JP2017511365A5 - - Google Patents
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- Publication number
- JP2017511365A5 JP2017511365A5 JP2016562835A JP2016562835A JP2017511365A5 JP 2017511365 A5 JP2017511365 A5 JP 2017511365A5 JP 2016562835 A JP2016562835 A JP 2016562835A JP 2016562835 A JP2016562835 A JP 2016562835A JP 2017511365 A5 JP2017511365 A5 JP 2017511365A5
- Authority
- JP
- Japan
- Prior art keywords
- triazolo
- optionally substituted
- amino
- pyrazin
- pyrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2014/075560 WO2015157955A1 (en) | 2014-04-17 | 2014-04-17 | Heterocyclic btk inhibit ors |
| CNPCT/CN2014/075560 | 2014-04-17 | ||
| PCT/CN2015/076766 WO2015158283A1 (en) | 2014-04-17 | 2015-04-16 | Heterocyclic kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017511365A JP2017511365A (ja) | 2017-04-20 |
| JP2017511365A5 true JP2017511365A5 (enExample) | 2018-05-31 |
Family
ID=54323386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562835A Pending JP2017511365A (ja) | 2014-04-17 | 2015-04-16 | 複素環キナーゼ阻害薬 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10280184B2 (enExample) |
| EP (1) | EP3131900A4 (enExample) |
| JP (1) | JP2017511365A (enExample) |
| CN (1) | CN106459045A (enExample) |
| AU (1) | AU2015246482A1 (enExample) |
| BR (1) | BR112016024057A2 (enExample) |
| CA (1) | CA2946036A1 (enExample) |
| MX (1) | MX2016013564A (enExample) |
| WO (2) | WO2015157955A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9932340B2 (en) * | 2014-12-18 | 2018-04-03 | Abbvie Inc. | Substituted indoles |
| AU2016261730A1 (en) * | 2015-05-12 | 2017-11-16 | Zeno Royalties & Milestones, LLC | Bicyclic compounds |
| WO2017087318A1 (en) * | 2015-11-20 | 2017-05-26 | Mingsight Pharmaceuticals, Inc. | Treatment of autoimmune disease |
| EP3433246B1 (en) | 2016-03-24 | 2022-05-04 | Mission Therapeutics Limited | 1-cyano-pyrrolidine derivatives as dbu inhibitors |
| GB201616511D0 (en) * | 2016-09-29 | 2016-11-16 | Mission Therapeutics Limited | Novel compounds |
| BR112019010880A2 (pt) | 2016-11-28 | 2019-10-01 | Praxis Precision Medicines, Inc. | compostos e seus métodos de uso |
| US11261188B2 (en) | 2016-11-28 | 2022-03-01 | Praxis Precision Medicines, Inc. | Fused heteroaryl compounds, and methods thereof for treating diseases, disorders, and conditions relating to aberrant function of a sodium channel |
| WO2018148745A1 (en) | 2017-02-13 | 2018-08-16 | Praxis Precision Medicines , Inc. | Compounds and their methods of use |
| AU2018237123B2 (en) | 2017-03-22 | 2022-08-04 | Xibin Liao | Bruton's tyrosine kinase inhibitors |
| US11731966B2 (en) | 2017-04-04 | 2023-08-22 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11278535B2 (en) | 2017-08-15 | 2022-03-22 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US20190292188A1 (en) | 2018-02-27 | 2019-09-26 | Incyte Corporation | Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors |
| MA52940A (fr) | 2018-05-18 | 2021-04-28 | Incyte Corp | Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b |
| CN117756800A (zh) | 2018-05-30 | 2024-03-26 | 普拉克西斯精密药物股份有限公司 | 离子通道调节剂 |
| CN113166153B (zh) | 2018-07-05 | 2024-11-01 | 因赛特公司 | 作为a2a/a2b抑制剂的稠合吡嗪衍生物 |
| EA202092908A1 (ru) | 2018-09-28 | 2021-05-14 | Праксис Пресижн Медсинз, Инк. | Модуляторы ионных каналов |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| EP4023647B1 (en) * | 2019-08-30 | 2025-04-09 | TSD Life Sciences Co., Ltd. | Imidazopyridine derivative and pharmaceutical composition comprising same as active ingredient |
| US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
| AU2020392128A1 (en) | 2019-11-27 | 2022-06-09 | Praxis Precision Medicines, Inc. | Formulations of ion channel modulators and methods of preparation and use of ion channel modulators |
| EP3915990A1 (en) | 2020-05-26 | 2021-12-01 | Centre National de la Recherche Scientifique | 4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-3,6-dihydropyridine-1-(2h)-carboxamide derivatives as limk and/or rock kinases inhibitors for use in the treatment of cancer |
| JP7535600B2 (ja) * | 2020-06-01 | 2024-08-16 | ナンジン ルイジエ ファーマ シーオー．，エルティーディー． | 化合物および脾臓チロシンキナーゼ阻害剤としてのその使用 |
| TW202214634A (zh) * | 2020-06-09 | 2022-04-16 | 大陸商賽諾哈勃藥業（成都）有限公司 | 雜環化合物及其衍生物 |
| GB202014114D0 (en) * | 2020-09-08 | 2020-10-21 | Synairgen Res Ltd | Use of inhaled interferon-beta to treat virus-induced exacerbations in copd patients undergoing treatment with a systemic corticosteroid |
| BR112023009116A2 (pt) * | 2020-11-13 | 2023-10-03 | Biogen Ma Inc | Derivados de pirazolo[1,5-a]pirazina como inibidores de btk |
| JP2025515728A (ja) * | 2022-05-10 | 2025-05-20 | バイオジェン・エムエイ・インコーポレイテッド | Ｎ－メチル－Ｎ－（（１ｓ，３ｓ）－３－メチル－３－（（６－（１－メチル－１Ｈ－ピラゾール－４－イル）ピラゾロ［１，５－ａ］ピラジン－４－イル）オキシ）シクロブチル）アクリルアミドの結晶多形 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004528295A (ja) * | 2001-01-30 | 2004-09-16 | サイトピア ピーティワイ リミテッド | キナーゼ阻害方法 |
| DE60210755T2 (de) * | 2001-03-09 | 2006-11-16 | Pfizer Products Inc., Groton | Triazolopyridine als entzündungshemmende mittel |
| US7405295B2 (en) | 2003-06-04 | 2008-07-29 | Cgi Pharmaceuticals, Inc. | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds |
| WO2005085252A1 (en) * | 2004-03-04 | 2005-09-15 | Biofocus Discovery Limited | Imidazo ‘1,2-a’ pyrazine compounds which interact with protein kinases |
| DE102004030782A1 (de) * | 2004-06-25 | 2006-01-19 | Fev Motorentechnik Gmbh | Fahrzeug-Steuergerät mit einem neuronalen Netz |
| US7713973B2 (en) * | 2004-10-15 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| EP1931641B1 (en) * | 2005-09-09 | 2010-08-25 | Schering Corporation | NOVEL 4-CYANO, 4-AMINO, AND 4-AMINOMETHYL DERIVATIVES OF PYRAZOLO[1,5-a]PYRIDINES, PYRAZOLO[1,5-c]PYRIMIDINES AND 2H-INDAZOLE COMPOUNDS AND 5-CYANO, 5-AMINO, AND 5-AMINOMETHYL DERIVATIVES OF IMIDAZO[1,2-a]PYRIDINES, AND IMIDAZO[1,5-a]PYRAZINES COMPOUNDS AS CYCLIN DEPENDENT KINASE INHI |
| DE102007032349A1 (de) * | 2007-07-11 | 2009-01-15 | Bayer Healthcare Ag | Imidazo-, Pyrazolopyrazine und Imidazotriazine und ihre Verwendung |
| PE20091074A1 (es) | 2007-12-13 | 2009-07-26 | Bayer Healthcare Ag | Triazolotriazinas y triazolopirazinas y su uso |
| JP5643105B2 (ja) | 2007-12-14 | 2014-12-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規イミダゾ［１，２−ａ］ピリジン及びイミダゾ［１，２−ｂ］ピリダジン誘導体 |
| EP2307413B1 (en) | 2008-07-15 | 2015-09-09 | F. Hoffmann-La Roche AG | Novel phenyl-imidazopyridines and pyridazines |
| TWI453207B (zh) * | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| EA021293B1 (ru) | 2008-12-08 | 2015-05-29 | Джилид Коннектикут, Инк. | ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| WO2010068810A2 (en) * | 2008-12-10 | 2010-06-17 | Cgi Pharmaceuticals, Inc. | Certain substituted amides, method of making, and method of use thereof |
| WO2010068806A1 (en) * | 2008-12-10 | 2010-06-17 | Cgi Pharmaceuticals, Inc. | Amide derivatives as btk inhibitors in the treatment of allergic, autoimmune and inflammatory disorders as well as cancer |
| EP2343294A1 (en) * | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
| PT2545052E (pt) | 2010-03-11 | 2015-02-18 | Gilead Connecticut Inc | Inibidores da syk à base de imidazopiridinas |
| TWI541243B (zh) | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
| EP2651950A1 (en) | 2010-12-17 | 2013-10-23 | Bayer Intellectual Property GmbH | 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| US20140255392A1 (en) | 2011-04-06 | 2014-09-11 | Bayer Intellectual Property Gmbh | Substituted imidazopyridines and intermediates thereof |
| WO2012163724A1 (en) * | 2011-05-31 | 2012-12-06 | F. Hoffmann-La Roche Ag | Triazolopyridine compounds |
| EP2773645A1 (en) | 2011-11-01 | 2014-09-10 | F.Hoffmann-La Roche Ag | Imidazopyridazine compounds |
| KR20140096100A (ko) * | 2011-11-03 | 2014-08-04 | 에프. 호프만-라 로슈 아게 | 이환 피페라진 화합물 |
| US8742098B2 (en) * | 2011-12-09 | 2014-06-03 | Hoffmann-La Roche Inc. | Inhibitors of Bruton's tyrosine kinase |
-
2014
- 2014-04-17 WO PCT/CN2014/075560 patent/WO2015157955A1/en not_active Ceased
-
2015
- 2015-04-16 US US15/304,131 patent/US10280184B2/en active Active
- 2015-04-16 AU AU2015246482A patent/AU2015246482A1/en not_active Abandoned
- 2015-04-16 BR BR112016024057A patent/BR112016024057A2/pt not_active Application Discontinuation
- 2015-04-16 MX MX2016013564A patent/MX2016013564A/es unknown
- 2015-04-16 EP EP15780191.1A patent/EP3131900A4/en not_active Withdrawn
- 2015-04-16 JP JP2016562835A patent/JP2017511365A/ja active Pending
- 2015-04-16 WO PCT/CN2015/076766 patent/WO2015158283A1/en not_active Ceased
- 2015-04-16 CN CN201580031633.1A patent/CN106459045A/zh active Pending
- 2015-04-16 CA CA2946036A patent/CA2946036A1/en not_active Abandoned
-
2018
- 2018-12-21 US US16/230,408 patent/US20190135836A1/en not_active Abandoned
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