RU2694902C1 - Системы и способы доставки лекарственных средств для лечения рака мочевого пузыря гемцитабином - Google Patents

Системы и способы доставки лекарственных средств для лечения рака мочевого пузыря гемцитабином Download PDF

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RU2694902C1
RU2694902C1 RU2016136103A RU2016136103A RU2694902C1 RU 2694902 C1 RU2694902 C1 RU 2694902C1 RU 2016136103 A RU2016136103 A RU 2016136103A RU 2016136103 A RU2016136103 A RU 2016136103A RU 2694902 C1 RU2694902 C1 RU 2694902C1
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gemcitabine
bladder
drug
patient
day
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Деннис ГИЗИНГ
Хэцзинь Ли
Карен Дениэл
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ТАРИС Биомедикал ЛЛК
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Veterinary Medicine (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
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  • Neurosurgery (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Nanotechnology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
RU2016136103A 2014-03-06 2015-03-06 Системы и способы доставки лекарственных средств для лечения рака мочевого пузыря гемцитабином RU2694902C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461949215P 2014-03-06 2014-03-06
US61/949,215 2014-03-06
PCT/US2015/019262 WO2015134911A1 (en) 2014-03-06 2015-03-06 Drug delivery systems and methods for treatment of bladder cancer with gemcitabine

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RU2694902C1 true RU2694902C1 (ru) 2019-07-18

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US (3) US20150250717A1 (https=)
EP (2) EP3113782B1 (https=)
JP (5) JP6901858B2 (https=)
KR (1) KR102338079B1 (https=)
CN (2) CN106102751A (https=)
AU (4) AU2015226901B2 (https=)
BR (1) BR112016020381A8 (https=)
CA (1) CA2939979C (https=)
DK (2) DK3113782T3 (https=)
ES (2) ES3051417T3 (https=)
FI (1) FI4124339T3 (https=)
HR (2) HRP20251264T1 (https=)
HU (1) HUE060704T2 (https=)
IL (2) IL247347B2 (https=)
LT (2) LT4124339T (https=)
MX (1) MX2016011333A (https=)
PL (2) PL4124339T3 (https=)
PT (2) PT3113782T (https=)
RS (2) RS67337B1 (https=)
RU (1) RU2694902C1 (https=)
SG (2) SG10202101978SA (https=)
SI (1) SI4124339T1 (https=)
SM (2) SMT202500385T1 (https=)
WO (1) WO2015134911A1 (https=)

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SG10202101978SA (en) 2021-04-29
PT4124339T (pt) 2025-11-04
CN106102751A (zh) 2016-11-09
LT3113782T (lt) 2022-11-25
NZ723303A (en) 2023-10-27
BR112016020381A2 (pt) 2017-08-15
WO2015134911A1 (en) 2015-09-11
PL4124339T3 (pl) 2025-11-17
CN119950539A (zh) 2025-05-09
AU2022215156A1 (en) 2022-09-01
IL247347B2 (en) 2025-03-01
BR112016020381A8 (pt) 2018-05-02
EP3113782A1 (en) 2017-01-11
IL311410B2 (en) 2025-11-01
SMT202200449T1 (it) 2023-01-13
JP7383681B2 (ja) 2023-11-20
JP2017508749A (ja) 2017-03-30
PL3113782T3 (pl) 2023-01-23
JP2019218410A (ja) 2019-12-26
IL247347A0 (en) 2016-11-30
MX2016011333A (es) 2016-12-07
JP7061595B2 (ja) 2022-04-28
CA2939979C (en) 2023-03-21
HRP20221252T1 (hr) 2022-12-09
US12582599B2 (en) 2026-03-24
PT3113782T (pt) 2023-01-05
FI4124339T3 (fi) 2025-10-17
US20220117886A1 (en) 2022-04-21
SMT202500385T1 (it) 2025-11-10
AU2015226901A1 (en) 2016-09-01
SI4124339T1 (sl) 2025-11-28
HUE060704T2 (hu) 2023-04-28
IL311410B1 (en) 2025-07-01
IL311410A (en) 2024-05-01
ES2930435T3 (es) 2022-12-13
ES3051417T3 (en) 2025-12-29
AU2020217383B2 (en) 2022-09-08
US20150250717A1 (en) 2015-09-10
EP3113782B1 (en) 2022-09-28
US20220347091A1 (en) 2022-11-03
JP6901858B2 (ja) 2021-07-14
SG11201607342QA (en) 2016-10-28
JP2024009034A (ja) 2024-01-19
EP4124339A1 (en) 2023-02-01
IL247347B1 (en) 2024-11-01
AU2022215156B2 (en) 2024-09-05
DK4124339T3 (da) 2025-10-13
AU2024259822A1 (en) 2024-11-28
KR102338079B1 (ko) 2021-12-09
JP2022022235A (ja) 2022-02-03
RS67337B1 (sr) 2025-11-28
AU2015226901B2 (en) 2020-05-14
HRP20251264T1 (hr) 2025-12-05
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