JP2017508749A5 - - Google Patents
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- Publication number
- JP2017508749A5 JP2017508749A5 JP2016555554A JP2016555554A JP2017508749A5 JP 2017508749 A5 JP2017508749 A5 JP 2017508749A5 JP 2016555554 A JP2016555554 A JP 2016555554A JP 2016555554 A JP2016555554 A JP 2016555554A JP 2017508749 A5 JP2017508749 A5 JP 2017508749A5
- Authority
- JP
- Japan
- Prior art keywords
- bladder
- gemcitabine
- patient
- day
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 34
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 32
- 229960005277 gemcitabine Drugs 0.000 claims 32
- 229940079593 drug Drugs 0.000 claims 13
- 238000011200 topical administration Methods 0.000 claims 6
- 238000012377 drug delivery Methods 0.000 claims 5
- 210000002700 urine Anatomy 0.000 claims 5
- 230000002459 sustained effect Effects 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 239000002357 osmotic agent Substances 0.000 claims 3
- 239000002562 thickening agent Substances 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 210000005068 bladder tissue Anatomy 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000003232 mucoadhesive effect Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000005086 pumping Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000005063 solubilization Methods 0.000 claims 1
- 230000007928 solubilization Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 210000003708 urethra Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461949215P | 2014-03-06 | 2014-03-06 | |
| US61/949,215 | 2014-03-06 | ||
| PCT/US2015/019262 WO2015134911A1 (en) | 2014-03-06 | 2015-03-06 | Drug delivery systems and methods for treatment of bladder cancer with gemcitabine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019184023A Division JP7061595B2 (ja) | 2014-03-06 | 2019-10-04 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017508749A JP2017508749A (ja) | 2017-03-30 |
| JP2017508749A5 true JP2017508749A5 (https=) | 2018-03-08 |
| JP6901858B2 JP6901858B2 (ja) | 2021-07-14 |
Family
ID=52697553
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555554A Active JP6901858B2 (ja) | 2014-03-06 | 2015-03-06 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2019184023A Active JP7061595B2 (ja) | 2014-03-06 | 2019-10-04 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2021183995A Active JP7383681B2 (ja) | 2014-03-06 | 2021-11-11 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2023190543A Active JP7802743B2 (ja) | 2014-03-06 | 2023-11-08 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2026001498A Pending JP2026062972A (ja) | 2014-03-06 | 2026-01-07 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019184023A Active JP7061595B2 (ja) | 2014-03-06 | 2019-10-04 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2021183995A Active JP7383681B2 (ja) | 2014-03-06 | 2021-11-11 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2023190543A Active JP7802743B2 (ja) | 2014-03-06 | 2023-11-08 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
| JP2026001498A Pending JP2026062972A (ja) | 2014-03-06 | 2026-01-07 | 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US20150250717A1 (https=) |
| EP (2) | EP3113782B1 (https=) |
| JP (5) | JP6901858B2 (https=) |
| KR (1) | KR102338079B1 (https=) |
| CN (2) | CN106102751A (https=) |
| AU (4) | AU2015226901B2 (https=) |
| BR (1) | BR112016020381A8 (https=) |
| CA (1) | CA2939979C (https=) |
| DK (2) | DK3113782T3 (https=) |
| ES (2) | ES3051417T3 (https=) |
| FI (1) | FI4124339T3 (https=) |
| HR (2) | HRP20251264T1 (https=) |
| HU (1) | HUE060704T2 (https=) |
| IL (2) | IL247347B2 (https=) |
| LT (2) | LT4124339T (https=) |
| MX (1) | MX2016011333A (https=) |
| PL (2) | PL4124339T3 (https=) |
| PT (2) | PT3113782T (https=) |
| RS (2) | RS67337B1 (https=) |
| RU (1) | RU2694902C1 (https=) |
| SG (2) | SG10202101978SA (https=) |
| SI (1) | SI4124339T1 (https=) |
| SM (2) | SMT202500385T1 (https=) |
| WO (1) | WO2015134911A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013308465B2 (en) | 2012-08-31 | 2018-05-17 | Taris Biomedical Llc | Drug delivery systems and methods for treatment of prostate disease comprising gemicitabine |
| CN113413393B (zh) | 2013-08-19 | 2025-03-04 | 塔里斯生物医药公司 | 多单元药物递送装置和方法 |
| US20150250717A1 (en) * | 2014-03-06 | 2015-09-10 | Taris Biomedical Llc | Drug delivery systems and methods for treatment of bladder cancer with gemcitabine |
| CN118453872A (zh) * | 2016-05-06 | 2024-08-09 | 塔里斯生物医药公司 | 治疗下尿路尿道上皮癌的方法 |
| SG10201913998YA (en) | 2017-07-25 | 2020-03-30 | Taris Biomedical Llc | Methods of treating tumor metastasis |
| IL302714B1 (en) * | 2017-11-08 | 2026-01-01 | Taris Biomedical Llc | Methods for treating and maintaining bladder cancer using gemcitabine |
| CN112839653A (zh) | 2018-08-01 | 2021-05-25 | 塔里斯生物医药公司 | 使用曲司氯铵治疗膀胱过度活动症的方法 |
| EP4039279A4 (en) * | 2019-10-03 | 2023-11-01 | Seikagaku Corporation | TRANSMUCOSAL MEDICINAL ACTIVE DELIVERY SYSTEM FOR THE BLADDER SUBMUCOSA |
| RU2713443C2 (ru) * | 2019-11-01 | 2020-02-05 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Способ комбинированного лечения мышечно-инвазивного рака мочевого пузыря т3-т4 n0-+m0 |
| US20230073301A1 (en) * | 2020-01-27 | 2023-03-09 | Isola Therapeutics, Inc. | Tissue dosing for intraluminal local drug delivery |
| CN112169066B (zh) * | 2020-10-29 | 2023-05-12 | 安徽省立医院(中国科学技术大学附属第一医院) | 具有控制器的连续缓释给药留置管 |
| CN113616666A (zh) * | 2021-08-24 | 2021-11-09 | 傅广波 | 膀胱黏膜下注射吉西他滨在治疗膀胱癌中的应用 |
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| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4111203A (en) * | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system with means for improving delivery kinetics of system |
| US6171298B1 (en) | 1996-05-03 | 2001-01-09 | Situs Corporation | Intravesical infuser |
| WO2002055058A2 (en) | 2001-01-09 | 2002-07-18 | Microchips, Inc. | Flexible microchip devices for ophthalmic and other applications |
| WO2009139984A2 (en) | 2008-04-04 | 2009-11-19 | Lipella Pharmaceuticals, Inc. | Method of treatment for bladder dysfunction |
| AU2003278881A1 (en) * | 2002-09-23 | 2004-04-08 | Microchips, Inc. | Micro-reservoir osmotic release systems and microtube array device |
| US20040260272A1 (en) | 2002-10-22 | 2004-12-23 | Friedman Craig D. | Method and system for intravesicular delivery of therapeutic agents |
| DE602004012081T2 (de) * | 2003-03-31 | 2009-03-19 | Intarcia Therapeutics, Inc., Emeryville | Osmotische pumpe mit mitteln zum ableiten des innendrucks |
| US8361490B2 (en) | 2004-09-16 | 2013-01-29 | Theracoat Ltd. | Biocompatible drug delivery apparatus and methods |
| JP5265359B2 (ja) | 2005-08-11 | 2013-08-14 | マサチューセッツ インスティテュート オブ テクノロジー | 膀胱内薬物送達デバイスおよび方法 |
| EP2012801A4 (en) * | 2006-04-24 | 2009-08-05 | Gloucester Pharmaceuticals Inc | GEMCITABINE COMBINATION THERAPY |
| EP1913962A1 (en) | 2006-10-22 | 2008-04-23 | Ophir Perelson | Expandable medical device for the treatment and prevention of cardiovascular diseases |
| US9586035B2 (en) | 2007-12-11 | 2017-03-07 | Massachusetts Institute Of Technology | Implantable drug delivery device and methods for treatment of the bladder and other body vesicles or lumens |
| JP2011528275A (ja) | 2008-07-17 | 2011-11-17 | ミセル テクノロジーズ，インク． | 薬物送達医療デバイス |
| EA201170297A1 (ru) | 2008-08-09 | 2011-08-30 | Массачусетс Инститьют Оф Текнолоджи | Имплантируемое устройство для доставки лекарственных средств и способ лечения мужской мочеполовой системы и окружающих тканей |
| CN102470237A (zh) | 2009-06-26 | 2012-05-23 | 塔里斯生物医药公司 | 用于可植入药物递送装置的固体药物片剂 |
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| PL3884988T3 (pl) | 2009-12-17 | 2025-09-08 | Taris Biomedical Llc | Urządzenie implantowalne z tolerancją wewnątrzpęcherzową |
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| US20110218488A1 (en) | 2010-03-05 | 2011-09-08 | Taris Biomedical, Inc. | Systems and Methods for Implanting Devices in the Bladder and Other Genitourinary Sites |
| CA2801314A1 (en) | 2010-06-02 | 2011-12-08 | Abraxis Bioscience, Llc | Methods of treating bladder cancer |
| DK2600800T3 (da) | 2010-08-05 | 2020-11-16 | Taris Biomedical Llc | Indretning til lægemiddellevering i en ureterstent og kit dertil |
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| JP6463266B2 (ja) | 2012-08-31 | 2019-01-30 | タリス バイオメディカル エルエルシー | 膀胱癌の治療のためのオキサリプラチンを含む薬物送達システム及び方法 |
| AU2013308465B2 (en) * | 2012-08-31 | 2018-05-17 | Taris Biomedical Llc | Drug delivery systems and methods for treatment of prostate disease comprising gemicitabine |
| BR112015005351A2 (pt) | 2012-09-18 | 2017-07-04 | Taris Biomedical Llc | sistemas para distribuição de drogas e métodos para tratamento de disfunção de esvaziamento da bexiga e outros distúrbios do trato urinário inferior |
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| CN113413393B (zh) * | 2013-08-19 | 2025-03-04 | 塔里斯生物医药公司 | 多单元药物递送装置和方法 |
| BR112016010103A8 (pt) * | 2013-11-05 | 2018-01-30 | Taris Biomedical Llc | métodos, kits e dispositivos de suprimento de fármaco osmótico. |
| US20150250717A1 (en) | 2014-03-06 | 2015-09-10 | Taris Biomedical Llc | Drug delivery systems and methods for treatment of bladder cancer with gemcitabine |
| RU2591946C2 (ru) | 2014-06-24 | 2016-07-20 | Владимир Эдуардович Анников | Способ изготовления гелеобразного водосодержащего взрывчатого состава |
| JP6856380B2 (ja) | 2014-06-26 | 2021-04-07 | タリス バイオメディカル エルエルシー | 弾性ポリマー−薬物マトリックス系を含む膀胱内薬物送達デバイス及び方法 |
| KR102658706B1 (ko) | 2015-04-23 | 2024-04-17 | 타리스 바이오메디컬 엘엘씨 | 약물-투과성 성분을 구비한 약물 전달 장치 및 방법 |
| CN118453872A (zh) | 2016-05-06 | 2024-08-09 | 塔里斯生物医药公司 | 治疗下尿路尿道上皮癌的方法 |
| SG10201913998YA (en) | 2017-07-25 | 2020-03-30 | Taris Biomedical Llc | Methods of treating tumor metastasis |
| IL302714B1 (en) | 2017-11-08 | 2026-01-01 | Taris Biomedical Llc | Methods for treating and maintaining bladder cancer using gemcitabine |
| CN112839653A (zh) | 2018-08-01 | 2021-05-25 | 塔里斯生物医药公司 | 使用曲司氯铵治疗膀胱过度活动症的方法 |
-
2015
- 2015-03-06 US US14/641,009 patent/US20150250717A1/en not_active Abandoned
- 2015-03-06 MX MX2016011333A patent/MX2016011333A/es unknown
- 2015-03-06 DK DK15711373.9T patent/DK3113782T3/da active
- 2015-03-06 BR BR112016020381A patent/BR112016020381A8/pt not_active Application Discontinuation
- 2015-03-06 SG SG10202101978SA patent/SG10202101978SA/en unknown
- 2015-03-06 CN CN201580011259.9A patent/CN106102751A/zh active Pending
- 2015-03-06 PL PL22196596.5T patent/PL4124339T3/pl unknown
- 2015-03-06 SM SM20250385T patent/SMT202500385T1/it unknown
- 2015-03-06 EP EP15711373.9A patent/EP3113782B1/en active Active
- 2015-03-06 LT LTEP22196596.5T patent/LT4124339T/lt unknown
- 2015-03-06 ES ES22196596T patent/ES3051417T3/es active Active
- 2015-03-06 PL PL15711373.9T patent/PL3113782T3/pl unknown
- 2015-03-06 SG SG11201607342QA patent/SG11201607342QA/en unknown
- 2015-03-06 SI SI201532080T patent/SI4124339T1/sl unknown
- 2015-03-06 KR KR1020167027303A patent/KR102338079B1/ko active Active
- 2015-03-06 HR HRP20251264TT patent/HRP20251264T1/hr unknown
- 2015-03-06 FI FIEP22196596.5T patent/FI4124339T3/fi active
- 2015-03-06 LT LTEPPCT/US2015/019262T patent/LT3113782T/lt unknown
- 2015-03-06 RS RS20251017A patent/RS67337B1/sr unknown
- 2015-03-06 CN CN202510128139.2A patent/CN119950539A/zh active Pending
- 2015-03-06 ES ES15711373T patent/ES2930435T3/es active Active
- 2015-03-06 AU AU2015226901A patent/AU2015226901B2/en active Active
- 2015-03-06 DK DK22196596.5T patent/DK4124339T3/da active
- 2015-03-06 EP EP22196596.5A patent/EP4124339B1/en active Active
- 2015-03-06 HR HRP20221252TT patent/HRP20221252T1/hr unknown
- 2015-03-06 RS RS20220937A patent/RS63675B1/sr unknown
- 2015-03-06 PT PT157113739T patent/PT3113782T/pt unknown
- 2015-03-06 CA CA2939979A patent/CA2939979C/en active Active
- 2015-03-06 IL IL247347A patent/IL247347B2/en unknown
- 2015-03-06 PT PT221965965T patent/PT4124339T/pt unknown
- 2015-03-06 WO PCT/US2015/019262 patent/WO2015134911A1/en not_active Ceased
- 2015-03-06 IL IL311410A patent/IL311410B2/en unknown
- 2015-03-06 JP JP2016555554A patent/JP6901858B2/ja active Active
- 2015-03-06 HU HUE15711373A patent/HUE060704T2/hu unknown
- 2015-03-06 RU RU2016136103A patent/RU2694902C1/ru active
- 2015-03-06 SM SM20220449T patent/SMT202200449T1/it unknown
-
2019
- 2019-10-04 JP JP2019184023A patent/JP7061595B2/ja active Active
-
2020
- 2020-08-12 AU AU2020217383A patent/AU2020217383B2/en active Active
-
2021
- 2021-11-11 JP JP2021183995A patent/JP7383681B2/ja active Active
- 2021-12-23 US US17/561,540 patent/US20220117886A1/en not_active Abandoned
-
2022
- 2022-07-07 US US17/811,296 patent/US12582599B2/en active Active
- 2022-08-08 AU AU2022215156A patent/AU2022215156B2/en active Active
-
2023
- 2023-11-08 JP JP2023190543A patent/JP7802743B2/ja active Active
-
2024
- 2024-11-08 AU AU2024259822A patent/AU2024259822A1/en active Pending
-
2026
- 2026-01-07 JP JP2026001498A patent/JP2026062972A/ja active Pending
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