JP2017515099A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017515099A5 JP2017515099A5 JP2016555958A JP2016555958A JP2017515099A5 JP 2017515099 A5 JP2017515099 A5 JP 2017515099A5 JP 2016555958 A JP2016555958 A JP 2016555958A JP 2016555958 A JP2016555958 A JP 2016555958A JP 2017515099 A5 JP2017515099 A5 JP 2017515099A5
- Authority
- JP
- Japan
- Prior art keywords
- matrix
- particles
- ligand
- liquid
- separation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011159 matrix material Substances 0.000 claims 17
- 239000002245 particle Substances 0.000 claims 15
- 238000000926 separation method Methods 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 239000003446 ligand Substances 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 6
- 150000003141 primary amines Chemical class 0.000 claims 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 229920000083 poly(allylamine) Polymers 0.000 claims 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- 108010058846 Ovalbumin Proteins 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229940092253 ovalbumin Drugs 0.000 claims 2
- 230000001172 regenerating effect Effects 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000011543 agarose gel Substances 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 239000012670 alkaline solution Substances 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 239000012062 aqueous buffer Substances 0.000 claims 1
- 239000012928 buffer substance Substances 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 claims 1
- 102000034238 globular proteins Human genes 0.000 claims 1
- 108091005896 globular proteins Proteins 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 210000003463 organelle Anatomy 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 150000003335 secondary amines Chemical class 0.000 claims 1
- 150000003512 tertiary amines Chemical class 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1450290-0 | 2014-03-14 | ||
| SE1450290 | 2014-03-14 | ||
| PCT/SE2015/050186 WO2015137860A1 (en) | 2014-03-14 | 2015-02-18 | Separation matrices for purification of biological particles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017515099A JP2017515099A (ja) | 2017-06-08 |
| JP2017515099A5 true JP2017515099A5 (https=) | 2018-03-22 |
| JP6702587B2 JP6702587B2 (ja) | 2020-06-03 |
Family
ID=54072158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555958A Active JP6702587B2 (ja) | 2014-03-14 | 2015-02-18 | 生物粒子の精製用分離マトリックス |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11285460B2 (https=) |
| EP (1) | EP3116645B1 (https=) |
| JP (1) | JP6702587B2 (https=) |
| CN (2) | CN114917884A (https=) |
| WO (1) | WO2015137860A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6702587B2 (ja) | 2014-03-14 | 2020-06-03 | ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ | 生物粒子の精製用分離マトリックス |
| GB201515339D0 (en) * | 2015-08-28 | 2015-10-14 | Ge Healthcare Bio Sciences Ab | A seperation matrix and a method of seperating antibodies |
| WO2017083286A1 (en) | 2015-11-09 | 2017-05-18 | University Of Notre Dame | Particle size purification method and devices |
| US10934366B2 (en) | 2016-09-29 | 2021-03-02 | Bio-Rad Laboratories, Inc. | Protein-nanoparticle conjugate purification methods |
| US10814305B2 (en) | 2016-09-29 | 2020-10-27 | Bio-Rad Laboratories, Inc. | Agarose-filled ceramic apatite |
| WO2019170634A1 (en) * | 2018-03-05 | 2019-09-12 | Chiral Technologies Europe Sas | Composite material for bioseparations |
| US10737259B2 (en) | 2018-08-31 | 2020-08-11 | Pall Corporation | Salt tolerant anion exchange medium |
| US11045773B2 (en) | 2018-08-31 | 2021-06-29 | Pall Corporation | Salt tolerant porous medium |
| WO2021061790A1 (en) | 2019-09-24 | 2021-04-01 | Regeneron Pharmaceuticals, Inc. | Systems and methods for chromatography use and regeneration |
| EP4106897A4 (en) | 2020-02-19 | 2023-10-25 | Bio-Rad Laboratories, Inc. | Method of preparing polymer-filled chromatography resin |
| CN119730953A (zh) * | 2022-08-03 | 2025-03-28 | 皮尔斯生物科技有限公司 | 用于分离分子的组分及其制备和使用方法 |
| EP4385618A1 (en) | 2022-12-16 | 2024-06-19 | Chiral Technologies Europe SAS | Composite material for bioseparations |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9600590D0 (sv) * | 1996-02-19 | 1996-02-19 | Pharmacia Biotech Ab | Sätt för kromatografisk separation av peptider och nukleinsyra samt ny högaffin jonbytesmatris |
| US6072101A (en) * | 1997-11-19 | 2000-06-06 | Amcol International Corporation | Multicomponent superabsorbent gel particles |
| SE9904197D0 (sv) * | 1999-11-22 | 1999-11-22 | Amersham Pharm Biotech Ab | A method for anion exchange adsorption on matrices carrying mixed mode ligands |
| AU2002352017A1 (en) * | 2001-11-21 | 2003-06-10 | Basf Aktiengesellschaft | Superabsorbent polymer particles |
| SE0202551D0 (sv) * | 2002-08-27 | 2002-08-27 | Amersham Biosciences Ab | Chromatographic two-layer particles |
| SE0302911D0 (sv) * | 2003-10-31 | 2003-10-31 | Amersham Biosciences Ab | Novel separation matrix |
| SE0303532D0 (sv) | 2003-12-23 | 2003-12-23 | Amersham Biosciences Ab | Purification of immunoglobulins |
| US20050181378A1 (en) * | 2004-02-18 | 2005-08-18 | Applera Corporation | Polyelectrolyte-coated size-exclusion ion-exchange particles |
| KR101150050B1 (ko) * | 2004-02-27 | 2012-07-05 | 지이 헬스케어 바이오-사이언시스 에이비 | 항체 정제 방법 |
| SE0401665D0 (sv) * | 2004-06-24 | 2004-06-24 | Amersham Biosciences Ab | Purification of immunoglobulins |
| US7332101B2 (en) * | 2004-06-25 | 2008-02-19 | Massachusetts Institute Of Technology | Permanently linked, rigid, magnetic chains |
| US9266041B2 (en) * | 2004-10-21 | 2016-02-23 | Ge Healthcare Bio-Sciences Ab | Chromatography ligand |
| AU2007294455A1 (en) * | 2006-09-05 | 2008-03-13 | Innovative Purification Technologies Pty Ltd | Affinity separation methods and systems |
| GB2445579A (en) * | 2007-01-11 | 2008-07-16 | Secr Defence | An encoded microsphere |
| US9433922B2 (en) | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| CN102015094B (zh) * | 2008-04-22 | 2016-11-09 | 通用电气医疗集团生物工艺研发股份公司 | 层析介质 |
| US9005436B2 (en) * | 2008-05-10 | 2015-04-14 | Brigham Young University | Porous composite particulate materials, methods of making and using same, and related apparatuses |
| US20110065900A1 (en) * | 2008-05-30 | 2011-03-17 | Ge Healthcare Bio-Science Ab | Separation method utilizing polyallylamine ligands |
| IN2012DN06243A (https=) * | 2010-02-19 | 2015-09-25 | Ge Healthcare Bio Sciences Ab | |
| US20120077249A1 (en) * | 2010-04-20 | 2012-03-29 | Millipore Corporation | Separation Of Virus And/Or Protein From Nucleic Acids By Primary Amines |
| US20120006752A1 (en) * | 2010-05-07 | 2012-01-12 | Millipore Corporation | Enhanced Clarification Media |
| JP2013530406A (ja) * | 2010-07-09 | 2013-07-25 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | クロマトグラフィー方法及びそれに使用される媒体 |
| US20130244229A1 (en) * | 2010-11-30 | 2013-09-19 | Jan Bergstrom | Buffering compositions enclosed in a size exclusion matrix |
| US9272246B2 (en) * | 2011-03-28 | 2016-03-01 | 3M Innovative Properties Company | Ligand functional substrates |
| US9096648B2 (en) | 2011-08-19 | 2015-08-04 | Emd Millipore Corporation | Methods of reducing level of one or more impurities in a sample during protein purification |
| US9580692B2 (en) * | 2012-02-29 | 2017-02-28 | Ge Healthcare Bioprocess R&D Ab | Method for endotoxin removal |
| JP6702587B2 (ja) | 2014-03-14 | 2020-06-03 | ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ | 生物粒子の精製用分離マトリックス |
-
2015
- 2015-02-18 JP JP2016555958A patent/JP6702587B2/ja active Active
- 2015-02-18 CN CN202210695588.1A patent/CN114917884A/zh active Pending
- 2015-02-18 WO PCT/SE2015/050186 patent/WO2015137860A1/en not_active Ceased
- 2015-02-18 CN CN201580013843.8A patent/CN106102903A/zh active Pending
- 2015-02-18 US US15/120,845 patent/US11285460B2/en active Active
- 2015-02-18 EP EP15761376.1A patent/EP3116645B1/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017515099A5 (https=) | ||
| US8481298B2 (en) | Separation matrix for viral purification | |
| JP5772816B2 (ja) | アフィニティークロマトグラフィー用充填剤およびイムノグロブリンを単離する方法 | |
| TWI709571B (zh) | 免疫球蛋白結合蛋白質及使用此之親和性載體 | |
| CN104174385B (zh) | 一种用于血液灌流的胆红素吸附剂 | |
| DK148617B (da) | Materiale med kationisk karakter, der paa reversibel eller irreversibel maade kan binde biologiske makromolekylaere stoffer og lavmolekylaere stoffer, og fremgangsmaade til dets fremstilling | |
| BRPI0714292A2 (pt) | mÉtodo para purificaÇço do vÍrus influenza | |
| JP6702587B2 (ja) | 生物粒子の精製用分離マトリックス | |
| CN105658313B (zh) | 硫酸化纤维素水合物膜、其制备方法和该膜作为病毒纯化用吸附膜的用途 | |
| JPWO2015041218A1 (ja) | 新規抗体精製方法及びそれから得られる抗体（ＮｏｖｅｌＡｎｔｉｂｏｄｙＰｕｒｉｆｉｃａｔｉｏｎＭｅｔｈｏｄａｎｄＡｎｔｉｂｏｄｙｏｂｔａｉｎｅｄｔｈｅｒｅｆｒｏｍ）、並びに陽イオン交換基を用いた新規抗体精製法及びそれから得られる抗体（ＮｏｖｅｌＡｎｔｉｂｏｄｙＰｕｒｉｆｉｃａｔｉｏｎｍｅｔｈｏｄｕｓｉｎｇＣａｔｉｏｎＥｘｃｈａｎｇｅｒａｎｄＡｎｔｉｂｏｄｙｏｂｔａｉｎｅｄｔｈｅｒｅｆｒｏｍ） | |
| CN104892734B (zh) | 疏水作用层析提纯口蹄疫灭活病毒抗原的方法 | |
| CN104818254A (zh) | 离子交换色谱纯化口蹄疫灭活病毒抗原的方法 | |
| JP6797416B2 (ja) | クロマトグラフィーのための方法 | |
| JP4739233B2 (ja) | 免疫グロブリンの精製 | |
| JP2013194054A5 (https=) | ||
| JPWO2007123242A1 (ja) | ＩｇＧ精製用分離剤、及びそれを用いたＩｇＧ単量体の精製方法 | |
| US11352388B2 (en) | Method for chromatography | |
| CN103933947A (zh) | 用于清除类风湿因子的血液净化材料及其制备方法 | |
| WO2017076553A1 (en) | Method for the separation of virus compositions including depletion and purification thereof | |
| JP2002541155A (ja) | 生物学的調製物の精製 | |
| JP6722187B2 (ja) | アフィニティー担体およびイムノグロブリンを単離する方法 | |
| CN101503462B (zh) | 一种去除流感病毒原液中内毒素的方法 | |
| EP1141021B1 (en) | Removal/purification of serum albumins | |
| CN103555703A (zh) | 一种季铵化壳聚糖-超氧化歧化酶修饰物及其制备 | |
| Sakata et al. | Chromatographic removal of host cell DNA from cellular products using columns packed with cationic copolymer beads |