JP2017513476A5 - - Google Patents
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- JP2017513476A5 JP2017513476A5 JP2016562499A JP2016562499A JP2017513476A5 JP 2017513476 A5 JP2017513476 A5 JP 2017513476A5 JP 2016562499 A JP2016562499 A JP 2016562499A JP 2016562499 A JP2016562499 A JP 2016562499A JP 2017513476 A5 JP2017513476 A5 JP 2017513476A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibody variable
- antigen binding
- region
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14164523.4A EP2930188A1 (en) | 2014-04-13 | 2014-04-13 | Trifunctional antigen-binding molecule |
| EP14164523.4 | 2014-04-13 | ||
| PCT/EP2015/057919 WO2015158636A1 (en) | 2014-04-13 | 2015-04-12 | Trifunctional antigen-binding molecule |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513476A JP2017513476A (ja) | 2017-06-01 |
| JP2017513476A5 true JP2017513476A5 (cg-RX-API-DMAC7.html) | 2018-05-31 |
| JP6635940B2 JP6635940B2 (ja) | 2020-01-29 |
Family
ID=50478320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562499A Expired - Fee Related JP6635940B2 (ja) | 2014-04-13 | 2015-04-12 | 三機能性抗原結合分子 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20170037128A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2930188A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6635940B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102392598B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN106661108A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015249006B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016023362A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2945053A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK3131928T4 (cg-RX-API-DMAC7.html) |
| MX (1) | MX382970B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2753882C2 (cg-RX-API-DMAC7.html) |
| SI (1) | SI3131928T2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015158636A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113549153A (zh) | 2014-05-29 | 2021-10-26 | 宏观基因有限公司 | 三特异性结合分子和其使用方法 |
| JP6839101B2 (ja) * | 2015-06-15 | 2021-03-03 | ヌマブ セラピューティクス アクチェンゲゼルシャフト | ヘテロ二量体多重特異性抗体フォーマット |
| EP3156417A1 (en) * | 2015-10-13 | 2017-04-19 | Affimed GmbH | Multivalent fv antibodies |
| KR20250089564A (ko) | 2017-02-08 | 2025-06-18 | 드래곤플라이 쎄라퓨틱스, 인크. | 천연 킬러 세포의 활성화를 위한 다중-특이적 결합 단백질 및 암 치료에서의 그의 치료적 용도 |
| KR20190120782A (ko) | 2017-02-20 | 2019-10-24 | 드래곤플라이 쎄라퓨틱스, 인크. | Her2, nkg2d 및 cd16에 결합하는 단백질 |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| US20200362054A1 (en) * | 2017-11-21 | 2020-11-19 | Brian Granda | Trispecific binding molecules against tumor-associated antigents and use thereof |
| CA3079363A1 (en) * | 2017-11-21 | 2019-05-31 | Innate Pharma | Multispecific antigen binding proteins |
| EP3737692A4 (en) | 2018-01-09 | 2021-09-29 | Elstar Therapeutics, Inc. | CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES |
| PE20210375A1 (es) | 2018-02-08 | 2021-03-02 | Dragonfly Therapeutics Inc | Terapia de combinacion del cancer que incluye proteinas de union multiespecificas que activan a las celulas asesinas naturales |
| CA3090244A1 (en) | 2018-02-08 | 2019-08-15 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the nkg2d receptor |
| CN112119093A (zh) | 2018-02-20 | 2020-12-22 | 蜻蜓治疗公司 | 结合cd33、nkg2d和cd16的多特异性结合蛋白和使用方法 |
| EP3765517A1 (en) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| WO2019175368A1 (en) * | 2018-03-14 | 2019-09-19 | Affimed Gmbh | Bispecific egfr/cd16 antigen-binding protein |
| CN111527108A (zh) * | 2018-03-27 | 2020-08-11 | 西雅图免疫公司 | 制导和导航控制蛋白的制造和使用方法 |
| EP3802609A2 (en) | 2018-05-24 | 2021-04-14 | Janssen Biotech, Inc. | Psma binding agents and uses thereof |
| AU2019297451A1 (en) | 2018-07-03 | 2021-01-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| BR112021002276A2 (pt) | 2018-08-08 | 2021-05-04 | Dragonfly Therapeutics, Inc. | proteínas de ligação a nkg2d, cd16 e um antígeno associado ao tumor |
| CA3108427A1 (en) | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| PL3843757T3 (pl) | 2018-08-27 | 2024-08-05 | Affimed Gmbh | Kriokonserwowane komórki nk wstępnie obciążone konstruktem przeciwciała |
| CA3130754A1 (en) | 2019-02-21 | 2020-08-27 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| WO2020172605A1 (en) | 2019-02-21 | 2020-08-27 | Elstar Therapeutics, Inc. | Antibody molecules that bind to nkp30 and uses thereof |
| MA55717A (fr) | 2019-04-19 | 2022-02-23 | Janssen Biotech Inc | Méthodes de traitement du cancer de la prostate avec un anticorps anti-psma/cd3 |
| US12037378B2 (en) | 2019-05-21 | 2024-07-16 | Novartis Ag | Variant CD58 domains and uses thereof |
| JOP20210309A1 (ar) | 2019-05-21 | 2023-01-30 | Novartis Ag | جزيئات ربط بـ cd19 واستخدامتها |
| CA3160927A1 (en) | 2019-12-27 | 2021-07-01 | Affimed Gmbh | Method for the production of bispecific fcyriii x cd30 antibody construct |
| GB2609554B (en) | 2020-01-03 | 2025-08-20 | Marengo Therapeutics Inc | Anti-TCR antibody molecules and uses thereof |
| US12157771B2 (en) | 2020-05-06 | 2024-12-03 | Dragonfly Therapeutics, Inc. | Proteins binding NKG2D, CD16 and CLEC12A |
| JP2023545099A (ja) | 2020-10-08 | 2023-10-26 | アフィメド ゲーエムベーハー | 三重特異性バインダー |
| CA3200317A1 (en) * | 2020-11-06 | 2022-05-12 | Amgen Inc. | Multitargeting bispecific antigen-binding molecules of increased selectivity |
| EP4247850A1 (en) | 2020-11-20 | 2023-09-27 | Simcere Innovation, Inc. | Armed dual car-t compositions and methods for cancer immunotherapy |
| JP2024504758A (ja) | 2021-01-28 | 2024-02-01 | ヤンセン バイオテツク，インコーポレーテツド | Ｐｓｍａ結合タンパク質及びその使用 |
| WO2022187539A1 (en) | 2021-03-03 | 2022-09-09 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind nkg2d, cd16 and a tumor-associated antigen |
| CA3214757A1 (en) | 2021-04-08 | 2022-10-13 | Andreas Loew | Multifuntional molecules binding to tcr and uses thereof |
| EP4376958A1 (en) | 2021-07-30 | 2024-06-05 | Affimed GmbH | Duplexbodies |
| CN114044822B (zh) * | 2021-10-28 | 2023-06-27 | 杭州博茵生物技术有限公司 | 血清淀粉样蛋白a抗体的重链和轻链可变区、抗体及运用 |
| CN114316060B (zh) * | 2021-12-15 | 2023-06-13 | 北京市肿瘤防治研究所 | 抗人cd19与cd206双特异性抗体及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3720353B2 (ja) | 1992-12-04 | 2005-11-24 | メディカル リサーチ カウンシル | 多価および多重特異性の結合タンパク質、それらの製造および使用 |
| UA40577C2 (uk) * | 1993-08-02 | 2001-08-15 | Мерк Патент Гмбх | Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин |
| WO1998003670A1 (en) * | 1996-07-23 | 1998-01-29 | Tanox Pharma B.V. | Induction of t cell tolerance using a soluble molecule that can simultaneously block two costimulatory pathways |
| US6306393B1 (en) * | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| ES2276735T3 (es) * | 2001-09-14 | 2007-07-01 | Affimed Therapeutics Ag | Anticuerpos fv multimericos de cadena sencilla en tandem. |
| PL372144A1 (en) * | 2001-12-26 | 2005-07-11 | Immunomedics, Inc. | Methods of generating multispecific, multivalent agents from v sb h /sb and v sb l /sb domains |
| PL1673398T3 (pl) * | 2003-10-16 | 2011-05-31 | Amgen Res Munich Gmbh | Multispecyficzne deimmunizowane cząsteczki wiążące CD3 |
| JP5399712B2 (ja) * | 2005-12-21 | 2014-01-29 | アムゲン リサーチ （ミュンヘン） ゲーエムベーハー | 可溶性ｃｅａに対する抵抗性を有する医薬組成物 |
| BRPI0910482A2 (pt) * | 2008-04-29 | 2019-09-24 | Abbott Lab | imunoglobinas de domínio variável duplo e usos das mesmas |
| MX2011011925A (es) * | 2009-05-27 | 2011-12-06 | Hoffmann La Roche | Anticuerpos triespecificos o tetraespecificos. |
| EP2332994A1 (en) * | 2009-12-09 | 2011-06-15 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Trispecific therapeutics against acute myeloid leukaemia |
| WO2012054748A2 (en) * | 2010-10-22 | 2012-04-26 | Seattle Genetics, Inc. | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the pi3k-akt mtor pathway |
-
2014
- 2014-04-13 EP EP14164523.4A patent/EP2930188A1/en not_active Withdrawn
-
2015
- 2015-04-12 SI SI201531107T patent/SI3131928T2/sl unknown
- 2015-04-12 RU RU2016138347A patent/RU2753882C2/ru active
- 2015-04-12 MX MX2016013218A patent/MX382970B/es unknown
- 2015-04-12 JP JP2016562499A patent/JP6635940B2/ja not_active Expired - Fee Related
- 2015-04-12 KR KR1020167030836A patent/KR102392598B1/ko active Active
- 2015-04-12 CA CA2945053A patent/CA2945053A1/en active Pending
- 2015-04-12 EP EP15719420.0A patent/EP3131928B2/en active Active
- 2015-04-12 AU AU2015249006A patent/AU2015249006B2/en not_active Ceased
- 2015-04-12 DK DK15719420.0T patent/DK3131928T4/da active
- 2015-04-12 WO PCT/EP2015/057919 patent/WO2015158636A1/en not_active Ceased
- 2015-04-12 BR BR112016023362A patent/BR112016023362A2/pt active Search and Examination
- 2015-04-12 CN CN201580019685.7A patent/CN106661108A/zh active Pending
-
2016
- 2016-10-11 US US15/290,255 patent/US20170037128A1/en not_active Abandoned
-
2021
- 2021-11-03 US US17/517,869 patent/US20220048994A1/en not_active Abandoned
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