JP2017508000A5 - - Google Patents

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Publication number
JP2017508000A5
JP2017508000A5 JP2016563908A JP2016563908A JP2017508000A5 JP 2017508000 A5 JP2017508000 A5 JP 2017508000A5 JP 2016563908 A JP2016563908 A JP 2016563908A JP 2016563908 A JP2016563908 A JP 2016563908A JP 2017508000 A5 JP2017508000 A5 JP 2017508000A5
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JP
Japan
Prior art keywords
pharmaceutical composition
composition according
eno1
subject
diabetes
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Application number
JP2016563908A
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English (en)
Japanese (ja)
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JP2017508000A (ja
JP6644006B2 (ja
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Priority claimed from PCT/US2015/011275 external-priority patent/WO2015106295A2/en
Publication of JP2017508000A publication Critical patent/JP2017508000A/ja
Publication of JP2017508000A5 publication Critical patent/JP2017508000A5/ja
Application granted granted Critical
Publication of JP6644006B2 publication Critical patent/JP6644006B2/ja
Expired - Fee Related legal-status Critical Current
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JP2016563908A 2014-01-13 2015-01-13 エノラーゼ1(eno1)組成物及びその使用 Expired - Fee Related JP6644006B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461926913P 2014-01-13 2014-01-13
US61/926,913 2014-01-13
US201462009783P 2014-06-09 2014-06-09
US62/009,783 2014-06-09
US201562100881P 2015-01-07 2015-01-07
US62/100,881 2015-01-07
PCT/US2015/011275 WO2015106295A2 (en) 2014-01-13 2015-01-13 Enolase 1 (eno1) compositions and uses thereof

Publications (3)

Publication Number Publication Date
JP2017508000A JP2017508000A (ja) 2017-03-23
JP2017508000A5 true JP2017508000A5 (cg-RX-API-DMAC7.html) 2018-02-22
JP6644006B2 JP6644006B2 (ja) 2020-02-12

Family

ID=53524434

Family Applications (2)

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JP2016563908A Expired - Fee Related JP6644006B2 (ja) 2014-01-13 2015-01-13 エノラーゼ1(eno1)組成物及びその使用
JP2016563909A Expired - Fee Related JP6629234B2 (ja) 2014-01-13 2015-01-13 エノラーゼ1(eno1)組成物及びその使用

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JP2016563909A Expired - Fee Related JP6629234B2 (ja) 2014-01-13 2015-01-13 エノラーゼ1(eno1)組成物及びその使用

Country Status (14)

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US (4) US10188708B2 (cg-RX-API-DMAC7.html)
EP (2) EP3094379A4 (cg-RX-API-DMAC7.html)
JP (2) JP6644006B2 (cg-RX-API-DMAC7.html)
KR (1) KR20160106175A (cg-RX-API-DMAC7.html)
CN (3) CN106102835B (cg-RX-API-DMAC7.html)
AU (2) AU2015204452A1 (cg-RX-API-DMAC7.html)
BR (1) BR112016016153A2 (cg-RX-API-DMAC7.html)
CA (2) CA2936691A1 (cg-RX-API-DMAC7.html)
EA (1) EA201691420A1 (cg-RX-API-DMAC7.html)
HK (1) HK1231425A1 (cg-RX-API-DMAC7.html)
IL (1) IL246720A0 (cg-RX-API-DMAC7.html)
MX (1) MX2016009102A (cg-RX-API-DMAC7.html)
SG (1) SG11201605698XA (cg-RX-API-DMAC7.html)
WO (2) WO2015106295A2 (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3094379A4 (en) * 2014-01-13 2017-06-28 Berg LLC Enolase 1 (eno1) compositions and uses thereof
CN107847560A (zh) * 2015-06-22 2018-03-27 博格有限责任公司 包括eno1的组合物以及其在治疗肥胖症或超重和减少体重增加的方法中的用途
WO2017062363A1 (en) * 2015-10-05 2017-04-13 Joslin Diabetes Center Methods of use of betatrophin
AU2017278261A1 (en) 2016-06-05 2019-01-31 Berg Llc Systems and methods for patient stratification and identification of potential biomarkers
CN107991493B (zh) * 2017-11-22 2020-03-31 中国医科大学附属第一医院 抗eno1自身抗体在对ait孕妇筛查和预测流产风险中的应用
CN112111462B (zh) * 2020-09-14 2022-08-23 兰州大学 烯醇化酶eno1单克隆抗体及其应用
CA3236326A1 (en) * 2021-11-26 2023-06-01 Hunilife Biotechnology, Inc. Methods to regulate glycolysis via targeting extracellular alpha-enolase for treating human diseases
CN114533902A (zh) * 2022-02-28 2022-05-27 河南师范大学 一种过表达lrrc15基因的质粒载体及其制备方法和应用
CN115786317A (zh) * 2022-12-12 2023-03-14 江苏三联生物工程股份有限公司 重组神经元特异性烯醇化酶及其制备方法与应用

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69233126T2 (de) 1992-09-25 2004-04-15 Neorx Corp., Seattle Therapeutischer inhibitor der vaskulären glatten muskelzellen
AU4278296A (en) 1994-10-25 1996-05-15 Immulogic Pharmaceutical Corporation Compositions and treatment for multiple sclerosis
US5552524A (en) 1995-01-31 1996-09-03 Eli Lilly And Company Anti-obesity proteins
US20030044795A1 (en) 1996-09-06 2003-03-06 Inger Byrajalsen Biochemical markers of the human endometrium
US7078375B1 (en) 1996-10-25 2006-07-18 Peter Mose Larsen Diabetes-mediating proteins and therapeutic uses thereof
US6329501B1 (en) 1997-05-29 2001-12-11 Auburn University Methods and compositions for targeting compounds to muscle
IL148225A0 (en) 1999-09-01 2002-09-12 Subsidiary No 3 Inc Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
WO2001016323A2 (en) 1999-09-01 2001-03-08 Subsidiary N0.3, Inc. Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
WO2001030973A2 (en) 1999-10-25 2001-05-03 Princeton University Genetic sequences associated with neural cell proliferation and disease
US20030166549A1 (en) * 2000-02-02 2003-09-04 Klaus Schughart Targeting peptides
US20030203372A1 (en) 2000-12-08 2003-10-30 Ward Neil Raymond Analysis method
US20040236091A1 (en) 2001-03-28 2004-11-25 Chicz Roman M. Translational profiling
US20040058326A1 (en) 2001-07-27 2004-03-25 Brooksbank Robert Alan Identification and use of molecules implicated in pain
US20050191627A1 (en) 2001-09-28 2005-09-01 Incyte Corporation Enzymes
WO2003064501A1 (en) 2002-01-31 2003-08-07 Clarke Slemon Conformationally restricted compounds as dendrimer cores
US20050222023A1 (en) 2002-02-07 2005-10-06 Hans-Peter Hauser Albumin-fused kunitz domain peptides
JP2004081111A (ja) 2002-08-27 2004-03-18 Yamaguchi Technology Licensing Organization Ltd 虚血性心疾患の治療薬として新規活性を有するα−エノラーゼおよびその利用法
CA2503748A1 (en) 2002-11-08 2004-05-27 Genentech, Inc. Compositions and methods for the treatment of natural killer cell related diseases
US8124582B2 (en) 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
CN101518535A (zh) * 2002-12-06 2009-09-02 法布罗根股份有限公司 脂肪调节
AU2003294828A1 (en) 2002-12-17 2004-07-09 Sinogenomax Co. Ltd. Chinese National Human Genomecenter Specific markers for pancreatic cancer
AU2003300178A1 (en) 2002-12-30 2004-07-29 Ppd Development, Lp Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
WO2004084950A2 (en) 2003-03-24 2004-10-07 Case Western Reserve University Cell targeting methods and compositions
US7473531B1 (en) 2003-08-08 2009-01-06 Colora Corporation Pancreatic cancer targets and uses thereof
WO2005019258A2 (en) 2003-08-11 2005-03-03 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
JP2005073621A (ja) 2003-09-01 2005-03-24 Japan Science & Technology Agency 脳腫瘍マーカーと脳腫瘍の診断方法
CA2540529C (en) 2003-10-03 2012-03-13 Vib Vzw Means and methods for the recruitment and identification of stem cells
US8133733B2 (en) * 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
EP1664775A4 (en) 2004-07-06 2008-03-12 Kuhnil Pharm Co Ltd COMPOSITION FOR THE DIAGNOSIS OF RETINAL VASCULAR DISEASE COMPRISING ALDOLASE AND DIAGNOSTIC METHOD USING THE SAME
WO2007046818A2 (en) 2004-11-16 2007-04-26 Board Of Regents, The University Of Texas System Compositions and methods related to synchronous selection of homing peptides for multiple tissues by in vivo phage display
EP1843781B1 (en) * 2005-01-03 2015-03-18 Jeon, Sook-yeong Composition for prevention, treatment and diagnosis of chronic inflammatory airway diseases
US7608413B1 (en) 2005-03-25 2009-10-27 Celera Corporation Kidney disease targets and uses thereof
JP5137814B2 (ja) 2005-04-06 2013-02-06 ジェンザイム・コーポレーション 治療ターゲティングのための酸不安定リンカーを介するpegおよびポリシアルリソソーム酵素のコンジュゲート
US20070248628A1 (en) 2005-12-06 2007-10-25 Keller Lorraine H Immunogens in cancer stem cells
TWI304443B (en) 2005-12-30 2008-12-21 Nat Health Research Institutes Alpha-enolase specific antibody and method of use
WO2008012362A2 (en) 2006-07-27 2008-01-31 Oxford Genome Sciences (Uk) Ltd New protein isoforms and uses thereof
ATE542831T1 (de) 2006-09-29 2012-02-15 Ribovax Biotechnologies Sa Neue antigene und antikörper, die mit adenokarzinomen des pankreasgangs assoziiert sind
US20100047256A1 (en) 2007-01-25 2010-02-25 Imperial Innovations Limited Methods
WO2008134761A2 (en) 2007-04-30 2008-11-06 Intezyne Technologies, Inc. Modification of biological targeting groups for the treatment of cancer
CN103212085A (zh) * 2007-07-12 2013-07-24 普罗森那技术公司 用于使化合物靶向多种选定器官或组织的分子
EP2080812A1 (en) 2008-01-18 2009-07-22 Transmedi SA Compositions and methods of detecting post-stop peptides
JP5429707B2 (ja) 2008-03-27 2014-02-26 国立大学法人群馬大学 微粒子およびその製造方法
US20110130346A1 (en) * 2008-05-30 2011-06-02 Isis Innovation Limited Peptide conjugates for delvery of biologically active compounds
JP2011528557A (ja) 2008-07-18 2011-11-24 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド 過体重動物と関連する障害を治療するための組成物および方法
EP2194382A1 (en) 2008-12-03 2010-06-09 Universität des Saarlandes An in-vitro method or assay for detecting a tumor or a cancerous disease by screening for antibodies
US20110269665A1 (en) 2009-06-26 2011-11-03 Avi Biopharma, Inc. Compound and method for treating myotonic dystrophy
IT1398782B1 (it) 2009-09-11 2013-03-18 Novelli Peptide monofosforilato isolato derivato dall'alfa-enolasi umana utile per la diagnosi e il trattamento dell'adenocarcinoma pancreatico, anticorpi diretti contro il suddetto peptide monofosforilato e loro usi.
US20120309684A1 (en) 2009-11-30 2012-12-06 Isis Innovation Limited Conjugates for delivery of biologically active compounds
WO2011072290A2 (en) * 2009-12-11 2011-06-16 The Regents Of The University Of Michigan Targeted dendrimer-drug conjugates
WO2011147981A2 (en) 2010-05-28 2011-12-01 Mind-Nrg Sa Neuregulin isoforms, neuregulin polypeptides and uses thereof
WO2012065034A1 (en) 2010-11-12 2012-05-18 Merck Sharp & Dohme Corp. Enolase peptide conjugate vaccines against staphylococcus aureus
ES2560012T3 (es) * 2011-05-10 2016-02-17 Institut National De La Santé Et De La Recherche Médicale (Inserm) Métodos y composiciones farmacéuticas para el tratamiento de enfermedades autoinmunitarias
GB201113814D0 (en) 2011-08-10 2011-09-28 Proteome Sciences R & D Gmbh & Co Kg Materials and methods for determining sensitivity potential of compounds
EP2751128B1 (en) 2011-08-30 2021-03-03 United Kingdom Research and Innovation Cell-penetrating peptides having a central hydrophobic domain
CN109276717B (zh) 2011-12-14 2022-04-12 得克萨斯系统大学董事会 用于癌症疗法的连带基因失活生物标志和靶标
WO2014018851A1 (en) 2012-07-26 2014-01-30 Joslin Diabetes Center, Inc. Predicting and treating diabetic complications
EP2914247A4 (en) 2012-10-30 2016-06-29 Particle Sciences Inc DRUG DELIVERY PARTICLE FORMULATIONS WITH TARGETING ELEMENTS
EP3094379A4 (en) * 2014-01-13 2017-06-28 Berg LLC Enolase 1 (eno1) compositions and uses thereof
CN107847560A (zh) 2015-06-22 2018-03-27 博格有限责任公司 包括eno1的组合物以及其在治疗肥胖症或超重和减少体重增加的方法中的用途
WO2017011836A1 (en) 2015-07-16 2017-01-19 Berg Llc Enolase 1 (eno1) compositions and uses thereof

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