JP2017511365A5 - - Google Patents
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- Publication number
- JP2017511365A5 JP2017511365A5 JP2016562835A JP2016562835A JP2017511365A5 JP 2017511365 A5 JP2017511365 A5 JP 2017511365A5 JP 2016562835 A JP2016562835 A JP 2016562835A JP 2016562835 A JP2016562835 A JP 2016562835A JP 2017511365 A5 JP2017511365 A5 JP 2017511365A5
- Authority
- JP
- Japan
- Prior art keywords
- triazolo
- optionally substituted
- amino
- pyrazin
- pyrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2014/075560 | 2014-04-17 | ||
| PCT/CN2014/075560 WO2015157955A1 (en) | 2014-04-17 | 2014-04-17 | Heterocyclic btk inhibit ors |
| PCT/CN2015/076766 WO2015158283A1 (en) | 2014-04-17 | 2015-04-16 | Heterocyclic kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017511365A JP2017511365A (ja) | 2017-04-20 |
| JP2017511365A5 true JP2017511365A5 (OSRAM) | 2018-05-31 |
Family
ID=54323386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016562835A Pending JP2017511365A (ja) | 2014-04-17 | 2015-04-16 | 複素環キナーゼ阻害薬 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10280184B2 (OSRAM) |
| EP (1) | EP3131900A4 (OSRAM) |
| JP (1) | JP2017511365A (OSRAM) |
| CN (1) | CN106459045A (OSRAM) |
| AU (1) | AU2015246482A1 (OSRAM) |
| BR (1) | BR112016024057A2 (OSRAM) |
| CA (1) | CA2946036A1 (OSRAM) |
| MX (1) | MX2016013564A (OSRAM) |
| WO (2) | WO2015157955A1 (OSRAM) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9932340B2 (en) * | 2014-12-18 | 2018-04-03 | Abbvie Inc. | Substituted indoles |
| EP3294737A4 (en) * | 2015-05-12 | 2018-10-03 | Kalyra Pharmaceuticals, Inc. | Bicyclic compounds |
| SG11201804210XA (en) * | 2015-11-20 | 2018-06-28 | Mingsight Pharmaceuticals Inc | Treatment of autoimmune disease |
| WO2017163078A1 (en) * | 2016-03-24 | 2017-09-28 | Mission Therapeutics Limited | 1-cyano-pyrrolidine derivatives as dbu inhibitors |
| GB201616511D0 (en) | 2016-09-29 | 2016-11-16 | Mission Therapeutics Limited | Novel compounds |
| WO2018098491A1 (en) | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| EP3548033B1 (en) | 2016-11-28 | 2024-04-10 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11492345B2 (en) | 2017-02-13 | 2022-11-08 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| KR102627756B1 (ko) * | 2017-03-22 | 2024-01-23 | 쑤저우 바이지부공 파마수티컬 테크널러지 컴퍼니 리미티드 | 브루톤 타이로신 키나제 억제제 |
| US11731966B2 (en) | 2017-04-04 | 2023-08-22 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11278535B2 (en) | 2017-08-15 | 2022-03-22 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| AU2019227607C1 (en) | 2018-02-27 | 2023-07-20 | Incyte Corporation | Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors |
| MA52940A (fr) | 2018-05-18 | 2021-04-28 | Incyte Corp | Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b |
| CN119350320A (zh) | 2018-05-30 | 2025-01-24 | 普拉克西斯精密药物股份有限公司 | 离子通道调节剂 |
| CA3105721A1 (en) * | 2018-07-05 | 2020-01-09 | Incyte Corporation | Fused pyrazine derivatives as a2a / a2b inhibitors |
| EA202092908A1 (ru) | 2018-09-28 | 2021-05-14 | Праксис Пресижн Медсинз, Инк. | Модуляторы ионных каналов |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| JP7345220B2 (ja) * | 2019-08-30 | 2023-09-15 | ティーエスディー ライフ サイエンス カンパニー リミテッド | イミダゾピリジン誘導体及びこれを有効成分として含有する薬学的組成物 |
| US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
| EP3915990A1 (en) | 2020-05-26 | 2021-12-01 | Centre National de la Recherche Scientifique | 4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-3,6-dihydropyridine-1-(2h)-carboxamide derivatives as limk and/or rock kinases inhibitors for use in the treatment of cancer |
| EP4157848A4 (en) * | 2020-06-01 | 2024-07-17 | Nanjing Ruijie Pharma Co., Ltd. | COMPOUNDS AND THEIR USES AS SPLEEN TYROSINE KINASE INHIBITORS |
| WO2021249417A1 (zh) * | 2020-06-09 | 2021-12-16 | 赛诺哈勃药业（成都）有限公司 | 杂环化合物及其衍生物 |
| GB202014114D0 (en) * | 2020-09-08 | 2020-10-21 | Synairgen Res Ltd | Use of inhaled interferon-beta to treat virus-induced exacerbations in copd patients undergoing treatment with a systemic corticosteroid |
| US20240083900A1 (en) * | 2020-11-13 | 2024-03-14 | Biogen Ma Inc. | Pyrazolo[1,5-a]pyrazine derivatives as btk inhibitors |
| WO2023220049A1 (en) * | 2022-05-10 | 2023-11-16 | Biogen Ma Inc. | Crystalline polymorphs of n-methyl-n-((1s,3s)-3-methyl-3-((6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)oxy)cyclobutyl)acrylamide |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040102455A1 (en) | 2001-01-30 | 2004-05-27 | Burns Christopher John | Method of inhibiting kinases |
| CN1496366A (zh) * | 2001-03-09 | 2004-05-12 | �Ʒ� | 作为抗炎剂的三唑并吡啶 |
| US7405295B2 (en) * | 2003-06-04 | 2008-07-29 | Cgi Pharmaceuticals, Inc. | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds |
| WO2005085252A1 (en) * | 2004-03-04 | 2005-09-15 | Biofocus Discovery Limited | Imidazo ‘1,2-a’ pyrazine compounds which interact with protein kinases |
| DE102004030782A1 (de) * | 2004-06-25 | 2006-01-19 | Fev Motorentechnik Gmbh | Fahrzeug-Steuergerät mit einem neuronalen Netz |
| US7713973B2 (en) * | 2004-10-15 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| CN101300233A (zh) * | 2005-09-09 | 2008-11-05 | 先灵公司 | 氮杂稠合的细胞周期蛋白依赖性激酶抑制剂 |
| DE102007032349A1 (de) * | 2007-07-11 | 2009-01-15 | Bayer Healthcare Ag | Imidazo-, Pyrazolopyrazine und Imidazotriazine und ihre Verwendung |
| PE20091074A1 (es) | 2007-12-13 | 2009-07-26 | Bayer Healthcare Ag | Triazolotriazinas y triazolopirazinas y su uso |
| EP2229390B1 (en) | 2007-12-14 | 2014-04-09 | F. Hoffmann-La Roche AG | Novel imidazoý1,2-a¨pyridine and imidazoý1,2-b¨pyridazine derivatives |
| CA2726460C (en) | 2008-07-15 | 2017-02-21 | F. Hoffmann-La Roche Ag | Novel phenyl-imidazopyridines and pyridazines |
| TWI453207B (zh) * | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| SG171993A1 (en) | 2008-12-08 | 2011-07-28 | Gilead Connecticut Inc | Imidazopyrazine syk inhibitors |
| WO2010068806A1 (en) | 2008-12-10 | 2010-06-17 | Cgi Pharmaceuticals, Inc. | Amide derivatives as btk inhibitors in the treatment of allergic, autoimmune and inflammatory disorders as well as cancer |
| WO2010068810A2 (en) * | 2008-12-10 | 2010-06-17 | Cgi Pharmaceuticals, Inc. | Certain substituted amides, method of making, and method of use thereof |
| EP2343294A1 (en) * | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
| NZ602362A (en) | 2010-03-11 | 2014-11-28 | Gilead Connecticut Inc | Imidazopyridines syk inhibitors |
| TWI541243B (zh) | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
| CA2821834A1 (en) * | 2010-12-17 | 2012-06-21 | Bayer Intellectual Property Gmbh | 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| WO2012136531A1 (en) | 2011-04-06 | 2012-10-11 | Bayer Pharma Aktiengesellschaft | Substituted imidazopyridines and intermediates thereof |
| WO2012163724A1 (en) * | 2011-05-31 | 2012-12-06 | F. Hoffmann-La Roche Ag | Triazolopyridine compounds |
| RU2662443C2 (ru) * | 2011-11-01 | 2018-07-26 | Ф. Хоффманн-Ля Рош Аг | Имидазопиридазины |
| JP5808869B2 (ja) | 2011-11-03 | 2015-11-10 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 二環式ピペラジン化合物 |
| BR112014013582A8 (pt) * | 2011-12-09 | 2017-06-13 | Hoffmann La Roche | inibidores de quinase de tirosina de bruton |
-
2014
- 2014-04-17 WO PCT/CN2014/075560 patent/WO2015157955A1/en not_active Ceased
-
2015
- 2015-04-16 US US15/304,131 patent/US10280184B2/en active Active
- 2015-04-16 AU AU2015246482A patent/AU2015246482A1/en not_active Abandoned
- 2015-04-16 EP EP15780191.1A patent/EP3131900A4/en not_active Withdrawn
- 2015-04-16 JP JP2016562835A patent/JP2017511365A/ja active Pending
- 2015-04-16 BR BR112016024057A patent/BR112016024057A2/pt not_active Application Discontinuation
- 2015-04-16 WO PCT/CN2015/076766 patent/WO2015158283A1/en not_active Ceased
- 2015-04-16 CA CA2946036A patent/CA2946036A1/en not_active Abandoned
- 2015-04-16 CN CN201580031633.1A patent/CN106459045A/zh active Pending
- 2015-04-16 MX MX2016013564A patent/MX2016013564A/es unknown
-
2018
- 2018-12-21 US US16/230,408 patent/US20190135836A1/en not_active Abandoned
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