JP2017513476A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017513476A5 JP2017513476A5 JP2016562499A JP2016562499A JP2017513476A5 JP 2017513476 A5 JP2017513476 A5 JP 2017513476A5 JP 2016562499 A JP2016562499 A JP 2016562499A JP 2016562499 A JP2016562499 A JP 2016562499A JP 2017513476 A5 JP2017513476 A5 JP 2017513476A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibody variable
- antigen binding
- region
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14164523.4A EP2930188A1 (en) | 2014-04-13 | 2014-04-13 | Trifunctional antigen-binding molecule |
| EP14164523.4 | 2014-04-13 | ||
| PCT/EP2015/057919 WO2015158636A1 (en) | 2014-04-13 | 2015-04-12 | Trifunctional antigen-binding molecule |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513476A JP2017513476A (ja) | 2017-06-01 |
| JP2017513476A5 true JP2017513476A5 (https=) | 2018-05-31 |
| JP6635940B2 JP6635940B2 (ja) | 2020-01-29 |
Family
ID=50478320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562499A Expired - Fee Related JP6635940B2 (ja) | 2014-04-13 | 2015-04-12 | 三機能性抗原結合分子 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20170037128A1 (https=) |
| EP (2) | EP2930188A1 (https=) |
| JP (1) | JP6635940B2 (https=) |
| KR (1) | KR102392598B1 (https=) |
| CN (1) | CN106661108A (https=) |
| AU (1) | AU2015249006B2 (https=) |
| BR (1) | BR112016023362A2 (https=) |
| CA (1) | CA2945053A1 (https=) |
| DK (1) | DK3131928T4 (https=) |
| MX (1) | MX382970B (https=) |
| RU (1) | RU2753882C2 (https=) |
| SI (1) | SI3131928T2 (https=) |
| WO (1) | WO2015158636A1 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3152235B1 (en) | 2014-05-29 | 2021-08-25 | MacroGenics, Inc. | Tri-specific binding molecules and methods of use thereof |
| EP3307776A1 (en) * | 2015-06-15 | 2018-04-18 | Numab Innovation AG | Hetero-dimeric multi-specific antibody format |
| EP3156417A1 (en) * | 2015-10-13 | 2017-04-19 | Affimed GmbH | Multivalent fv antibodies |
| SG11201907299XA (en) | 2017-02-08 | 2019-09-27 | Dragonfly Therapeutics Inc | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| IL268755B2 (en) | 2017-02-20 | 2025-12-01 | Dragonfly Therapeutics Inc | Proteins that bind her2, nkg2d, and cd16 |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| AU2018371114A1 (en) * | 2017-11-21 | 2020-05-07 | Innate Pharma | Multispecific antigen binding proteins |
| EP3713962A4 (en) * | 2017-11-21 | 2021-08-25 | Novartis AG | TRISPECIFIC BINDING MOLECULES AGAINST TUMOR-ASSOCIATED ANTIGENS AND THEIR USE |
| EP3737692A4 (en) | 2018-01-09 | 2021-09-29 | Elstar Therapeutics, Inc. | CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES |
| DK3749346T3 (da) | 2018-02-08 | 2024-09-09 | Dragonfly Therapeutics Inc | Antistof variable domænekombinationer rettet mod nkg2d-receptoren |
| EA202091887A1 (ru) | 2018-02-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Комбинированная терапия рака с применением мультиспецифических связывающих белков, которые активируют естественные клетки-киллеры |
| WO2019164930A1 (en) | 2018-02-20 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use |
| IL276903B2 (en) * | 2018-03-14 | 2025-12-01 | Affimed Gmbh | Bispecific egfr/cd16 antigen-binding protein |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| US20210008113A1 (en) * | 2018-03-27 | 2021-01-14 | Systimmune, Inc. | Methods of making and using guidance and navigation control proteins |
| SG11202011633SA (en) | 2018-05-24 | 2020-12-30 | Janssen Biotech Inc | Psma binding agents and uses thereof |
| EP3818083A2 (en) | 2018-07-03 | 2021-05-12 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| WO2020033630A1 (en) | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| US12378318B2 (en) | 2018-08-08 | 2025-08-05 | Dragonfly Therapeutics, Inc. | Proteins binding NKG2D, CD16 and a tumor-associated antigen |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| PT3843757T (pt) | 2018-08-27 | 2024-07-08 | Affimed Gmbh | Células nk criopreservadas pré-carregadas com uma construção de anticorpo |
| JP7710373B2 (ja) | 2019-02-21 | 2025-07-18 | マレンゴ・セラピューティクス，インコーポレーテッド | Ｔ細胞関連のがん細胞に結合する多機能性分子およびその使用 |
| AU2020224681A1 (en) | 2019-02-21 | 2021-09-16 | Marengo Therapeutics, Inc. | Antibody molecules that bind to NKp30 and uses thereof |
| BR112021020532A2 (pt) | 2019-04-19 | 2022-03-15 | Janssen Biotech Inc | Métodos para tratamento de câncer de próstata com um anticorpo anti-psma/cd3 |
| PE20220568A1 (es) | 2019-05-21 | 2022-04-20 | Novartis Ag | Moleculas de union a cd19 y usos de las mismas |
| EP3972993A1 (en) | 2019-05-21 | 2022-03-30 | Novartis AG | Variant cd58 domains and uses thereof |
| KR20220119467A (ko) | 2019-12-27 | 2022-08-29 | 아피메트 게엠베하 | 이중특이적 fcyriii x cd30 항체 작제물의 제조 방법 |
| CN116234829A (zh) | 2020-01-03 | 2023-06-06 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| MX2022013944A (es) | 2020-05-06 | 2022-11-30 | Dragonfly Therapeutics Inc | Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a). |
| JP2023545099A (ja) | 2020-10-08 | 2023-10-26 | アフィメド ゲーエムベーハー | 三重特異性バインダー |
| CN116323671A (zh) * | 2020-11-06 | 2023-06-23 | 安进公司 | 具有增加的选择性的多靶向性双特异性抗原结合分子 |
| EP4247850A1 (en) | 2020-11-20 | 2023-09-27 | Simcere Innovation, Inc. | Armed dual car-t compositions and methods for cancer immunotherapy |
| US20240059789A1 (en) | 2021-01-28 | 2024-02-22 | Janssen Biotech, Inc. | Psma binding proteins and uses thereof |
| JP2024508894A (ja) | 2021-03-03 | 2024-02-28 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｎｋｇ２ｄ、ｃｄ１６、及び腫瘍関連抗原に結合する多特異性結合タンパク質を使用して癌を治療する方法 |
| CA3214757A1 (en) | 2021-04-08 | 2022-10-13 | Andreas Loew | Multifuntional molecules binding to tcr and uses thereof |
| CA3216098A1 (en) | 2021-07-30 | 2023-02-02 | Uwe Reusch | Duplexbodies |
| CN114044822B (zh) * | 2021-10-28 | 2023-06-27 | 杭州博茵生物技术有限公司 | 血清淀粉样蛋白a抗体的重链和轻链可变区、抗体及运用 |
| CN114316060B (zh) * | 2021-12-15 | 2023-06-13 | 北京市肿瘤防治研究所 | 抗人cd19与cd206双特异性抗体及其制备方法和应用 |
| WO2026050572A2 (en) | 2024-08-29 | 2026-03-05 | Marengo Therapeutics, Inc. | Multifunctional molecules binding to tcr and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE199392T1 (de) | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| UA40577C2 (uk) * | 1993-08-02 | 2001-08-15 | Мерк Патент Гмбх | Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин |
| CA2260752A1 (en) * | 1996-07-23 | 1998-01-29 | Tanox Pharma B.V. | Induction of t cell tolerance using a soluble molecule that can simultaneously block two costimulatory pathways |
| US6306393B1 (en) * | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| DE60124912T2 (de) | 2001-09-14 | 2007-06-14 | Affimed Therapeutics Ag | Multimerische, einzelkettige, Tandem-Fv-Antikörper |
| EP1468097A4 (en) * | 2001-12-26 | 2006-01-11 | Immunomedics Inc | PROCESS FOR GENERATING MULTI-QUALITY REAGENTS WITH MULTIPLE SPECIFICITY FROM V SB H / SB AND V SB L / SB DOMAINS |
| DE602004030811D1 (de) * | 2003-10-16 | 2011-02-10 | Micromet Ag | Multispezifische deimmunisierte cd3-bindende moleküle |
| LT1976880T (lt) * | 2005-12-21 | 2016-10-10 | Amgen Research (Munich) Gmbh | Farmacinės kompozicijos, pasižyminčios atsparumu tirpiam cea |
| BRPI0910482A2 (pt) * | 2008-04-29 | 2019-09-24 | Abbott Lab | imunoglobinas de domínio variável duplo e usos das mesmas |
| TW201100543A (en) * | 2009-05-27 | 2011-01-01 | Hoffmann La Roche | Tri-or tetraspecific antibodies |
| EP2332994A1 (en) * | 2009-12-09 | 2011-06-15 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Trispecific therapeutics against acute myeloid leukaemia |
| AU2011316917B2 (en) * | 2010-10-22 | 2016-02-25 | Seagen Inc. | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the PI3K-AKT mTOR pathway |
-
2014
- 2014-04-13 EP EP14164523.4A patent/EP2930188A1/en not_active Withdrawn
-
2015
- 2015-04-12 EP EP15719420.0A patent/EP3131928B2/en active Active
- 2015-04-12 WO PCT/EP2015/057919 patent/WO2015158636A1/en not_active Ceased
- 2015-04-12 JP JP2016562499A patent/JP6635940B2/ja not_active Expired - Fee Related
- 2015-04-12 KR KR1020167030836A patent/KR102392598B1/ko not_active Expired - Fee Related
- 2015-04-12 SI SI201531107T patent/SI3131928T2/sl unknown
- 2015-04-12 RU RU2016138347A patent/RU2753882C2/ru active
- 2015-04-12 CA CA2945053A patent/CA2945053A1/en active Pending
- 2015-04-12 DK DK15719420.0T patent/DK3131928T4/da active
- 2015-04-12 BR BR112016023362A patent/BR112016023362A2/pt active Search and Examination
- 2015-04-12 MX MX2016013218A patent/MX382970B/es unknown
- 2015-04-12 AU AU2015249006A patent/AU2015249006B2/en not_active Ceased
- 2015-04-12 CN CN201580019685.7A patent/CN106661108A/zh active Pending
-
2016
- 2016-10-11 US US15/290,255 patent/US20170037128A1/en not_active Abandoned
-
2021
- 2021-11-03 US US17/517,869 patent/US20220048994A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017513476A5 (https=) | ||
| RU2016138347A (ru) | Трифункциональная антигенсвязывающая молекула | |
| WO2018057735A8 (en) | Antibodies for siglec-15 and methods of use thereof | |
| PH12018501284A1 (en) | Anti-tl1a/anti-tnf-alpha bispecific antigen binding proteins and uses thereof | |
| JP2018537415A5 (https=) | ||
| JP2017504578A5 (https=) | ||
| CN111601825A (zh) | 全人源的抗b细胞成熟抗原(bcma)单链抗体及其应用 | |
| MY207205A (en) | Cd3 antibody and pharmaceutical use thereof | |
| JP2014221064A5 (https=) | ||
| RU2011143905A (ru) | ПОЛИСПЕЦИФИЧНЫЕ АНТИТЕЛА, ВКЛЮЧАЮЩИЕ АНТИТЕЛА ПОЛНОЙ ДЛИНЫ И ОДНОЦЕПОЧЕЧНЫЕ ФРАГМЕНТЫ Fab | |
| JP2017176174A5 (https=) | ||
| EA201692504A1 (ru) | Триспецифичные связывающие молекулы и способы их применения | |
| EA201791666A1 (ru) | Антитела к cd3, антитела к cd123 и биспецифические антитела, которые специфически связываются с cd3 и/или cd123 | |
| RU2014109557A (ru) | Антитела, не содержащие fc-фрагмента, включающие два fab-фрагмента, и способы их применения | |
| WO2012145507A3 (en) | Monospecific and bispecific anti-igf-1r and anti-erbb3 antibodies | |
| MX356947B (es) | Anticuerpos bioespecíficos específicos para antígenos que activan células t y un antígeno tumoral y métodos de uso. | |
| CL2011003148A1 (es) | Proteina biespecifica de union a antigeno, que comprende a)2 cadenas ligeras y 2 cadenas pesadas de un anticuerpo que se une especificamente a un antigeno y 2 fragmentos fab, b)dos fragmentos fab adicionales de un anticuerpo que se une especificamente a un segundo antigeno; metodo de preparacion; composicion farmaceutica y uso. | |
| NZ588713A (en) | Antibodies to receptor of advanced glycation end products (rage) and uses thereof | |
| EA201790862A1 (ru) | Связывающиеся с эритроцитами терапевтические средства | |
| EA201490053A1 (ru) | Антитела, которые связываются с ox40, и их применение | |
| HK1207398A1 (en) | Cd3 binding polypeptides | |
| MX2013011176A (es) | Proteinas de union de tipo anticuerpo con region variable dual que tienen orientacion de la region de union con entrecruzamiento. | |
| RU2018102803A (ru) | Мультивалентные и мультиспецифические гибридные белки, связывающиеся с dr5 | |
| MX2023012489A (es) | Polipeptido de fusion biespecifico multifuncional. | |
| WO2017221072A3 (en) | Hla binding vaccine moieties and uses thereof |