JP2017503749A - 安定化されたポリペプチドおよびその使用 - Google Patents

安定化されたポリペプチドおよびその使用 Download PDF

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Publication number
JP2017503749A
JP2017503749A JP2016519779A JP2016519779A JP2017503749A JP 2017503749 A JP2017503749 A JP 2017503749A JP 2016519779 A JP2016519779 A JP 2016519779A JP 2016519779 A JP2016519779 A JP 2016519779A JP 2017503749 A JP2017503749 A JP 2017503749A
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Japan
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substituted
unsubstituted
cyclic
acyclic
branched
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JP2016519779A
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English (en)
Japanese (ja)
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JP2017503749A5 (OSRAM
Inventor
ヴァーダイン，グレゴリー，エル．
ナーゲル，イボンヌ，アリス
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Harvard University
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Harvard University
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Publication of JP2017503749A publication Critical patent/JP2017503749A/ja
Publication of JP2017503749A5 publication Critical patent/JP2017503749A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016519779A 2013-10-01 2014-10-01 安定化されたポリペプチドおよびその使用 Pending JP2017503749A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361885384P 2013-10-01 2013-10-01
US61/885,384 2013-10-01
US201461934618P 2014-01-31 2014-01-31
US61/934,618 2014-01-31
PCT/US2014/058680 WO2015051030A2 (en) 2013-10-01 2014-10-01 Stabilized polypeptides and uses thereof

Publications (2)

Publication Number Publication Date
JP2017503749A true JP2017503749A (ja) 2017-02-02
JP2017503749A5 JP2017503749A5 (OSRAM) 2018-08-30

Family

ID=52779285

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016519779A Pending JP2017503749A (ja) 2013-10-01 2014-10-01 安定化されたポリペプチドおよびその使用

Country Status (6)

Country Link
US (1) US20160244494A1 (OSRAM)
EP (1) EP3052520A4 (OSRAM)
JP (1) JP2017503749A (OSRAM)
CN (1) CN106103472A (OSRAM)
IL (1) IL244810A0 (OSRAM)
WO (1) WO2015051030A2 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2022092295A1 (OSRAM) * 2020-10-30 2022-05-05

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
CA2677045C (en) 2007-01-31 2016-10-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
KR101623985B1 (ko) 2007-03-28 2016-05-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
KR102104762B1 (ko) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
CN108929375A (zh) 2011-10-18 2018-12-04 爱勒让治疗公司 拟肽大环化合物
EP2819688A4 (en) 2012-02-15 2015-10-28 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES CROSS-LINKED WITH TRIAZOLE AND THIOETHER
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
WO2014138429A2 (en) 2013-03-06 2014-09-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and use thereof in regulating hif1alpha
CA2931547A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
SG10201902598VA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
CN106999541A (zh) 2014-09-24 2017-08-01 艾瑞朗医疗公司 拟肽大环化合物及其用途
MX2017011834A (es) 2015-03-20 2018-04-11 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN110114075B (zh) 2016-11-09 2024-01-12 俄亥俄州国家创新基金会 含有二硫化物的细胞穿透肽及其制备和使用方法
WO2018098282A2 (en) * 2016-11-22 2018-05-31 Ohio State Innovation Foundation Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof
WO2018098226A1 (en) 2016-11-22 2018-05-31 Ohio State Innovation Foundation Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha
JP2020533413A (ja) 2017-09-07 2020-11-19 フォグ ファーマシューティカルズ， インコーポレイテッド ベータ−カテニンの機能を調節する薬剤及びその方法
WO2019070962A1 (en) 2017-10-04 2019-04-11 Ohio State Innovation Foundation BICYCLIC PEPTIDE INHIBITORS
WO2019118893A1 (en) 2017-12-15 2019-06-20 Dana-Farber Cancer Institute, Inc. Stabilized peptide-mediated targeted protein degradation
WO2019136209A1 (en) * 2018-01-05 2019-07-11 President And Fellows Of Harvard College Stabilized polypeptides and uses thereof
US11793884B2 (en) 2018-01-29 2023-10-24 Ohio State Innovation Foundation Cyclic peptidyl inhibitors of CAL-PDZ binding domain
EP3749678A1 (en) 2018-02-07 2020-12-16 Dana Farber Cancer Institute, Inc. Cell-permeable stapled peptide modules for cellular delivery
EP3790890A4 (en) 2018-05-09 2022-03-02 Ohio State Innovation Foundation CYCLIC PEPTIDES OF CELL PENETRATION WITH ONE OR MORE HYDROPHOBIC RESIDUES
WO2020023502A1 (en) 2018-07-23 2020-01-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
EP3840766A4 (en) 2018-08-20 2022-06-22 Fog Pharmaceuticals, Inc. Collections of peptides, peptide agents, and methods of use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005118620A2 (en) * 2004-05-27 2005-12-15 New York University Methods for preparing internally constraied peptides and peptidomimetics
JP2008500260A (ja) * 2003-11-15 2008-01-10 ポリファー リミテッド テンプレート固定β−ヘアピンループ模倣体とそのファージディスプレイにおける使用
JP2010522769A (ja) * 2007-03-28 2010-07-08 プレジデント アンド フェロウズ オブ ハーバード カレッジ ステッチングされたポリペプチド
JP2012532929A (ja) * 2009-07-13 2012-12-20 プレジデント アンド フェロウズ オブ ハーバード カレッジ 二機能性のステープリングされたポリペプチドおよびそれらの使用
US20130177979A1 (en) * 2010-06-22 2013-07-11 University Of Central Florida Research Foundation, Inc. Methods and compositions for cell permeable stat3 inhibitor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1282722B1 (en) * 1999-10-15 2011-06-15 Avatar Medical, L.L.C. Stabilized proteins
WO2005044839A2 (en) * 2003-11-05 2005-05-19 Dana-Farber Cancer Institute, Inc. Stabilized alpha helical peptides and uses thereof
WO2006069001A2 (en) * 2004-12-20 2006-06-29 Baylor College Of Medicine Structural requirements for stat3 binding and recruitment to phosphototyrosine ligands
WO2010011313A2 (en) * 2008-07-23 2010-01-28 President And Fellows Of Harvard College Ligation of stapled polypeptides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008500260A (ja) * 2003-11-15 2008-01-10 ポリファー リミテッド テンプレート固定β−ヘアピンループ模倣体とそのファージディスプレイにおける使用
WO2005118620A2 (en) * 2004-05-27 2005-12-15 New York University Methods for preparing internally constraied peptides and peptidomimetics
JP2010522769A (ja) * 2007-03-28 2010-07-08 プレジデント アンド フェロウズ オブ ハーバード カレッジ ステッチングされたポリペプチド
JP2012532929A (ja) * 2009-07-13 2012-12-20 プレジデント アンド フェロウズ オブ ハーバード カレッジ 二機能性のステープリングされたポリペプチドおよびそれらの使用
US20130177979A1 (en) * 2010-06-22 2013-07-11 University Of Central Florida Research Foundation, Inc. Methods and compositions for cell permeable stat3 inhibitor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FEBS JOURNAL, vol. 279, JPN6018033421, 2012, pages 1495 - 1504, ISSN: 0004082446 *
NATURE, vol. 394, JPN6019028604, 1998, pages 145 - 151, ISSN: 0004241557 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2022092295A1 (OSRAM) * 2020-10-30 2022-05-05
WO2022092295A1 (ja) * 2020-10-30 2022-05-05 Ｘｅｎｏ－Ｉｎｔｅｒｆａｃｅ株式会社 βストランド型架橋ペプチド

Also Published As

Publication number Publication date
US20160244494A1 (en) 2016-08-25
WO2015051030A8 (en) 2015-05-07
EP3052520A4 (en) 2017-12-06
EP3052520A2 (en) 2016-08-10
CN106103472A (zh) 2016-11-09
WO2015051030A3 (en) 2015-06-25
WO2015051030A2 (en) 2015-04-09
IL244810A0 (en) 2016-05-31

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