JP2017508466A5 - - Google Patents

Info

Publication number

JP2017508466A5

JP2017508466A5 JP2016555705A JP2016555705A JP2017508466A5 JP 2017508466 A5 JP2017508466 A5 JP 2017508466A5 JP 2016555705 A JP2016555705 A JP 2016555705A JP 2016555705 A JP2016555705 A JP 2016555705A JP 2017508466 A5 JP2017508466 A5 JP 2017508466A5

Authority

JP

Japan

Prior art keywords

item

car

seq

nucleic acid

cells

Prior art date

2015-03-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 29
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 17
• 150000007523 nucleic acids Chemical group 0.000 claims description 11
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 7
• 230000005754 cellular signaling Effects 0.000 claims description 7
• 206010028980 Neoplasm Diseases 0.000 claims description 6
• 201000011510 cancer Diseases 0.000 claims description 6
• 108090000623 proteins and genes Proteins 0.000 claims description 6
• 108020004707 nucleic acids Proteins 0.000 claims description 4
• 102000039446 nucleic acids Human genes 0.000 claims description 4
• 238000004519 manufacturing process Methods 0.000 claims description 3
• 238000000034 method Methods 0.000 claims description 3
• 206010029260 Neuroblastoma Diseases 0.000 claims description 2
• 239000003085 diluting agent Substances 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims description 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
• 210000004027 cell Anatomy 0.000 claims 6
• 239000000203 mixture Substances 0.000 claims 3
• 125000006850 spacer group Chemical group 0.000 description 5
• 230000003834 intracellular effect Effects 0.000 description 3
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 2
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 2
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 2
• 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 2
• 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• 108020004705 Codon Proteins 0.000 description 1
• 239000003814 drug Substances 0.000 description 1