JP2017508744A5 - - Google Patents
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- JP2017508744A5 JP2017508744A5 JP2016555329A JP2016555329A JP2017508744A5 JP 2017508744 A5 JP2017508744 A5 JP 2017508744A5 JP 2016555329 A JP2016555329 A JP 2016555329A JP 2016555329 A JP2016555329 A JP 2016555329A JP 2017508744 A5 JP2017508744 A5 JP 2017508744A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- inhibitor
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- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 101150096839 Fcmr gene Proteins 0.000 claims 14
- 230000000694 effects Effects 0.000 claims 11
- 239000003112 inhibitor Substances 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 5
- 239000012275 CTLA-4 inhibitor Substances 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000012270 PD-1 inhibitor Substances 0.000 claims 4
- 239000012668 PD-1-inhibitor Substances 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 238000012790 confirmation Methods 0.000 claims 4
- 229940121655 pd-1 inhibitor Drugs 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 3
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 102100032814 ATP-dependent zinc metalloprotease YME1L1 Human genes 0.000 claims 2
- 101800000795 Proadrenomedullin N-20 terminal peptide Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- PIRWNASAJNPKHT-SHZATDIYSA-N pamp Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)N)C(C)C)C1=CC=CC=C1 PIRWNASAJNPKHT-SHZATDIYSA-N 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 101100463133 Caenorhabditis elegans pdl-1 gene Proteins 0.000 claims 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 229940125563 LAG3 inhibitor Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461949927P | 2014-03-07 | 2014-03-07 | |
| US61/949,927 | 2014-03-07 | ||
| PCT/IB2015/001033 WO2015132675A2 (en) | 2014-03-07 | 2015-03-06 | Methods and compositions for modifying the immune response |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019106087A Division JP2019147839A (ja) | 2014-03-07 | 2019-06-06 | 免疫応答を調節するための方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017508744A JP2017508744A (ja) | 2017-03-30 |
| JP2017508744A5 true JP2017508744A5 (Direct) | 2018-05-31 |
| JP6538707B2 JP6538707B2 (ja) | 2019-07-03 |
Family
ID=54016312
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555329A Expired - Fee Related JP6538707B2 (ja) | 2014-03-07 | 2015-03-06 | 免疫応答を調節するための方法及び組成物 |
| JP2019106087A Pending JP2019147839A (ja) | 2014-03-07 | 2019-06-06 | 免疫応答を調節するための方法及び組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019106087A Pending JP2019147839A (ja) | 2014-03-07 | 2019-06-06 | 免疫応答を調節するための方法及び組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20150252434A1 (Direct) |
| EP (2) | EP3113798B1 (Direct) |
| JP (2) | JP6538707B2 (Direct) |
| KR (1) | KR20160127817A (Direct) |
| AU (1) | AU2015225867B2 (Direct) |
| CA (3) | CA2941693A1 (Direct) |
| IL (1) | IL247614B (Direct) |
| WO (3) | WO2015132675A2 (Direct) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
| EP3113798B1 (en) | 2014-03-07 | 2019-06-05 | University Health Network | Methods and compositions for modifying the immune response |
| EP3098237B1 (en) | 2015-05-28 | 2018-08-01 | Universität Zu Köln | Anti-toso chimeric antigen receptor and its use |
| EP4364741A3 (en) | 2017-08-18 | 2024-07-03 | Cothera Bioscience, Inc. | Polymorphic form of tg02 |
| WO2020150639A1 (en) | 2019-01-18 | 2020-07-23 | Dracen Pharmaceuticals, Inc. | Combinaton therapy with a don prodrug and an immune checkpoint inhibitor |
| EA202192254A1 (ru) * | 2019-02-15 | 2021-11-29 | Юниверсити Хелт Нетворк | Fcmr-связывающие молекулы и их применение |
| WO2020219721A1 (en) * | 2019-04-23 | 2020-10-29 | The Broad Institute, Inc. | Compositions and methods characterizing metastasis |
| WO2020252336A1 (en) | 2019-06-12 | 2020-12-17 | Vanderbilt University | Dibenzylamines as amino acid transport inhibitors |
| WO2020252353A1 (en) | 2019-06-12 | 2020-12-17 | Vanderbilt University | Amino acid transport inhibitors and the uses thereof |
| AU2020302928A1 (en) | 2019-06-27 | 2022-02-03 | Medstar Health, Inc. | HDAC6-activated macrophages, compositions, and uses thereof |
| CN114127073B (zh) | 2019-07-16 | 2024-05-31 | 密歇根大学董事会 | 作为eed抑制剂的咪唑并嘧啶和其用途 |
| JP7196798B2 (ja) | 2019-08-09 | 2022-12-27 | 株式会社Soken | 超音波センサ |
| WO2021041664A1 (en) | 2019-08-27 | 2021-03-04 | The Regents Of The University Of Michigan | Cereblon e3 ligase inhibitors |
| CN115605268A (zh) * | 2020-03-26 | 2023-01-13 | 康尔义明生物制药公司（Ca） | 抗pd-1抗体及使用方法 |
| US12522623B2 (en) | 2020-03-26 | 2026-01-13 | Regents Of The University Of Michigan | Small molecule STAT protein degraders |
| WO2022187423A1 (en) | 2021-03-03 | 2022-09-09 | The Regents Of The University Of Michigan | Cereblon ligands |
| WO2025151487A2 (en) | 2024-01-08 | 2025-07-17 | Regents Of The University Of Michigan | Small-molecule inhibitors of adar1 |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
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| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
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| EP0229046B1 (fr) | 1985-03-30 | 1994-05-04 | BALLIVET, Marc | Procede d'obtention d'adn, arn, peptides, polypeptides ou proteines, par une technique de recombinaison d'adn |
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| EP3113798B1 (en) | 2014-03-07 | 2019-06-05 | University Health Network | Methods and compositions for modifying the immune response |
-
2015
- 2015-03-06 EP EP15757961.6A patent/EP3113798B1/en active Active
- 2015-03-06 KR KR1020167027415A patent/KR20160127817A/ko not_active Ceased
- 2015-03-06 US US14/641,023 patent/US20150252434A1/en not_active Abandoned
- 2015-03-06 EP EP19170244.8A patent/EP3616718A1/en not_active Withdrawn
- 2015-03-06 WO PCT/IB2015/001033 patent/WO2015132675A2/en not_active Ceased
- 2015-03-06 US US14/640,318 patent/US20150250853A1/en not_active Abandoned
- 2015-03-06 JP JP2016555329A patent/JP6538707B2/ja not_active Expired - Fee Related
- 2015-03-06 WO PCT/IB2015/000996 patent/WO2015132672A2/en not_active Ceased
- 2015-03-06 AU AU2015225867A patent/AU2015225867B2/en not_active Ceased
- 2015-03-06 CA CA2941693A patent/CA2941693A1/en not_active Abandoned
- 2015-03-06 CA CA2941697A patent/CA2941697A1/en not_active Abandoned
- 2015-03-07 CA CA2941691A patent/CA2941691A1/en not_active Abandoned
- 2015-03-07 US US14/641,358 patent/US10533222B2/en not_active Expired - Fee Related
- 2015-03-07 WO PCT/IB2015/000912 patent/WO2015132670A2/en not_active Ceased
-
2016
- 2016-09-04 IL IL247614A patent/IL247614B/en active IP Right Grant
-
2019
- 2019-06-06 JP JP2019106087A patent/JP2019147839A/ja active Pending
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