JP2017508768A5

JP2017508768A5 -

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Publication number: JP2017508768A5
Authority: JP; Japan
Prior art keywords: composition; pharmaceutical composition; subject; salvinorin; item
Prior art date: 2015-03-23
Legal status : Pending

Application number

JP2016558399A

Other languages

English (en)

Japanese (ja)

Other versions

JP2017508768A (ja

Filing date

2015-03-23

Publication date

2018-05-10

2015-03-23 Application filed filed Critical

2015-03-23 Priority claimed from PCT/US2015/021994 external-priority patent/WO2015143429A2/en

2017-03-30 Publication of JP2017508768A publication Critical patent/JP2017508768A/ja

2018-05-10 Publication of JP2017508768A5 publication Critical patent/JP2017508768A5/ja

Status Pending legal-status Critical Current

Links

OBSYBRPAKCASQB-AGQYDFLVSA-N salvinorin A Chemical group C=1([C@H]2OC(=O)[C@@H]3CC[C@]4(C)[C@@H]([C@]3(C2)C)C(=O)[C@@H](OC(C)=O)C[C@H]4C(=O)OC)C=COC=1 OBSYBRPAKCASQB-AGQYDFLVSA-N 0.000 claims description 49
239000000203 mixture Substances 0.000 claims description 30
239000008194 pharmaceutical composition Substances 0.000 claims description 30
OBSYBRPAKCASQB-UHFFFAOYSA-N Episalvinorin A Natural products COC(=O)C1CC(OC(C)=O)C(=O)C(C2(C3)C)C1(C)CCC2C(=O)OC3C=1C=COC=1 OBSYBRPAKCASQB-UHFFFAOYSA-N 0.000 claims description 25
IQXUYSXCJCVVPA-UHFFFAOYSA-N salvinorin A Natural products CC(=O)OC1CC(OC(=O)C)C2(C)CCC34CC(CC3(C)C2C1=O)(OC4=O)c5occc5 IQXUYSXCJCVVPA-UHFFFAOYSA-N 0.000 claims description 25
229920000858 Cyclodextrin Polymers 0.000 claims description 12
206010008089 Cerebral artery occlusion Diseases 0.000 claims description 10
208000010496 Heart Arrest Diseases 0.000 claims description 10
208000006011 Stroke Diseases 0.000 claims description 9
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 8
208000002381 Brain Hypoxia Diseases 0.000 claims description 6
201000006474 Brain Ischemia Diseases 0.000 claims description 6
206010008120 Cerebral ischaemia Diseases 0.000 claims description 6
206010008118 cerebral infarction Diseases 0.000 claims description 6
208000028389 Nerve injury Diseases 0.000 claims description 4
208000032851 Subarachnoid Hemorrhage Diseases 0.000 claims description 4
238000002680 cardiopulmonary resuscitation Methods 0.000 claims description 4
208000001286 intracranial vasospasm Diseases 0.000 claims description 4
230000008764 nerve damage Effects 0.000 claims description 4
ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 4
230000002490 cerebral effect Effects 0.000 claims description 3
230000004083 survival effect Effects 0.000 claims description 3
230000024883 vasodilation Effects 0.000 claims description 3
239000007864 aqueous solution Substances 0.000 claims description 2
210000004351 coronary vessel Anatomy 0.000 claims description 2
201000010099 disease Diseases 0.000 claims description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
238000001356 surgical procedure Methods 0.000 claims description 2
238000000034 method Methods 0.000 description 41
229930188950 salvinorin Natural products 0.000 description 24
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
238000001990 intravenous administration Methods 0.000 description 1

JP2016558399A 2014-03-21 2015-03-23 サルビノリン組成物およびその使用 Pending JP2017508768A (ja)