JP2017513476A5 - - Google Patents
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- Publication number
- JP2017513476A5 JP2017513476A5 JP2016562499A JP2016562499A JP2017513476A5 JP 2017513476 A5 JP2017513476 A5 JP 2017513476A5 JP 2016562499 A JP2016562499 A JP 2016562499A JP 2016562499 A JP2016562499 A JP 2016562499A JP 2017513476 A5 JP2017513476 A5 JP 2017513476A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibody variable
- antigen binding
- region
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14164523.4 | 2014-04-13 | ||
| EP14164523.4A EP2930188A1 (en) | 2014-04-13 | 2014-04-13 | Trifunctional antigen-binding molecule |
| PCT/EP2015/057919 WO2015158636A1 (en) | 2014-04-13 | 2015-04-12 | Trifunctional antigen-binding molecule |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513476A JP2017513476A (ja) | 2017-06-01 |
| JP2017513476A5 true JP2017513476A5 (https=) | 2018-05-31 |
| JP6635940B2 JP6635940B2 (ja) | 2020-01-29 |
Family
ID=50478320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562499A Expired - Fee Related JP6635940B2 (ja) | 2014-04-13 | 2015-04-12 | 三機能性抗原結合分子 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20170037128A1 (https=) |
| EP (2) | EP2930188A1 (https=) |
| JP (1) | JP6635940B2 (https=) |
| KR (1) | KR102392598B1 (https=) |
| CN (1) | CN106661108A (https=) |
| AU (1) | AU2015249006B2 (https=) |
| BR (1) | BR112016023362A2 (https=) |
| CA (1) | CA2945053A1 (https=) |
| DK (1) | DK3131928T4 (https=) |
| MX (1) | MX382970B (https=) |
| RU (1) | RU2753882C2 (https=) |
| SI (1) | SI3131928T2 (https=) |
| WO (1) | WO2015158636A1 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA035419B9 (ru) | 2014-05-29 | 2020-08-07 | Мэкроудженикс, Инк. | Триспецифичные связывающие молекулы и способы их применения |
| IL293435B1 (en) * | 2015-06-15 | 2026-04-01 | Numab Therapeutics AG | Heterodimeric multispecific antibody format |
| EP3156417A1 (en) * | 2015-10-13 | 2017-04-19 | Affimed GmbH | Multivalent fv antibodies |
| AU2018219887B2 (en) | 2017-02-08 | 2024-08-15 | Dragonfly Therapeutics, LLC | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| CN110944661A (zh) | 2017-02-20 | 2020-03-31 | 蜻蜓疗法股份有限公司 | 结合her2、nkg2d和cd16的蛋白质 |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| JP7542438B2 (ja) * | 2017-11-21 | 2024-08-30 | ノバルティス アーゲー | 腫瘍関連抗原に対する三重特異性結合分子及びその使用 |
| EP3713959A1 (en) * | 2017-11-21 | 2020-09-30 | Innate Pharma | Multispecific antigen binding proteins |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| CA3237846A1 (en) | 2018-02-08 | 2019-08-15 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the nkg2d receptor |
| BR112020015994A2 (pt) | 2018-02-08 | 2020-12-15 | Dragonfly Therapeutics, Inc. | Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer |
| WO2019164930A1 (en) | 2018-02-20 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use |
| BR112020018492A2 (pt) * | 2018-03-14 | 2020-12-29 | Affimed Gmbh | Proteína de ligação ao antígeno egfr/cd16 biespecífica |
| EP3765517A1 (en) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| SG11202008474QA (en) * | 2018-03-27 | 2020-10-29 | Systimmune Inc | Guidance and navigation control proteins and method of making and using thereof |
| PE20211916A1 (es) | 2018-05-24 | 2021-09-28 | Janssen Biotech Inc | Agentes aglutinantes del psma y usos de estos |
| CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| EP3833392A4 (en) | 2018-08-08 | 2022-05-18 | Dragonfly Therapeutics, Inc. | MULTISPECIFIC BINDING PROTEINS FOR BINDING CD33, NKG2D AND CD16 AND METHODS OF USE |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| KR102835308B1 (ko) | 2018-08-08 | 2025-07-21 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질 |
| HRP20240821T1 (hr) | 2018-08-27 | 2024-09-27 | Affimed Gmbh | Stanice nk čuvane zamrzavanjem, koje su prethodno ubačene uz protutijelni konstrukt |
| GB2599228B (en) | 2019-02-21 | 2024-02-07 | Marengo Therapeutics Inc | Multifunctional molecules that bind to T cell related cancer cells and uses thereof |
| CN119039441A (zh) | 2019-02-21 | 2024-11-29 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| US11591395B2 (en) | 2019-04-19 | 2023-02-28 | Janssen Biotech, Inc. | Methods of treating prostate cancer with an anti-PSMA/CD3 antibody |
| JP7489407B2 (ja) | 2019-05-21 | 2024-05-23 | ノバルティス アーゲー | Ｃｄ１９結合分子及びその使用 |
| US12037378B2 (en) | 2019-05-21 | 2024-07-16 | Novartis Ag | Variant CD58 domains and uses thereof |
| AU2020414409A1 (en) | 2019-12-27 | 2022-06-16 | Affimed Gmbh | Method for the production of bispecific FcyRIIl x CD30 antibody construct |
| AU2020416273A1 (en) | 2020-01-03 | 2022-07-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| JP7512394B2 (ja) | 2020-05-06 | 2024-07-08 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｎｋｇ２ｄ、ｃｄ１６及びｃｌｅｃ１２ａに結合するタンパク質 |
| CN116368154A (zh) | 2020-10-08 | 2023-06-30 | 阿菲姆德股份有限公司 | 三特异性结合剂 |
| CR20230229A (es) * | 2020-11-06 | 2023-09-05 | Amgen Res Munich Gmbh | Moléculas de unión a antígeno biespecíficas con múltiples dianas de selectividad aumentada |
| JP2023550148A (ja) | 2020-11-20 | 2023-11-30 | シンシア・イノベーション・インコーポレイテッド | がん免疫治療に用いられる武装二重ｃａｒ－ｔ組成物及び方法 |
| EP4284838A2 (en) | 2021-01-28 | 2023-12-06 | Janssen Biotech, Inc. | Psma binding proteins and uses thereof |
| EP4301774A4 (en) | 2021-03-03 | 2025-08-13 | Dragonfly Therapeutics Inc | METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN |
| WO2022216993A2 (en) | 2021-04-08 | 2022-10-13 | Marengo Therapeutics, Inc. | Multifuntional molecules binding to tcr and uses thereof |
| CA3216098A1 (en) | 2021-07-30 | 2023-02-02 | Uwe Reusch | Duplexbodies |
| CN114044822B (zh) * | 2021-10-28 | 2023-06-27 | 杭州博茵生物技术有限公司 | 血清淀粉样蛋白a抗体的重链和轻链可变区、抗体及运用 |
| CN114316060B (zh) * | 2021-12-15 | 2023-06-13 | 北京市肿瘤防治研究所 | 抗人cd19与cd206双特异性抗体及其制备方法和应用 |
| WO2026050572A2 (en) | 2024-08-29 | 2026-03-05 | Marengo Therapeutics, Inc. | Multifunctional molecules binding to tcr and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2156149T3 (es) | 1992-12-04 | 2001-06-16 | Medical Res Council | Proteinas de union multivalente y multiespecificas, su fabricacion y su uso. |
| UA40577C2 (uk) * | 1993-08-02 | 2001-08-15 | Мерк Патент Гмбх | Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин |
| ATE283925T1 (de) * | 1996-07-23 | 2004-12-15 | Tanox Pharma B V | Induzierung von t zell toleranz unter verwendung eines löslichen moleküls, dass gleichzeitig zwei kostimulierungswege blockieren kann |
| US6306393B1 (en) * | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| EP1293514B1 (en) * | 2001-09-14 | 2006-11-29 | Affimed Therapeutics AG | Multimeric single chain tandem Fv-antibodies |
| WO2003057829A2 (en) * | 2001-12-26 | 2003-07-17 | Immunomedics, Inc. | Methods of generating multispecific, multivalent agents from vh and vl domains |
| MXPA06004035A (es) * | 2003-10-16 | 2006-08-31 | Micromet Ag | Aglutinantes cd3 de-inmunizados multi-especificos. |
| JP5399712B2 (ja) * | 2005-12-21 | 2014-01-29 | アムゲン リサーチ （ミュンヘン） ゲーエムベーハー | 可溶性ｃｅａに対する抵抗性を有する医薬組成物 |
| SG190572A1 (en) * | 2008-04-29 | 2013-06-28 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| PE20120540A1 (es) * | 2009-05-27 | 2012-05-09 | Hoffmann La Roche | Anticuerpos triespecificos o tetraespecificos |
| EP2332994A1 (en) * | 2009-12-09 | 2011-06-15 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Trispecific therapeutics against acute myeloid leukaemia |
| EP3581206B8 (en) * | 2010-10-22 | 2025-02-19 | Seagen Inc. | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the pi3k-akt mtor pathway |
-
2014
- 2014-04-13 EP EP14164523.4A patent/EP2930188A1/en not_active Withdrawn
-
2015
- 2015-04-12 BR BR112016023362A patent/BR112016023362A2/pt active Search and Examination
- 2015-04-12 EP EP15719420.0A patent/EP3131928B2/en active Active
- 2015-04-12 SI SI201531107T patent/SI3131928T2/sl unknown
- 2015-04-12 AU AU2015249006A patent/AU2015249006B2/en not_active Ceased
- 2015-04-12 CA CA2945053A patent/CA2945053A1/en active Pending
- 2015-04-12 JP JP2016562499A patent/JP6635940B2/ja not_active Expired - Fee Related
- 2015-04-12 WO PCT/EP2015/057919 patent/WO2015158636A1/en not_active Ceased
- 2015-04-12 CN CN201580019685.7A patent/CN106661108A/zh active Pending
- 2015-04-12 MX MX2016013218A patent/MX382970B/es unknown
- 2015-04-12 KR KR1020167030836A patent/KR102392598B1/ko not_active Expired - Fee Related
- 2015-04-12 DK DK15719420.0T patent/DK3131928T4/da active
- 2015-04-12 RU RU2016138347A patent/RU2753882C2/ru active
-
2016
- 2016-10-11 US US15/290,255 patent/US20170037128A1/en not_active Abandoned
-
2021
- 2021-11-03 US US17/517,869 patent/US20220048994A1/en not_active Abandoned
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