JP2017515099A5 - - Google Patents
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- Publication number
- JP2017515099A5 JP2017515099A5 JP2016555958A JP2016555958A JP2017515099A5 JP 2017515099 A5 JP2017515099 A5 JP 2017515099A5 JP 2016555958 A JP2016555958 A JP 2016555958A JP 2016555958 A JP2016555958 A JP 2016555958A JP 2017515099 A5 JP2017515099 A5 JP 2017515099A5
- Authority
- JP
- Japan
- Prior art keywords
- matrix
- particles
- ligand
- liquid
- separation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011159 matrix material Substances 0.000 claims 17
- 239000002245 particle Substances 0.000 claims 15
- 238000000926 separation method Methods 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 239000003446 ligand Substances 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 6
- 150000003141 primary amines Chemical class 0.000 claims 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 229920000083 poly(allylamine) Polymers 0.000 claims 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- 108010058846 Ovalbumin Proteins 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229940092253 ovalbumin Drugs 0.000 claims 2
- 230000001172 regenerating effect Effects 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000011543 agarose gel Substances 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 239000012670 alkaline solution Substances 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 239000012062 aqueous buffer Substances 0.000 claims 1
- 239000012928 buffer substance Substances 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 claims 1
- 102000034238 globular proteins Human genes 0.000 claims 1
- 108091005896 globular proteins Proteins 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 210000003463 organelle Anatomy 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 150000003335 secondary amines Chemical class 0.000 claims 1
- 150000003512 tertiary amines Chemical class 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1450290-0 | 2014-03-14 | ||
| SE1450290 | 2014-03-14 | ||
| PCT/SE2015/050186 WO2015137860A1 (en) | 2014-03-14 | 2015-02-18 | Separation matrices for purification of biological particles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017515099A JP2017515099A (ja) | 2017-06-08 |
| JP2017515099A5 true JP2017515099A5 (https=) | 2018-03-22 |
| JP6702587B2 JP6702587B2 (ja) | 2020-06-03 |
Family
ID=54072158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555958A Active JP6702587B2 (ja) | 2014-03-14 | 2015-02-18 | 生物粒子の精製用分離マトリックス |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11285460B2 (https=) |
| EP (1) | EP3116645B1 (https=) |
| JP (1) | JP6702587B2 (https=) |
| CN (2) | CN114917884A (https=) |
| WO (1) | WO2015137860A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015137860A1 (en) | 2014-03-14 | 2015-09-17 | Ge Healthcare Bio-Sciences Ab | Separation matrices for purification of biological particles |
| GB201515339D0 (en) * | 2015-08-28 | 2015-10-14 | Ge Healthcare Bio Sciences Ab | A seperation matrix and a method of seperating antibodies |
| WO2017083286A1 (en) | 2015-11-09 | 2017-05-18 | University Of Notre Dame | Particle size purification method and devices |
| US10934366B2 (en) | 2016-09-29 | 2021-03-02 | Bio-Rad Laboratories, Inc. | Protein-nanoparticle conjugate purification methods |
| US10814305B2 (en) | 2016-09-29 | 2020-10-27 | Bio-Rad Laboratories, Inc. | Agarose-filled ceramic apatite |
| EP3762121B1 (en) * | 2018-03-05 | 2024-04-24 | Chiral Technologies Europe SAS | Composite material for bioseparations |
| US10737259B2 (en) | 2018-08-31 | 2020-08-11 | Pall Corporation | Salt tolerant anion exchange medium |
| US11045773B2 (en) | 2018-08-31 | 2021-06-29 | Pall Corporation | Salt tolerant porous medium |
| EP4653865A3 (en) | 2019-09-24 | 2026-02-18 | Regeneron Pharmaceuticals, Inc. | Systems and methods for chromatography use and regeneration |
| EP4106897A4 (en) | 2020-02-19 | 2023-10-25 | Bio-Rad Laboratories, Inc. | Method of preparing polymer-filled chromatography resin |
| US20240091742A1 (en) * | 2022-08-03 | 2024-03-21 | Pierce Biotechnology Inc. | Components for separating molecules and methods of making and using the same |
| EP4385618A1 (en) | 2022-12-16 | 2024-06-19 | Chiral Technologies Europe SAS | Composite material for bioseparations |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9600590D0 (sv) * | 1996-02-19 | 1996-02-19 | Pharmacia Biotech Ab | Sätt för kromatografisk separation av peptider och nukleinsyra samt ny högaffin jonbytesmatris |
| US6072101A (en) * | 1997-11-19 | 2000-06-06 | Amcol International Corporation | Multicomponent superabsorbent gel particles |
| SE9904197D0 (sv) | 1999-11-22 | 1999-11-22 | Amersham Pharm Biotech Ab | A method for anion exchange adsorption on matrices carrying mixed mode ligands |
| AU2002352017A1 (en) * | 2001-11-21 | 2003-06-10 | Basf Aktiengesellschaft | Superabsorbent polymer particles |
| SE0202551D0 (sv) * | 2002-08-27 | 2002-08-27 | Amersham Biosciences Ab | Chromatographic two-layer particles |
| SE0302911D0 (sv) | 2003-10-31 | 2003-10-31 | Amersham Biosciences Ab | Novel separation matrix |
| SE0303532D0 (sv) | 2003-12-23 | 2003-12-23 | Amersham Biosciences Ab | Purification of immunoglobulins |
| US20050181378A1 (en) * | 2004-02-18 | 2005-08-18 | Applera Corporation | Polyelectrolyte-coated size-exclusion ion-exchange particles |
| AU2005216847B2 (en) | 2004-02-27 | 2010-04-01 | Cytiva Bioprocess R&D Ab | A process for the purification of antibodies |
| SE0401665D0 (sv) * | 2004-06-24 | 2004-06-24 | Amersham Biosciences Ab | Purification of immunoglobulins |
| US7332101B2 (en) * | 2004-06-25 | 2008-02-19 | Massachusetts Institute Of Technology | Permanently linked, rigid, magnetic chains |
| US9266041B2 (en) * | 2004-10-21 | 2016-02-23 | Ge Healthcare Bio-Sciences Ab | Chromatography ligand |
| GB2454153A (en) | 2006-09-05 | 2009-04-29 | Innovative Purification Techno | Affinity separation methods and systems |
| GB2445579A (en) | 2007-01-11 | 2008-07-16 | Secr Defence | An encoded microsphere |
| US9433922B2 (en) | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| WO2009131526A1 (en) | 2008-04-22 | 2009-10-29 | Ge Healthcare Bio-Sciences Ab | Chromatography medium |
| WO2009140207A1 (en) * | 2008-05-10 | 2009-11-19 | Brigham Young University | Porous composite particulate materials, methods of making and using same, and related apparatuses |
| WO2009145722A1 (en) | 2008-05-30 | 2009-12-03 | Ge Healthcare Bio-Sciences Ab | Separation method utilizing polyallylamine ligands |
| IN2012DN06243A (https=) | 2010-02-19 | 2015-09-25 | Ge Healthcare Bio Sciences Ab | |
| US20120077249A1 (en) | 2010-04-20 | 2012-03-29 | Millipore Corporation | Separation Of Virus And/Or Protein From Nucleic Acids By Primary Amines |
| US20120006752A1 (en) | 2010-05-07 | 2012-01-12 | Millipore Corporation | Enhanced Clarification Media |
| CN102958602A (zh) | 2010-07-09 | 2013-03-06 | 通用电气健康护理生物科学股份公司 | 层析方法及为此使用的介质 |
| WO2012074468A1 (en) * | 2010-11-30 | 2012-06-07 | Ge Healthcare Bio-Sciences Ab | Buffering compositions enclosed in a size exclusion matrix |
| US9272246B2 (en) * | 2011-03-28 | 2016-03-01 | 3M Innovative Properties Company | Ligand functional substrates |
| US9096648B2 (en) | 2011-08-19 | 2015-08-04 | Emd Millipore Corporation | Methods of reducing level of one or more impurities in a sample during protein purification |
| US9580692B2 (en) * | 2012-02-29 | 2017-02-28 | Ge Healthcare Bioprocess R&D Ab | Method for endotoxin removal |
| WO2015137860A1 (en) | 2014-03-14 | 2015-09-17 | Ge Healthcare Bio-Sciences Ab | Separation matrices for purification of biological particles |
-
2015
- 2015-02-18 WO PCT/SE2015/050186 patent/WO2015137860A1/en not_active Ceased
- 2015-02-18 EP EP15761376.1A patent/EP3116645B1/en active Active
- 2015-02-18 JP JP2016555958A patent/JP6702587B2/ja active Active
- 2015-02-18 US US15/120,845 patent/US11285460B2/en active Active
- 2015-02-18 CN CN202210695588.1A patent/CN114917884A/zh active Pending
- 2015-02-18 CN CN201580013843.8A patent/CN106102903A/zh active Pending
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