CN106536563B - 嵌合抗原受体 - Google Patents

嵌合抗原受体 Download PDF

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CN106536563B
CN106536563B CN201580011327.1A CN201580011327A CN106536563B CN 106536563 B CN106536563 B CN 106536563B CN 201580011327 A CN201580011327 A CN 201580011327A CN 106536563 B CN106536563 B CN 106536563B
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car
cells
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cell
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CN106536563A (zh
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M.普莱
J.安德森
S.托马斯
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Autolus Ltd
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UCL Business Ltd
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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CN201580011327.1A 2014-03-06 2015-03-06 嵌合抗原受体 Active CN106536563B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1403972.1 2014-03-06
GB201403972A GB201403972D0 (en) 2014-03-06 2014-03-06 Chimeric antigen receptor
PCT/GB2015/050649 WO2015132604A1 (en) 2014-03-06 2015-03-06 Chimeric antigen receptor

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CN106536563A CN106536563A (zh) 2017-03-22
CN106536563B true CN106536563B (zh) 2020-02-07

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US (3) US10975162B2 (OSRAM)
EP (4) EP3114147B1 (OSRAM)
JP (1) JP6422134B2 (OSRAM)
KR (1) KR101965040B1 (OSRAM)
CN (1) CN106536563B (OSRAM)
AU (1) AU2015225950B2 (OSRAM)
CA (1) CA2941159C (OSRAM)
CL (1) CL2016002196A1 (OSRAM)
DK (1) DK3114147T3 (OSRAM)
ES (1) ES2673123T3 (OSRAM)
GB (1) GB201403972D0 (OSRAM)
HU (1) HUE038625T2 (OSRAM)
MX (1) MX360707B (OSRAM)
NZ (1) NZ723471A (OSRAM)
PL (1) PL3114147T3 (OSRAM)
PT (1) PT3114147T (OSRAM)
RU (1) RU2685479C2 (OSRAM)
SG (1) SG11201606790XA (OSRAM)
TR (1) TR201807939T4 (OSRAM)
WO (1) WO2015132604A1 (OSRAM)

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