JP2017503749A5 - - Google Patents
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- Publication number
- JP2017503749A5 JP2017503749A5 JP2016519779A JP2016519779A JP2017503749A5 JP 2017503749 A5 JP2017503749 A5 JP 2017503749A5 JP 2016519779 A JP2016519779 A JP 2016519779A JP 2016519779 A JP2016519779 A JP 2016519779A JP 2017503749 A5 JP2017503749 A5 JP 2017503749A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- cyclic
- acyclic
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361885384P | 2013-10-01 | 2013-10-01 | |
| US61/885,384 | 2013-10-01 | ||
| US201461934618P | 2014-01-31 | 2014-01-31 | |
| US61/934,618 | 2014-01-31 | ||
| PCT/US2014/058680 WO2015051030A2 (en) | 2013-10-01 | 2014-10-01 | Stabilized polypeptides and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017503749A JP2017503749A (ja) | 2017-02-02 |
| JP2017503749A5 true JP2017503749A5 (OSRAM) | 2018-08-30 |
Family
ID=52779285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519779A Pending JP2017503749A (ja) | 2013-10-01 | 2014-10-01 | 安定化されたポリペプチドおよびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20160244494A1 (OSRAM) |
| EP (1) | EP3052520A4 (OSRAM) |
| JP (1) | JP2017503749A (OSRAM) |
| CN (1) | CN106103472A (OSRAM) |
| IL (1) | IL244810A0 (OSRAM) |
| WO (1) | WO2015051030A2 (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| PL2118123T3 (pl) | 2007-01-31 | 2016-06-30 | Dana Farber Cancer Inst Inc | Stabilizowane peptydy p53 i ich zastosowania |
| KR101525754B1 (ko) | 2007-03-28 | 2015-06-09 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
| CA2807685C (en) | 2010-08-13 | 2020-10-06 | Aileron Therapeutics, Inc. | P53 derived peptidomimetic macrocycle |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| CA2864120A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| BR112014020103A2 (pt) | 2012-02-15 | 2018-10-09 | Aileron Therapeutics, Inc. | macrociclos peptidomiméticos |
| WO2014138429A2 (en) | 2013-03-06 | 2014-09-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and use thereof in regulating hif1alpha |
| CN105764491A (zh) | 2013-12-09 | 2016-07-13 | 度瑞公司 | 药物活性剂复合物、聚合物复合物，以及包括其的组合物和方法 |
| SG10201902598VA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof |
| MX2017003797A (es) | 2014-09-24 | 2017-06-15 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos y usos de los mismos. |
| US10253067B2 (en) | 2015-03-20 | 2019-04-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| WO2017004548A1 (en) | 2015-07-01 | 2017-01-05 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| EP3538125A4 (en) | 2016-11-09 | 2020-10-07 | Ohio State Innovation Foundation | DISULPHIDE-BOUND CELL PENETRATION PEPTIDES, THEIR PREPARATION AND USE METHODS |
| US11352394B2 (en) | 2016-11-22 | 2022-06-07 | Ohio State Innovation Foundation | Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof |
| WO2018098226A1 (en) | 2016-11-22 | 2018-05-31 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha |
| EA202090513A1 (ru) | 2017-09-07 | 2020-08-24 | Фог Фармасьютикалз, Инк. | Агенты, модулирующие функции бета-катенина, и связанные способы |
| WO2019070962A1 (en) | 2017-10-04 | 2019-04-11 | Ohio State Innovation Foundation | BICYCLIC PEPTIDE INHIBITORS |
| CN112119085B (zh) | 2017-12-15 | 2025-04-01 | 丹娜-法伯癌症研究院有限公司 | 稳定肽-介导的靶向蛋白降解 |
| US11434263B2 (en) | 2018-01-05 | 2022-09-06 | President And Fellows Of Harvard College | Stabilized polypeptides and uses thereof |
| US11793884B2 (en) | 2018-01-29 | 2023-10-24 | Ohio State Innovation Foundation | Cyclic peptidyl inhibitors of CAL-PDZ binding domain |
| CA3089279A1 (en) | 2018-02-07 | 2019-08-15 | Dana-Farber Cancer Institute, Inc. | Cell-permeable stapled peptide modules for cellular delivery |
| US11987647B2 (en) | 2018-05-09 | 2024-05-21 | Ohio State Innovation Foundation | Cyclic cell-penetrating peptides with one or more hydrophobic residues |
| WO2020023502A1 (en) | 2018-07-23 | 2020-01-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| BR112021003113A2 (pt) | 2018-08-20 | 2021-05-11 | Fog Pharmaceuticals, Inc. | coleções de peptídeos, agentes de peptídeos e métodos de uso dos mesmos |
| US20230174576A1 (en) * | 2020-10-30 | 2023-06-08 | Xeno-Interface Inc. | Beta-strand bridge peptide |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1207301A (en) * | 1999-10-15 | 2001-04-30 | Avatar Medical, Llc | Stabilized proteins |
| DK2332968T3 (en) * | 2003-11-05 | 2016-08-22 | Dana Farber Cancer Inst Inc | Alpha-helix peptides suitable for activating or inhibiting cell death |
| CN100595277C (zh) * | 2003-11-15 | 2010-03-24 | 波利弗尔有限公司 | 模板固定的β发夹环模拟物及其在噬菌体展示中的用途 |
| WO2005118620A2 (en) * | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| WO2006069001A2 (en) * | 2004-12-20 | 2006-06-29 | Baylor College Of Medicine | Structural requirements for stat3 binding and recruitment to phosphototyrosine ligands |
| KR101525754B1 (ko) * | 2007-03-28 | 2015-06-09 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
| WO2010011313A2 (en) * | 2008-07-23 | 2010-01-28 | President And Fellows Of Harvard College | Ligation of stapled polypeptides |
| WO2011008260A2 (en) * | 2009-07-13 | 2011-01-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| WO2011163423A2 (en) * | 2010-06-22 | 2011-12-29 | University Of Central Florida Research Foundation, Inc. | Methods and compositions for cell permeable stat3 inhibitor |
-
2014
- 2014-10-01 CN CN201480065507.3A patent/CN106103472A/zh active Pending
- 2014-10-01 WO PCT/US2014/058680 patent/WO2015051030A2/en not_active Ceased
- 2014-10-01 EP EP14850442.6A patent/EP3052520A4/en not_active Withdrawn
- 2014-10-01 US US15/026,473 patent/US20160244494A1/en not_active Abandoned
- 2014-10-01 JP JP2016519779A patent/JP2017503749A/ja active Pending
-
2016
- 2016-03-29 IL IL244810A patent/IL244810A0/en unknown
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