JP2017504666A - 高分子放射線源 - Google Patents
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- C08G64/20—General preparatory processes
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Abstract
Description
・キレート剤を使用しなかった。
・アセチルアセトンを使用した。
・D03A系キレーター(BFC)を使用した。
Claims (20)
- 放射性ポリマーの製造方法であって、
放射性同位元素と、アミンを含む二官能性リガンドとの錯体を供給する工程と、
前記錯体をポリマーと混合する工程と、
を含む製造方法。 - 前記放射性同位元素と二官能性リガンドとの錯体が、金属放射性同位元素と二官能性キレート剤との錯体として実施される、請求項1に記載の製造方法。
- 前記金属放射性同位元素が、89Sr、169Yb、90Y、192Ir、l03Pd、177Lu、149Pm、140La、153Sm、186Re、188Re、166Ho、166Dy、137Cs、57Co、169Er、165Dy、97Ru、193mPt、l95mPt、105Rh、68Ni、67Cu、64Cu、109Cd、111Ag、198Au、199Au、201Tl、175Yb、47Sc、159Gd、および212Biからなる群から選択される放射性同位元素から選択される、請求項2に記載の製造方法。
- 前記放射性同位元素と二官能性リガンドとの錯体が、ヨウ素化されたボルトンハンター試薬として実施される、請求項1に記載の製造方法。
- 前記ヨウ素化されたボルトンハンター試薬が、25Iおよび131Iからなる群から選択される非金属放射性同位元素を含む、請求項4に記載の製造方法。
- ポリマーと結合した放射性同位元素と二官能性リガンドとの錯体を含む放射性ポリマー。
- 前記放射性同位元素と二官能性リガンドとの錯体が、金属放射性同位元素と二官能性キレート剤との錯体として実装される、請求項6に記載の放射性ポリマー。
- 前記金属放射性同位元素が、89Sr、169Yb、90Y、192Ir、l03Pd、177Lu、149Pm、140La、153Sm、186Re、188Re、166Ho、166Dy、137Cs、57Co、169Er、165Dy、97Ru、193mPt、l95mPt、105Rh、68Ni、67Cu、64Cu、109Cd、111Ag、198Au、199Au、201Tl、175Yb、47Sc、159Gd、および212Biからなる群から選択される放射性同位元素から選択される、請求項7に記載の放射性ポリマー。
- 前記放射性同位元素と二官能性リガンドとの錯体が、ヨウ素化されたボルトンハンター試薬として実装される、請求項6に記載の放射性ポリマー。
- 前記ヨウ素化されたボルトンハンター試薬が、25Iおよび131Iからなる群から選択される非金属放射性同位元素を含む、請求項9に記載の放射性ポリマー。
- 高分子放射線源の製造方法であって、
治療領域の外形表面および形状データを含む画像データを取得する工程と、
前記画像データにしたがって放射性ポリマーを高分子放射線源に成形する工程と、
を含む製造方法。 - 前記放射性ポリマーが、ポリマーと結合した放射性同位元素と二官能性リガンドとの錯体として実施される、請求項11に記載の製造方法。
- 前記放射性同位元素が、89Sr、90Sr、169Yb、90Y、192Ir、25I、131I、103Pd、177Lu、149Pm、140La、153Sm、186Re、188Re、166Ho、166Dy、137Cs、57Co、169Er、165Dy、97Ru、193mPt、l95mPt、105Rh、68Ni、67Cu、64Cu、109Cd、111Ag、198Au、199Au、201Tl、175Yb、47Sc、159Gd、および212Biからなる群から選択される、請求項11に記載の製造方法。
- 前記高分子放射線源が、少なくとも部分的に高分子のケースに入れられた少なくとも1つの放射性同位元素を含む、請求項11に記載の製造方法。
- 前記放射性同位元素が、89Sr、90Sr、169Yb、32P、33P、90Y、192Ir、25I、131I、103Pd、177Lu、149Pm、140La、153Sm、186Re、188Re、166Ho、166Dy、137Cs、57Co、169Er、165Dy、97Ru、193mPt、l95mPt、105Rh、68Ni、67Cu、64Cu、109Cd、111Ag、198Au、199Au、201Tl、175Yb、47Sc、159Gd、212Bi、および77Asからなる群から選択される、請求項14に記載の製造方法。
- 前記放射性同位元素が、微粒子放射性同位元素として実施される、請求項15に記載の製造方法。
- 前記高分子放射線源が、アルファ粒子放射体、ベータマイナスおよびベータプラス放射体、オージェ電子放射体、ガンマ線放射体、およびX線放射体からなる群から選択される放射線放射体を含む、請求項14に記載の製造方法。
- 前記放射性同位元素が、中性子放射化ガラスを含む、請求項14に記載の製造方法。
- 前記中性子放射化ガラスが、サマリウム−153、ホルミウム−166、エルビウム−169、ジスプロシウム−165、レニウム−186、レニウム−188、およびイットリウム−90を含む、アルミノケイ酸塩、ケイ酸アルミン酸マグネシウム、およびアルミノゲルマン酸カリウムからなる群から選択される、請求項18に記載の製造方法。
- 遮蔽材で構成される放射線遮蔽層を前記高分子放射線源に加える工程をさらに含む、請求項14に記載の製造方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361891361P | 2013-10-15 | 2013-10-15 | |
US61/891,361 | 2013-10-15 | ||
PCT/US2014/060205 WO2015057531A2 (en) | 2013-10-15 | 2014-10-12 | Polymeric radiation-sources |
Publications (2)
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JP2017504666A true JP2017504666A (ja) | 2017-02-09 |
JP6777971B2 JP6777971B2 (ja) | 2020-10-28 |
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JP2016524449A Active JP6777971B2 (ja) | 2013-10-15 | 2014-10-12 | 高分子放射線源 |
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US (3) | US10384078B2 (ja) |
EP (1) | EP3057621A4 (ja) |
JP (1) | JP6777971B2 (ja) |
CN (1) | CN105813657B (ja) |
AU (1) | AU2014334706B2 (ja) |
CA (1) | CA2927500C (ja) |
IL (1) | IL245099A (ja) |
WO (1) | WO2015057531A2 (ja) |
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KR101783881B1 (ko) | 2016-05-18 | 2017-10-10 | 서울대학교병원 | 액상 방사성 동위원소를 이용한 원격 후장착 방사선 근접 치료 장치 |
DE102016122715B4 (de) * | 2016-11-24 | 2019-07-25 | Surgiceye Gmbh | Scaffold-Brachytherapy mit integrierter Visualisierung |
US11351395B2 (en) | 2017-02-09 | 2022-06-07 | Oncobeta International Gmbh | Model for applying radiation, method for producing the same, and use thereof |
GB201714392D0 (en) | 2017-09-07 | 2017-10-25 | Marsteller Laurence | Methods and devices for treating glaucoma |
US20230241411A1 (en) * | 2017-09-07 | 2023-08-03 | Radiance Therapeutics, Inc. | Methods, systems, and compositions for maintaining functioning drainage blebs associated with minimally invasive micro sclerostomy |
JP2022502160A (ja) | 2018-09-28 | 2022-01-11 | ラディアンス セラピューティクス、インコーポレイテッド | 低侵襲マイクロ強膜切開術に関連した、機能しているドレナージ小疱を維持するための方法、システム、及び組成物 |
USD933225S1 (en) | 2018-11-29 | 2021-10-12 | Radiance Therapeutics, Inc. | Ophthalmic brachytherapy device |
USD933226S1 (en) | 2018-11-29 | 2021-10-12 | Radiance Therapeutics, Inc. | Ophthalmic brachytherapy set |
CN113556994A (zh) | 2018-11-29 | 2021-10-26 | 光辉疗法公司 | 应用β辐射的眼科近距离放射治疗系统和装置 |
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US11406843B2 (en) | 2022-08-09 |
AU2014334706A1 (en) | 2016-05-19 |
CN105813657A (zh) | 2016-07-27 |
US20230096064A1 (en) | 2023-03-30 |
EP3057621A4 (en) | 2017-06-21 |
IL245099A (en) | 2017-11-30 |
EP3057621A2 (en) | 2016-08-24 |
CA2927500C (en) | 2021-12-28 |
CN105813657B (zh) | 2020-09-11 |
IL245099A0 (en) | 2016-06-30 |
WO2015057531A2 (en) | 2015-04-23 |
JP6777971B2 (ja) | 2020-10-28 |
CA2927500A1 (en) | 2015-04-23 |
US20150105602A1 (en) | 2015-04-16 |
WO2015057531A3 (en) | 2015-10-29 |
US10384078B2 (en) | 2019-08-20 |
AU2014334706B2 (en) | 2018-07-19 |
US20200086141A1 (en) | 2020-03-19 |
US11957933B2 (en) | 2024-04-16 |
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