KR20170004003A (enExample) |
| CN (1) | CN106456762A (enExample) |
| AU (1) | AU2015264322A1 (enExample) |
| BR (1) | BR112016026730A2 (enExample) |
| CA (1) | CA2947602A1 (enExample) |
| IL (1) | IL248555A0 (enExample) |
| MA (1) | MA39885A (enExample) |
| RU (1) | RU2016147398A (enExample) |
| SG (1) | SG11201609357PA (enExample) |
| WO (1) | WO2015179400A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200503075B (en) * | 2002-11-07 | 2006-09-27 | Immunogen Inc | Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same |
| AU2016285552B2 (en) * | 2015-06-29 | 2022-10-13 | Immunogen, Inc. | Anti-CD123 antibodies and conjugates and derivatives thereof |
| WO2017214433A1 (en) * | 2016-06-09 | 2017-12-14 | Seattle Genetics, Inc. | Combinations of pbd-based antibody drug conjugates with flt3 inhibitors |
| RU2019114863A (ru) * | 2016-11-02 | 2020-12-03 | Иммуноджен, Инк. | Комбинированное лечение конъюгатами антитело-лекарственное средство и ингибиторами parp |
| WO2018183494A1 (en) * | 2017-03-31 | 2018-10-04 | Immunogen, Inc. | Cd19-targeting antibody-drug conjugates |
| EP3624839A4 (en) * | 2017-05-17 | 2021-06-16 | Immunogen, Inc. | DOSING PLANS FOR ANTI-CD33 IMMUNE CONJUGATES |
| US20190160089A1 (en) * | 2017-10-31 | 2019-05-30 | Immunogen, Inc. | Combination treatment with antibody-drug conjugates and cytarabine |
| CN119857155A (zh) | 2017-11-29 | 2025-04-22 | 海德堡医药研究有限责任公司 | 用于耗尽cd5+细胞的组合物和方法 |
| WO2019222130A1 (en) * | 2018-05-15 | 2019-11-21 | Immunogen, Inc. | Combination treatment with antibody-drug conjugates and flt3 inhibitors |
| WO2020010262A1 (en) * | 2018-07-06 | 2020-01-09 | University Of Washington | High throughput drug screening of cancer stem cells |
| WO2020051013A2 (en) * | 2018-08-24 | 2020-03-12 | The Trustees Of Columbia University In The City Of New York | Anti-cd33 and nkg2d ligand chimeras for treatment of myeloid malignancies |
| WO2020264211A1 (en) * | 2019-06-26 | 2020-12-30 | Memorial Sloan Kettering Cancer Center | Anti-cd33 antibodies for treating cancer |
| WO2025265055A1 (en) * | 2024-06-21 | 2025-12-26 | The Johns Hopkins University | Materials and methods for treating myeloid neoplasms |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6007814A (en) * | 1992-06-15 | 1999-12-28 | Sloan-Kettering Institute For Cancer Research | Therapeutic uses of the hypervariable region of monoclonal antibody M195 and constructs thereof |
| ZA200503075B (en) * | 2002-11-07 | 2006-09-27 | Immunogen Inc | Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same |
| WO2010126552A1 (en) * | 2009-04-30 | 2010-11-04 | Immunogen, Inc. | Potent cell-binding agent drug conjugates |
| WO2012044696A2 (en) * | 2010-09-30 | 2012-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Prediction of clinical outcome in hematological malignancies using a self-renewal expression signature |
| JP5826863B2 (ja) * | 2011-02-15 | 2015-12-02 | イミュノジェン・インコーポレーテッド | 細胞傷害性ベンゾジアゼピン誘導体 |
| WO2012138749A1 (en) * | 2011-04-04 | 2012-10-11 | Immunogen, Inc. | Methods for decreasing ocular toxicity of antibody drug conjugates |
-
2015
- 2015-05-19 EP EP15795831.5A patent/EP3145542A4/en not_active Withdrawn
- 2015-05-19 US US15/311,632 patent/US20170080102A1/en not_active Abandoned
- 2015-05-19 JP JP2016568657A patent/JP2017517507A/ja active Pending
- 2015-05-19 WO PCT/US2015/031580 patent/WO2015179400A2/en not_active Ceased
- 2015-05-19 AU AU2015264322A patent/AU2015264322A1/en not_active Abandoned
- 2015-05-19 RU RU2016147398A patent/RU2016147398A/ru not_active Application Discontinuation
- 2015-05-19 BR BR112016026730A patent/BR112016026730A2/pt not_active IP Right Cessation
- 2015-05-19 CN CN201580026480.1A patent/CN106456762A/zh active Pending
- 2015-05-19 SG SG11201609357PA patent/SG11201609357PA/en unknown
- 2015-05-19 CA CA2947602A patent/CA2947602A1/en not_active Abandoned
- 2015-05-19 MA MA039885A patent/MA39885A/fr unknown
- 2015-05-19 KR KR1020167035135A patent/KR20170004003A/ko not_active Withdrawn
-
2016
- 2016-10-27 IL IL248555A patent/IL248555A0/en unknown
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