JP2017511132A - ヒト造血幹／前駆細胞のエクスビボ拡大のための組成物および方法 - Google Patents

ヒト造血幹／前駆細胞のエクスビボ拡大のための組成物および方法 Download PDF

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JP2017511132A
JP2017511132A JP2016559216A JP2016559216A JP2017511132A JP 2017511132 A JP2017511132 A JP 2017511132A JP 2016559216 A JP2016559216 A JP 2016559216A JP 2016559216 A JP2016559216 A JP 2016559216A JP 2017511132 A JP2017511132 A JP 2017511132A
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cells
hematopoietic
cell
nuclease
hspc
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リー チャイ
リー チャイ
央 立津
央 立津
ダニエル ジェフリー テネン
ダニエル ジェフリー テネン
ジェームス エリオット ブラッドナー
ジェームス エリオット ブラッドナー
アレクサンダー フェデレーション
アレクサンダー フェデレーション
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Brigham and Womens Hospital Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/065—Modulators of histone acetylation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
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  • Developmental Biology & Embryology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Biochemistry (AREA)
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  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
JP2016559216A 2014-03-26 2015-03-25 ヒト造血幹／前駆細胞のエクスビボ拡大のための組成物および方法 Pending JP2017511132A (ja)

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US201461970787P 2014-03-26 2014-03-26
US61/970,787 2014-03-26
PCT/US2015/022557 WO2015148716A1 (en) 2014-03-26 2015-03-25 Compositions and methods for ex vivo expansion of human hematopoietic stem/progenitor cells

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JP2020076805A Withdrawn JP2020124212A (ja) 2014-03-26 2020-04-23 ヒト造血幹／前駆細胞のエクスビボ拡大のための組成物および方法
JP2022085669A Pending JP2022113722A (ja) 2014-03-26 2022-05-26 ヒト造血幹／前駆細胞のエクスビボ拡大のための組成物および方法

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JP2022085669A Pending JP2022113722A (ja) 2014-03-26 2022-05-26 ヒト造血幹／前駆細胞のエクスビボ拡大のための組成物および方法

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US (2) US20170173083A1 (https=)
EP (2) EP3122181A4 (https=)
JP (3) JP2017511132A (https=)
CN (2) CN112063586A (https=)
WO (1) WO2015148716A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020124212A (ja) * 2014-03-26 2020-08-20 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． ヒト造血幹／前駆細胞のエクスビボ拡大のための組成物および方法
US11390884B2 (en) 2015-05-11 2022-07-19 Editas Medicine, Inc. Optimized CRISPR/cas9 systems and methods for gene editing in stem cells

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ES2966886T3 (es) 2014-05-09 2024-04-24 Univ Yale Partículas recubiertas con poliglicerol hiperramificado y métodos de elaboración y uso de las mismas
CN108026526B (zh) 2015-06-09 2023-05-12 爱迪塔斯医药公司 用于改善移植的crispr/cas相关方法和组合物
US10669528B2 (en) 2015-06-25 2020-06-02 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
CN105238758A (zh) * 2015-09-17 2016-01-13 中国科学院广州生物医药与健康研究院 一种体外获得造血干/祖细胞的方法
JP2019508037A (ja) 2016-02-16 2019-03-28 イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔ 標的化遺伝子編集を増強するための組成物およびその使用方法
EP4049665B1 (en) * 2016-03-15 2025-03-12 The Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion
WO2017205977A1 (en) * 2016-06-01 2017-12-07 Universite De Montreal Selection of human hematopoetic stem cells using epcr
CN106119204A (zh) * 2016-06-20 2016-11-16 何力丰 一种可用于干细胞和基因治疗的改造细胞的基因技术
SG11201901199WA (en) * 2016-08-18 2019-03-28 Nat Univ Singapore Substituted azole derivatives for generation, proliferation and differentiation of hematopoietic stem and progenitor cells
EP3541410B1 (en) * 2016-11-16 2024-03-27 Yeditepe Üniversitesi A combination inhibiting meis proteins
WO2018187493A1 (en) 2017-04-04 2018-10-11 Yale University Compositions and methods for in utero delivery
US11866726B2 (en) 2017-07-14 2024-01-09 Editas Medicine, Inc. Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
CN109207427B (zh) * 2018-09-17 2020-12-08 诺未科技（银川）有限公司 一种将人造血祖细胞转变为造血干细胞的方法
CN109706119B (zh) * 2018-04-13 2020-11-27 诺未科技（北京）有限公司 扩增造血干细胞的培养体系、方法及其用途
CN110799641B (zh) * 2018-04-13 2021-02-19 诺未科技（北京）有限公司 丁酸钠的用途及含有丁酸钠的培养体系
IL260445B (en) * 2018-07-05 2019-08-29 Lempo Therapeutics Ltd Methods and compositions for modulating myeloperoxidase (mpo) expression
US20210214699A1 (en) * 2018-07-05 2021-07-15 Lempo Therapeutics Ltd Methods and compositions for modulating myeloperoxidase (mpo) expression
CN109207426B (zh) * 2018-09-17 2020-08-21 诺未科技（北京）有限公司 一种将人造血祖细胞转变为造血干细胞的方法
CN109593714A (zh) * 2018-12-28 2019-04-09 诺未科技（北京）有限公司 扩增造血干细胞的培养体系、方法及其用途
WO2020057107A1 (zh) * 2018-09-17 2020-03-26 诺未科技（北京）有限公司 一种组合物及其用途
CN109593716B (zh) * 2018-12-28 2021-04-09 诺未科技（北京）有限公司 扩增造血干细胞的培养体系、方法及其用途
CN109593715B (zh) * 2018-12-28 2020-12-08 北京承诺未来科技有限公司 扩增造血干细胞的培养体系、方法及其用途
CN109536447A (zh) * 2018-12-28 2019-03-29 诺未科技（北京）有限公司 扩增造血干细胞的培养体系、方法及其用途
CN109609455A (zh) * 2018-12-28 2019-04-12 诺未科技（北京）有限公司 扩增造血干细胞的培养体系、方法及其用途
CN110592017B (zh) * 2019-07-12 2021-02-19 中国医学科学院血液病医院(中国医学科学院血液学研究所) 组蛋白甲基转移酶抑制剂在制备促进巨核细胞增殖或血小板产生的产品中的用途
MX2022007376A (es) 2019-12-20 2022-09-02 Tenaya Therapeutics Inc Fluoroalqull-oxadiazoles y sus usos.
IL307883A (en) 2021-04-23 2023-12-01 Tenaya Therapeutics Inc HDAC6 inhibitors for use in the treatment of dilated myocardial disease
US20240252502A1 (en) 2021-05-04 2024-08-01 Tenaya Therapeutics, Inc. Hdac6 inhibitors for treatment of metabolic disease and hfpef
CN114958744A (zh) * 2022-07-12 2022-08-30 上海派思维新生物医药科技有限公司 一种离体干细胞扩大培养方法和应用
WO2024154828A1 (ja) 2023-01-20 2024-07-25 国立大学法人熊本大学 培地、製造方法、及び細胞製剤
WO2025215092A1 (en) 2024-04-10 2025-10-16 Institut National de la Santé et de la Recherche Médicale Selective hdac6 inhibitors for use in the treatment of myotonic dystrophy type 1

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JP2012510512A (ja) * 2008-12-03 2012-05-10 マサチューセッツ インスティテュート オブ テクノロジー 記憶を推進するためのｈｄａｃ２の阻害
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020124212A (ja) * 2014-03-26 2020-08-20 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． ヒト造血幹／前駆細胞のエクスビボ拡大のための組成物および方法
US11390884B2 (en) 2015-05-11 2022-07-19 Editas Medicine, Inc. Optimized CRISPR/cas9 systems and methods for gene editing in stem cells

Also Published As

Publication number Publication date
WO2015148716A1 (en) 2015-10-01
US20200121721A1 (en) 2020-04-23
EP3777534A1 (en) 2021-02-17
JP2020124212A (ja) 2020-08-20
EP3122181A4 (en) 2018-04-25
JP2022113722A (ja) 2022-08-04
CN112063586A (zh) 2020-12-11
US20170173083A1 (en) 2017-06-22
EP3122181A1 (en) 2017-02-01
CN106455542A (zh) 2017-02-22

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