JP2017508759A5 - - Google Patents
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- JP2017508759A5 JP2017508759A5 JP2016556862A JP2016556862A JP2017508759A5 JP 2017508759 A5 JP2017508759 A5 JP 2017508759A5 JP 2016556862 A JP2016556862 A JP 2016556862A JP 2016556862 A JP2016556862 A JP 2016556862A JP 2017508759 A5 JP2017508759 A5 JP 2017508759A5
- Authority
- JP
- Japan
- Prior art keywords
- chromatography
- plasma
- column
- affinity
- fraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000000034 method Methods 0.000 claims 18
- 239000003446 ligand Substances 0.000 claims 13
- 238000001042 affinity chromatography Methods 0.000 claims 11
- 108060003951 Immunoglobulin Proteins 0.000 claims 9
- 102000018358 immunoglobulin Human genes 0.000 claims 9
- 108010088751 Albumins Proteins 0.000 claims 8
- 102000009027 Albumins Human genes 0.000 claims 8
- 238000000746 purification Methods 0.000 claims 8
- 102000008946 Fibrinogen Human genes 0.000 claims 7
- 108010049003 Fibrinogen Proteins 0.000 claims 7
- 229940012952 fibrinogen Drugs 0.000 claims 7
- 238000004440 column chromatography Methods 0.000 claims 6
- 239000006228 supernatant Substances 0.000 claims 6
- 102000004506 Blood Proteins Human genes 0.000 claims 5
- 108010017384 Blood Proteins Proteins 0.000 claims 5
- 238000004255 ion exchange chromatography Methods 0.000 claims 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 4
- 238000005571 anion exchange chromatography Methods 0.000 claims 3
- 239000012141 concentrate Substances 0.000 claims 3
- 238000012434 mixed-mode chromatography Methods 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 230000000717 retained effect Effects 0.000 claims 3
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims 2
- 108010043958 Peptoids Proteins 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 229960002446 octanoic acid Drugs 0.000 claims 2
- 238000001556 precipitation Methods 0.000 claims 2
- 239000012465 retentate Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- -1 Nanofichin Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 238000005349 anion exchange Methods 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 238000005277 cation exchange chromatography Methods 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 239000000535 fibrinogen concentrate Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 claims 1
- 230000015784 hyperosmotic salinity response Effects 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000001542 size-exclusion chromatography Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1451997 | 2014-03-11 | ||
| FR1451997A FR3018450B1 (fr) | 2014-03-11 | 2014-03-11 | Procede de preparation de proteines plasmatiques humaines |
| PCT/FR2015/050598 WO2015136217A1 (fr) | 2014-03-11 | 2015-03-10 | Procédé de préparation de protéines plasmatiques humaines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017508759A JP2017508759A (ja) | 2017-03-30 |
| JP2017508759A5 true JP2017508759A5 (https=) | 2018-04-19 |
Family
ID=51210517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556862A Pending JP2017508759A (ja) | 2014-03-11 | 2015-03-10 | ヒト血漿タンパク質を調製するための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20170073396A1 (https=) |
| EP (1) | EP3116527B1 (https=) |
| JP (1) | JP2017508759A (https=) |
| KR (1) | KR20160130495A (https=) |
| CN (1) | CN106103473A (https=) |
| AU (1) | AU2015228649A1 (https=) |
| CA (1) | CA2942203A1 (https=) |
| ES (1) | ES2759259T3 (https=) |
| FR (1) | FR3018450B1 (https=) |
| IL (1) | IL247508A0 (https=) |
| MX (1) | MX2016011641A (https=) |
| TW (1) | TW201620925A (https=) |
| WO (1) | WO2015136217A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3018450B1 (fr) | 2014-03-11 | 2016-04-15 | Lab Francais Du Fractionnement | Procede de preparation de proteines plasmatiques humaines |
| US10809247B2 (en) * | 2015-10-15 | 2020-10-20 | Plasma Technologies, Llc | Methods for extracting proteins from blood plasma |
| JP7163187B2 (ja) * | 2016-04-05 | 2022-10-31 | ヘモネティクス・コーポレーション | 血液からの免疫グロブリンの濃縮のための方法および装置 |
| KR20190026000A (ko) | 2016-07-06 | 2019-03-12 | 라보라토이레 프란카이즈 듀 프락티온네먼트 에트 데스 바이오테크놀로지스 | 안정적 액체 피브리노겐 |
| FR3053592B1 (fr) * | 2016-07-06 | 2020-05-29 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Fibrinogene liquide stable |
| EP3275897A1 (en) * | 2016-07-27 | 2018-01-31 | Biotest AG | Process for preparing immunoglobulin compositions |
| US20190161756A1 (en) | 2016-07-28 | 2019-05-30 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Anti-Immunoglobulin G Aptamers and Uses Thereof |
| FR3061020B1 (fr) | 2016-12-22 | 2019-05-17 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Composition de fibrinogene humain |
| EP3560946B1 (en) * | 2016-12-22 | 2022-02-02 | KM Biologics Co., Ltd. | Chromatographic method for collecting blood coagulation factor vii with high yield |
| AU2018233184B2 (en) * | 2017-03-16 | 2022-06-16 | Evolve Biologics Inc. | Method for purification of albumin |
| CN107216384A (zh) * | 2017-05-11 | 2017-09-29 | 深圳市卫光生物制品股份有限公司 | 一种人血浆转铁蛋白分离纯化的方法 |
| CN107033237B (zh) * | 2017-05-11 | 2021-07-20 | 深圳市卫光生物制品股份有限公司 | 一种人血浆载脂蛋白a-i的分离纯化方法 |
| CN107827974B (zh) * | 2017-11-10 | 2021-01-01 | 中国科学院过程工程研究所 | 一种人纤维蛋白原的制备方法 |
| CN108101981B (zh) * | 2018-01-15 | 2019-06-04 | 四川远大蜀阳药业有限责任公司 | 一种静注免疫球蛋白的生产工艺 |
| FR3081328B1 (fr) * | 2018-05-24 | 2021-01-01 | Lab Francais Du Fractionnement | Composition d'immunoglobulines humaines concentrees |
| FR3090321B1 (fr) * | 2018-12-21 | 2023-07-14 | Lab Francais Du Fractionnement | Procédé de filtration du fibrinogène |
| JP2022531317A (ja) * | 2019-05-03 | 2022-07-06 | ジェネンテック， インコーポレイテッド | 精製プラットフォームから得られた組成物中の酵素加水分解活性速度を低下させる方法 |
| CN110314414B (zh) * | 2019-07-23 | 2021-10-19 | 宝锐生物科技泰州有限公司 | 凝血因子xiii的分离纯化方法及其应用 |
| EP4090666A1 (en) | 2020-01-15 | 2022-11-23 | F. Hoffmann-La Roche AG | Methods to decrease impurities from recombinant protein manufacturing processes |
| EP3945095A1 (en) * | 2020-07-28 | 2022-02-02 | Bia Separations D.O.O. | A process for the purification of prothrombin complex concentrate (pcc) and fix from complete plasma or cryo-poor plasma |
| EP4329836A4 (en) * | 2021-06-11 | 2025-04-30 | Astaria Global, LLC | SYSTEM AND METHOD FOR ISOLATING ALPHA 2M MOLECULES |
| CN113754757B (zh) * | 2021-07-01 | 2024-06-14 | 华兰生物工程股份有限公司 | 一种人纤维蛋白原的制备方法 |
| CA3223881A1 (en) * | 2021-07-29 | 2023-02-02 | Roopsee ANAND | Method of purifying immunoglobulin g and uses thereof |
| CN113563457B (zh) * | 2021-08-20 | 2023-02-24 | 华兰生物工程股份有限公司 | 一种同时制备人纤维蛋白原、凝血因子ⅷ和纤溶酶原的方法 |
| CN114835801B (zh) * | 2022-06-20 | 2023-09-22 | 华润博雅生物制药集团股份有限公司 | 一种c1酯酶抑制剂及其制备方法 |
| CN117069836B (zh) * | 2023-09-22 | 2024-08-27 | 武汉中生毓晋生物医药有限责任公司 | 一种抗人t细胞兔免疫球蛋白的制备方法 |
| CN121021671B (zh) * | 2025-10-29 | 2026-02-06 | 通化安睿特生物制药股份有限公司 | 一种重组人血清白蛋白的纯化方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1055825A (fr) | 1951-02-20 | 1954-02-22 | Perfectionnement aux montures de lunettes optiques, solaires et faces supplémentaires solaires | |
| BE517346A (https=) | 1952-04-21 | |||
| CN1072419A (zh) * | 1991-11-20 | 1993-05-26 | 中国科学院大连化学物理研究所 | 径向色谱柱用离子交换介质的合成 |
| FR2706466B1 (fr) | 1993-06-14 | 1995-08-25 | Aetsrn | Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré. |
| ATE211486T1 (de) * | 1995-09-22 | 2002-01-15 | Zlb Bioplasma Ag | Verfahren zur gewinnung von immunglobulinen aus fraktionen, die bei der fraktionierung von menschlichem blutplasma entstehen |
| DK2270044T3 (en) * | 1998-06-09 | 2015-01-26 | Csl Behring Ag | Liquid immunoglobulin G (IgG) product |
| IL140155A (en) * | 1998-06-09 | 2005-12-18 | Statens Seruminstitut | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products |
| DE19858892A1 (de) * | 1998-12-19 | 2000-06-21 | Merck Patent Gmbh | Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße |
| SE0001128D0 (sv) * | 2000-03-30 | 2000-03-30 | Amersham Pharm Biotech Ab | A method of producing IgG |
| FR2824568B1 (fr) | 2001-05-11 | 2004-04-09 | Lab Francais Du Fractionnement | Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique |
| BRPI0514435B8 (pt) | 2004-08-20 | 2021-05-25 | American Nat Red Cross | isolamento sequêncial de proteínas e esquemas de purificação através de cromatografia por afinidade |
| EP1775001A1 (en) * | 2005-10-13 | 2007-04-18 | Xendo Holding B.V. | Device for chromatographic separations |
| FR2895263B1 (fr) * | 2005-12-26 | 2008-05-30 | Lab Francais Du Fractionnement | Concentre d'immunoglobines g (lg) appauvri en anticorps anti-a et anti-b, et en igg polyreactives |
| WO2007144476A1 (fr) * | 2006-06-16 | 2007-12-21 | Groupe Novasep | Procede de separation sequence multicolonnes |
| WO2008153472A1 (en) | 2007-06-15 | 2008-12-18 | Ge Healthcare Bio-Sciences Ab | Chromatography method |
| FR2929533B1 (fr) | 2008-04-03 | 2010-04-30 | Novasep | Procede de separation multicolonnes a gradient. |
| FR2939667B1 (fr) * | 2008-12-17 | 2012-01-27 | Fractionnement Et Des Biotechonologies Lab Franc | Composition d'immunoglobine g comme medicament pour le traitement de l'ictere neonatal par incompatibilite foetomaternelle dans le systeme abo |
| FR2942233B1 (fr) * | 2009-02-19 | 2015-03-13 | Lfb Biotechnologies | Moyens pour la purification d'une proteine du plasma sanguin, et procedes pour sa mise en oeuvre |
| FR2970003B1 (fr) | 2010-12-30 | 2013-01-25 | Lfb Biotechnologies | Procede d'immobilisation d'acides nucleiques |
| FR2977893B1 (fr) | 2011-07-11 | 2015-02-20 | Lab Francais Du Fractionnement | Procede de preparation d'un concentre d'immunoglobulines polyvalentes |
| EP2656892A1 (en) | 2012-04-23 | 2013-10-30 | Merck Patent GmbH | Chromatography method |
| FR3018450B1 (fr) | 2014-03-11 | 2016-04-15 | Lab Francais Du Fractionnement | Procede de preparation de proteines plasmatiques humaines |
-
2014
- 2014-03-11 FR FR1451997A patent/FR3018450B1/fr active Active
-
2015
- 2015-03-10 MX MX2016011641A patent/MX2016011641A/es unknown
- 2015-03-10 US US15/125,483 patent/US20170073396A1/en not_active Abandoned
- 2015-03-10 KR KR1020167028103A patent/KR20160130495A/ko not_active Withdrawn
- 2015-03-10 CN CN201580012945.8A patent/CN106103473A/zh active Pending
- 2015-03-10 JP JP2016556862A patent/JP2017508759A/ja active Pending
- 2015-03-10 AU AU2015228649A patent/AU2015228649A1/en not_active Abandoned
- 2015-03-10 CA CA2942203A patent/CA2942203A1/fr not_active Abandoned
- 2015-03-10 EP EP15717016.8A patent/EP3116527B1/fr not_active Revoked
- 2015-03-10 ES ES15717016T patent/ES2759259T3/es active Active
- 2015-03-10 WO PCT/FR2015/050598 patent/WO2015136217A1/fr not_active Ceased
- 2015-03-11 TW TW104107803A patent/TW201620925A/zh unknown
-
2016
- 2016-08-28 IL IL247508A patent/IL247508A0/en unknown
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