JP2017511365A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017511365A5 JP2017511365A5 JP2016562835A JP2016562835A JP2017511365A5 JP 2017511365 A5 JP2017511365 A5 JP 2017511365A5 JP 2016562835 A JP2016562835 A JP 2016562835A JP 2016562835 A JP2016562835 A JP 2016562835A JP 2017511365 A5 JP2017511365 A5 JP 2017511365A5
- Authority
- JP
- Japan
- Prior art keywords
- triazolo
- optionally substituted
- amino
- pyrazin
- pyrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2014/075560 | 2014-04-17 | ||
| PCT/CN2014/075560 WO2015157955A1 (en) | 2014-04-17 | 2014-04-17 | Heterocyclic btk inhibit ors |
| PCT/CN2015/076766 WO2015158283A1 (en) | 2014-04-17 | 2015-04-16 | Heterocyclic kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017511365A JP2017511365A (ja) | 2017-04-20 |
| JP2017511365A5 true JP2017511365A5 (enExample) | 2018-05-31 |
Family
ID=54323386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562835A Pending JP2017511365A (ja) | 2014-04-17 | 2015-04-16 | 複素環キナーゼ阻害薬 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10280184B2 (enExample) |
| EP (1) | EP3131900A4 (enExample) |
| JP (1) | JP2017511365A (enExample) |
| CN (1) | CN106459045A (enExample) |
| AU (1) | AU2015246482A1 (enExample) |
| BR (1) | BR112016024057A2 (enExample) |
| CA (1) | CA2946036A1 (enExample) |
| MX (1) | MX2016013564A (enExample) |
| WO (2) | WO2015157955A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9932340B2 (en) * | 2014-12-18 | 2018-04-03 | Abbvie Inc. | Substituted indoles |
| CA2984496A1 (en) * | 2015-05-12 | 2016-11-17 | Kalyra Pharmaceuticals, Inc. | Bicyclic compounds |
| SG11201804210XA (en) * | 2015-11-20 | 2018-06-28 | Mingsight Pharmaceuticals Inc | Treatment of autoimmune disease |
| WO2017163078A1 (en) * | 2016-03-24 | 2017-09-28 | Mission Therapeutics Limited | 1-cyano-pyrrolidine derivatives as dbu inhibitors |
| GB201616511D0 (en) * | 2016-09-29 | 2016-11-16 | Mission Therapeutics Limited | Novel compounds |
| WO2018098499A1 (en) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018098491A1 (en) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018148745A1 (en) | 2017-02-13 | 2018-08-16 | Praxis Precision Medicines , Inc. | Compounds and their methods of use |
| US11554118B2 (en) * | 2017-03-22 | 2023-01-17 | Xibin Liao | Bruton's tyrosine kinase inhibitors |
| US11731966B2 (en) | 2017-04-04 | 2023-08-22 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2019035951A1 (en) | 2017-08-15 | 2019-02-21 | Praxis Precision Medicines, Inc. | COMPOUNDS AND THEIR METHODS OF USE |
| BR122023024273A2 (pt) | 2018-02-27 | 2024-02-20 | Incyte Corporation | Compostos imidazopirimidinas e triazolopirimidinas, seus usos, método para inibir uma atividade de um receptor de adenosina e composição farmacêutica dos mesmos |
| EP3810610A1 (en) | 2018-05-18 | 2021-04-28 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| IL309843B2 (en) | 2018-05-30 | 2026-05-01 | Praxis Prec Medicines Inc | History of [4,2,1]triazolo[3,4-a]pyridines and their use as sodium ion channel modulators |
| AU2019297361B2 (en) * | 2018-07-05 | 2024-06-27 | Incyte Corporation | Fused pyrazine derivatives as A2A / A2B inhibitors |
| EA202092908A1 (ru) | 2018-09-28 | 2021-05-14 | Праксис Пресижн Медсинз, Инк. | Модуляторы ионных каналов |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| WO2021040502A1 (ko) * | 2019-08-30 | 2021-03-04 | 주식회사 티에스디라이프사이언스 | 이미다조피리딘 유도체 및 이를 유효성분으로 함유하는 약학적 조성물 |
| US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
| AU2020392128A1 (en) | 2019-11-27 | 2022-06-09 | Praxis Precision Medicines, Inc. | Formulations of ion channel modulators and methods of preparation and use of ion channel modulators |
| EP3915990A1 (en) | 2020-05-26 | 2021-12-01 | Centre National de la Recherche Scientifique | 4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-3,6-dihydropyridine-1-(2h)-carboxamide derivatives as limk and/or rock kinases inhibitors for use in the treatment of cancer |
| WO2021244430A1 (en) * | 2020-06-01 | 2021-12-09 | Nanjing Ruijie Pharma Co., Ltd. | Compounds and their uses as spleen tyrosine kinase inhibitors |
| WO2021249417A1 (zh) * | 2020-06-09 | 2021-12-16 | 赛诺哈勃药业（成都）有限公司 | 杂环化合物及其衍生物 |
| GB202014114D0 (en) * | 2020-09-08 | 2020-10-21 | Synairgen Res Ltd | Use of inhaled interferon-beta to treat virus-induced exacerbations in copd patients undergoing treatment with a systemic corticosteroid |
| EP4244223A1 (en) * | 2020-11-13 | 2023-09-20 | Biogen MA Inc. | Pyrazolo[1,5-a]pyrazine derivatives as btk inhibitors |
| CA3250706A1 (en) | 2022-04-26 | 2023-11-02 | Praxis Precision Medicines, Inc. | TREATMENT OF NEUROLOGICAL DISORDERS |
| JP2025515728A (ja) * | 2022-05-10 | 2025-05-20 | バイオジェン・エムエイ・インコーポレイテッド | Ｎ－メチル－Ｎ－（（１ｓ，３ｓ）－３－メチル－３－（（６－（１－メチル－１Ｈ－ピラゾール－４－イル）ピラゾロ［１，５－ａ］ピラジン－４－イル）オキシ）シクロブチル）アクリルアミドの結晶多形 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1363702A4 (en) * | 2001-01-30 | 2007-08-22 | Cytopia Pty Ltd | PROCESS FOR INHIBITING KINASES |
| IL156567A0 (en) * | 2001-03-09 | 2004-01-04 | Pfizer Prod Inc | Triazolopyridines as anti-inflammatory agents |
| WO2005014599A1 (en) | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
| WO2005085252A1 (en) * | 2004-03-04 | 2005-09-15 | Biofocus Discovery Limited | Imidazo ‘1,2-a’ pyrazine compounds which interact with protein kinases |
| DE102004030782A1 (de) * | 2004-06-25 | 2006-01-19 | Fev Motorentechnik Gmbh | Fahrzeug-Steuergerät mit einem neuronalen Netz |
| DE602005023333D1 (de) * | 2004-10-15 | 2010-10-14 | Takeda Pharmaceutical | Kinaseinhibitoren |
| US7700773B2 (en) | 2005-09-09 | 2010-04-20 | Schering Corporation | 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridines, pyrazolo[1,5-c]pyrimidines and 2H-indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridines, and imidazo[1,5-a]pyrazines as cyclin dependent kinase inhibitors |
| DE102007032349A1 (de) * | 2007-07-11 | 2009-01-15 | Bayer Healthcare Ag | Imidazo-, Pyrazolopyrazine und Imidazotriazine und ihre Verwendung |
| PE20091074A1 (es) * | 2007-12-13 | 2009-07-26 | Bayer Healthcare Ag | Triazolotriazinas y triazolopirazinas y su uso |
| CN101952283B (zh) * | 2007-12-14 | 2013-04-17 | 霍夫曼-拉罗奇有限公司 | 咪唑并[1，2-a]吡啶和咪唑并[1，2-b]哒嗪衍生物 |
| CA2726460C (en) * | 2008-07-15 | 2017-02-21 | F. Hoffmann-La Roche Ag | Novel phenyl-imidazopyridines and pyridazines |
| TWI453207B (zh) * | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| KR101743784B1 (ko) * | 2008-12-08 | 2017-06-05 | 질레드 코네티컷 인코포레이티드 | 이미다조피라진 ｓｙｋ 억제제 |
| WO2010068806A1 (en) | 2008-12-10 | 2010-06-17 | Cgi Pharmaceuticals, Inc. | Amide derivatives as btk inhibitors in the treatment of allergic, autoimmune and inflammatory disorders as well as cancer |
| WO2010068810A2 (en) | 2008-12-10 | 2010-06-17 | Cgi Pharmaceuticals, Inc. | Certain substituted amides, method of making, and method of use thereof |
| EP2343294A1 (en) * | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
| ES2530449T3 (es) * | 2010-03-11 | 2015-03-02 | Gilead Connecticut Inc | Inhibidores de Syk de imidazopiridinas |
| TWI541243B (zh) * | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
| CN103429591A (zh) * | 2010-12-17 | 2013-12-04 | 拜耳知识产权有限责任公司 | 在治疗过度增殖性病症中用作mps-1和tkk抑制剂的6-取代的咪唑并吡嗪 |
| CA2832310A1 (en) | 2011-04-06 | 2012-10-11 | Bayer Intellectual Property Gmbh | Substituted imidazopyridines and intermediates thereof |
| WO2012163724A1 (en) * | 2011-05-31 | 2012-12-06 | F. Hoffmann-La Roche Ag | Triazolopyridine compounds |
| CA2849194A1 (en) * | 2011-11-01 | 2013-05-10 | F. Hoffmann-La Roche Ag | Imidazopyridazine compounds |
| KR20140096100A (ko) * | 2011-11-03 | 2014-08-04 | 에프. 호프만-라 로슈 아게 | 이환 피페라진 화합물 |
| JP5832664B2 (ja) | 2011-12-09 | 2015-12-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ブルトン型チロシンキナーゼの阻害剤 |
-
2014
- 2014-04-17 WO PCT/CN2014/075560 patent/WO2015157955A1/en not_active Ceased
-
2015
- 2015-04-16 EP EP15780191.1A patent/EP3131900A4/en not_active Withdrawn
- 2015-04-16 CN CN201580031633.1A patent/CN106459045A/zh active Pending
- 2015-04-16 CA CA2946036A patent/CA2946036A1/en not_active Abandoned
- 2015-04-16 WO PCT/CN2015/076766 patent/WO2015158283A1/en not_active Ceased
- 2015-04-16 AU AU2015246482A patent/AU2015246482A1/en not_active Abandoned
- 2015-04-16 JP JP2016562835A patent/JP2017511365A/ja active Pending
- 2015-04-16 BR BR112016024057A patent/BR112016024057A2/pt not_active Application Discontinuation
- 2015-04-16 MX MX2016013564A patent/MX2016013564A/es unknown
- 2015-04-16 US US15/304,131 patent/US10280184B2/en active Active
-
2018
- 2018-12-21 US US16/230,408 patent/US20190135836A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7323723B2 (ja) | Ｎａｖ１．８阻害剤としての２－オキソイミダゾリジン－４－カルボキサミド | |
| JP7398391B2 (ja) | Ｎ－［４－オキソ－２，３－ジヒドロ－１，５－ベンズオキサゼピン－３－イル］－５，６－ジヒドロ－４Ｈ－ピロロ［１，２－ｂ］ピラゾール－２－カルボキサミド誘導体及び例えば過敏性腸症候群（ＩＢＳ）を処置するためのＲＩＰ１キナーゼ阻害剤としての関連化合物 | |
| US9617258B2 (en) | Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides | |
| RU2711869C2 (ru) | Имидазопирролопиразиновые производные, полезные для лечения заболеваний, вызванных аномальной активностью протеинкиназ Jak1, Jak3 или Syk | |
| HRP20201641T1 (hr) | Novi spojevi i njihove farmaceutske kompozicije za liječenje inflamatornih poremećaja | |
| RU2019115115A (ru) | Производные пиперидина в качестве ингибиторов убиквитин-специфической протеазы 7 | |
| JP2022502490A5 (enExample) | ||
| WO2011157397A1 (en) | Heteroaryl imidazolone derivatives as jak inhibitors | |
| RU2009136299A (ru) | Новые производные 3-({1,2,4}триазоло{4,3-а}пиридин-7-ил)бензамида | |
| TW201725202A (zh) | 新穎經取代吲唑、其製法、包含其之醫藥製劑及其製備藥劑之用途 | |
| US20190135836A1 (en) | Heterocyclic kinase inhibitors | |
| US9040534B2 (en) | [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators | |
| JP2013539762A (ja) | フロ［３，２−ｄ］ピリミジン化合物 | |
| JP2020526549A5 (enExample) | ||
| JP2017193592A5 (enExample) | ||
| JP2023525762A5 (enExample) | ||
| SI3083625T1 (en) | Pyrimidopyrimidinones, useful as Wee-1 kinase inhibitors | |
| JP2013523884A5 (enExample) | ||
| JP2017531672A5 (enExample) | ||
| JP2020536915A5 (enExample) | ||
| JP2024507935A5 (enExample) | ||
| JP2017501177A5 (enExample) | ||
| JP2008504281A5 (enExample) | ||
| JP2023522693A5 (enExample) | ||
| WO2024052513A1 (en) | Heterocyclic derivatives as janus kinase inhibitors |