JP2017508804A5 - - Google Patents
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- JP2017508804A5 JP2017508804A5 JP2016575626A JP2016575626A JP2017508804A5 JP 2017508804 A5 JP2017508804 A5 JP 2017508804A5 JP 2016575626 A JP2016575626 A JP 2016575626A JP 2016575626 A JP2016575626 A JP 2016575626A JP 2017508804 A5 JP2017508804 A5 JP 2017508804A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- compound
- weight
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 72
- 229940125904 compound 1 Drugs 0.000 claims description 41
- 239000007962 solid dispersion Substances 0.000 claims description 19
- 101001042041 Bos taurus Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Proteins 0.000 claims description 17
- 101000960234 Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Proteins 0.000 claims description 17
- 102100039905 Isocitrate dehydrogenase [NADP] cytoplasmic Human genes 0.000 claims description 17
- 230000035772 mutation Effects 0.000 claims description 17
- 239000013078 crystal Substances 0.000 claims description 12
- 208000037844 advanced solid tumor Diseases 0.000 claims description 11
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 10
- 201000007450 intrahepatic cholangiocarcinoma Diseases 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 9
- 102200069690 rs121913500 Human genes 0.000 claims description 9
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 9
- 108700028369 Alleles Proteins 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 claims description 8
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 8
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 claims description 7
- 102200069708 rs121913499 Human genes 0.000 claims description 7
- HWXBTNAVRSUOJR-UHFFFAOYSA-N 2-hydroxyglutaric acid Chemical compound OC(=O)C(O)CCC(O)=O HWXBTNAVRSUOJR-UHFFFAOYSA-N 0.000 claims description 6
- 238000004458 analytical method Methods 0.000 claims description 6
- 238000004611 spectroscopical analysis Methods 0.000 claims description 6
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims description 5
- 208000005243 Chondrosarcoma Diseases 0.000 claims description 5
- 206010009944 Colon cancer Diseases 0.000 claims description 5
- 108090000790 Enzymes Proteins 0.000 claims description 5
- 102000004190 Enzymes Human genes 0.000 claims description 5
- 206010018338 Glioma Diseases 0.000 claims description 5
- 206010060862 Prostate cancer Diseases 0.000 claims description 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 5
- 208000029742 colonic neoplasm Diseases 0.000 claims description 5
- 230000001419 dependent effect Effects 0.000 claims description 5
- 201000001441 melanoma Diseases 0.000 claims description 5
- 208000032612 Glial tumor Diseases 0.000 claims description 4
- 210000001124 body fluid Anatomy 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 238000004949 mass spectrometry Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000010839 body fluid Substances 0.000 claims description 3
- 102200069689 rs121913500 Human genes 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 claims description 2
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 claims description 2
- 238000005259 measurement Methods 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 229920003169 water-soluble polymer Polymers 0.000 claims description 2
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims 6
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 5
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 3
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 3
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 3
- 229960001681 croscarmellose sodium Drugs 0.000 claims 3
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 3
- 239000006185 dispersion Substances 0.000 claims 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000007884 disintegrant Substances 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 2
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 2
- 239000000314 lubricant Substances 0.000 claims 2
- 235000019359 magnesium stearate Nutrition 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 239000000080 wetting agent Substances 0.000 claims 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920002744 polyvinyl acetate phthalate Polymers 0.000 claims 1
- 238000010922 spray-dried dispersion Methods 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
- 238000000034 method Methods 0.000 description 42
- 206010028980 Neoplasm Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- 229940126062 Compound A Drugs 0.000 description 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
- 206010041067 Small cell lung cancer Diseases 0.000 description 1
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 208000000587 small cell lung carcinoma Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461953480P | 2014-03-14 | 2014-03-14 | |
| US61/953,480 | 2014-03-14 | ||
| PCT/US2015/020346 WO2015138837A1 (en) | 2014-03-14 | 2015-03-13 | Pharmaceutical compositions of therapeutically active compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019085619A Division JP2019163278A (ja) | 2014-03-14 | 2019-04-26 | 治療活性化合物の医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017508804A JP2017508804A (ja) | 2017-03-30 |
| JP2017508804A5 true JP2017508804A5 (enExample) | 2018-04-26 |
| JP6524119B2 JP6524119B2 (ja) | 2019-06-05 |
Family
ID=54072439
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016575626A Active JP6524119B2 (ja) | 2014-03-14 | 2015-03-13 | 治療活性化合物の医薬組成物 |
| JP2019085619A Withdrawn JP2019163278A (ja) | 2014-03-14 | 2019-04-26 | 治療活性化合物の医薬組成物 |
| JP2021035053A Withdrawn JP2021088605A (ja) | 2014-03-14 | 2021-03-05 | 治療活性化合物の医薬組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019085619A Withdrawn JP2019163278A (ja) | 2014-03-14 | 2019-04-26 | 治療活性化合物の医薬組成物 |
| JP2021035053A Withdrawn JP2021088605A (ja) | 2014-03-14 | 2021-03-05 | 治療活性化合物の医薬組成物 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20170007661A1 (enExample) |
| EP (1) | EP3116491B1 (enExample) |
| JP (3) | JP6524119B2 (enExample) |
| KR (1) | KR102458157B1 (enExample) |
| CN (2) | CN112206232A (enExample) |
| AU (2) | AU2015229212B2 (enExample) |
| BR (2) | BR112016021012B1 (enExample) |
| CA (1) | CA2942070A1 (enExample) |
| CY (1) | CY1125205T1 (enExample) |
| DK (1) | DK3116491T3 (enExample) |
| EA (2) | EA202090098A1 (enExample) |
| ES (1) | ES2881858T3 (enExample) |
| HR (1) | HRP20211233T1 (enExample) |
| HU (1) | HUE055209T2 (enExample) |
| IL (1) | IL247721B (enExample) |
| LT (1) | LT3116491T (enExample) |
| MA (1) | MA39725B1 (enExample) |
| MX (2) | MX2016011865A (enExample) |
| NZ (1) | NZ723860A (enExample) |
| PH (1) | PH12016501788B1 (enExample) |
| PL (1) | PL3116491T3 (enExample) |
| PT (1) | PT3116491T (enExample) |
| RS (1) | RS62178B1 (enExample) |
| SI (1) | SI3116491T1 (enExample) |
| SM (1) | SMT202100444T1 (enExample) |
| UA (2) | UA129317C2 (enExample) |
| WO (1) | WO2015138837A1 (enExample) |
| ZA (1) | ZA201606134B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| WO2015010297A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9968595B2 (en) | 2014-03-14 | 2018-05-15 | Agios Pharmaceuticals, Inc. | Pharmaceutical compositions of therapeutically active compounds |
| UA123401C2 (uk) | 2015-10-15 | 2021-03-31 | Аджиос Фармасьютікалз, Інк. | Комбінована терапія для лікування злоякісних пухлин |
| DK3362066T3 (da) | 2015-10-15 | 2021-11-22 | Les Laboratoires Servier Sas | Kombinationsterapi til behandling af maligniteter |
| IL298663A (en) | 2015-12-04 | 2023-01-01 | Agios Pharmaceuticals Inc | Methods for treating acute myeloid leukemia characterized by the presence of a mutant allele of idh2 and the absence of a mutant allele of nras |
| WO2017123808A1 (en) | 2016-01-15 | 2017-07-20 | The J. David Gladstone Institutes | Methods of treating disease by metabolic control of t-cell differentiation |
| WO2017146795A1 (en) * | 2016-02-26 | 2017-08-31 | Agios Pharmaceuticals, Inc. | Idh1 inhibitors for the treatment of haematological malignancies and solid tumours |
| WO2018085486A1 (en) * | 2016-11-02 | 2018-05-11 | University Of Cincinnati | Compositions and methods for treating patients suffering from glioma or leukemia |
| JP2020506905A (ja) * | 2017-01-20 | 2020-03-05 | コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | （ｒ）−ｎ−（（４−メトキシ−６−メチル−２−オキソ−１，２−ジヒドロピリジン−３−イル）メチル）−２−メチル−１−（１−（１−（２，２，２−トリフルオロエチル）ピペリジン−４−イル）エチル）−１ｈ−インドール−３−カルボキサミド固体分散液 |
| HUE061207T2 (hu) | 2017-09-22 | 2023-05-28 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Kristályos szulfamidvegyület |
| US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
| IL315423B1 (en) * | 2018-07-06 | 2026-04-01 | Servier Lab | Ivusidnib forms and pharmaceutical preparations |
| US20210069113A1 (en) * | 2019-09-11 | 2021-03-11 | Modavar Pharmaceuticals LLC | Solid unit dosage form for dose individualized drug delivery |
| TW202227446A (zh) | 2020-08-12 | 2022-07-16 | 美商施維雅製藥有限公司 | 有機化合物之固態形式 |
| CA3194380A1 (en) | 2020-10-02 | 2022-04-07 | Michael MORGEN | Acetic acid as processing aid in spray drying for basic drugs |
| CN112022812B (zh) * | 2020-11-03 | 2021-01-29 | 上海亚盛医药科技有限公司 | 一种包含杂环类化合物的组合物、其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8343548B2 (en) * | 2006-08-08 | 2013-01-01 | Shin-Etsu Chemical Co., Ltd. | Solid dosage form comprising solid dispersion |
| MX2009006806A (es) * | 2006-12-22 | 2009-08-27 | Vertex Pharma | Secado por rocio fluidizado. |
| US20100273808A1 (en) * | 2008-11-21 | 2010-10-28 | Millennium Pharmaceticals, Inc. | Lactate salt of 4-[6-methoxy-7-(3-piperidin-1-yl-propoxy)quinazolin-4-yl]piperazine-1-carboxylic acid(4-isopropoxyphenyl)-amide and pharmaceutical compositions thereof for the treatment of cancer and other diseases or disorders |
| ES2740424T3 (es) * | 2009-03-13 | 2020-02-05 | Agios Pharmaceuticals Inc | Métodos y composiciones para trastornos relacionados con la proliferación celular |
| US20120238576A1 (en) * | 2009-06-08 | 2012-09-20 | California Capital Equity, Llc | Triazine Derivatives and their Therapeutical Applications |
| US8652534B2 (en) * | 2009-10-14 | 2014-02-18 | Berry Pharmaceuticals, LLC | Compositions and methods for treatment of mammalian skin |
| PL2630146T3 (pl) * | 2010-10-21 | 2020-11-02 | Medivation Technologies Llc | Krystaliczna sól tosylanowa (8S,9R)-5-fluoro-8-(4-fluorofenylo)-9-(1-metylo-1H-1,2,4-triazol-5-ilo)-8,9-dihydro-2H-pirydo[4,3,2-de]ftalazyno-3(7H)-onu |
| CN102827170A (zh) * | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| LT2800743T (lt) * | 2012-01-06 | 2018-06-25 | Agios Pharmaceuticals, Inc. | Terapiškai aktyvūs junginiai ir jų panaudojimo būdai |
| US9474779B2 (en) * | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| WO2014015422A1 (en) * | 2012-07-27 | 2014-01-30 | Ontario Institute For Cancer Research | Cellulose-based nanoparticles for drug delivery |
| WO2015127173A1 (en) * | 2014-02-20 | 2015-08-27 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
-
2015
- 2015-03-13 EA EA202090098A patent/EA202090098A1/ru unknown
- 2015-03-13 CN CN202010472904.XA patent/CN112206232A/zh active Pending
- 2015-03-13 DK DK15761216.9T patent/DK3116491T3/da active
- 2015-03-13 CA CA2942070A patent/CA2942070A1/en active Pending
- 2015-03-13 PL PL15761216T patent/PL3116491T3/pl unknown
- 2015-03-13 RS RS20210962A patent/RS62178B1/sr unknown
- 2015-03-13 ES ES15761216T patent/ES2881858T3/es active Active
- 2015-03-13 LT LTEP15761216.9T patent/LT3116491T/lt unknown
- 2015-03-13 SM SM20210444T patent/SMT202100444T1/it unknown
- 2015-03-13 CN CN201580019581.6A patent/CN106163507B/zh active Active
- 2015-03-13 US US15/125,884 patent/US20170007661A1/en not_active Abandoned
- 2015-03-13 UA UAA202006348A patent/UA129317C2/uk unknown
- 2015-03-13 KR KR1020167027887A patent/KR102458157B1/ko active Active
- 2015-03-13 JP JP2016575626A patent/JP6524119B2/ja active Active
- 2015-03-13 MX MX2016011865A patent/MX2016011865A/es unknown
- 2015-03-13 HR HRP20211233TT patent/HRP20211233T1/hr unknown
- 2015-03-13 EA EA201691844A patent/EA034366B1/ru unknown
- 2015-03-13 BR BR112016021012-3A patent/BR112016021012B1/pt active IP Right Grant
- 2015-03-13 NZ NZ723860A patent/NZ723860A/en unknown
- 2015-03-13 EP EP15761216.9A patent/EP3116491B1/en active Active
- 2015-03-13 SI SI201531665T patent/SI3116491T1/sl unknown
- 2015-03-13 WO PCT/US2015/020346 patent/WO2015138837A1/en not_active Ceased
- 2015-03-13 AU AU2015229212A patent/AU2015229212B2/en active Active
- 2015-03-13 PT PT157612169T patent/PT3116491T/pt unknown
- 2015-03-13 HU HUE15761216A patent/HUE055209T2/hu unknown
- 2015-03-13 BR BR122023021436-6A patent/BR122023021436A2/pt not_active Application Discontinuation
- 2015-03-13 MA MA39725A patent/MA39725B1/fr unknown
- 2015-03-13 UA UAA201610408A patent/UA122962C2/uk unknown
-
2016
- 2016-09-05 ZA ZA2016/06134A patent/ZA201606134B/en unknown
- 2016-09-08 IL IL247721A patent/IL247721B/en active IP Right Grant
- 2016-09-13 MX MX2021001739A patent/MX2021001739A/es unknown
- 2016-09-13 PH PH12016501788A patent/PH12016501788B1/en unknown
-
2019
- 2019-04-26 JP JP2019085619A patent/JP2019163278A/ja not_active Withdrawn
- 2019-09-18 AU AU2019232825A patent/AU2019232825B2/en active Active
-
2021
- 2021-03-05 JP JP2021035053A patent/JP2021088605A/ja not_active Withdrawn
- 2021-08-02 CY CY20211100687T patent/CY1125205T1/el unknown
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